MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

keratoacanthoma

(UMLS:C0022572)

Definition:: A benign, non-neoplastic, usually self-limiting epithelial lesion closely resembling squamous cell carcinoma clinically and histopathologically. It occurs in solitary, multiple, and eruptive forms. The solitary and multiple forms occur on sunlight exposed areas and are identical histologically; they affect primarily white males. The eruptive form usually involves both sexes and appears as a generalized papular eruption.
UMLS ID:: C0022572
MeSH ID:: D007636

Classification:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.800.417

Synonym(s)

keratoacanthoma

KA - Keratoacanthoma

Keratoacanthoma

Keratoacanthoma, NOS

Molluscum sebaceum

keratoacanthomas

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Vemurafenib	FAERS: 60 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
2	Sorafenib	FAERS: 20		OFFSIDES SIDER US FAERS
3	Simvastatin	FAERS: 6		US FAERS
4	dabrafenib	FAERS: 5 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
5	apremilast	FAERS: 4		US FAERS
6	3-ingenyl angelate	FAERS: 2		US FAERS
7	HhAntag691	FAERS: 2		US FAERS
8	Imatinib Mesylate	FAERS: 2		US FAERS
9	Leflunomide	FAERS: 2		US FAERS
10	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	FAERS: 1		US FAERS
11	Dimethyl Fumarate	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
12	Fingolimod Hydrochloride	FAERS: 1		US FAERS
13	Fluorouracil	FAERS: 1		US FAERS
14	Hydroxyurea	FAERS: 1		US FAERS
15	Ibandronic Acid	FAERS: 1		US FAERS
16	Imiquimod	FAERS: 1		US FAERS
17	Isotretinoin	FAERS: 1		US FAERS
18	Lenalidomide	FAERS: 1		OFFSIDES US FAERS
19	Methotrexate	FAERS: 1		US FAERS
20	Octreotide	FAERS: 1		US FAERS
21	Ruxolitinib phosphate	FAERS: 1		US FAERS
22	Tacrolimus	FAERS: 1		US FAERS
23	Temozolomide	FAERS: 1		US FAERS
24	Terbinafine	FAERS: 1		US FAERS
25	Teriparatide	FAERS: 1		US FAERS
26	apixaban	FAERS: 1		US FAERS
27	midostaurin	FAERS: 1		US FAERS
28	ponatinib	FAERS: 1		US FAERS
29	tofacitinib	FAERS: 1		US FAERS
30	5-[[4-[2-(5-Ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione;hydron;chloride			OFFSIDES
31	Cyclosporine	Canada Vigilance: 1		Canada Vigilance
32	Diphenoxylate			OFFSIDES
33	Dutasteride			OFFSIDES
34	GW0742		19748995	CTD
35	Hydralazine			OFFSIDES
36	Nabumetone			OFFSIDES
37	Nortriptyline			OFFSIDES
38	Pamidronate			OFFSIDES
39	Spironolactone			OFFSIDES
40	Sulfamethoxazole			OFFSIDES
41	Vitamin A			OFFSIDES
42	calcipotriene			OFFSIDES
43	estragole-2',3'-oxide		6825084	CTD
44	gadoversetamide			OFFSIDES
45	mancozeb		2208079	CTD
46	proxigermanium			SIDER
47	regorafenib			SIDER
48	rofecoxib			OFFSIDES
49	safrole oxide		6825084	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Pyoderma Gangrenosum	45.8%
2	Breast Diseases	42.9%
3	Dermatitis	42.9%
4	Exanthema	42.9%
5	Facial Dermatoses	42.9%
6	Hair Diseases	42.9%
7	Hand Dermatoses	42.9%
8	Keratosis	42.9%
9	Nail Diseases	42.9%
10	Photosensitivity Disorders	42.9%
11	Prurigo	42.9%
12	Pyoderma	42.9%
13	Rosacea	42.9%
14	Sebaceous Gland Diseases	42.9%
15	Skin Diseases, Vesiculobullous	42.9%
16	Skin Ulcer	42.9%
17	Sweat Gland Diseases	42.9%
18	Skin Diseases, Papulosquamous	42.9%
19	Skin Diseases, Vascular	42.9%
20	Acneiform Eruptions	42.9%
21	Ocular Rosacea	42.9%
22	Subcorneal pustular dermatosis	42.9%
