MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Osteosarcoma

(UMLS:C0029463)

Definition:: A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)
UMLS ID:: C0029463
MeSH ID:: D012516

Classification:

Name:

Neoplasms
MeSH Tree Number(s):: C04.557.450.565.575.650|C04.557.450.795.620

Synonym(s)

Osteosarcoma

BONE CANCER, OSTEOGENIC SARCOMA

Bone cell cancer

OSTEOGENIC SARCOMA

OSTEOSARCOMA

OSTEOSARCOMA, MALIGNANT

Osteochondrosarcoma

Osteogenic Sarcoma

Osteogenic sarcoma

10.

Osteogenic sarcoma, NOS

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Teriparatide	FAERS: 11		SIDER US FAERS
2	Sorafenib	FAERS: 3		US FAERS
3	pazopanib	FAERS: 3		US FAERS
4	Methotrexate	FAERS: 2	View details 310278 857581 1838364 2327660 2816647 2877729 2918955 3461742 3465876 3875390 6582805 6584197 6602269 6940649 6971958 7660382 7663031 7682088 7949255 8164455 8269609 8569964 8625136 9122123 9164227 9761357 10194544 10206466 10766557 10774566 10959910 11275465 11410803 11915742 12376811 12533039 12605394 12692801 12721279 14970366 15043115 15139068 15805003 15863997 16140527 16164401 16246977 16912244 17609630 19131789 19159907 19863208 19956493 20155268 20158913 20347613 21301589 21624110 21887680 22016816 23911960 24967384	CTD US FAERS
5	Alendronate	FAERS: 1		US FAERS
6	Clonazepam	FAERS: 1		US FAERS
7	Fingolimod Hydrochloride	FAERS: 1		US FAERS
8	Fluoxetine	FAERS: 1		US FAERS
9	Insulin Glargine	FAERS: 1		US FAERS
10	Methotrexate	FAERS: 1		US FAERS
11	Tenofovir	FAERS: 1		US FAERS
12	Venlafaxine Hydrochloride	FAERS: 1		US FAERS
13	bicalutamide	FAERS: 1		US FAERS
14	regorafenib	FAERS: 1		US FAERS
15	salmon calcitonin	FAERS: 1		US FAERS
16	1-(2-hydroxyethyl)-1-nitrosourea		1987363 3468300 6847770	CTD
17	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one		22326785	CTD
18	6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol		21673434	CTD
19	Alendronate		15049011	CTD
20	Bortezomib		19894220	CTD
21	Cyclophosphamide		View details 857581 2327660 6940649 10206466 11275465 14760101 16453328 22016816	CTD
22	Cyclosporine		7808368	CTD
23	Dactinomycin		11275465	CTD
24	Disulfiram		18047805	CTD
25	Doxorubicin		View details 271071 273467 857581 1576145 1793151 1942931 3162299 3166461 3185363 6940649 7660382 7663031 7682088 7760889 7775232 7808368 7823290 10206466 10398795 10766557 10774566 11410803 14767549 15043115 15930896 16035077 16140527 16246977 16333817 16857723 17389531 17609630 17708400 17762406 20158913 20347613 20543097 21624110 21887680 22016816 23911960	CTD
26	Epirubicin		23845851	CTD
27	Etoposide		View details 7808368 10206466 16912244 20347613	CTD
28	Gallic Acid		22387266	CTD
29	Ifosfamide		View details 7660382 7663031 9761357 9851889 10194544 10766557 10774566 14760101 14767549 15043115 15503294 16246977 16453328 16912244 17389531 19826134 20347613	CTD
30	Irinotecan		24380837	CTD
