MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Rhinophyma

(UMLS:C0035466)

Definition:: A manifestation of severe ROSACEA resulting in significant enlargement of the NOSE and occurring primarily in men. It is caused by hypertrophy of the SEBACEOUS GLANDS and surrounding CONNECTIVE TISSUE. The nose is reddened and marked with TELANGIECTASIS.
UMLS ID:: C0035466
MeSH ID:: D012224

Classification:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.800.716.500|C17.800.794.650

Synonym(s)

Rhinophyma

Hypertrophic rosacea

rhinophyma

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Epoprostenol	FAERS: 1		US FAERS

Similar ADE(s)

	Name	Semantic Similarity
1	Acne Vulgaris	53.3%
2	Acne	53.3%
3	Pyoderma Gangrenosum	48%
4	Sebaceous Gland Neoplasms	42.7%
5	Lupus Erythematosus, Cutaneous	41.4%
6	Panniculitis	41.4%
7	Systemic Scleroderma	41.4%
8	Morphea	41.4%
9	Breast Diseases	40.9%
10	Dermatitis	40.9%
11	Exanthema	40.9%
12	Facial Dermatoses	40.9%
13	Hair Diseases	40.9%
14	Hand Dermatoses	40.9%
15	keratoacanthoma	40.9%
16	Keratosis	40.9%
17	Nail Diseases	40.9%
18	Photosensitivity Disorders	40.9%
19	Prurigo	40.9%
20	Pyoderma	40.9%
21	Skin Diseases, Vesiculobullous	40.9%
22	Skin Ulcer	40.9%
23	Sweat Gland Diseases	40.9%
24	Skin Diseases, Papulosquamous	40.9%
25	Skin Diseases, Vascular	40.9%
26	Acneiform Eruptions	40.9%
27	Subcorneal pustular dermatosis	40.9%
28	Chronic Actinic Dermatitis	40.9%
29	Contact Dermatitis	40%
30	Eczema	40%
31	Erythema Multiforme	40%
32	Intertrigo	40%
33	Neurodermatitis	40%
34	Perioral Dermatitis	40%
35	Acne Conglobata	39.3%
36	Dermatitis, Phototoxic	35.3%
37	Pityriasis Lichenoides et Varioliformis Acuta	35.3%
38	Pityriasis Lichenoides	35.3%
39	Phototoxicity	35.3%
40	Foot Ulcer	34.7%
41	Dermatitis, Atopic	34.3%
42	Epidermolysis Bullosa	34.3%
43	Dermatitis Herpetiformis	32.4%
44	Xeroderma Pigmentosum	32.2%
45	Foot Diseases	32.1%
46	Acrodermatitis	32%
47	Porokeratosis	32%
48	Gianotti-Crosti Syndrome	32%
49	Keratoderma, Palmoplantar	32%
50	Skin Abnormalities	31%
51	Skin Diseases, Infectious	31%
52	Skin Neoplasms	31%
53	Pigmentation Disorders	31%
54	Panniculitis, Lupus Erythematosus	30.8%
55	Lipomatosis	30.5%
56	Pruritus	30.5%
57	Erythema	30.5%
58	Necrolytic Migratory Erythema	30.5%
59	Cutaneous Fistula	30.5%
60	Nephrogenic Fibrosing Dermopathy	30.5%
61	Nephrogenic Systemic Fibrosis	30.5%
62	Necrobiosis Lipoidica Diabeticorum	29.8%
63	Dermatitis, Irritant	29.5%
64	Dermatitis, Photoallergic	29.3%
65	Urticaria Pigmentosa	27.5%
66	Xeroderma	27%
67	Dermatomyositis	26.9%
68	Anhidrosis	26.7%
69	Cholesteatoma	26.7%
70	Pressure Ulcer	26.7%
71	Folliculitis	26.7%
