MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Pyoderma Gangrenosum

(UMLS:C0085652)

Definition:: An idiopathic, rapidly evolving, and severely debilitating disease occurring most commonly in association with chronic ulcerative colitis. It is characterized by the presence of boggy, purplish ulcers with undermined borders, appearing mostly on the legs. The majority of cases are in people between 40 and 60 years old. Its etiology is unknown.
UMLS ID:: C0085652
MeSH ID:: D017511

Classification:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.800.695.675|C17.800.862.675|C17.800.893.675

Synonym(s)

Pyoderma Gangrenosum

PYODERMA GANGRENOSA

PYODERMA GANGRENOSUM

Pyoderma gangrenosum

gangrenosum pyoderma

gangrenosum; pyoderma

gangrenous pyoderma

pyoderma gangenosum

pyoderma gangrenosa

10.

pyoderma gangrenosum

11.

pyoderma gangrenous

12.

pyoderma; gangrenosum

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Isotretinoin	FAERS: 59		US FAERS
2	Azacitidine	FAERS: 19 Canada Vigilance: 4		Canada Vigilance OFFSIDES SIDER US FAERS
3	Sunitinib	FAERS: 13		OFFSIDES SIDER US FAERS
4	Lenalidomide	FAERS: 9		OFFSIDES US FAERS
5	PCI 32765	FAERS: 9		US FAERS
6	Teriparatide	FAERS: 8		US FAERS
7	Thalidomide	FAERS: 7	12499476	CTD US FAERS
8	Propylthiouracil	FAERS: 6		US FAERS
9	pazopanib	FAERS: 6		US FAERS
10	Leflunomide	FAERS: 4		OFFSIDES US FAERS
11	Hydroxyurea	FAERS: 3		OFFSIDES US FAERS
12	Imatinib Mesylate	FAERS: 3		US FAERS
13	Imatinib Mesylate	FAERS: 3		US FAERS
14	Methotrexate	FAERS: 3 Canada Vigilance: 2		Canada Vigilance US FAERS
15	Sunitinib	FAERS: 3		OFFSIDES US FAERS
16	pazopanib	FAERS: 3		US FAERS
17	Cyclosporine	FAERS: 2		US FAERS
18	Glatiramer Acetate	FAERS: 2		OFFSIDES US FAERS
19	INCB018424	FAERS: 2		US FAERS
20	LCZ 696	FAERS: 2		US FAERS
21	Mesalamine	FAERS: 2		SIDER US FAERS
22	Moxifloxacin	FAERS: 2		US FAERS
23	Ruxolitinib phosphate	FAERS: 2		US FAERS
24	Sorafenib	FAERS: 2		US FAERS
25	Sulfasalazine	FAERS: 2		OFFSIDES US FAERS
26	anagrelide	FAERS: 2		US FAERS
27	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	FAERS: 1		US FAERS
28	Alendronate	FAERS: 1		US FAERS
29	Anastrozole	FAERS: 1		OFFSIDES US FAERS
30	Axitinib	FAERS: 1		US FAERS
31	Azathioprine	FAERS: 1		OFFSIDES US FAERS
32	Bosentan	FAERS: 1		US FAERS
33	Budesonide	FAERS: 1		US FAERS
34	Cabozantinib S-malate	FAERS: 1		US FAERS
35	Cilastatin, Imipenem Drug Combination	FAERS: 1		US FAERS
36	Ciprofloxacin	FAERS: 1		OFFSIDES US FAERS
37	Clindamycin	FAERS: 1		US FAERS
38	Clofazimine	FAERS: 1	7387877	CTD US FAERS