23	Erythematotelangiectatic Rosacea	42.9%
24	Papulopustular Rosacea	42.9%
25	Chronic Actinic Dermatitis	42.9%
26	Acne Vulgaris	40.9%
27	Contact Dermatitis	40.9%
28	Eczema	40.9%
29	Erythema Multiforme	40.9%
30	Intertrigo	40.9%
31	Neurodermatitis	40.9%
32	Rhinophyma	40.9%
33	Perioral Dermatitis	40.9%
34	Acne	40.9%
35	Lupus Erythematosus, Cutaneous	38.1%
36	Panniculitis	38.1%
37	Systemic Scleroderma	38.1%
38	Morphea	38.1%
39	Dermatitis, Phototoxic	37.2%
40	Pityriasis Lichenoides et Varioliformis Acuta	37.2%
41	Pityriasis Lichenoides	37.2%
42	Phototoxicity	37.2%
43	Foot Ulcer	37.1%
44	Dermatitis, Irritant	33.3%
45	Acne Conglobata	33.3%
46	Anhidrosis	31%
47	Cholesteatoma	31%
48	Pressure Ulcer	31%
49	Dermatitis Herpetiformis	31%
50	Folliculitis	31%
51	Foot Dermatoses	31%
52	Gynecomastia	31%
53	Hypertrichosis	31%
54	Hypohidrosis	31%
55	Hypotrichosis	31%
56	Leg Ulcer	31%
57	Miliaria	31%
58	Parakeratosis	31%
59	Parapsoriasis	31%
60	Pityriasis	31%
61	Psoriasis	31%
62	Sweet Syndrome	31%
63	Hidradenitis	31%
64	Onycholysis	31%
65	Miliaria Rubra	31%
66	Hyperpigmentation	31%
67	Lichenoid Eruptions	31%
68	Chloracne	31%
69	Acrodermatitis	30.5%
70	Sebaceous Gland Neoplasms	30.5%
71	Porokeratosis	30.5%
72	Gianotti-Crosti Syndrome	30.5%
73	Keratoderma, Palmoplantar	30.5%
74	Dermatitis, Atopic	30.3%
75	Epidermolysis Bullosa	30.3%
76	Foot Diseases	30%
77	Diaper Rash	29.7%
78	Dermatitis, Photoallergic	29.6%
79	Panniculitis, Lupus Erythematosus	29.3%
80	Skin Abnormalities	28.6%
81	Skin Diseases, Infectious	28.6%
82	Skin Neoplasms	28.6%
83	Pigmentation Disorders	28.6%
84	Lipomatosis	27.9%
85	Pruritus	27.9%
86	Erythema	27.9%
87	Necrolytic Migratory Erythema	27.9%
88	Cutaneous Fistula	27.9%
89	Nephrogenic Fibrosing Dermopathy	27.9%
90	Nephrogenic Systemic Fibrosis	27.9%
91	Necrobiosis Lipoidica Diabeticorum	27.5%
92	Urticaria Pigmentosa	27.3%
93	Lupus Erythematosus, Discoid	27.3%
94	Scleroderma, Limited	27.3%
95	Xeroderma Pigmentosum	27.1%
96	Dermatitis, Occupational	26.3%
97	Lichen Planus	25.4%
98	Melanosis	25.4%
99	Chloasma	25.4%
100	Pityriasis Rosea	25.4%
101	Pityriasis Rubra Pilaris	25.4%
102	Vitiligo	25.4%
103	Lichen Nitidus	25.4%
104	Dermatitis, Allergic Contact	25%
105	Papillon-Lefevre Disease	24.8%
106	Xeroderma	24.7%
107	Connective Tissue Diseases	23.1%
108	Erythema Induratum	22.8%
109	Acanthosis Nigricans	22.7%
110	Alopecia Areata	22.7%
111	Lentigo	22.7%
112	Erythema Infectiosum	22.4%
113	Cutis Laxa	22.4%
114	Exanthema Subitum	22.3%
115	Erythema Nodosum	21.9%
116	Dermatomyositis	21.8%
117	Toxic Epidermal Necrolysis	21.1%
118	Stevens-Johnson Syndrome	21.1%
119	Acantholysis	20.9%
120	Breast Cyst	20.9%
121	Actinic keratosis	20.9%
122	Pemphigoid, Benign Mucous Membrane	20.9%
123	Pemphigus	20.9%
124	Piedra	20.9%
125	Sunburn	20.9%
126	Tinea Capitis	20.7%
127	Onychomycosis	20.7%
128	Mastocytosis	20.5%
129	Argyria	20.5%
130	Hirsutism	20.5%
131	Lactation Disorder	20.5%
132	Mastitis	20.5%
133	Urticaria	20.5%
134	Adiposis Dolorosa	20.2%
135	Ectodermal Dysplasia	20.2%
136	Pruritus Vulvae	20.2%
137	Aplasia Cutis Congenita	20.2%
138	Mastocytoma	20.1%
139	Pruritus Ani	20.1%
140	Hyperkeratosis, Epidermolytic	19.5%
141	Granuloma Annulare	19.3%
142	Pseudoxanthoma Elasticum	18.6%
143	Ecthyma	18.2%
144	Alopecia	17.2%
145	Sweating, Gustatory	17.2%
146	Androgenetic Alopecia	17.2%
