MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Pleural Effusion, Malignant

(UMLS:C0080032)

Definition:: Presence of fluid in the PLEURAL CAVITY as a complication of malignant disease. Malignant pleural effusions often contain actual malignant cells.
UMLS ID:: C0080032
MeSH ID:: D016066

Classification 1:

Name:

Neoplasms
MeSH Tree Number(s):: C04.588.894.797.640.700

Classification 2:

Name:

Respiratory Tract Diseases
MeSH Tree Number(s):: C08.528.652.700|C08.528.694.700|C08.785.640.700

Synonym(s)

Pleural Effusion, Malignant

Malignant Pleural Effusion

Malignant effusion

Malignant pleural effusion

Neoplastic pleural effusion

PLEURAL EFFUSION MALIGNANT

Pleural effusion due to malignancy

effusion malignant

effusion malignant pleural

10.

effusion pleural malignant

11.

effusion; pleura, malignant

12.

malignant effusion

13.

malignant pleural effusion

14.

malignant pleural effusions

15.

pleura; effusion, malignant

16.

pleural effusion malignant

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	pirarubicin		1653558	CTD
2	tetrandrine		18495333	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Lung Neoplasms	33.8%
2	Pleurisy	33.8%
3	Tracheal Neoplasms	32.7%
4	Chylothorax	28.1%
5	Hydropneumothorax	28.1%
6	Hydrothorax	28.1%
7	Pneumothorax	28.1%
8	Pleuropneumonia	26.5%
9	Bronchial Neoplasms	25.1%
10	Hemothorax	23.4%
11	Bronchitis	23.1%
12	Tracheobronchomegaly	22.9%
13	Multiple Pulmonary Nodules	22.1%
14	Bronchial Diseases	20.6%
15	Lung diseases	20.6%
16	Respiration Disorders	20.6%
17	Thoracic Diseases	20.6%
18	Tracheal Diseases	20.6%
19	Pneumonia	20.3%
20	Lobar Pneumonia	20.3%
21	Respiratory Distress Syndrome, Adult	20.3%
22	Tracheitis	20.3%
23	Pneumonitis	20.3%
24	Asthma	20.1%
25	Bronchopneumonia	20%
26	Laryngeal neoplasm	19.8%
27	Granuloma, Laryngeal	18%
28	Laryngeal Diseases	17.7%
29	Nose Diseases	17.7%
30	Laryngitis	17.5%
31	Lung Diseases, Fungal	17.5%
32	Rhinitis	17.5%
33	Vocal Cord Dysfunction	17.5%
34	Nose Neoplasms	17.5%
35	Respiratory Distress Syndrome, Newborn	17.3%
36	Respiratory Tract Infections	17.3%
37	Bronchial Fistula	17.3%
38	Lung Abscess	17.3%
39	Pleural Neoplasms	17.3%
40	Bronchitis, Chronic	17.2%
41	Tuberculosis, Pulmonary	17.2%
42	Granuloma, Respiratory Tract	17.1%
43	Respiratory Hypersensitivity	17.1%
44	Respiratory Tract Fistula	17.1%
45	Pleural Effusion, Malignant	16.5%
46	Bronchiolitis	15.5%
47	Choanal Atresia	15.3%
48	Laryngocele	15.3%
49	Sinusitis	14.3%
50	Aspergillosis, Allergic Bronchopulmonary	14.3%
51	Paranasal Sinus Neoplasms	14.1%
52	Aspiration Pneumonia	13.2%
53	Primary Ciliary Dyskinesia	13%
54	Scimitar Syndrome	12.1%
55	Altitude Sickness	12%
56	Atelectasis	12%
57	Bronchospasm	12%
