MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Erythema Chronicum Migrans

(UMLS:C0014740)

Definition:: A deep type of gyrate erythema that follows a bite by an ixodid tick; it is a stage-1 manifestation of LYME DISEASE. The site of the bite is characterized by a red papule that expands peripherally as a nonscaling, palpable band that clears centrally. This condition is often associated with systemic symptoms such as chills, fever, headache, malaise, nausea, vomiting, fatigue, backache, and stiff neck.
UMLS ID:: C0014740
MeSH ID:: D015787

Classification 1:

Name:

Bacterial Infections and Mycoses
MeSH Tree Number(s):: C01.252.400.155.569.200|C01.252.400.825.480.400|C01.252.825.310|C01.252.847.193.569.200|C01.539.800.720.310

Classification 2:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.800.229.200|C17.800.838.765.310

Synonym(s)

Erythema Chronicum Migrans

Borrelia; infection, burgdorferi (erythema chronicum migrans)

Bulls-Eye Rash

ECM - Erythema chronicum migrans

Erythema Migrans

Erythema chronica migrans

Erythema chronicum migrans

Erythema chronicum migrans skin condition

Erythema migrans

10.

annular lesion with erythema chronicum migrans

11.

chronicum migrans; erythema

12.

erythema chronicum migrans

13.

erythema migrans chronicum

14.

