MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

leiomyosarcoma

(UMLS:C0023269)

Definition:: A sarcoma containing large spindle cells of smooth muscle. Although it rarely occurs in soft tissue, it is common in the viscera. It is the most common soft tissue sarcoma of the gastrointestinal tract and uterus. The median age of patients is 60 years. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p1865)
UMLS ID:: C0023269
MeSH ID:: D007890

Classification:

Name:

Neoplasms
MeSH Tree Number(s):: C04.557.450.590.455|C04.557.450.795.455

Synonym(s)

leiomyosarcoma

LEIOMYOSARCOMA

LEIOMYOSARCOMA, MALIGNANT

LMS - Leiomyosarcoma

Leiomyosarcoma

Leiomyosarcoma (excluding uterine leiomyosarcoma)

Leiomyosarcoma - not uterine

Leiomyosarcoma NOS

Leiomyosarcoma, NOS

10.

Leiomyosarcoma, no subtype

11.

Leiomyosarcomas

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Fingolimod Hydrochloride	FAERS: 6 Canada Vigilance: 2		Canada Vigilance US FAERS
2	pazopanib	FAERS: 6 Canada Vigilance: 1		Canada Vigilance US FAERS
3	Tamoxifen	FAERS: 5		OFFSIDES US FAERS
4	Norgestrel	FAERS: 4 Canada Vigilance: 1		Canada Vigilance US FAERS
5	pazopanib	FAERS: 4		US FAERS
6	Doxorubicin	FAERS: 3	View details 2224762 11330370 15314480 15878560	CTD US FAERS
7	Lenalidomide	FAERS: 3		US FAERS
8	Ruxolitinib phosphate	FAERS: 3		US FAERS
9	Ketamine	FAERS: 2		US FAERS
10	Teriparatide	FAERS: 2		US FAERS
11	Trabectedin	FAERS: 2		US FAERS
12	teriflunomide	FAERS: 2		US FAERS
13	Aprepitant	FAERS: 1		US FAERS
14	Baclofen	FAERS: 1		US FAERS
15	Dacarbazine	FAERS: 1	11330370	CTD US FAERS
16	Imatinib Mesylate	FAERS: 1		US FAERS
17	Leuprolide	FAERS: 1		US FAERS
18	Loperamide	FAERS: 1		US FAERS
19	Pregabalin	FAERS: 1		US FAERS
20	Sunitinib	FAERS: 1		US FAERS
21	Tacrolimus	FAERS: 1		US FAERS
22	Temozolomide	FAERS: 1		OFFSIDES US FAERS
23	Thalidomide	FAERS: 1		US FAERS
24	Viekira Pak	FAERS: 1		US FAERS
25	Warfarin	FAERS: 1		US FAERS
26	ledipasvir, sofosbuvir drug combination	FAERS: 1		US FAERS
27	liposomal doxorubicin	FAERS: 1		US FAERS
28	rofecoxib	FAERS: 1		US FAERS
29	5-(3-methyl-1-triazeno)imidazole-4-carboxamide		1127724	CTD
30	Anastrozole			OFFSIDES
31	Aspirin		6692300	CTD
32	Carboplatin		12748258	CTD
33	Cyclophosphamide		View details 1898235 2294239 3978554 6876288 7844616 11487082 12748258	CTD
34	Dactinomycin		12748258	CTD
35	Deamino Arginine Vasopressin			OFFSIDES
36	Docetaxel		10458265	CTD
37	Etoposide		12748258 15878560	CTD
38	Formaldehyde		12562630	CTD
39	Fosinopril			OFFSIDES
40	Ifosfamide		15878560	CTD
41	Mesna		15878560	CTD
42	Methylnitronitrosoguanidine		6692300	CTD
43	Minoxidil			OFFSIDES
44	Paclitaxel		9774950	CTD
45	Prednisone		7844616 12748258	CTD
46	Taurocholic Acid		6692300	CTD
47	Vincristine		1421432 7844616 12748258	CTD