58	Bronchiectasis	12%
59	Pulmonary Hypertension	12%
60	Pulmonary Alveolar Proteinosis	12%
61	Pulmonary Edema	12%
62	Pulmonary Fibrosis	12%
63	Respiratory Insufficiency	12%
64	Tracheal Stenosis	12%
65	Bronchial Hyperreactivity	12%
66	Hamman-Rich syndrome	12%
67	Lung Diseases, Interstitial	12%
68	Respiratory Depression	12%
69	Lung Diseases, Obstructive	12%
70	Respiratory Failure	12%
71	Acute Chest Syndrome	11.9%
72	Pneumoconiosis	11.7%
73	Pneumonia, Viral	11.7%
74	Idiopathic Pulmonary Fibrosis	11.5%
75	Pneumonia, Bacterial	11.5%
76	Laryngospasm	11.3%
77	Meconium Aspiration Syndrome	11.3%
78	Hyaline Membrane Disease	11.3%
79	Asthma, Exercise-Induced	11.3%
80	Status Asthmaticus	11.3%
81	Rhinoscleroma	10.9%
82	Maxillary Sinus Neoplasms	10.4%
83	Granuloma, Lethal Midline	10.1%
84	Laryngeal Edema	10.1%
85	Nose Deformities, Acquired	10.1%
86	Lung Injury	10.1%
87	Hepatopulmonary Syndrome	10.1%
88	Respiratory Aspiration	10.1%
89	Asthma, Occupational	10.1%
90	Apnea	10%
91	Cheyne-Stokes Respiration	10%
92	Common Cold	10%
93	Dyspnea	10%
94	Hyperventilation	10%
95	Influenza	10%
96	Mouth Breathing	10%
97	Tachypnea	10%
98	Catarrh	10%
99	Kartagener Syndrome	10%
100	Hoarseness	10%
101	Radiation Pneumonitis	10%
102	Radiation Fibrosis	10%
103	Pulmonary Embolism	10%
104	Pulmonary Eosinophilia	9.9%
105	Severe Acute Respiratory Syndrome	9.9%
106	Eosinophilic Pneumonia	9.9%
107	Laryngopharyngeal Reflux	9.9%
108	Pneumonia, Lipid	9.8%
109	Thymus Neoplasms	9.7%
110	Mediastinal Cyst	9.2%
111	Pericardial Cyst	9.2%
112	Thymic Cyst	9.2%
113	Abdominal Neoplasms	9%
114	Head and Neck Neoplasms	9%
115	Soft Tissue Neoplasms	9%
116	Bronchiolitis Obliterans	9%
117	Asthma, Aspirin-Induced	8.8%
118	Pharyngitis	8.8%
119	Farmer's Lung	8.7%
120	Laryngostenosis	8.7%
121	Nasal Polyps	8.7%
122	Hemoptysis	8.6%
123	Hay fever	8.6%
124	Rhinitis, Allergic, Perennial	8.6%
125	Pertussis	8.6%
126	Asbestosis	8.5%
127	Berylliosis	8.5%
128	Silicosis	8.5%
129	Airway Obstruction	7.9%
130	Choking	7.9%
131	Epiglottitis	7.9%
132	Chronic Obstructive Airway Disease	7.9%
133	Mediastinitis	7.9%
134	Middle Lobe Syndrome	7.9%
135	Acute Lung Injury	7.9%
136	Blastomycosis	7.9%
137	Digestive System Neoplasms	7.8%
138	Endocrine Gland Neoplasms	7.8%
139	Eye Neoplasms	7.8%
140	Nervous System Neoplasms	7.8%
141	Cystic Fibrosis	7.7%
142	Voice Disorders	7.6%
143	Voice Disturbance	7.6%
144	Bone neoplasms	7.6%
145	Skin Neoplasms	7.6%
146	Hematologic Neoplasms	7.6%
147	Epistaxis	7.6%
148	Splenic Neoplasms	7.5%
149	Pleural Diseases	6.9%
150	Laryngomalacia	6.8%
151	Vocal Cord Paralysis	6.7%
152	Persistent Fetal Circulation Syndrome	6.7%
153	Croup	6.6%
154	Histiocytosis, Langerhans-Cell	6.6%
155	Mediastinal Emphysema	6.6%
156	Rhinitis, Vasomotor	6.6%