39	Clopidogrel	FAERS: 1		US FAERS
40	Clozapine	FAERS: 1		US FAERS
41	Crizotinib	FAERS: 1		US FAERS
42	Deoxycholic Acid	FAERS: 1		US FAERS
43	Dimethyl Fumarate	FAERS: 1		US FAERS
44	Erlotinib Hydrochloride	FAERS: 1		US FAERS
45	Everolimus	FAERS: 1		US FAERS
46	Fingolimod Hydrochloride	FAERS: 1		US FAERS
47	Ibandronic Acid	FAERS: 1		US FAERS
48	Interferon alpha-2	FAERS: 1		US FAERS
49	Lansoprazole	FAERS: 1		US FAERS
50	Levetiracetam	FAERS: 1		US FAERS
51	Levofloxacin	FAERS: 1		US FAERS
52	MDV 3100	FAERS: 1		US FAERS
53	Methotrexate	FAERS: 1		US FAERS
54	Minoxidil	FAERS: 1		US FAERS
55	Mycophenolic Acid	FAERS: 1		US FAERS
56	Octreotide	FAERS: 1		US FAERS
57	Ortho Evra	FAERS: 1		US FAERS
58	Prednisone	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
59	Ribavirin	FAERS: 1		OFFSIDES US FAERS
60	Tacrolimus	FAERS: 1	17076739	CTD US FAERS
61	cabazitaxel	FAERS: 1		US FAERS
62	rofecoxib	FAERS: 1		US FAERS
63	tofacitinib	FAERS: 1		US FAERS
64	Acetaminophen			OFFSIDES
65	Alitretinoin	Canada Vigilance: 1		Canada Vigilance
66	Allopurinol			OFFSIDES
67	Ambroxol			OFFSIDES
68	Aspartic Acid			OFFSIDES
69	Benztropine			OFFSIDES
70	Bleomycin			OFFSIDES
71	Bortezomib			OFFSIDES
72	Bromhexine			OFFSIDES
73	Cefazolin			OFFSIDES
74	Chlorpheniramine			OFFSIDES
75	Cimetidine			OFFSIDES
76	Clobetasol			OFFSIDES
77	Cocaine		19087813	CTD
78	Colchicine			OFFSIDES
79	Dacarbazine			OFFSIDES
80	Dapsone			OFFSIDES
81	Dermazin		16327720	CTD
82	Desoximetasone			OFFSIDES
83	Diclofenac	Canada Vigilance: 1		Canada Vigilance
84	Docetaxel	Canada Vigilance: 1		Canada Vigilance
85	Erythromycin			OFFSIDES
86	Famotidine			OFFSIDES
87	Flurazepam			OFFSIDES
88	Gabexate			OFFSIDES
89	Guanfacine			OFFSIDES
90	Hydroxyzine			OFFSIDES
91	Imiquimod			OFFSIDES
92	Isoniazid			OFFSIDES
93	Lithium Carbonate			OFFSIDES
94	Mercaptopurine			OFFSIDES
95	Methylprednisolone Acetate			OFFSIDES
96	Methylprednisolone Hemisuccinate			OFFSIDES
97	Minocycline			OFFSIDES
98	Ofloxacin			OFFSIDES
99	Orphenadrine			OFFSIDES
100	Oxaprozin			OFFSIDES
101	Oxcarbazepine			OFFSIDES
102	Oxytetracycline			OFFSIDES
103	Penicillin V			OFFSIDES
104	Penicillins			OFFSIDES
105	Perphenazine			OFFSIDES
106	Phentermine			OFFSIDES
107	Pramipexole			OFFSIDES
108	Pyridoxal			OFFSIDES
109	Quinidine			OFFSIDES
110	Saridon			OFFSIDES
111	Sodium gualenate			OFFSIDES
112	Tetracycline			OFFSIDES
113	Tremorine			OFFSIDES
114	Tretinoin			OFFSIDES
115	alfacalcidol			OFFSIDES
116	brotizolam			OFFSIDES
117	cyclobenzaprine			OFFSIDES
118	estradiol 17 beta-cypionate			OFFSIDES
119	etizolam			OFFSIDES