erythema migrans due to Lyme disease

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Azithromycin		12708094	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Lyme Neuroborreliosis	49.3%
2	Mycetoma	47.9%
3	Ecthyma	47.5%
4	Erysipelas	45.5%
5	Staphylococcal Skin Infections	45.5%
6	Relapsing Fever	45.1%
7	Hidradenitis Suppurativa	44.8%
8	Erythrasma	43.5%
9	Erythema Induratum	39.9%
10	Leptospirosis	38%
11	Rhinoscleroma	36.8%
12	Impetigo	36.7%
13	Staphylococcal Scalded Skin Syndrome	32.9%
14	Human Ehrlichiosis	30.5%
15	Furunculosis	30.4%
16	furuncle	30.4%
17	Dermatomycoses	29.6%
18	Syphilis	29.4%
19	Central Nervous System Bacterial Infections	29.1%
20	Human anaplasmosis	28.1%
21	Bacteremia	27.5%
22	Japanese Spotted Fever	26.7%
23	carbuncle	26.7%
24	Gram-Positive Bacterial Infections	26%
25	Borrelia Infections	25.3%
26	Bacterial Endocarditis	25.3%
27	Neurosyphilis	25.1%
28	Erythema Chronicum Migrans	24%
29	Chlamydia Infections	23.6%
30	Gonorrhea	23.6%
31	Bordetella Infections	23.3%
32	Brucellosis	23.3%
33	Campylobacter infection	23.3%
34	Enterobacteriaceae Infections	23.3%
35	Pseudomonas Infections	23.3%
36	Q Fever	23.3%
37	Vibrio Infections	23.3%
38	Helicobacter Infections	23.3%
39	Neisseriaceae Infections	23.3%
40	Burkholderia Infections	23.3%
41	Flavobacteriaceae Infections	23.3%
42	Moraxellaceae Infections	23.3%
43	Burkholderia cepacia Infection	23.3%
44	Lyme Disease	23.3%
45	Bacterial Vaginosis	23%
46	Skin Diseases, Bacterial	22.7%
47	Candidiasis, Chronic Mucocutaneous	21.7%
48	Cutaneous Candidiasis	21.7%
49	Erythema Multiforme	21%
50	Pneumonia, Bacterial	20.9%
51	Pyoderma Gangrenosum	20.6%
52	Subacute Bacterial Endocarditis	20.4%
53	Ulcerative stomatitis	19.7%
54	Rocky Mountain Spotted Fever	19.6%
55	Chromoblastomycosis	19.1%
56	Dermatophytosis	19.1%
57	Sporotrichosis	19.1%
58	Tinea	19.1%
59	Tinea Versicolor	19.1%
60	Trichophytosis	19.1%
61	Hyalohyphomycosis	19.1%
62	Cellulitis	19.1%
63	Tinea Capitis	18.9%
64	Onychomycosis	18.9%
65	Pertussis	18.7%
66	Mycoses	18.5%
67	Xeroderma Pigmentosum	18.5%
68	Blastomycosis	18.4%
69	Erythema Infectiosum	17.9%
70	Dermatitis, Atopic	17.2%
71	Epidermolysis Bullosa	17.2%
72	Piedra	16.6%
73	Central Nervous System Infection	16.6%
74	Lymphogranuloma Venereum	16.2%
75	Lupus Erythematosus, Cutaneous	16.1%
76	Panniculitis	16.1%
77	Systemic Scleroderma	16.1%
78	Morphea	16.1%
79	Tinea Pedis	15.7%
80	Syphilis, Congenital	15.6%
81	Erythema Nodosum	15.3%
82	Actinomycetales Infections	15.2%
83	Clostridium Infections	15.2%
84	Listeriosis	15.2%
85	Staphylococcal Infections	15.2%
86	Streptococcal Infections	15.2%
87	Bacillaceae Infections	15.2%
88	Clostridium difficile infection	15.2%
89	Hordeolum	15.2%
90	Acne Vulgaris	15.2%
91	Contact Dermatitis	15.2%
92	Eczema	15.2%
93	Intertrigo	15.2%
94	Neurodermatitis	15.2%
95	Rhinophyma	15.2%
96	Perioral Dermatitis	15.2%
97	Acne	15.2%
98	Bacterial conjunctivitis	15.1%
99	Ophthalmia Neonatorum	15.1%
100	Trachoma	15.1%
101	Sweet Syndrome	15%
102	Gram-Negative Bacterial Infections	14.9%
103	Meningitis, Haemophilus	14.8%
104	Infection	14.8%
105	Acinetobacter Infections	14.7%
106	Bacteroides Infections	14.7%
107	Cholera	14.7%
108	Escherichia coli Infections	14.7%
109	Haemophilus Infections	14.7%
110	Klebsiella Infections	14.7%
111	Meningococcal Infections	14.7%
112	Mycoplasma Infections	14.7%
113	Pasteurella Infections	14.7%