157	Pulmonary Aspergillosis	6.6%
158	Bronchopulmonary Aspergillosis	6.6%
159	Hypoventilation	6.6%
160	Acidosis, Respiratory	6.6%
161	Alkalosis, Respiratory	6.6%
162	Sarcoidosis, Pulmonary	6.6%
163	Sleep Apnea Syndromes	6.6%
164	Pulmonary Infarction	6.6%
165	Parathyroid Neoplasms	6.3%
166	Peritoneal Neoplasms	6.3%
167	Thyroid Neoplasm	6.3%
168	Thyroid carcinoma	6.3%
169	Multiple Endocrine Neoplasia	6.2%
170	Thymoma	6.1%
171	Pulmonary Emphysema	5.9%
172	Hamartoma	5.8%
173	Neoplasms, Hormone-Dependent	5.8%
174	Neoplasms, Multiple Primary	5.8%
175	Paraneoplastic Syndromes	5.8%
176	Precancerous Conditions	5.8%
177	Neoplasms, Second Primary	5.8%
178	Paraneoplastic Encephalomyelitis	5.8%
179	Mammary Neoplasms, Experimental	5.7%
180	Tonsillitis	5.7%
181	Pancreatic Neoplasm	5.6%
182	Dyspnea, Paroxysmal	5.6%
183	Respiratory Paralysis	5.6%
184	Granulomatosis with polyangiitis	5.6%
185	Retroperitoneal Neoplasms	5%
186	Aphonia	4.9%
187	Retropharyngeal Abscess	4.9%
188	Dysphonia	4.9%
189	Anti-Glomerular Basement Membrane Disease	4.9%
190	Bronchopulmonary Dysplasia	4.9%
191	Acanthoma	4.9%
192	Bronchomalacia	4.9%
193	Tracheomalacia	4.9%
194	Cyst	4.9%
195	Neoplastic Processes	4.9%
196	Neoplastic Syndromes, Hereditary	4.9%
197	Pregnancy Complications, Neoplastic	4.9%
198	Sleep Apnea, Obstructive	4.9%
199	Sleep Apnea, Central	4.9%
200	Neoplasms, Experimental	4.8%
201	Nasopharyngitis	4.4%
202	Esophageal Neoplasms	4.4%
203	Transfusion-Related Acute Lung Injury	4.3%
204	Invasive Pulmonary Aspergillosis	4.2%
205	Mouth Neoplasms	4.2%
206	Central Nervous System Neoplasms	4.2%
207	Vascular Neoplasms	4.2%
208	Neoplasms, Radiation-Induced	4.2%
209	Genital Neoplasms, Female	4.1%
210	Breast Neoplasms, Male	4.1%
211	Triple Negative Breast Neoplasms	4.1%
212	Carcinoma, Lobular	4.1%
213	Testicular Neoplasms	4%
214	Thyroid Nodule	3.7%
215	Peritonsillar Abscess	3.7%
216	Adrenal Gland Neoplasms	3.6%
217	Gastrointestinal Neoplasms	3.6%
218	Genital Neoplasms, Male	3.6%
219	Liver neoplasms	3.6%
220	Uveal Neoplasms	3.6%
221	Urologic Neoplasms	3.6%
222	Sebaceous Gland Neoplasms	3.5%
223	Spinal Neoplasms	3.5%
224	Bone Marrow Neoplasms	3.5%
225	Tuberous Sclerosis	3.5%
226	Multiple Endocrine Neoplasia Type 1	3.5%
227	Trophoblastic Neoplasms	3.3%
228	Leukemia, Experimental	3.3%
229	Carcinoma, Ehrlich Tumor	3.3%
230	Dermoid Cyst	3.3%
231	Carcinoma, Lewis Lung	3.3%
232	Liver Neoplasms, Experimental	3.3%
233	Eosinophilic Granuloma	3.3%
234	Carcinoma 256, Walker	3.3%
235	Meningioma	3.3%
236	Carcinoma, Pancreatic Ductal	3.2%
237	Erythroplasia	3%
238	Follicular cyst	3%
239	leukemia	3%
240	Mucocele	3%
241	Neoplasms, Germ Cell and Embryonal	3%
242	Neoplasms, Glandular and Epithelial	3%
243	Pilonidal Cyst	3%