120	ferrous fumarate			OFFSIDES
121	flomoxef			OFFSIDES
122	flurbiprofen axetil			OFFSIDES
123	levocabastine			OFFSIDES
124	loxoprofen			OFFSIDES
125	moexipril			OFFSIDES
126	nefazodone			OFFSIDES
127	pazufloxacin			OFFSIDES
128	polaprezinc			OFFSIDES
129	ramosetron			OFFSIDES
130	roxatidine acetate			OFFSIDES
131	sennoside A&B			OFFSIDES
132	tandospirone			OFFSIDES
133	telmisartan, hydrochlorothiazide drug combination			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Foot Ulcer	49.7%
2	Lupus Erythematosus, Cutaneous	49.3%
3	Panniculitis	49.3%
4	Systemic Scleroderma	49.3%
5	Morphea	49.3%
6	Acne Vulgaris	48%
7	Contact Dermatitis	48%
8	Eczema	48%
9	Erythema Multiforme	48%
10	Intertrigo	48%
11	Neurodermatitis	48%
12	Rhinophyma	48%
13	Perioral Dermatitis	48%
14	Acne	48%
15	Breast Diseases	45.8%
16	Dermatitis	45.8%
17	Exanthema	45.8%
18	Facial Dermatoses	45.8%
19	Hair Diseases	45.8%
20	Hand Dermatoses	45.8%
21	keratoacanthoma	45.8%
22	Keratosis	45.8%
23	Nail Diseases	45.8%
24	Photosensitivity Disorders	45.8%
25	Prurigo	45.8%
26	Rosacea	45.8%
27	Sebaceous Gland Diseases	45.8%
28	Skin Diseases, Vesiculobullous	45.8%
29	Sweat Gland Diseases	45.8%
30	Skin Diseases, Papulosquamous	45.8%
31	Acneiform Eruptions	45.8%
32	Ocular Rosacea	45.8%
33	Subcorneal pustular dermatosis	45.8%
34	Erythematotelangiectatic Rosacea	45.8%
35	Papulopustular Rosacea	45.8%
36	Chronic Actinic Dermatitis	45.8%
37	Dermatitis, Atopic	45%
38	Epidermolysis Bullosa	45%
39	Dermatitis, Phototoxic	44.3%
40	Pityriasis Lichenoides et Varioliformis Acuta	44.3%
41	Pityriasis Lichenoides	44.3%
42	Phototoxicity	44.3%
43	Xeroderma Pigmentosum	43.9%
44	Pressure Ulcer	43.3%
45	Leg Ulcer	43.3%
46	Dermatitis Herpetiformis	40.4%
47	Acrodermatitis	40%
48	Sebaceous Gland Neoplasms	40%
49	Pyoderma Gangrenosum	40%
50	Porokeratosis	40%
51	Gianotti-Crosti Syndrome	40%
52	Keratoderma, Palmoplantar	40%
53	Panniculitis, Lupus Erythematosus	39.6%
54	Necrobiosis Lipoidica Diabeticorum	38.4%
55	Foot Diseases	38%
56	Dermatitis, Photoallergic	37.9%
57	Skin Abnormalities	37%
58	Skin Diseases, Infectious	37%
59	Skin Neoplasms	37%
60	Pigmentation Disorders	37%
61	Lipomatosis	36.5%
62	Pruritus	36.5%
63	Erythema	36.5%
64	Necrolytic Migratory Erythema	36.5%
65	Cutaneous Fistula	36.5%
66	Nephrogenic Fibrosing Dermopathy	36.5%
67	Nephrogenic Systemic Fibrosis	36.5%
68	Dermatitis, Irritant	35.5%
69	Acne Conglobata	35.5%
70	Erythema Induratum	34.8%
71	Urticaria	34.7%
72	Xeroderma	34.6%
73	Dermatomyositis	34.5%
74	Urticaria Pigmentosa	34.5%
75	Ecthyma	32.5%
76	Lupus Erythematosus, Discoid	32%