31	Leucovorin		View details 310278 3461742 3465876 3875390 6582805 6602269 6971958 7949255 8569964 16164401	CTD
32	Melphalan		6940649	CTD
33	Paclitaxel		16140185	CTD
34	Pamidronate		15934617	CTD
35	Platinum		16314621	CTD
36	Radium			SIDER
37	Sunitinib	Canada Vigilance: 1		Canada Vigilance
38	U 0126		22326785	CTD
39	Verapamil		7808368	CTD
40	Vincristine		View details 310278 857581 6940649 22016816	CTD
41	YM 529		22326785	CTD
42	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide		23313376	CTD
43	bisphenol A		23886186	CTD
44	bufalin		23091618	CTD
45	cinobufagin		23164673	CTD
46	mancozeb		12562632	CTD
47	nutlin 3		21624110	CTD
48	pterostilbene		23313376	CTD
49	valspodar		24380837	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Chondrosarcoma	61.8%
2	synovial sarcoma	61.8%
3	Clear Cell Sarcoma of Soft Tissue	61.8%
4	Giant Cell Tumor of Bone	53.4%
5	Fibrosarcoma	52.8%
6	leiomyosarcoma	52.2%
7	liposarcoma	52.2%
8	Alveolar Soft Part Sarcoma	52.2%
9	Malignant Fibrous Histiocytoma	48.3%
10	Carcinosarcoma	46.2%
11	Hemangiosarcoma	46.2%
12	lymphangiosarcoma	46.2%
13	Osteoblastoma	44.1%
14	Osteoma	44.1%
15	Phyllodes Tumor	43.3%
16	Desmoplastic Small Round Cell Tumor	43.3%
17	Sarcoma, Myeloid	41%
18	Dermatofibrosarcoma	39.4%
19	Dermatofibrosarcoma Protuberans	39.4%
20	Angiomyolipoma	39.4%
21	Myxoma	39%
22	Neoplasms, Fibrous Tissue	39%
23	Chondroma	39%
24	Enchondroma	39%
25	Rhabdomyosarcoma	37.5%
26	Sarcoma, Experimental	32.8%
27	Carcinoma 256, Walker	32.4%
28	leukemia	31.5%
29	Neoplasms, Germ Cell and Embryonal	31.5%
30	Neoplasms, Glandular and Epithelial	31.5%
31	Germ Cell Cancer	31.5%
32	Alveolar rhabdomyosarcoma	30.2%
33	Sarcoma 180	28.2%
34	fibroma	27.1%
35	Fibromatosis	27.1%
36	Chondromatosis	27.1%
37	Neuroectodermal Tumors	26.9%
38	Lipoma	26.2%
39	Myoma	26.2%
40	Angiolipoma	26.2%
41	Myelolipoma	26.2%
42	Smooth Muscle Tumor	26.2%
43	Neurofibrosarcoma	25.9%
44	Endometrial Stromal Sarcoma	24.5%
45	Adenofibroma	24.4%
46	Fibroadenoma	24.4%
47	Neoplasms, Neuroepithelial	24.3%
48	Gliomatosis cerebri	24.3%
49	Mastocytosis	24.1%
50	Gastrointestinal Stromal Tumors	23.8%
51	Histiocytic Disorders, Malignant	23.7%
52	Fibromatosis, Aggressive	21.2%
53	Fibromatosis, Abdominal	21.2%
54	Mastocytoma	20.6%
55	Mastocytosis, Systemic	20.4%
56	melanoma	20.3%
57	Hamartoma	20.2%
58	Neoplasms, Hormone-Dependent	20.2%
59	Neoplasms, Multiple Primary	20.2%
60	Paraneoplastic Syndromes	20.2%
61	Precancerous Conditions	20.2%
62	Neoplasms, Second Primary	20.2%
63	Meningioma	19.2%
64	Lymphoma	18.9%
65	Sarcoma	18.9%
66	Lymphangioleiomyomatosis	18.8%
67	Rhabdomyoma	18.6%
68	Composite Lymphoma	17.9%
69	Adenoma	17.8%
70	Ameloblastoma	17.8%
71	Angiokeratoma	17.8%
72	Carcinoma	17.8%
73	Chordoma	17.8%
74	Hemangioma	17.8%
75	hemangiopericytoma	17.8%
76	Lymphangioma	17.8%
77	Mesenchymoma	17.8%
78	Nevus	17.8%
79	Teratoma	17.8%
80	Hepatoblastoma	17.8%
81	Mixed Tumor, Mullerian	17.8%
82	Germinoma	17.8%