244	Thyroglossal Cyst	3%
245	Synovial Cyst	3%
246	Germ Cell Cancer	3%
247	Aberrant Crypt Foci	3%
248	Leukemia, Radiation-Induced	2.9%
249	Leukoplakia, Oral	2.9%
250	Paraneoplastic Cerebellar Degeneration	2.9%
251	Sarcoma, Experimental	2.8%
252	ovarian neoplasm	2.8%
253	Neuroectodermal Tumors	2.8%
254	Nephroblastoma	2.7%
255	Melanoma, Experimental	2.7%
256	Neoplasms, Neuroepithelial	2.6%
257	Gliomatosis cerebri	2.6%
258	Pituitary Adenoma	2.6%
259	Pituitary Neoplasms	2.6%
260	Limbic Encephalitis	2.6%
261	Leukoplakia	2.5%
262	Lymphocele	2.5%
263	Pancreatic Cyst	2.5%
264	Barrett Esophagus	2.5%
265	Breast Cyst	2.5%
266	Histiocytic Disorders, Malignant	2.5%
267	Actinic keratosis	2.5%
268	Neoplasm Invasiveness	2.5%
269	Neoplasm Metastasis	2.5%
270	Neoplasm Recurrence, Local	2.5%
271	Parovarian Cyst	2.5%
272	Carcinogenesis	2.5%
273	Myxoid cyst	2.5%
274	Metastasis	2.5%
275	Meningeal Neoplasms	2.5%
276	Hepatocellular Adenoma	2.5%
277	Palatal Neoplasms	2.5%
278	Acoustic Neuroma	2.4%
279	Retinoblastoma	2.4%
280	Lambert-Eaton Myasthenic Syndrome	2.3%
281	insulinoma	2.3%
282	Lymphomatoid Granulomatosis	2.2%
283	Vipoma	2.2%
284	Carcinosarcoma	2.2%
285	Hemangiosarcoma	2.2%
286	Leukemia L1210	2.2%
287	Leukemia P388	2.2%
288	lymphangiosarcoma	2.2%
289	Gastrinoma	2.2%
290	Glucagonoma	2.2%
291	Prolactinoma	2.2%
292	Growth Hormone-Secreting Pituitary Adenoma	2.2%
293	Ear Neoplasms	2.2%
294	Eyelid Neoplasms	2.2%
295	Lymphoma	2.1%
296	Corpus Luteum Cyst	2.1%
297	Ovarian Cysts	2.1%
298	Brain Neoplasms	2.1%
299	Salivary Gland Neoplasms	2.1%
300	Spinal Cord Neoplasms	2.1%
301	Tongue Neoplasms	2.1%
302	Opsoclonus-Myoclonus Syndrome	2.1%
303	melanoma	2.1%
304	Uterine Neoplasms	2.1%
305	Vaginal Neoplasms	2.1%
306	Vulvar Neoplasms	2.1%
307	Uterine Cancer	2.1%
308	Fallopian Tube Neoplasms	2.1%
309	Composite Lymphoma	2.1%
310	Choriocarcinoma	2%
311	granulosa cell tumor	1.9%
312	Carcinoma, Ovarian Epithelial	1.9%
313	Adenomatous Polyposis Coli	1.9%
314	Myelitis, Transverse	1.9%
315	Sarcoma 180	1.9%
316	Pharyngeal Neoplasms	1.9%
317	Choledochal Cyst	1.9%
318	Basal Cell Nevus Syndrome	1.9%
319	Leukemia, Plasma Cell	1.9%
320	Central Nervous System Cysts	1.9%
321	Peutz-Jeghers Syndrome	1.9%
322	Bile Duct Neoplasms	1.9%
323	gallbladder neoplasm	1.9%
324	Intestinal Neoplasms	1.9%
325	Penile Neoplasms	1.9%
326	Prostatic Neoplasms	1.9%
327	Stomach Neoplasms	1.9%
328	Polycythemia Vera	1.8%
329	Leydig Cell Tumor	1.8%
330	Mesoblastic Nephroma	1.8%
331	Optic Nerve Glioma	1.8%
332	Adenoma	1.7%
333	Ameloblastoma	1.7%
334	Angiokeratoma	1.7%
335	Carcinoma	1.7%
336	Chordoma	1.7%
337	Hemangioma	1.7%
338	hemangiopericytoma	1.7%
339	Lymphangioma	1.7%
340	Mesenchymoma	1.7%
341	Nevus	1.7%
342	Teratoma	1.7%
