MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Dermatitis Herpetiformis

(UMLS:C0011608)

Definition:: Rare, chronic, papulo-vesicular disease characterized by an intensely pruritic eruption consisting of various combinations of symmetrical, erythematous, papular, vesicular, or bullous lesions. The disease is strongly associated with the presence of HLA-B8 and HLA-DR3 antigens. A variety of different autoantibodies has been detected in small numbers in patients with dermatitis herpetiformis.
UMLS ID:: C0011608
MeSH ID:: D003874

Classification 1:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.800.174.360|C17.800.865.360

Classification 2:

Name:

Immune System Diseases
MeSH Tree Number(s):: C20.111.318

Synonym(s)

Dermatitis Herpetiformis

DERMATITIS HERPETIFORMIS

DH - Dermatitis herpetiformis

DUHRING DISEASE

Dermatitis herpetiformis

Dermatitis;herpetiformis

Dermatosis herpetiformis

Duhring

Duhring's disease

10.

Duhring-Brocq disease

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Thyroxine	FAERS: 3		US FAERS
2	Clonazepam	FAERS: 2		US FAERS
3	Gabapentin	FAERS: 2		US FAERS
4	Ibuprofen	FAERS: 2		US FAERS
5	Lisinopril	FAERS: 2		US FAERS
6	Pantoprazole	FAERS: 2		US FAERS
7	gadodiamide	FAERS: 2 Canada Vigilance: 1		Canada Vigilance US FAERS
8	tofacitinib	FAERS: 2		US FAERS
9	zafirlukast	FAERS: 2		US FAERS
10	Acetaminophen	FAERS: 1		US FAERS
11	Atorvastatin	FAERS: 1		US FAERS
12	Buspirone	FAERS: 1		US FAERS
13	Calcitriol	FAERS: 1		US FAERS
14	Celecoxib	FAERS: 1		US FAERS
15	Clozapine	FAERS: 1		US FAERS
16	Dapsone	FAERS: 1	View details 188385 1732379 1944718 2266352 2510873 2836133 3013789 4342845 4369028 6322702 7888363 10971353	CTD US FAERS
17	Desvenlafaxine Succinate	FAERS: 1		US FAERS
18	Doxazosin	FAERS: 1		US FAERS
19	Doxycycline	FAERS: 1		US FAERS
20	Duloxetine Hydrochloride	FAERS: 1		US FAERS
21	Estradiol	FAERS: 1		US FAERS
22	Fenofibrate	FAERS: 1		US FAERS
23	Glatiramer Acetate	FAERS: 1		US FAERS
24	Hydroxychloroquine	FAERS: 1		US FAERS
25	Jalyn	FAERS: 1		US FAERS
26	Levofloxacin	FAERS: 1		US FAERS
27	Loratadine and pseudoephedrine sulfate	FAERS: 1		US FAERS
28	Metoprolol	FAERS: 1		US FAERS
29	Naproxen	FAERS: 1		US FAERS
30	Nitroglycerin	FAERS: 1		US FAERS
31	Omeprazole	FAERS: 1		US FAERS
32	Pantoprazole	FAERS: 1		US FAERS
33	Propafenone	FAERS: 1		US FAERS
34	Ramipril	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
35	Thyroxine	FAERS: 1		US FAERS
36	Valacyclovir	FAERS: 1		US FAERS
37	Vemurafenib	FAERS: 1		US FAERS
38	Venlafaxine Hydrochloride	FAERS: 1		US FAERS
39	anagrelide	FAERS: 1		US FAERS
40	argatroban	FAERS: 1		US FAERS
41	mirabegron	FAERS: 1		US FAERS
42	posaconazole	FAERS: 1		US FAERS

Similar ADE(s)