114	Proteus Infections	14.7%
115	Rickettsia Infections	14.7%
116	Salmonella infections	14.7%
117	Scrub Typhus	14.7%
118	Serratia Infections	14.7%
119	Ureaplasma Infections	14.7%
120	Dermatitis, Phototoxic	14.5%
121	Pityriasis Lichenoides et Varioliformis Acuta	14.5%
122	Pityriasis Lichenoides	14.5%
123	Phototoxicity	14.5%
124	Meningitis, Listeria	14.4%
125	Toxic Epidermal Necrolysis	14.2%
126	Stevens-Johnson Syndrome	14.2%
127	Panniculitis, Lupus Erythematosus	14.2%
128	Pelvic Infection	14.1%
129	Wound Infection	14.1%
130	Soft Tissue Infection	14.1%
131	Community-Acquired Infections	14.1%
132	Fusariosis	14%
133	Necrobiosis Lipoidica Diabeticorum	13.9%
134	Erysipelothrix infection	13.9%
135	Dermatitis Herpetiformis	13.8%
136	Skin Diseases, Infectious	13.8%
137	Acrodermatitis	13.7%
138	Sebaceous Gland Neoplasms	13.7%
139	Porokeratosis	13.7%
140	Gianotti-Crosti Syndrome	13.7%
141	Keratoderma, Palmoplantar	13.7%
142	Breast Diseases	13.5%
143	Dermatitis	13.5%
144	Exanthema	13.5%
145	Facial Dermatoses	13.5%
146	Hair Diseases	13.5%
147	Hand Dermatoses	13.5%
148	keratoacanthoma	13.5%
149	Keratosis	13.5%
150	Nail Diseases	13.5%
151	Photosensitivity Disorders	13.5%
152	Prurigo	13.5%
153	Pyoderma	13.5%
154	Rosacea	13.5%
155	Sebaceous Gland Diseases	13.5%
156	Skin Diseases, Vesiculobullous	13.5%
157	Skin Ulcer	13.5%
158	Sweat Gland Diseases	13.5%
159	Skin Diseases, Papulosquamous	13.5%
160	Skin Diseases, Vascular	13.5%
161	Acneiform Eruptions	13.5%
162	Ocular Rosacea	13.5%
163	Subcorneal pustular dermatosis	13.5%
164	Erythematotelangiectatic Rosacea	13.5%
165	Papulopustular Rosacea	13.5%
166	Chronic Actinic Dermatitis	13.5%
167	Dermatitis, Photoallergic	13.2%
168	Dermatomyositis	13.1%
169	Exanthema Subitum	13.1%
170	Foot Ulcer	13%
171	Eye Infection	12.8%
172	Respiratory Tract Infections	12.8%
173	Bone Diseases, Infectious	12.7%
174	Pregnancy Complications, Infectious	12.7%
175	Arthritis, Infectious	12.6%
176	Suppuration	12.6%
177	Xeroderma	12.6%
178	Cross Infection	12.5%
179	Septicemia	12.5%
180	Sepsis	12.5%
181	Pseudoxanthoma Elasticum	12.5%
182	Meningitis, Pneumococcal	12.4%
183	Panophthalmitis	12.4%
184	Foot Diseases	12.3%
185	Meningitis, Bacterial	12.2%
186	Skin Abnormalities	12.1%
187	Skin Neoplasms	12.1%
188	Pigmentation Disorders	12.1%
189	Lipomatosis	12%
190	Pruritus	12%
191	Necrolytic Migratory Erythema	12%
192	Cutaneous Fistula	12%
193	Nephrogenic Fibrosing Dermopathy	12%
194	Nephrogenic Systemic Fibrosis	12%
195	Opportunistic Infections	11.8%
196	Dysentery, Bacillary	11.8%
197	Urticaria Pigmentosa	11.6%
198	Ectodermal Dysplasia	11.5%
199	Aplasia Cutis Congenita	11.5%
200	Joint Tuberculosis	11.4%
201	Tuberculosis, Osteoarticular	11.4%
202	Bone Tuberculosis	11.4%
203	Urinary tract infection	11.4%
204	Fungemia	11.4%
205	Brain Abscess	11.3%
206	Candidemia	11.3%
207	Endotoxemia	11%
208	Mastocytosis	10.8%
209	Dermatitis, Irritant	10.8%
210	Acne Conglobata	10.8%
211	Sexually Transmitted Diseases	10.6%
212	Cutis Laxa	10.5%
213	Psittacosis	10.5%
214	Paratyphoid Fever	10.5%
215	Plague	10.5%
216	Typhoid Fever	10.5%
217	TYPHUS	10.5%
218	Yersinia pseudotuberculosis Infections	10.5%
219	Bubonic Plague	10.5%
220	Ichthyosis, X-Linked	10.4%
221	Sjogren-Larsson Syndrome	10.3%
222	Lupus Erythematosus, Discoid	10.1%
223	Scleroderma, Limited	10.1%
224	Tuberculosis, Meningeal	10.1%