343	Hepatoblastoma	1.7%
344	Mixed Tumor, Mullerian	1.7%
345	Germinoma	1.7%
346	Teratocarcinoma	1.7%
347	Angiofibroma	1.7%
348	Sarcoma	1.7%
349	Epithelioma	1.7%
350	Bladder Neoplasm	1.6%
351	Kidney Neoplasm	1.6%
352	Ureteral Neoplasms	1.6%
353	Urethral Neoplasms	1.6%
354	Basal cell carcinoma	1.6%
355	Carcinoma, Papillary	1.6%
356	Squamous cell carcinoma	1.6%
357	Chondrosarcoma	1.6%
358	Craniopharyngioma	1.6%
359	Cystadenoma	1.6%
360	leiomyosarcoma	1.6%
361	liposarcoma	1.6%
362	Mesothelioma	1.6%
363	synovial sarcoma	1.6%
364	Neuroectodermal Tumor, Melanotic	1.6%
365	Angiomyolipoma	1.6%
366	Clear Cell Sarcoma of Soft Tissue	1.6%
367	Alveolar Soft Part Sarcoma	1.6%
368	Neuroendocrine Tumors	1.6%
369	Sarcoma, Myeloid	1.6%
370	Carcinoma, Basal Cell	1.6%
371	Meningeal Carcinomatosis	1.6%
372	Adenoma, Acidophil	1.6%
373	Ganglioneuroma	1.6%
374	Glioma	1.6%
375	Malignant Glioma	1.6%
376	Medulloblastoma	1.6%
377	Adrenocortical carcinoma	1.4%
378	Endometrial Stromal Sarcoma	1.4%
379	Supratentorial Neoplasms	1.4%
380	Carcinoid Tumor	1.4%
381	Endometrial Neoplasms	1.4%
382	Neurilemmoma	1.4%
383	Hutchinson's Melanotic Freckle	1.4%
384	Melanoma, Amelanotic	1.4%
385	Pancreatic Pseudocyst	1.4%
386	Plasmacytoma	1.4%
387	Malignant histiocytosis	1.4%
388	Lymphatic Metastasis	1.4%
389	Neoplasms, Unknown Primary	1.4%
390	Leukemic Infiltration	1.4%
391	Histiocytic sarcoma	1.4%
392	Neoplasm Micrometastasis	1.4%
393	Cystadenocarcinoma	1.4%
394	Fibrosarcoma	1.4%
395	Osteosarcoma	1.4%
396	Mucoepidermoid Carcinoma	1.4%
397	Renal Cell Carcinoma	1.3%
398	Papillary Renal Cell Carcinoma	1.3%
399	Denys-Drash Syndrome	1.3%
400	Xeroderma Pigmentosum	1.3%
401	Hypopharyngeal Neoplasms	1.2%
402	Hypopharyngeal Cancer	1.2%
403	Lymphangioleiomyomatosis	1.2%
404	Adenofibroma	1.2%
405	Fibroadenoma	1.2%
406	Malignant Fibrous Histiocytoma	1.2%
407	Parotid Neoplasms	1.2%
408	Prostatic Neoplasms, Castration-Resistant	1.2%
409	Nelson Syndrome	1.2%
410	Hodgkin Disease	1.2%
411	Lymphoma, Non-Hodgkin	1.2%
412	Polycystic Ovary Syndrome	1.2%
413	Hydatidiform Mole	1.2%
414	Astrocytoma	1.2%
415	Ependymoma	1.2%
416	oligodendroglioma	1.2%
417	Ganglioglioma	1.2%
418	gliosarcoma	1.2%
419	Anaplastic astrocytoma	1.2%
420	Anaplastic Oligodendroglioma	1.2%
421	Nasopharyngeal carcinoma	1.1%
422	Bowen's Disease	1.1%
423	Paraganglioma	1.1%
424	Rhabdomyosarcoma	1.1%
425	Giant Cell Tumor of Bone	1.1%
426	Cecal Neoplasms	1.1%
427	Duodenal Neoplasms	1.1%
428	Carcinoma, Endometrioid	1%
429	Brain Stem Neoplasms	1%
430	Malignant Carcinoid Syndrome	1%
431	Primary amyloidosis	1%
432	Nasopharyngeal Neoplasms	1%
433	Neurofibrosarcoma	1%
434	Adenocarcinoma	1%
435	Carcinoma in Situ	1%
436	Carcinoma, Transitional Cell	1%