48	Vindesine		7438126	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Alveolar Soft Part Sarcoma	71%
2	Chondrosarcoma	58.1%
3	liposarcoma	58.1%
4	synovial sarcoma	58.1%
5	Clear Cell Sarcoma of Soft Tissue	58.1%
6	Rhabdomyosarcoma	52.8%
7	Fibrosarcoma	52.2%
8	Osteosarcoma	52.2%
9	Carcinosarcoma	50.4%
10	Hemangiosarcoma	50.4%
11	lymphangiosarcoma	50.4%
12	Malignant Fibrous Histiocytoma	49.3%
13	Phyllodes Tumor	47.3%
14	Myoma	47.3%
15	Smooth Muscle Tumor	47.3%
16	Desmoplastic Small Round Cell Tumor	47.3%
17	Angiomyolipoma	45.2%
18	Sarcoma, Myeloid	45.2%
19	Alveolar rhabdomyosarcoma	43.8%
20	Dermatofibrosarcoma	40.3%
21	Dermatofibrosarcoma Protuberans	40.3%
22	Carcinoma 256, Walker	36.1%
23	Sarcoma, Experimental	35.5%
24	Rhabdomyoma	35.3%
25	Giant Cell Tumor of Bone	33.6%
26	leukemia	33.3%
27	Neoplasms, Germ Cell and Embryonal	33.3%
28	Neoplasms, Glandular and Epithelial	33.3%
29	Germ Cell Cancer	33.3%
30	Sarcoma 180	31.6%
31	Lipoma	30.1%
32	Myxoma	30.1%
33	Angiolipoma	30.1%
34	Myelolipoma	30.1%
35	Neoplasms, Bone Tissue	30.1%
36	Neoplasms, Fibrous Tissue	30.1%
37	Chondroma	30.1%
38	Enchondroma	30.1%
39	Neuroectodermal Tumors	29.5%
40	Neoplasms, Neuroepithelial	27.3%
41	Gliomatosis cerebri	27.3%
42	Endometrial Stromal Sarcoma	27.2%
43	Neurofibrosarcoma	27%
44	Histiocytic Disorders, Malignant	25%
45	Adenofibroma	23.6%
46	Fibroadenoma	23.6%
47	melanoma	23.2%
48	Sarcoma	22.8%
49	leiomyosarcoma	22.6%
50	fibroma	22.5%
51	Fibromatosis	22.5%
52	Osteoblastoma	22.5%
53	Osteoma	22.5%
54	Chondromatosis	22.5%
55	Lymphangioleiomyomatosis	21.5%
56	Meningioma	21.1%
57	Hamartoma	20.9%
58	Neoplasms, Hormone-Dependent	20.9%
59	Neoplasms, Multiple Primary	20.9%
60	Paraneoplastic Syndromes	20.9%
61	Precancerous Conditions	20.9%
62	Neoplasms, Second Primary	20.9%
63	Lymphoma	20%
64	Adenoma	19.6%
65	Ameloblastoma	19.6%
66	Angiokeratoma	19.6%
67	Carcinoma	19.6%
68	Chordoma	19.6%
69	Hemangioma	19.6%
70	hemangiopericytoma	19.6%
71	Lymphangioma	19.6%
72	Mesenchymoma	19.6%
73	Nevus	19.6%
74	Teratoma	19.6%
75	Hepatoblastoma	19.6%
76	Mixed Tumor, Mullerian	19.6%
77	Germinoma	19.6%
78	Teratocarcinoma	19.6%
79	Angiofibroma	19.6%
80	Composite Lymphoma	19.6%
81	Epithelioma	19.6%
82	Leukemia, Plasma Cell	19.5%
83	Basal cell carcinoma	19.4%
84	Carcinoma, Papillary	19.4%
85	Squamous cell carcinoma	19.4%
86	Craniopharyngioma	19.4%
87	Cystadenoma	19.4%
88	Mesothelioma	19.4%
89	Neuroectodermal Tumor, Melanotic	19.4%
90	Neuroendocrine Tumors	19.4%
91	Carcinoma, Basal Cell	19.4%
92	Adenoma, Acidophil	19.2%
93	Ganglioneuroma	19.2%
94	Glioma	19.2%
95	Malignant Glioma	19.2%
96	Medulloblastoma	19%
97	Trophoblastic Neoplasms	18.7%
98	Fibromatosis, Aggressive	18.7%
99	Fibromatosis, Abdominal	18.7%