	Name	Semantic Similarity
1	Pemphigus	43.8%
2	Contact Dermatitis	43.2%
3	Eczema	43.2%
4	Erythema Multiforme	43.2%
5	Intertrigo	43.2%
6	Neurodermatitis	43.2%
7	Perioral Dermatitis	43.2%
8	Pyoderma Gangrenosum	40.4%
9	Dermatitis, Atopic	39.5%
10	Epidermolysis Bullosa	37%
11	Acrodermatitis	36%
12	Gianotti-Crosti Syndrome	36%
13	Dermatitis, Phototoxic	35.4%
14	Phototoxicity	35.4%
15	Lupus Erythematosus, Cutaneous	33.3%
16	Panniculitis	33.3%
17	Systemic Scleroderma	33.3%
18	Morphea	33.3%
19	Dermatitis, Photoallergic	32.5%
20	Acne Vulgaris	32.4%
21	Rhinophyma	32.4%
22	Acne	32.4%
23	Dermatitis, Irritant	32%
24	Breast Diseases	31%
25	Exanthema	31%
26	Facial Dermatoses	31%
27	Hair Diseases	31%
28	Hand Dermatoses	31%
29	keratoacanthoma	31%
30	Keratosis	31%
31	Nail Diseases	31%
32	Photosensitivity Disorders	31%
33	Prurigo	31%
34	Pyoderma	31%
35	Rosacea	31%
36	Sebaceous Gland Diseases	31%
37	Skin Ulcer	31%
38	Sweat Gland Diseases	31%
39	Skin Diseases, Papulosquamous	31%
40	Skin Diseases, Vascular	31%
41	Acneiform Eruptions	31%
42	Ocular Rosacea	31%
43	Erythematotelangiectatic Rosacea	31%
44	Papulopustular Rosacea	31%
45	Chronic Actinic Dermatitis	31%
46	Toxic Epidermal Necrolysis	30.4%
47	Stevens-Johnson Syndrome	30.4%
48	Dermatitis, Allergic Contact	30%
49	Pityriasis Lichenoides et Varioliformis Acuta	29.8%
50	Pityriasis Lichenoides	29.8%
51	Xeroderma Pigmentosum	29.4%
52	Foot Ulcer	28.2%
53	Erythema Nodosum	28%
54	Dermatitis, Occupational	27.6%
55	Acantholysis	27.4%
56	Pemphigoid, Benign Mucous Membrane	27.4%
57	Sebaceous Gland Neoplasms	27%
58	Porokeratosis	27%
59	Keratoderma, Palmoplantar	27%
60	Panniculitis, Lupus Erythematosus	26.7%
61	Diaper Rash	26.5%
62	Drug Eruptions	25.8%
63	Necrobiosis Lipoidica Diabeticorum	25.8%
64	Foot Diseases	25.7%
65	Lupus Erythematosus, Systemic	25%
66	Skin Abnormalities	25%
67	Skin Diseases, Infectious	25%
68	Skin Neoplasms	25%
69	Overlap syndrome	25%
70	Pigmentation Disorders	25%
71	Lipomatosis	24.7%
72	Pruritus	24.7%
73	Erythema	24.7%
74	Necrolytic Migratory Erythema	24.7%
75	Cutaneous Fistula	24.7%
76	Nephrogenic Fibrosing Dermopathy	24.7%
77	Nephrogenic Systemic Fibrosis	24.7%
78	Acne Conglobata	24%
79	Mastocytosis	23.7%
80	Erythema Induratum	23.4%
81	Xeroderma	23.3%
82	Dermatomyositis	23.2%
83	Urticaria Pigmentosa	23.2%
84	Lupus Erythematosus, Discoid	21.6%
85	Scleroderma, Limited	21.6%
86	Antiphospholipid Syndrome	20.7%
87	Cutis Laxa	20.5%
88	Anhidrosis	20.3%
89	Cholesteatoma	20.3%
90	Pressure Ulcer	20.3%
91	Folliculitis	20.3%
92	Foot Dermatoses	20.3%
93	Gynecomastia	20.3%
94	Hypertrichosis	20.3%
95	Hypohidrosis	20.3%
96	Hypotrichosis	20.3%
97	Leg Ulcer	20.3%
98	Miliaria	20.3%
99	Parakeratosis	20.3%
100	Parapsoriasis	20.3%
101	Pityriasis	20.3%
102	Psoriasis	20.3%
103	Sweet Syndrome	20.3%
104	Hidradenitis	20.3%
105	Onycholysis	20.3%
106	Miliaria Rubra	20.3%