147	Auriculotemporal Syndrome	17.2%
148	Lice Infestations	16.9%
149	Varicose Ulcer	16.9%
150	Breast Neoplasms, Male	16.9%
151	Triple Negative Breast Neoplasms	16.9%
152	Galactorrhea	16.7%
153	Hidradenitis Suppurativa	16.6%
154	Ichthyosis, X-Linked	15.8%
155	Behcet Syndrome	15.8%
156	Sjogren-Larsson Syndrome	15.7%
157	Dermatomycoses	15.5%
158	Mucocutaneous Lymph Node Syndrome	15.5%
159	Skin Diseases, Bacterial	15.5%
160	Tinea Pedis	15.5%
161	Lichen Planus, Oral	15.4%
162	Drug Eruptions	15.3%
163	Lipodystrophy	15.3%
164	Livedo Reticularis	15.3%
165	Malignant Atrophic Papulosis	15.3%
166	Polyarteritis Nodosa	15%
167	Takayasu Arteritis	15%
168	Collagen Diseases	14.3%
169	Mixed Connective Tissue Disease	14.3%
170	Mucinoses	14.3%
171	Albinism	13.8%
172	Erythema Chronicum Migrans	13.5%
173	Larva Migrans	12.8%
174	Leishmaniasis	12.8%
175	Molluscum Contagiosum	12.8%
176	Angioedema	12.7%
177	Onchocerciasis	12.6%
178	Chromoblastomycosis	12.5%
179	Dermatophytosis	12.5%
180	Nail-Patella Syndrome	12.5%
181	Sporotrichosis	12.5%
182	Tinea	12.5%
183	Tinea Versicolor	12.5%
184	Trichophytosis	12.5%
185	Hyalohyphomycosis	12.5%
186	Acute Generalized Exanthematous Pustulosis	12.4%
187	Porphyrias, Hepatic	12.3%
188	Mycetoma	12.3%
189	Leishmaniasis, Cutaneous	11.2%
190	Eczema Herpeticum	11.2%
191	Fusariosis	11.1%
192	Hereditary Angioedema Type III	10.4%
193	Hereditary Angioedema Types I and II	10.4%
194	Scleromyxedema	10.3%
195	Warts	10.3%
196	Candidiasis, Chronic Mucocutaneous	10%
197	Cutaneous Candidiasis	10%
198	Cartilage Diseases	10%
199	Rheumatism	10%
200	Chondromalacia	10%
201	Erysipelas	9.9%
202	Serum Sickness	9.9%
203	Staphylococcal Skin Infections	9.9%
204	Variegate Porphyria	9.9%
205	Acute intermittent porphyria	9.9%
206	Porphyria Cutanea Tarda	9.9%
207	Erythrasma	9.9%
208	Carcinoma, Lobular	9.9%
209	Arthritis, Psoriatic	9.9%
210	Lupus Erythematosus, Systemic	9.5%
211	Overlap syndrome	9.5%
212	CREST Syndrome	9.4%
213	Angioedemas, Hereditary	9.1%
214	Epidermodysplasia Verruciformis	9%
215	Herpes Labialis	9%
216	Diabetic Foot	8.9%
217	Staphylococcal Scalded Skin Syndrome	8.8%
218	Peutz-Jeghers Syndrome	8.6%
219	carbuncle	8.2%
220	Condylomata Acuminata	7.5%
221	Furunculosis	7.4%
222	furuncle	7.4%
223	Giant Cell Arteritis	7.4%
224	Temporal Arteritis	7.4%
225	Impetigo	7.3%
226	Blastomycosis	7.1%
227	HIV-Associated Lipodystrophy Syndrome	7%
228	Mesenteric Panniculitis	7%
229	Panniculitis, Peritoneal	7%
230	Tietze's Syndrome	7%
231	Orbital Cellulitis	7%
232	Myxoid cyst	7%
233	Myxedema	6.8%
234	Dupuytren Contracture	6.8%
235	Rhinoscleroma	6.4%
236	Cellulitis	5.4%
237	Menkes Kinky Hair Syndrome	5.3%
238	Osteochondritis	5.3%
239	Polymyalgia Rheumatica	5.3%
240	Osteogenesis Imperfecta	5.1%
241	Keloid	5%
242	Rheumatoid Arthritis	4.2%
243	Rheumatoid Nodule	4.2%
244	Juvenile arthritis	4.2%
245	Lupus Nephritis	4%
246	Noonan Syndrome	3.8%
247	Laryngomalacia	3.5%
248	Pectus carinatum	3.4%
249	Marfan Syndrome	3.4%
250	Felty Syndrome	3.3%
251	Bronchomalacia	3.3%
252	Tracheomalacia	3.3%
253	Homocystinuria	3.3%
254	Rheumatoid Vasculitis	2.8%
255	Mucopolysaccharidosis III	2.7%
256	Sicca Syndrome	2.4%
257	Sjogren's Syndrome	2.4%
258	Mucopolysaccharidosis II	1.8%
259	Lupus Vasculitis, Central Nervous System	1.6%

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