83	Teratocarcinoma	17.8%
84	Angiofibroma	17.8%
85	Epithelioma	17.8%
86	Leukemia, Plasma Cell	17.5%
87	Trophoblastic Neoplasms	17.3%
88	Leukemia, Experimental	17.2%
89	Basal cell carcinoma	16.9%
90	Carcinoma, Papillary	16.9%
91	Squamous cell carcinoma	16.9%
92	Craniopharyngioma	16.9%
93	Cystadenoma	16.9%
94	Mesothelioma	16.9%
95	Neuroectodermal Tumor, Melanotic	16.9%
96	Neuroendocrine Tumors	16.9%
97	Carcinoma, Basal Cell	16.9%
98	Osteosarcoma	16.8%
99	Carcinoma, Ehrlich Tumor	16.5%
100	Dermoid Cyst	16.5%
101	Carcinoma, Lewis Lung	16.5%
102	Adenoma, Acidophil	16.3%
103	Ganglioneuroma	16.3%
104	Glioma	16.3%
105	Malignant Glioma	16.3%
106	Medulloblastoma	15.4%
107	Cyst	15.3%
108	Neoplastic Processes	15.3%
109	Neoplastic Syndromes, Hereditary	15.3%
110	Pregnancy Complications, Neoplastic	15.3%
111	Neoplasms, Experimental	15%
112	Neoplasms, Bone Tissue	15%
113	Melanoma, Experimental	14.8%
114	Leukemia, Radiation-Induced	14.5%
115	Cystadenocarcinoma	14.4%
116	Mucoepidermoid Carcinoma	14.4%
117	Carcinoid Tumor	14.3%
118	Neurilemmoma	14.3%
119	Hutchinson's Melanotic Freckle	14.3%
120	Melanoma, Amelanotic	14.3%
121	Plasmacytoma	13.5%
122	Malignant histiocytosis	13.4%
123	Histiocytic sarcoma	13.4%
124	Dupuytren Contracture	13.1%
125	Thymoma	13%
126	Leukemia L1210	13%
127	Leukemia P388	13%
128	Acanthoma	13%
129	Urticaria Pigmentosa	12.9%
130	Choriocarcinoma	12.6%
131	Carcinoma, Lobular	12.6%
132	Astrocytoma	12.4%
133	Ependymoma	12.4%
134	oligodendroglioma	12.4%
135	Ganglioglioma	12.4%
136	gliosarcoma	12.4%
137	Anaplastic astrocytoma	12.4%
138	Anaplastic Oligodendroglioma	12.4%
139	Neoplasms, Radiation-Induced	12%
140	Bowen's Disease	12%
141	Paraganglioma	12%
142	Multiple Endocrine Neoplasia	11.9%
143	Malignant Carcinoid Syndrome	11.4%
144	Adenocarcinoma	11.2%
145	Carcinoma in Situ	11.2%
146	Carcinoma, Transitional Cell	11.2%
147	Dysgerminoma	11.2%
148	Hemangioendothelioma	11.2%
149	Neuroma	11.2%
150	Papilloma	11.2%
151	Pseudomyxoma Peritonei	11.2%
152	Seminoma	11.2%
153	Papillomatosis	11.2%
154	Adenomatosis, Pulmonary	11.2%
155	Adenomatous Polyps	11.2%
156	Carcinoma, Large Cell	11.2%
157	Carcinoma, Small Cell	11.2%
158	Hodgkin Disease	10.7%
159	Lymphoma, Non-Hodgkin	10.7%
160	Retinoblastoma	10.5%
161	Abdominal Neoplasms	10.5%
162	Erythroplasia	10.5%
163	Follicular cyst	10.5%
164	Head and Neck Neoplasms	10.5%
165	Mucocele	10.5%
166	Pilonidal Cyst	10.5%
167	Soft Tissue Neoplasms	10.5%
168	Thoracic Neoplasms	10.5%
169	Thyroglossal Cyst	10.5%
170	Synovial Cyst	10.5%
171	Aberrant Crypt Foci	10.5%
172	Glioblastoma	10.4%
173	Neuroblastoma	10.4%
174	Glioblastoma Multiforme	10.4%
175	Paraneoplastic Encephalomyelitis	10.1%
176	Mammary Neoplasms, Experimental	9.9%
177	Pheochromocytoma	9.5%
178	Ganglioneuroblastoma	9.5%
179	Nephroblastoma	9.3%
180	Lymphomatoid Granulomatosis	9.2%
181	Primary amyloidosis	9%
182	Tuberous Sclerosis	8.7%