72	Foot Dermatoses	26.7%
73	Gynecomastia	26.7%
74	Hypertrichosis	26.7%
75	Hypohidrosis	26.7%
76	Hypotrichosis	26.7%
77	Leg Ulcer	26.7%
78	Lupus Erythematosus, Discoid	26.7%
79	Miliaria	26.7%
80	Parakeratosis	26.7%
81	Parapsoriasis	26.7%
82	Pityriasis	26.7%
83	Psoriasis	26.7%
84	Sweet Syndrome	26.7%
85	Hidradenitis	26.7%
86	Onycholysis	26.7%
87	Miliaria Rubra	26.7%
88	Hyperpigmentation	26.7%
89	Lichenoid Eruptions	26.7%
90	Chloracne	26.7%
91	Scleroderma, Limited	26.7%
92	Erythema Induratum	25.7%
93	Dermatitis, Occupational	24.7%
94	Diaper Rash	24.4%
95	Cutis Laxa	24.3%
96	Mastocytosis	24.2%
97	Connective Tissue Diseases	23.8%
98	Dermatitis, Allergic Contact	23.7%
99	Papillon-Lefevre Disease	23.5%
100	Erythema Infectiosum	23.5%
101	Exanthema Subitum	23.3%
102	Erythema Nodosum	23%
103	Ectodermal Dysplasia	22.9%
104	Aplasia Cutis Congenita	22.9%
105	Pseudoxanthoma Elasticum	22.3%
106	Toxic Epidermal Necrolysis	22%
107	Stevens-Johnson Syndrome	22%
108	Tinea Capitis	21.2%
109	Onychomycosis	21.2%
110	Rosacea	20.5%
111	Sebaceous Gland Diseases	20.5%
112	Ocular Rosacea	20.5%
113	Erythematotelangiectatic Rosacea	20.5%
114	Papulopustular Rosacea	20.5%
115	Acantholysis	20.3%
116	Breast Cyst	20.3%
117	Actinic keratosis	20.3%
118	Pemphigoid, Benign Mucous Membrane	20.3%
119	Pemphigus	20.3%
120	Piedra	20.3%
121	Sunburn	20.3%
122	Argyria	20%
123	Hirsutism	20%
124	Lactation Disorder	20%
125	Mastitis	20%
126	Rhinophyma	20%
127	Urticaria	20%
128	Granuloma Annulare	19.9%
129	Adiposis Dolorosa	19.8%
130	Pruritus Vulvae	19.8%
131	Lichen Planus	19.8%
132	Melanosis	19.8%
133	Chloasma	19.8%
134	Pityriasis Rosea	19.8%
135	Pityriasis Rubra Pilaris	19.8%
136	Vitiligo	19.8%
137	Lichen Nitidus	19.8%
138	Mastocytoma	19.8%
139	Pruritus Ani	19.8%
140	Ecthyma	19.7%
141	Hyperkeratosis, Epidermolytic	19.4%
142	Ichthyosis, X-Linked	17.9%
143	Sjogren-Larsson Syndrome	17.8%
144	Behcet Syndrome	17.5%
145	Hidradenitis Suppurativa	16.9%
146	Acanthosis Nigricans	16.4%
147	Alopecia Areata	16.4%
148	Lentigo	16.4%
149	Dermatomycoses	16.2%
150	Mucocutaneous Lymph Node Syndrome	16.2%
151	Skin Diseases, Bacterial	16.2%
152	Drug Eruptions	16%
153	Lipodystrophy	16%
154	Livedo Reticularis	16%
155	Malignant Atrophic Papulosis	16%
156	Polyarteritis Nodosa	15.8%
157	Takayasu Arteritis	15.8%
158	Albinism	15.5%
159	Tinea Pedis	15.3%
160	Erythema Chronicum Migrans	15.2%
161	Alopecia	15.1%
162	Sweating, Gustatory	15.1%
163	Androgenetic Alopecia	15.1%
164	Auriculotemporal Syndrome	15.1%
165	Lice Infestations	14.9%
166	Varicose Ulcer	14.9%
167	Breast Neoplasms, Male	14.9%
168	Triple Negative Breast Neoplasms	14.9%
169	Galactorrhea	14.8%