225	Aspergillosis	10%
226	Candidiasis	10%
227	Coccidioidomycosis	10%
228	Histoplasmosis	10%
229	Paracoccidioidomycosis	10%
230	Zygomycosis	10%
231	Phaeohyphomycosis	10%
232	Pneumocystis Infections	10%
233	Dermatitis, Occupational	9.9%
234	Actinomycosis	9.9%
235	Corynebacterium Infections	9.9%
236	Gas Gangrene	9.9%
237	Mycobacterium Infections	9.9%
238	Nocardia Infections	9.9%
239	Pneumococcal Infections	9.9%
240	Scarlet Fever	9.9%
241	Tetanus	9.9%
242	Pulmonary Nocardiosis	9.9%
243	Dermatitis, Allergic Contact	9.7%
244	Papillon-Lefevre Disease	9.7%
245	Hyperkeratosis, Epidermolytic	9.7%
246	Salmonella Infections, Animal	9.6%
247	Neuroaspergillosis	9.4%
248	Salmonella food poisoning	9.4%
249	Behcet Syndrome	9.1%
250	Otomycosis	9%
251	Central Nervous System Fungal Infections	8.9%
252	Diaper Rash	8.6%
253	Anhidrosis	8.5%
254	Cholesteatoma	8.5%
255	Pressure Ulcer	8.5%
256	Folliculitis	8.5%
257	Foot Dermatoses	8.5%
258	Gynecomastia	8.5%
259	Hypertrichosis	8.5%
260	Hypohidrosis	8.5%
261	Hypotrichosis	8.5%
262	Leg Ulcer	8.5%
263	Miliaria	8.5%
264	Parakeratosis	8.5%
265	Parapsoriasis	8.5%
266	Pityriasis	8.5%
267	Psoriasis	8.5%
268	Hidradenitis	8.5%
269	Onycholysis	8.5%
270	Miliaria Rubra	8.5%
271	Hyperpigmentation	8.5%
272	Lichenoid Eruptions	8.5%
273	Chloracne	8.5%
274	Granuloma Annulare	8.5%
275	Albinism	8.4%
276	Lice Infestations	8.3%
277	Lung Diseases, Fungal	8.2%
278	Rheumatic Fever	8%
279	Enterocolitis, Pseudomembranous	7.9%
280	pseudomembranous colitis	7.9%
281	Connective Tissue Diseases	7.9%
282	Waterhouse-Friderichsen Syndrome	7.8%
283	Tuberculosis, Spinal	7.8%
284	Invasive Pulmonary Aspergillosis	7.8%
285	Acantholysis	7.7%
286	Breast Cyst	7.7%
287	Actinic keratosis	7.7%
288	Pemphigoid, Benign Mucous Membrane	7.7%
289	Pemphigus	7.7%
290	Sunburn	7.7%
291	Argyria	7.6%
292	Hirsutism	7.6%
293	Lactation Disorder	7.6%
294	Mastitis	7.6%
295	Urticaria	7.6%
296	Adiposis Dolorosa	7.6%
297	Pruritus Vulvae	7.6%
298	Mastocytoma	7.6%
299	Pruritus Ani	7.6%
300	Larva Migrans	7.5%
301	Leishmaniasis	7.5%
302	Molluscum Contagiosum	7.5%
303	Onchocerciasis	7.5%
304	Endophthalmitis	7.5%
305	Peritonitis	7.5%
306	Osteomyelitis	7.4%
307	Periostitis	7.4%
308	Surgical Wound Infection	7.4%
309	Abscess	7.4%
310	Adnexitis	7.4%
311	Empyema	7.4%
312	Pelvic Inflammatory Disease	7.4%
313	Botulism	7.3%
314	Diphtheria	7.3%
315	Leprosy	7.3%
316	Mycobacterium Infections, Nontuberculous	7.3%
317	Tuberculosis	7.3%
318	Mycobacterium abscessus Infection	7.3%
319	Meningitis, Cryptococcal	7.1%
320	Mucocutaneous Lymph Node Syndrome	6.9%
321	Warts	6.9%
322	Drug Eruptions	6.9%
323	Lipodystrophy	6.9%
324	Livedo Reticularis	6.9%
325	Malignant Atrophic Papulosis	6.9%
326	Polyarteritis Nodosa	6.8%
327	Takayasu Arteritis	6.8%
328	Superinfection	6.8%
329	Corneal Ulcer	6.7%
330	Puerperal Infection	6.7%
331	Spondylitis	6.7%
332	Appendicitis	6.7%
333	Bacteriuria	6.7%
334	Pyuria	6.7%
335	Pyomyositis	6.7%
336	Endotoxic shock	6.6%
337	Septic Shock	6.6%
338	Toxic Shock Syndrome	6.6%
339	Rheumatic Heart Disease	6.5%
340	Lemierre Syndrome	6.5%
341	Nail-Patella Syndrome	6.3%
342	Porphyrias, Hepatic	6.3%
343	Lichen Planus	6.1%
344	Melanosis	6.1%
345	Chloasma	6.1%
346	Pityriasis Rosea	6.1%
347	Pityriasis Rubra Pilaris	6.1%
348	Vitiligo	6.1%
349	Lichen Nitidus	6.1%
350	Arthritis, Reactive	6%
351	Mycobacterium avium-intracellulare Infection	5.9%