100	Leukemia, Experimental	18.5%
101	Mastocytosis	18.5%
102	Gastrointestinal Stromal Tumors	18.3%
103	Carcinoma, Ehrlich Tumor	18.2%
104	Dermoid Cyst	18.2%
105	Carcinoma, Lewis Lung	18.2%
106	Carcinoid Tumor	17.3%
107	Neurilemmoma	17.3%
108	Hutchinson's Melanotic Freckle	17.3%
109	Melanoma, Amelanotic	17.3%
110	Melanoma, Experimental	17.2%
111	Mastocytoma	17%
112	Cystadenocarcinoma	16.9%
113	Mucoepidermoid Carcinoma	16.9%
114	Mastocytosis, Systemic	16.9%
115	Cyst	15.8%
116	Neoplastic Processes	15.8%
117	Neoplastic Syndromes, Hereditary	15.8%
118	Pregnancy Complications, Neoplastic	15.8%
119	Leukemia, Radiation-Induced	15.6%
120	Neoplasms, Experimental	15.5%
121	Astrocytoma	15.3%
122	Ependymoma	15.3%
123	oligodendroglioma	15.3%
124	Ganglioglioma	15.3%
125	gliosarcoma	15.3%
126	Anaplastic astrocytoma	15.3%
127	Anaplastic Oligodendroglioma	15.3%
128	Plasmacytoma	14.8%
129	Malignant histiocytosis	14.6%
130	Leukemia L1210	14.6%
131	Leukemia P388	14.6%
132	Histiocytic sarcoma	14.6%
133	Acanthoma	14.6%
134	Choriocarcinoma	14.6%
135	Carcinoma, Lobular	14.6%
136	Bowen's Disease	14.4%
137	Paraganglioma	14.4%
138	Thymoma	14.4%
139	Malignant Carcinoid Syndrome	14.3%
140	Glioblastoma	13.3%
141	Neuroblastoma	13.3%
142	Glioblastoma Multiforme	13.3%
143	Adenocarcinoma	12.9%
144	Carcinoma in Situ	12.9%
145	Carcinoma, Transitional Cell	12.9%
146	Dysgerminoma	12.9%
147	Hemangioendothelioma	12.9%
148	Neuroma	12.9%
149	Papilloma	12.9%
150	Pseudomyxoma Peritonei	12.9%
151	Seminoma	12.9%
152	Papillomatosis	12.9%
153	Adenomatosis, Pulmonary	12.9%
154	Adenomatous Polyps	12.9%
155	Carcinoma, Large Cell	12.9%
156	Carcinoma, Small Cell	12.9%
157	Multiple Endocrine Neoplasia	12.6%
158	Neoplasms, Radiation-Induced	12.4%
159	Retinoblastoma	12.4%
160	Ganglioneuroblastoma	12.4%
161	Pheochromocytoma	12%
162	Hodgkin Disease	11.7%
163	Lymphoma, Non-Hodgkin	11.7%
164	Dupuytren Contracture	11.5%
165	Urticaria Pigmentosa	11.3%
166	Abdominal Neoplasms	11.1%
167	Erythroplasia	11.1%
168	Follicular cyst	11.1%
169	Head and Neck Neoplasms	11.1%
170	Mucocele	11.1%
171	Pilonidal Cyst	11.1%
172	Soft Tissue Neoplasms	11.1%
173	Thoracic Neoplasms	11.1%
174	Thyroglossal Cyst	11.1%
175	Synovial Cyst	11.1%
176	Aberrant Crypt Foci	11.1%
177	Carcinoid Heart Disease	10.9%
178	Paraneoplastic Encephalomyelitis	10.8%
179	Mammary Neoplasms, Experimental	10.6%
180	Lymphomatoid Granulomatosis	10.3%
181	Nephroblastoma	10.1%
182	Primary amyloidosis	9.8%
183	Leukemia, Myelomonocytic, Chronic	9.7%
184	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	9.7%
185	Adenoid Cystic Carcinoma	9.6%
186	Adenocarcinoma, Clear Cell	9.6%
187	Cholangiocarcinoma	9.6%
188	Cervical Intraepithelial Neoplasia	9.6%
189	Hemangioblastoma	9.6%
190	Lymphoma, Extranodal NK-T-Cell	9.6%