170	Collagen Diseases	13.6%
171	Mixed Connective Tissue Disease	13.6%
172	Nail-Patella Syndrome	13.6%
173	Mucinoses	13.6%
174	Porphyrias, Hepatic	13.5%
175	Mycetoma	13.1%
176	Lichen Planus, Oral	12.6%
177	Larva Migrans	12.1%
178	Leishmaniasis	12.1%
179	Molluscum Contagiosum	12.1%
180	Angioedema	12%
181	Onchocerciasis	11.9%
182	Chromoblastomycosis	11.8%
183	Dermatophytosis	11.8%
184	Sporotrichosis	11.8%
185	Tinea	11.8%
186	Tinea Versicolor	11.8%
187	Trichophytosis	11.8%
188	Hyalohyphomycosis	11.8%
189	Acute Generalized Exanthematous Pustulosis	11.8%
190	Cartilage Diseases	10.7%
191	Rheumatism	10.7%
192	Chondromalacia	10.7%
193	Lupus Erythematosus, Systemic	10.3%
194	Overlap syndrome	10.3%
195	Warts	10.2%
196	Candidiasis, Chronic Mucocutaneous	9.9%
197	Cutaneous Candidiasis	9.9%
198	Erysipelas	9.8%
199	Leishmaniasis, Cutaneous	9.8%
200	Serum Sickness	9.8%
201	Staphylococcal Skin Infections	9.8%
202	Variegate Porphyria	9.8%
203	Acute intermittent porphyria	9.8%
204	Porphyria Cutanea Tarda	9.8%
205	Eczema Herpeticum	9.8%
206	Erythrasma	9.8%
207	Carcinoma, Lobular	9.8%
208	CREST Syndrome	9.8%
209	Arthritis, Psoriatic	9.8%
210	Fusariosis	9.7%
211	Scleromyxedema	8.9%
212	Hereditary Angioedema Type III	8.7%
213	Hereditary Angioedema Types I and II	8.7%
214	Giant Cell Arteritis	8.7%
215	Temporal Arteritis	8.7%
216	Angioedemas, Hereditary	8.3%
217	Epidermodysplasia Verruciformis	8.2%
218	Herpes Labialis	8.2%
219	Diabetic Foot	8.2%
220	Staphylococcal Scalded Skin Syndrome	8.1%
221	Dupuytren Contracture	8%
222	Peutz-Jeghers Syndrome	7.5%
223	Blastomycosis	7.4%
224	HIV-Associated Lipodystrophy Syndrome	7.3%
225	carbuncle	7.2%
226	Condylomata Acuminata	7.1%
227	Furunculosis	7%
228	furuncle	7%
229	Impetigo	6.9%
230	Mesenteric Panniculitis	6.8%
231	Panniculitis, Peritoneal	6.8%
232	Tietze's Syndrome	6.8%
233	Orbital Cellulitis	6.8%
234	Myxoid cyst	6.8%
235	Rhinoscleroma	6.7%
236	Cellulitis	6.7%
237	Myxedema	6.7%
238	Menkes Kinky Hair Syndrome	6.5%
239	Osteochondritis	5.5%
240	Polymyalgia Rheumatica	5.5%
241	Osteogenesis Imperfecta	5.4%
242	Keloid	5.3%
243	Noonan Syndrome	5%
244	Rheumatoid Arthritis	4.5%
245	Juvenile arthritis	4.5%
246	Marfan Syndrome	4.5%
247	Lupus Nephritis	4.4%
248	Homocystinuria	4.4%
249	Rheumatoid Nodule	3.9%
250	Laryngomalacia	3.9%
251	Pectus carinatum	3.9%
252	Felty Syndrome	3.3%
253	Bronchomalacia	3.3%
254	Tracheomalacia	3.3%
255	Rheumatoid Vasculitis	2.8%
256	Mucopolysaccharidosis III	2.8%
257	Sicca Syndrome	2.5%
258	Sjogren's Syndrome	2.5%
259	Lupus Vasculitis, Central Nervous System	2%
260	Mucopolysaccharidosis II	1.9%

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