107	Hyperpigmentation	20.3%
108	Lichenoid Eruptions	20.3%
109	Chloracne	20.3%
110	Erythema Infectiosum	20.3%
111	Urticaria	20.3%
112	Pseudoxanthoma Elasticum	20.2%
113	Exanthema Subitum	20.2%
114	Ectodermal Dysplasia	20.2%
115	Aplasia Cutis Congenita	20.2%
116	Papillon-Lefevre Disease	19.9%
117	Serum Sickness	19.4%
118	Acute Generalized Exanthematous Pustulosis	19.3%
119	Tinea Capitis	18.4%
120	Onychomycosis	18.4%
121	Connective Tissue Diseases	17.9%
122	Ecthyma	17.4%
123	Hyperkeratosis, Epidermolytic	17.4%
124	Granuloma Annulare	16.8%
125	Ichthyosis, X-Linked	16.5%
126	Addison Disease	16.4%
127	Breast Cyst	16.4%
128	Actinic keratosis	16.4%
129	Piedra	16.4%
130	Sjogren-Larsson Syndrome	16.4%
131	Sunburn	16.4%
132	Autoimmune thyroiditis	16.4%
133	Primary Adrenal Insufficiency	16.4%
134	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	16.3%
135	Autoimmune hepatitis	16.3%
136	Argyria	16.2%
137	Hirsutism	16.2%
138	Lactation Disorder	16.2%
139	Mastitis	16.2%
140	Adiposis Dolorosa	16.1%
141	Pruritus Vulvae	16.1%
142	Mastocytoma	16.1%
143	Pruritus Ani	16.1%
144	Rheumatoid Arthritis	15.7%
145	Juvenile arthritis	15.7%
146	Behcet Syndrome	15.6%
147	Dermatitis	15.5%
148	Skin Diseases, Vesiculobullous	15.5%
149	Subcorneal pustular dermatosis	15.5%
150	Lichen Planus	15.1%
151	Melanosis	15.1%
152	Chloasma	15.1%
153	Pityriasis Rosea	15.1%
154	Pityriasis Rubra Pilaris	15.1%
155	Vitiligo	15.1%
156	Lichen Nitidus	15.1%
157	Hidradenitis Suppurativa	14.9%
158	Autoimmune Lymphoproliferative Syndrome	14.7%
159	Albinism	14%
160	Erythema Chronicum Migrans	13.8%
161	Latent Autoimmune Diabetes in Adults	13.7%
162	Dermatitis Herpetiformis	13.6%
163	Dermatomycoses	13.6%
164	Mucocutaneous Lymph Node Syndrome	13.6%
165	Skin Diseases, Bacterial	13.6%
166	Tinea Pedis	13.5%
167	Lipodystrophy	13.5%
168	Livedo Reticularis	13.5%
169	Malignant Atrophic Papulosis	13.5%
170	Polyarteritis Nodosa	13.3%
171	Takayasu Arteritis	13.3%
172	Angioedema	12.9%
173	Giant Cell Arteritis	12.9%
174	Temporal Arteritis	12.9%
175	Acanthosis Nigricans	12.6%
176	Alopecia Areata	12.6%
177	Lentigo	12.6%
178	Lupus Nephritis	12.3%
179	Alopecia	12.2%
180	Sweating, Gustatory	12.2%
181	Androgenetic Alopecia	12.2%
182	Auriculotemporal Syndrome	12.2%
183	Lice Infestations	12.1%
184	Varicose Ulcer	12.1%
185	Breast Neoplasms, Male	12.1%
186	Triple Negative Breast Neoplasms	12.1%
187	Galactorrhea	12%
188	Mycetoma	11.9%
189	Nail-Patella Syndrome	11.8%
190	Graves Disease	11.7%
191	Porphyrias, Hepatic	11.7%
192	Anti-Glomerular Basement Membrane Disease	11.5%
193	Felty Syndrome	11.4%
194	Myasthenia Gravis, Autoimmune, Experimental	11%
195	Hypersensitivity	10.7%
196	Immunologic Deficiency Syndromes	10.7%
197	Immunoproliferative Disorders	10.7%
198	Immune reconstitution syndrome	10.7%
199	Immune Reconstitution Inflammatory Syndrome	10.7%