437	Phyllodes Tumor	1%
438	Dysgerminoma	1%
439	Hemangioendothelioma	1%
440	Lipoma	1%
441	Myoma	1%
442	Myxoma	1%
443	Neuroma	1%
444	Papilloma	1%
445	Pseudomyxoma Peritonei	1%
446	Seminoma	1%
447	Papillomatosis	1%
448	Angiolipoma	1%
449	Myelolipoma	1%
450	Neoplasms, Bone Tissue	1%
451	Neoplasms, Fibrous Tissue	1%
452	Smooth Muscle Tumor	1%
453	Adenomatosis, Pulmonary	1%
454	Adenomatous Polyps	1%
455	Carcinoma, Large Cell	1%
456	Carcinoma, Small Cell	1%
457	Desmoplastic Small Round Cell Tumor	1%
458	Chondroma	1%
459	Enchondroma	1%
460	Colorectal Neoplasms	1%
461	Dermatofibrosarcoma	0.9%
462	Dermatofibrosarcoma Protuberans	0.9%
463	Glioblastoma	0.9%
464	Neuroblastoma	0.9%
465	Glioblastoma Multiforme	0.9%
466	Tonsillar Neoplasms	0.9%
467	Cerebellar Neoplasms	0.9%
468	Choroid Plexus Papilloma	0.9%
469	Waldenstrom Macroglobulinemia	0.8%
470	Multiple Myeloma	0.8%
471	Leukemia, Myelomonocytic, Chronic	0.8%
472	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	0.8%
473	Pheochromocytoma	0.8%
474	Alveolar rhabdomyosarcoma	0.8%
475	Appendiceal Neoplasms	0.8%
476	Colonic Neoplasms	0.8%
477	Rectal Neoplasms	0.8%
478	Ganglioneuroblastoma	0.8%
479	Carcinoid Heart Disease	0.8%
480	Zollinger-Ellison syndrome	0.7%
481	Mastocytosis	0.7%
482	Sturge-Weber Syndrome	0.7%
483	Cell Transformation, Viral	0.7%
484	Gastrointestinal Stromal Tumors	0.7%
485	Hemangioma, Cavernous	0.7%
486	Leukemia, T-Cell	0.7%
487	Leukemia, B-Cell	0.7%
488	neurofibroma	0.7%
489	Lymphoma, Follicular	0.7%
490	T-Cell Lymphoma	0.7%
491	Mantle cell lymphoma	0.7%
492	Adenoid Cystic Carcinoma	0.7%
493	fibroma	0.7%
494	Fibromatosis	0.7%
495	Osteoblastoma	0.7%
496	Osteoma	0.7%
497	Rhabdomyoma	0.7%
498	Chondromatosis	0.7%
499	Adenocarcinoma, Clear Cell	0.7%
500	Cholangiocarcinoma	0.7%
501	Cervical Intraepithelial Neoplasia	0.7%
502	Hemangioblastoma	0.7%
503	Lymphoma, Extranodal NK-T-Cell	0.7%
504	Anus Neoplasms	0.6%
505	Sigmoid Neoplasms	0.6%
506	Mastocytoma	0.5%
507	Mastocytosis, Systemic	0.5%
508	Leukemia, Myeloid, Chronic-Phase	0.5%
509	Fibromatosis, Aggressive	0.5%
510	Fibromatosis, Abdominal	0.5%
511	Klatskin Tumor	0.5%
512	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	0.5%
513	Leukemia, Large Granular Lymphocytic	0.5%
514	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	0.5%
515	Lymphoma, T-Cell, Cutaneous	0.5%
516	Lymphoma, AIDS-Related	0.5%
517	Enteropathy-Associated T-Cell Lymphoma	0.5%
518	Primary Effusion Lymphoma	0.5%
519	Burkitt Lymphoma	0.4%
520	Dupuytren Contracture	0.4%
521	Urticaria Pigmentosa	0.4%
522	Mycosis Fungoides	0.3%
523	Lymphomatoid Papulosis	0.3%
524	Plasmablastic lymphoma	0.3%
525	Sezary Syndrome	0.3%
526	Radicular Cyst	0.3%

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