191	Basal Cell Nevus Syndrome	9.2%
192	Tuberous Sclerosis	9.2%
193	Carcinoma, Pancreatic Ductal	8.8%
194	Digestive System Neoplasms	8.8%
195	Endocrine Gland Neoplasms	8.8%
196	Eye Neoplasms	8.8%
197	Nervous System Neoplasms	8.8%
198	Acoustic Neuroma	8.7%
199	Hepatocellular Adenoma	8.7%
200	Bone neoplasms	8.5%
201	Leukoplakia	8.5%
202	Lymphocele	8.5%
203	Pancreatic Cyst	8.5%
204	Skin Neoplasms	8.5%
205	Hematologic Neoplasms	8.5%
206	Mesoblastic Nephroma	8.5%
207	Barrett Esophagus	8.3%
208	Breast Cyst	8.3%
209	Hydatidiform Mole	8.3%
210	Actinic keratosis	8.3%
211	Mediastinal Cyst	8.3%
212	Neoplasm Invasiveness	8.3%
213	Neoplasm Metastasis	8.3%
214	Neoplasm Recurrence, Local	8.3%
215	Parovarian Cyst	8.3%
216	Pericardial Cyst	8.3%
217	Splenic Neoplasms	8.3%
218	Thymic Cyst	8.3%
219	Carcinogenesis	8.3%
220	Myxoid cyst	8.3%
221	Metastasis	8.3%
222	Klatskin Tumor	8%
223	Sturge-Weber Syndrome	7.9%
224	Optic Nerve Glioma	7.9%
225	Hemangioma, Cavernous	7.8%
226	Leukemia, T-Cell	7.7%
227	Leukemia, B-Cell	7.7%
228	neurofibroma	7.7%
229	Lymphoma, Follicular	7.7%
230	T-Cell Lymphoma	7.7%
231	Mantle cell lymphoma	7.7%
232	Multiple Endocrine Neoplasia Type 1	7.5%
233	Vipoma	7.5%
234	Prolactinoma	7.4%
235	Growth Hormone-Secreting Pituitary Adenoma	7.4%
236	Waldenstrom Macroglobulinemia	7.4%
237	Multiple Myeloma	7.4%
238	Leukemia, Myeloid, Chronic-Phase	7.2%
239	Parathyroid Neoplasms	6.7%
240	Peritoneal Neoplasms	6.7%
241	Thyroid Neoplasm	6.7%
242	Thyroid carcinoma	6.7%
243	Liver Neoplasms, Experimental	6.6%
244	Corpus Luteum Cyst	6.6%
245	Ovarian Cysts	6.6%
246	Retroperitoneal Neoplasms	6.5%
247	granulosa cell tumor	6.4%
248	Carcinoma, Ovarian Epithelial	6.4%
249	Adenomatous Polyposis Coli	6.3%
250	insulinoma	6%
251	Pancreatic Neoplasm	5.8%
252	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	5.8%
253	Leukemia, Large Granular Lymphocytic	5.8%
254	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	5.8%
255	Lymphoma, T-Cell, Cutaneous	5.7%
256	Lymphoma, AIDS-Related	5.7%
257	Enteropathy-Associated T-Cell Lymphoma	5.7%
258	Primary Effusion Lymphoma	5.7%
259	Choledochal Cyst	5.6%
260	Tracheal Neoplasms	5.6%
261	Adrenocortical carcinoma	5.5%
262	Peutz-Jeghers Syndrome	5.5%
263	Leukoplakia, Oral	5.5%
264	Paraneoplastic Cerebellar Degeneration	5.4%
265	Gastrinoma	5.4%
266	Glucagonoma	5.4%
267	Nasopharyngeal carcinoma	5.2%
268	Leydig Cell Tumor	5.1%
269	Mouth Neoplasms	5%
270	Central Nervous System Neoplasms	5%
271	Vascular Neoplasms	5%
272	Thymus Neoplasms	5%
273	Genital Neoplasms, Female	4.9%
274	Pancreatic Pseudocyst	4.9%
275	Lymphatic Metastasis	4.9%
276	Neoplasms, Unknown Primary	4.9%
277	Leukemic Infiltration	4.9%
278	Breast Neoplasms, Male	4.9%
279	Neoplasm Micrometastasis	4.9%