77	Scleroderma, Limited	32%
78	Dermatitis, Occupational	30.7%
79	Pyoderma	30.5%
80	Skin Ulcer	30.5%
81	Skin Diseases, Vascular	30.5%
82	Cutis Laxa	30.3%
83	Mastocytosis	30.2%
84	Erythema Infectiosum	30.1%
85	Pseudoxanthoma Elasticum	30.1%
86	Anhidrosis	30%
87	Cholesteatoma	30%
88	Ectodermal Dysplasia	30%
89	Exanthema Subitum	30%
90	Folliculitis	30%
91	Foot Dermatoses	30%
92	Gynecomastia	30%
93	Hypertrichosis	30%
94	Hypohidrosis	30%
95	Hypotrichosis	30%
96	Miliaria	30%
97	Parakeratosis	30%
98	Parapsoriasis	30%
99	Pityriasis	30%
100	Psoriasis	30%
101	Sweet Syndrome	30%
102	Hidradenitis	30%
103	Onycholysis	30%
104	Miliaria Rubra	30%
105	Hyperpigmentation	30%
106	Lichenoid Eruptions	30%
107	Chloracne	30%
108	Aplasia Cutis Congenita	30%
109	Dermatitis, Allergic Contact	29.7%
110	Erythema Nodosum	29.6%
111	Papillon-Lefevre Disease	29.5%
112	Toxic Epidermal Necrolysis	29.5%
113	Stevens-Johnson Syndrome	29.5%
114	Diaper Rash	29.4%
115	Mucocutaneous Lymph Node Syndrome	29.2%
116	Behcet Syndrome	29.2%
117	Livedo Reticularis	28.9%
118	Malignant Atrophic Papulosis	28.9%
119	Polyarteritis Nodosa	28.6%
120	Takayasu Arteritis	28.6%
121	Tinea Capitis	27.3%
122	Onychomycosis	27.3%
123	Connective Tissue Diseases	26.3%
124	Hyperkeratosis, Epidermolytic	25.9%
125	Varicose Ulcer	25.8%
126	Granuloma Annulare	24.9%
127	Ichthyosis, X-Linked	24.7%
128	Sjogren-Larsson Syndrome	24.5%
129	Acantholysis	24.3%
130	Breast Cyst	24.3%
131	Actinic keratosis	24.3%
132	Pemphigoid, Benign Mucous Membrane	24.3%
133	Pemphigus	24.3%
134	Piedra	24.3%
135	Sunburn	24.3%
136	Argyria	24%
137	Hirsutism	24%
138	Lactation Disorder	24%
139	Mastitis	24%
140	Adiposis Dolorosa	23.8%
141	Pruritus Vulvae	23.8%
142	Mastocytoma	23.8%
143	Pruritus Ani	23.8%
144	Lichen Planus	22.3%
145	Melanosis	22.3%
146	Chloasma	22.3%
147	Pityriasis Rosea	22.3%
148	Pityriasis Rubra Pilaris	22.3%
149	Vitiligo	22.3%
150	Lichen Nitidus	22.3%
151	Hidradenitis Suppurativa	22.2%
152	Angioedema	21.7%
153	Albinism	20.9%
154	Erythema Chronicum Migrans	20.6%
155	Dermatomycoses	20.2%
156	Skin Diseases, Bacterial	20.2%
157	Tinea Pedis	20.1%
158	Drug Eruptions	20%
159	Lipodystrophy	20%
160	Acanthosis Nigricans	18.5%
161	Alopecia Areata	18.5%
162	Lentigo	18.5%
163	Alopecia	18.1%
164	Sweating, Gustatory	18.1%
165	Androgenetic Alopecia	18.1%
166	Auriculotemporal Syndrome	18.1%
167	Lice Infestations	17.9%
168	Breast Neoplasms, Male	17.9%
169	Triple Negative Breast Neoplasms	17.9%
170	Galactorrhea	17.8%
171	Mycetoma	17.7%
172	Nail-Patella Syndrome	17.5%
173	Porphyrias, Hepatic	17.3%