200	Autoimmune thrombocytopenia	10.7%
201	Immune thrombocytopenic purpura	10.7%
202	Collagen Diseases	10.3%
203	Mixed Connective Tissue Disease	10.3%
204	Mucinoses	10.3%
205	Myasthenia Gravis	10.2%
206	Uveomeningoencephalitic Syndrome	10.2%
207	Larva Migrans	10.2%
208	Leishmaniasis	10.2%
209	Molluscum Contagiosum	10.2%
210	Lichen Planus, Oral	10.2%
211	Onchocerciasis	10.1%
212	Granulomatosis with polyangiitis	10%
213	Chromoblastomycosis	10%
214	Dermatophytosis	10%
215	Sporotrichosis	10%
216	Tinea	10%
217	Tinea Versicolor	10%
218	Trichophytosis	10%
219	Hyalohyphomycosis	10%
220	Rheumatoid Vasculitis	10%
221	Hereditary Angioedema Type III	9.7%
222	Hereditary Angioedema Types I and II	9.7%
223	Lupus Vasculitis, Central Nervous System	9.6%
224	Angioedemas, Hereditary	9.3%
225	Sicca Syndrome	8.9%
226	Sjogren's Syndrome	8.9%
227	Stiff-Person Syndrome	8.8%
228	Polyradiculoneuropathy	8.8%
229	Polyradiculoneuritis	8.8%
230	Warts	8.8%
231	CREST Syndrome	8.8%
232	HIV-Associated Lipodystrophy Syndrome	8.8%
233	Candidiasis, Chronic Mucocutaneous	8.6%
234	Cutaneous Candidiasis	8.6%
235	Cartilage Diseases	8.6%
236	Rheumatism	8.6%
237	Chondromalacia	8.6%
238	Transfusion Reaction	8.6%
239	Hypotensive Transfusion Reaction	8.6%
240	Neuromyelitis Optica	8.5%
241	Erysipelas	8.5%
242	Staphylococcal Skin Infections	8.5%
243	Variegate Porphyria	8.5%
244	Acute intermittent porphyria	8.5%
245	Porphyria Cutanea Tarda	8.5%
246	Erythrasma	8.5%
247	Carcinoma, Lobular	8.5%
248	Leukoencephalitis, Acute Hemorrhagic	8.5%
249	Arthritis, Psoriatic	8.5%
250	Multiple Sclerosis	8.4%
251	Leishmaniasis, Cutaneous	8.3%
252	Eczema Herpeticum	8.3%
253	Fusariosis	8.2%
254	Vasculitis, Central Nervous System	7.6%
255	Multiple Sclerosis, Chronic Progressive	7.4%
256	Multiple Sclerosis, Relapsing-Remitting	7.4%
257	Encephalomyelitis, Acute Disseminated	7.1%
258	Epidermodysplasia Verruciformis	7.1%
259	Herpes Labialis	7.1%
260	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	7.1%
261	Neuritis, Autoimmune, Experimental	7.1%
262	Diabetic Foot	7.1%
263	Staphylococcal Scalded Skin Syndrome	7%
264	Immune Complex Diseases	6.9%
265	Latex allergy	6.9%
266	Glomerulonephritis, Membranoproliferative	6.8%
267	Scleromyxedema	6.8%
268	Dupuytren Contracture	6.8%
269	Lambert-Eaton Myasthenic Syndrome	6.7%
270	Blastomycosis	6.7%
271	Peutz-Jeghers Syndrome	6.5%
272	carbuncle	6.3%
273	Condylomata Acuminata	6.2%
274	Guillain-Barre Syndrome	6.2%
275	Furunculosis	6.2%
276	furuncle	6.2%
277	Impetigo	6.1%
278	Rhinoscleroma	6.1%
279	Menkes Kinky Hair Syndrome	6%
280	Cellulitis	5.8%
281	Primary amyloidosis	5.7%
282	Monoclonal Gammopathy of Undetermined Significance	5.7%
283	Environmental Illness	5.7%
284	Lymphoproliferative Disorders	5.6%
285	Mesenteric Panniculitis	5.5%
286	Panniculitis, Peritoneal	5.5%
287	Paraproteinemias	5.5%
288	Tietze's Syndrome	5.5%
289	Orbital Cellulitis	5.5%