183	Carcinoid Heart Disease	8.5%
184	Leukemia, Myelomonocytic, Chronic	8.4%
185	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	8.4%
186	Digestive System Neoplasms	8.3%
187	Endocrine Gland Neoplasms	8.3%
188	Eye Neoplasms	8.3%
189	Nervous System Neoplasms	8.3%
190	Bone neoplasms	8%
191	Leukoplakia	8%
192	Lymphocele	8%
193	Pancreatic Cyst	8%
194	Skin Neoplasms	8%
195	Hematologic Neoplasms	8%
196	Basal Cell Nevus Syndrome	8%
197	Adenoid Cystic Carcinoma	8%
198	Adenocarcinoma, Clear Cell	8%
199	Cholangiocarcinoma	8%
200	Cervical Intraepithelial Neoplasia	8%
201	Hemangioblastoma	8%
202	Lymphoma, Extranodal NK-T-Cell	8%
203	Barrett Esophagus	7.9%
204	Breast Cyst	7.9%
205	Actinic keratosis	7.9%
206	Mediastinal Cyst	7.9%
207	Neoplasm Invasiveness	7.9%
208	Neoplasm Metastasis	7.9%
209	Neoplasm Recurrence, Local	7.9%
210	Parovarian Cyst	7.9%
211	Pericardial Cyst	7.9%
212	Splenic Neoplasms	7.9%
213	Thymic Cyst	7.9%
214	Carcinogenesis	7.9%
215	Myxoid cyst	7.9%
216	Metastasis	7.9%
217	Mesoblastic Nephroma	7.6%
218	Hepatocellular Adenoma	7.6%
219	Carcinoma, Pancreatic Ductal	7.4%
220	Acoustic Neuroma	7.1%
221	Hydatidiform Mole	7%
222	Sturge-Weber Syndrome	6.9%
223	Hemangioma, Cavernous	6.8%
224	Multiple Endocrine Neoplasia Type 1	6.8%
225	Leukemia, T-Cell	6.8%
226	Leukemia, B-Cell	6.8%
227	Waldenstrom Macroglobulinemia	6.7%
228	Multiple Myeloma	6.7%
229	neurofibroma	6.7%
230	Lymphoma, Follicular	6.7%
231	T-Cell Lymphoma	6.7%
232	Mantle cell lymphoma	6.7%
233	Prolactinoma	6.5%
234	Growth Hormone-Secreting Pituitary Adenoma	6.5%
235	Optic Nerve Glioma	6.4%
236	Klatskin Tumor	6.4%
237	Corpus Luteum Cyst	6.2%
238	Ovarian Cysts	6.2%
239	Parathyroid Neoplasms	6.2%
240	Peritoneal Neoplasms	6.2%
241	Thyroid Neoplasm	6.2%
242	Thyroid carcinoma	6.2%
243	Liver Neoplasms, Experimental	6.1%
244	Vipoma	6%
245	Leukemia, Myeloid, Chronic-Phase	6%
246	Retroperitoneal Neoplasms	5.9%
247	granulosa cell tumor	5.6%
248	Carcinoma, Ovarian Epithelial	5.6%
249	Adenomatous Polyposis Coli	5.6%
250	Pancreatic Neoplasm	5.3%
251	Choledochal Cyst	5.3%
252	Peutz-Jeghers Syndrome	5.2%
253	Tracheal Neoplasms	5%
254	insulinoma	5%
255	Leukoplakia, Oral	4.9%
256	Paraneoplastic Cerebellar Degeneration	4.9%
257	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	4.8%
258	Leukemia, Large Granular Lymphocytic	4.8%
259	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	4.8%
260	Lymphoma, T-Cell, Cutaneous	4.8%
261	Lymphoma, AIDS-Related	4.8%
262	Enteropathy-Associated T-Cell Lymphoma	4.8%
263	Primary Effusion Lymphoma	4.8%
264	Adrenocortical carcinoma	4.6%
265	Mouth Neoplasms	4.6%
266	Central Nervous System Neoplasms	4.6%
267	Vascular Neoplasms	4.6%
268	Thymus Neoplasms	4.6%
269	Genital Neoplasms, Female	4.5%
270	Pancreatic Pseudocyst	4.5%
271	Nasopharyngeal carcinoma	4.5%
272	Lymphatic Metastasis	4.5%
273	Neoplasms, Unknown Primary	4.5%
274	Leukemic Infiltration	4.5%