352	Lymph Node Tuberculosis	5.9%
353	Tuberculosis, Miliary	5.9%
354	Tuberculosis, Multidrug-Resistant	5.9%
355	Leprosy, Multibacillary	5.9%
356	Latent Tuberculosis	5.9%
357	Mucormycosis	5.9%
358	Leishmaniasis, Cutaneous	5.8%
359	Eczema Herpeticum	5.8%
360	Toxoplasmosis, Cerebral	5.7%
361	AIDS-Related Opportunistic Infections	5.6%
362	Erythema	5.5%
363	Psoas Abscess	5.5%
364	Abdominal Abscess	5.5%
365	Alopecia	5.4%
366	Sweating, Gustatory	5.4%
367	Androgenetic Alopecia	5.4%
368	Auriculotemporal Syndrome	5.4%
369	Varicose Ulcer	5.4%
370	Breast Neoplasms, Male	5.4%
371	Triple Negative Breast Neoplasms	5.4%
372	Galactorrhea	5.4%
373	Tuberculosis, Gastrointestinal	5.3%
374	Epidermodysplasia Verruciformis	5.3%
375	Herpes Labialis	5.3%
376	Borderline leprosy	5.3%
377	Leprosy, Lepromatous	5.3%
378	Tuberculoid leprosy	5.3%
379	Extensively Drug-Resistant Tuberculosis	5.3%
380	Oral candidiasis	5.3%
381	Tuberculosis, Central Nervous System	5.3%
382	Pulmonary Aspergillosis	5.2%
383	Bronchopulmonary Aspergillosis	5.2%
384	CREST Syndrome	5%
385	Angioedema	4.9%
386	Condylomata Acuminata	4.9%
387	Giant Cell Arteritis	4.9%
388	Temporal Arteritis	4.9%
389	Tuberculosis, Pulmonary	4.8%
390	Diverticulitis	4.8%
391	Acute Generalized Exanthematous Pustulosis	4.8%
392	Acanthosis Nigricans	4.8%
393	Alopecia Areata	4.8%
394	Lentigo	4.8%
395	Meningitis, Fungal	4.7%
396	Candidiasis, Vulvovaginal	4.7%
397	Collagen Diseases	4.5%
398	Mixed Connective Tissue Disease	4.5%
399	Mucinoses	4.5%
400	Lung Abscess	4.4%
401	Serum Sickness	4.4%
402	Variegate Porphyria	4.4%
403	Acute intermittent porphyria	4.4%
404	Porphyria Cutanea Tarda	4.4%
405	Carcinoma, Lobular	4.4%
406	Diverticulum	4.4%
407	Diverticulosis	4.4%
408	Arthritis, Psoriatic	4.4%
409	Discitis	4.4%
410	Mastoiditis	4.4%
411	Petrositis	4.4%
412	Lichen Planus, Oral	4.3%
413	Cartilage Diseases	4.1%
414	Rheumatism	4.1%
415	Chondromalacia	4.1%
416	Lupus Erythematosus, Systemic	4%
417	Overlap syndrome	4%
418	Retropharyngeal Abscess	4%
419	Menkes Kinky Hair Syndrome	4%
420	Epidural Abscess	4%
421	Peritonsillar Abscess	4%
422	Bacterial Infections	3.7%
423	HIV-Associated Lipodystrophy Syndrome	3.7%
424	Liver Abscess	3.6%
425	Dupuytren Contracture	3.6%
426	Tuberculosis, Renal	3.6%
427	Angioedemas, Hereditary	3.6%
428	Diabetic Foot	3.5%
429	Hereditary Angioedema Type III	3.4%
430	Hereditary Angioedema Types I and II	3.4%
431	Peutz-Jeghers Syndrome	3.1%
432	Scleromyxedema	2.8%
433	Noonan Syndrome	2.8%
434	Marfan Syndrome	2.6%
435	Aspergillosis, Allergic Bronchopulmonary	2.6%
436	Mesenteric Panniculitis	2.6%
437	Panniculitis, Peritoneal	2.6%
438	Tietze's Syndrome	2.6%
439	Orbital Cellulitis	2.6%
440	Myxoid cyst	2.6%
441	Homocystinuria	2.5%
442	Myxedema	2.5%
443	Osteochondritis	2.3%
444	Polymyalgia Rheumatica	2.3%
445	Osteogenesis Imperfecta	2.3%
446	Keloid	2.3%
447	Liver Abscess, Amebic	2.3%
448	Rheumatoid Arthritis	2.1%
449	Juvenile arthritis	2.1%
450	Lupus Nephritis	2.1%
451	Laryngomalacia	1.9%
452	Pectus carinatum	1.9%
453	Rheumatoid Nodule	1.6%
454	Felty Syndrome	1.5%
455	Bronchomalacia	1.5%
456	Tracheomalacia	1.5%
457	Rheumatoid Vasculitis	1.4%
458	Mucopolysaccharidosis III	1.3%
459	Lupus Vasculitis, Central Nervous System	1.3%
460	Sicca Syndrome	1.3%
461	Sjogren's Syndrome	1.3%
462	Mucopolysaccharidosis II	1.1%

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