280	Triple Negative Breast Neoplasms	4.9%
281	Renal Cell Carcinoma	4.8%
282	Papillary Renal Cell Carcinoma	4.8%
283	Mycosis Fungoides	4.8%
284	Lymphomatoid Papulosis	4.8%
285	Plasmablastic lymphoma	4.8%
286	Esophageal Neoplasms	4.7%
287	Denys-Drash Syndrome	4.7%
288	Limbic Encephalitis	4.7%
289	Carcinoma, Endometrioid	4.6%
290	Thyroid Nodule	4.3%
291	Lambert-Eaton Myasthenic Syndrome	4.1%
292	Testicular Neoplasms	4.1%
293	Burkitt Lymphoma	4.1%
294	Adrenal Gland Neoplasms	4.1%
295	Gastrointestinal Neoplasms	4.1%
296	Genital Neoplasms, Male	4.1%
297	Liver neoplasms	4.1%
298	Uveal Neoplasms	4.1%
299	Urologic Neoplasms	4%
300	Sebaceous Gland Neoplasms	3.9%
301	Spinal Neoplasms	3.9%
302	Bone Marrow Neoplasms	3.9%
303	Polycystic Ovary Syndrome	3.9%
304	Opsoclonus-Myoclonus Syndrome	3.7%
305	Sezary Syndrome	3.4%
306	Xeroderma Pigmentosum	3.3%
307	Myelitis, Transverse	3.3%
308	Meningeal Neoplasms	3.3%
309	Nose Neoplasms	3%
310	Palatal Neoplasms	2.8%
311	ovarian neoplasm	2.8%
312	Pituitary Adenoma	2.7%
313	Pituitary Neoplasms	2.7%
314	Ear Neoplasms	2.7%
315	Eyelid Neoplasms	2.7%
316	Lung Neoplasms	2.7%
317	Pleural Neoplasms	2.7%
318	Cell Transformation, Viral	2.6%
319	Brain Neoplasms	2.6%
320	Salivary Gland Neoplasms	2.6%
321	Spinal Cord Neoplasms	2.6%
322	Tongue Neoplasms	2.6%
323	Uterine Neoplasms	2.6%
324	Vaginal Neoplasms	2.6%
325	Vulvar Neoplasms	2.6%
326	Uterine Cancer	2.6%
327	Fallopian Tube Neoplasms	2.6%
328	Meningeal Carcinomatosis	2.4%
329	Pharyngeal Neoplasms	2.3%
330	Central Nervous System Cysts	2.2%
331	Bile Duct Neoplasms	2.2%
332	gallbladder neoplasm	2.2%
333	Intestinal Neoplasms	2.2%
334	Penile Neoplasms	2.2%
335	Prostatic Neoplasms	2.2%
336	Stomach Neoplasms	2.2%
337	Zollinger-Ellison syndrome	2.2%
338	Polycythemia Vera	2.2%
339	Bronchial Neoplasms	2%
340	Multiple Pulmonary Nodules	2%
341	Laryngeal neoplasm	2%
342	Supratentorial Neoplasms	1.9%
343	Endometrial Neoplasms	1.9%
344	Bladder Neoplasm	1.9%
345	Kidney Neoplasm	1.9%
346	Ureteral Neoplasms	1.9%
347	Urethral Neoplasms	1.9%
348	Hypopharyngeal Neoplasms	1.6%
349	Pleural Effusion, Malignant	1.6%
350	Hypopharyngeal Cancer	1.6%
351	Parotid Neoplasms	1.6%
352	Prostatic Neoplasms, Castration-Resistant	1.6%
353	Nelson Syndrome	1.6%
354	Brain Stem Neoplasms	1.6%
355	Choroid Plexus Papilloma	1.4%
356	Cecal Neoplasms	1.4%
357	Duodenal Neoplasms	1.4%
358	Tonsillar Neoplasms	1.3%
359	Cerebellar Neoplasms	1.3%
360	Nasopharyngeal Neoplasms	1.2%
361	Colorectal Neoplasms	1.2%
362	Radicular Cyst	1.1%
363	Appendiceal Neoplasms	1.1%
364	Colonic Neoplasms	1.1%
365	Rectal Neoplasms	1.1%
366	Paranasal Sinus Neoplasms	1.1%
367	Maxillary Sinus Neoplasms	0.9%
368	Anus Neoplasms	0.9%
369	Sigmoid Neoplasms	0.9%

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120234