275	Breast Neoplasms, Male	4.5%
276	Neoplasm Micrometastasis	4.5%
277	Triple Negative Breast Neoplasms	4.5%
278	Gastrinoma	4.4%
279	Glucagonoma	4.4%
280	Leydig Cell Tumor	4.2%
281	Esophageal Neoplasms	4.2%
282	Limbic Encephalitis	4.2%
283	Denys-Drash Syndrome	4.1%
284	Renal Cell Carcinoma	4%
285	Papillary Renal Cell Carcinoma	4%
286	Mycosis Fungoides	3.8%
287	Lymphomatoid Papulosis	3.8%
288	Plasmablastic lymphoma	3.8%
289	Thyroid Nodule	3.8%
290	Carcinoma, Endometrioid	3.8%
291	Lambert-Eaton Myasthenic Syndrome	3.7%
292	Testicular Neoplasms	3.7%
293	Adrenal Gland Neoplasms	3.7%
294	Gastrointestinal Neoplasms	3.7%
295	Genital Neoplasms, Male	3.7%
296	Liver neoplasms	3.7%
297	Uveal Neoplasms	3.7%
298	Urologic Neoplasms	3.7%
299	Sebaceous Gland Neoplasms	3.6%
300	Spinal Neoplasms	3.6%
301	Bone Marrow Neoplasms	3.6%
302	Polycystic Ovary Syndrome	3.5%
303	Burkitt Lymphoma	3.4%
304	Opsoclonus-Myoclonus Syndrome	3.3%
305	Xeroderma Pigmentosum	3.2%
306	Myelitis, Transverse	2.9%
307	Meningeal Neoplasms	2.8%
308	Sezary Syndrome	2.8%
309	Nose Neoplasms	2.6%
310	ovarian neoplasm	2.6%
311	Palatal Neoplasms	2.4%
312	Pituitary Adenoma	2.4%
313	Pituitary Neoplasms	2.4%
314	Ear Neoplasms	2.3%
315	Eyelid Neoplasms	2.3%
316	Lung Neoplasms	2.3%
317	Pleural Neoplasms	2.3%
318	Cell Transformation, Viral	2.3%
319	Brain Neoplasms	2.3%
320	Salivary Gland Neoplasms	2.3%
321	Spinal Cord Neoplasms	2.3%
322	Tongue Neoplasms	2.3%
323	Uterine Neoplasms	2.3%
324	Vaginal Neoplasms	2.3%
325	Vulvar Neoplasms	2.3%
326	Uterine Cancer	2.3%
327	Fallopian Tube Neoplasms	2.2%
328	Zollinger-Ellison syndrome	2%
329	Meningeal Carcinomatosis	2%
330	Pharyngeal Neoplasms	2%
331	Central Nervous System Cysts	1.9%
332	Bile Duct Neoplasms	1.9%
333	gallbladder neoplasm	1.9%
334	Intestinal Neoplasms	1.9%
335	Penile Neoplasms	1.9%
336	Prostatic Neoplasms	1.9%
337	Stomach Neoplasms	1.9%
338	Polycythemia Vera	1.9%
339	Laryngeal neoplasm	1.7%
340	Bronchial Neoplasms	1.6%
341	Bladder Neoplasm	1.6%
342	Kidney Neoplasm	1.6%
343	Ureteral Neoplasms	1.6%
344	Urethral Neoplasms	1.6%
345	Multiple Pulmonary Nodules	1.6%
346	Supratentorial Neoplasms	1.6%
347	Endometrial Neoplasms	1.6%
348	Hypopharyngeal Neoplasms	1.4%
349	Pleural Effusion, Malignant	1.4%
350	Hypopharyngeal Cancer	1.4%
351	Parotid Neoplasms	1.3%
352	Prostatic Neoplasms, Castration-Resistant	1.3%
353	Nelson Syndrome	1.3%
354	Brain Stem Neoplasms	1.3%
355	Cecal Neoplasms	1.1%
356	Duodenal Neoplasms	1.1%
357	Choroid Plexus Papilloma	1.1%
358	Tonsillar Neoplasms	1.1%
359	Cerebellar Neoplasms	1.1%
360	Nasopharyngeal Neoplasms	1%
361	Colorectal Neoplasms	1%
362	Radicular Cyst	0.9%
363	Paranasal Sinus Neoplasms	0.9%
364	Appendiceal Neoplasms	0.9%
365	Colonic Neoplasms	0.9%
366	Rectal Neoplasms	0.9%
367	Maxillary Sinus Neoplasms	0.7%
368	Anus Neoplasms	0.7%
369	Sigmoid Neoplasms	0.7%

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120234