290	Myxoid cyst	5.5%
291	Lymphopenia	5.4%
292	Myxedema	5.4%
293	anaphylaxis	5.1%
294	Food Allergy	5.1%
295	Anaphylactic shock	5.1%
296	Thrombocytopenic purpura	5.1%
297	Asthma, Aspirin-Induced	5%
298	Hypergammaglobulinemia	4.6%
299	Osteochondritis	4.6%
300	Polymyalgia Rheumatica	4.6%
301	Agammaglobulinemia	4.5%
302	Kounis Syndrome	4.5%
303	HIV Infections	4.5%
304	Osteogenesis Imperfecta	4.5%
305	Transfusion-Related Acute Lung Injury	4.5%
306	Myelitis, Transverse	4.5%
307	Noonan Syndrome	4.5%
308	Keloid	4.4%
309	Multiple Myeloma	4.4%
310	Respiratory Hypersensitivity	4.2%
311	Milk Allergy	4.2%
312	Schnitzler Syndrome	4.2%
313	Wheat Hypersensitivity	4.2%
314	Sezary Syndrome	4.2%
315	Sick Building Syndrome	4.1%
316	Multiple Chemical Sensitivity	4.1%
317	Marfan Syndrome	4.1%
318	Plasmacytoma	4.1%
319	Tumor Lysis Syndrome	4.1%
320	Vasculitis, Leukocytoclastic, Cutaneous	4.1%
321	Miller Fisher Syndrome	4.1%
322	HTLV-I Infections	4%
323	Job Syndrome	4%
324	Homocystinuria	4%
325	Laryngomalacia	3.4%
326	Pectus carinatum	3.4%
327	Lymphoma	3.4%
328	Chronic granulomatous disease	3.4%
329	Heavy Chain Disease	3.4%
330	Rheumatoid Nodule	3.3%
331	HIV Seropositivity	3.3%
332	Mastocytosis, Systemic	3.3%
333	Kernicterus	3%
334	Acquired Immunodeficiency Syndrome	2.9%
335	AIDS related complex	2.9%
336	Infectious Mononucleosis	2.9%
337	Cryoglobulinemia	2.9%
338	POEMS Syndrome	2.9%
339	Bronchomalacia	2.9%
340	Tracheomalacia	2.9%
341	Hodgkin Disease	2.8%
342	Leukemia, Plasma Cell	2.8%
343	Lymphoma, Non-Hodgkin	2.8%
344	Leukemia, T-Cell	2.8%
345	Leukemia, B-Cell	2.8%
346	Ataxia Telangiectasia	2.7%
347	Hydrops Fetalis	2.7%
348	AIDS-Related Opportunistic Infections	2.5%
349	Asthma, Exercise-Induced	2.5%
350	Status Asthmaticus	2.5%
351	HIV Wasting Syndrome	2.5%
352	AIDS Dementia Complex	2.5%
353	AIDS-Associated Nephropathy	2.5%
354	Lymphoma, Follicular	2.5%
355	T-Cell Lymphoma	2.5%
356	Mantle cell lymphoma	2.5%
357	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	2.5%
358	Leukemia, Large Granular Lymphocytic	2.5%
359	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	2.5%
360	Mucopolysaccharidosis III	2.4%
361	Asthma	2.4%
362	Composite Lymphoma	2.4%
363	Lymphangioleiomyomatosis	2.4%
364	Lymphoma, T-Cell, Cutaneous	2.3%
365	Lymphoma, AIDS-Related	2.3%
366	Enteropathy-Associated T-Cell Lymphoma	2.3%
367	Primary Effusion Lymphoma	2.3%
368	Mycosis Fungoides	2.2%
369	Lymphomatoid Papulosis	2.2%
370	Plasmablastic lymphoma	2.2%
371	Waldenstrom Macroglobulinemia	2.2%
372	Wiskott-Aldrich Syndrome	2.2%
373	Asthma, Occupational	2.2%
374	Farmer's Lung	2.2%
375	Hay fever	2.1%
376	Rhinitis, Allergic, Perennial	2.1%
377	Aspergillosis, Allergic Bronchopulmonary	2.1%
378	Lymphomatoid Granulomatosis	2%
379	Mucopolysaccharidosis II	1.8%
380	Burkitt Lymphoma	1.7%

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