174	Giant Cell Arteritis	17%
175	Temporal Arteritis	17%
176	Hereditary Angioedema Type III	15.9%
177	Hereditary Angioedema Types I and II	15.9%
178	Angioedemas, Hereditary	15.4%
179	Collagen Diseases	15.3%
180	Mixed Connective Tissue Disease	15.3%
181	Mucinoses	15.3%
182	Diabetic Foot	15.2%
183	Larva Migrans	15.1%
184	Leishmaniasis	15.1%
185	Molluscum Contagiosum	15.1%
186	Lichen Planus, Oral	15.1%
187	Onchocerciasis	14.9%
188	Chromoblastomycosis	14.8%
189	Dermatophytosis	14.8%
190	Sporotrichosis	14.8%
191	Tinea	14.8%
192	Tinea Versicolor	14.8%
193	Trichophytosis	14.8%
194	Hyalohyphomycosis	14.8%
195	Acute Generalized Exanthematous Pustulosis	14.8%
196	CREST Syndrome	13.1%
197	Warts	13%
198	Candidiasis, Chronic Mucocutaneous	12.7%
199	Cutaneous Candidiasis	12.7%
200	Cartilage Diseases	12.7%
201	Erysipelas	12.7%
202	Rheumatism	12.7%
203	Serum Sickness	12.7%
204	Staphylococcal Skin Infections	12.7%
205	Chondromalacia	12.7%
206	Variegate Porphyria	12.7%
207	Acute intermittent porphyria	12.7%
208	Porphyria Cutanea Tarda	12.7%
209	Erythrasma	12.6%
210	Carcinoma, Lobular	12.6%
211	Arthritis, Psoriatic	12.6%
212	Leishmaniasis, Cutaneous	12.3%
213	Lupus Erythematosus, Systemic	12.3%
214	Overlap syndrome	12.3%
215	Eczema Herpeticum	12.3%
216	Fusariosis	12.2%
217	Epidermodysplasia Verruciformis	10.6%
218	Herpes Labialis	10.6%
219	Staphylococcal Scalded Skin Syndrome	10.4%
220	Dupuytren Contracture	10%
221	Scleromyxedema	10%
222	Blastomycosis	9.9%
223	HIV-Associated Lipodystrophy Syndrome	9.8%
224	Peutz-Jeghers Syndrome	9.6%
225	carbuncle	9.3%
226	Condylomata Acuminata	9.3%
227	Furunculosis	9.2%
228	furuncle	9.2%
229	Impetigo	9.1%
230	Rhinoscleroma	9.1%
231	Menkes Kinky Hair Syndrome	9%
232	Cellulitis	8.6%
233	Mesenteric Panniculitis	8.1%
234	Panniculitis, Peritoneal	8.1%
235	Tietze's Syndrome	8.1%
236	Orbital Cellulitis	8.1%
237	Myxoid cyst	8.1%
238	Myxedema	8%
239	Osteochondritis	6.8%
240	Polymyalgia Rheumatica	6.8%
241	Osteogenesis Imperfecta	6.7%
242	Noonan Syndrome	6.7%
243	Keloid	6.6%
244	Marfan Syndrome	6.1%
245	Homocystinuria	5.9%
246	Rheumatoid Arthritis	5.8%
247	Juvenile arthritis	5.8%
248	Lupus Nephritis	5.6%
249	Laryngomalacia	5.1%
250	Pectus carinatum	5.1%
251	Rheumatoid Nodule	4.9%
252	Felty Syndrome	4.2%
253	Bronchomalacia	4.2%
254	Tracheomalacia	4.2%
255	Rheumatoid Vasculitis	3.7%
256	Mucopolysaccharidosis III	3.6%
257	Sicca Syndrome	3.3%
258	Sjogren's Syndrome	3.3%
259	Lupus Vasculitis, Central Nervous System	2.8%
260	Mucopolysaccharidosis II	2.6%

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