MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Erythema Induratum

(UMLS:C0014741)

Definition:: A type of panniculitis characterized histologically by the presence of granulomas, vasculitis, and necrosis. It is traditionally considered to be the tuberculous counterpart of nodular vasculitis, but is now known to occur without tuberculous precedent. It is seen most commonly in adolescent and menopausal women, is initiated or exacerbated by cold weather, and typically presents as one or more recurrent erythrocyanotic nodules or plaques on the calves. The nodules may progress to form indurations, ulcerations, and scars.
UMLS ID:: C0014741
MeSH ID:: D004891

Classification 1:

Name:

Bacterial Infections and Mycoses
MeSH Tree Number(s):: C01.252.410.040.552.846.583.260|C01.252.825.820.260|C01.539.800.720.820.260

Classification 2:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.300.710.329|C17.800.229.329|C17.800.566.329|C17.800.838.765.820.320

Synonym(s)

Erythema Induratum

Bazin

Bazin's disease

ERYTHEMA INDURATUM

Erythema induratum

Tuberculosis cutis indurativa

Tuberculous Bazin's disease

Tuberculous erythema induratum

bazin's disease

10.

erythema induratum

11.

erythema; induratum

12.

erythema; induratum, tuberculous

13.

induratum; erythema

14.

induratum; erythema, tuberculous

15.

tuberculosis; indurativa

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Azathioprine	FAERS: 2	US FAERS
2	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	FAERS: 1	US FAERS
3	Bosentan	FAERS: 1	OFFSIDES US FAERS
4	Citalopram	FAERS: 1	US FAERS
5	Diclofenac	FAERS: 1	US FAERS
6	Exenatide	FAERS: 1	US FAERS
7	Insulin Glargine	FAERS: 1	US FAERS
8	Iopamidol	FAERS: 1	US FAERS
9	PCI 32765	FAERS: 1	US FAERS
10	Sacubitril	FAERS: 1	US FAERS
11	Valproic Acid	FAERS: 1	US FAERS
12	pazopanib	FAERS: 1	US FAERS
13	Amiodarone		OFFSIDES
14	Cinacalcet		OFFSIDES
15	Enalapril		OFFSIDES
16	Fondaparinux		OFFSIDES
17	Glyburide		OFFSIDES
18	Leflunomide		OFFSIDES
19	Sevelamer		OFFSIDES
20	Tranexamic Acid		OFFSIDES
21	calcium acetate		OFFSIDES
22	paricalcitol		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Ecthyma	40.6%
2	Erythema Chronicum Migrans	39.9%
3	Panniculitis, Lupus Erythematosus	39.1%
4	Mycetoma	38.6%
5	Hidradenitis Suppurativa	37.2%
6	Pyoderma Gangrenosum	34.8%
7	Erysipelas	33.8%
8	Staphylococcal Skin Infections	33.8%
9	Erythrasma	33.6%
10	Lupus Erythematosus, Cutaneous	33.1%
11	Systemic Scleroderma	33.1%
12	Morphea	33.1%
13	Erythema Multiforme	31.5%
14	Xeroderma Pigmentosum	31.3%
15	Dermatitis, Atopic	29.1%
16	Epidermolysis Bullosa	29.1%
17	Dermatomyositis	26.9%
18	Dermatomycoses	26.9%
19	Necrobiosis Lipoidica Diabeticorum	26%
20	Acne Vulgaris	25.7%
21	Contact Dermatitis	25.7%
22	Eczema	25.7%
23	Intertrigo	25.7%
24	Neurodermatitis	25.7%
25	Rhinophyma	25.7%
26	Perioral Dermatitis	25.7%
27	Acne	25.7%
28	Impetigo	25.2%
29	Rhinoscleroma	25.1%
30	Pseudoxanthoma Elasticum	24.8%
31	Erythema Infectiosum	24.8%
32	Dermatitis, Phototoxic	24.8%
33	Pityriasis Lichenoides et Varioliformis Acuta	24.8%
34	Pityriasis Lichenoides	24.8%
35	Phototoxicity	24.8%
36	Dermatitis Herpetiformis	23.4%
37	Acrodermatitis	23.2%
38	Sebaceous Gland Neoplasms	23.2%
39	Porokeratosis	23.2%
40	Gianotti-Crosti Syndrome	23.2%
41	Keratoderma, Palmoplantar	23.2%
42	Cutis Laxa	23%
43	Staphylococcal Scalded Skin Syndrome	23%
44	Breast Diseases	22.8%
45	Dermatitis	22.8%
46	Exanthema	22.8%
47	Facial Dermatoses	22.8%
48	Hair Diseases	22.8%
49	Hand Dermatoses	22.8%
50	keratoacanthoma	22.8%
51	Keratosis	22.8%
52	Nail Diseases	22.8%
53	Photosensitivity Disorders	22.8%
54	Prurigo	22.8%
55	Pyoderma	22.8%
56	Rosacea	22.8%
57	Sebaceous Gland Diseases	22.8%
58	Skin Diseases, Vesiculobullous	22.8%
59	Skin Ulcer	22.8%
60	Sweat Gland Diseases	22.8%
61	Skin Diseases, Papulosquamous	22.8%
62	Skin Diseases, Vascular	22.8%
63	Acneiform Eruptions	22.8%
64	Ocular Rosacea	22.8%
65	Subcorneal pustular dermatosis	22.8%
66	Erythematotelangiectatic Rosacea	22.8%
67	Papulopustular Rosacea	22.8%
68	Chronic Actinic Dermatitis	22.8%
69	Erythema Nodosum	22.7%
70	Dermatitis, Photoallergic	22.5%
71	Toxic Epidermal Necrolysis	22.1%
72	Stevens-Johnson Syndrome	22.1%
73	Foot Ulcer	22%
74	Tinea Capitis	21.7%
75	Onychomycosis	21.7%
76	Xeroderma	21.3%
77	Furunculosis	21.2%
78	furuncle	21.2%
79	Lupus Erythematosus, Discoid	21%
80	Scleroderma, Limited	21%
81	Sweet Syndrome	20.9%
82	Cellulitis	20.8%
83	Foot Diseases	20.7%
84	Skin Abnormalities	20.4%
85	Skin Neoplasms	20.4%
86	Pigmentation Disorders	20.4%
87	Lipomatosis	20.3%
88	Pruritus	20.3%
89	Necrolytic Migratory Erythema	20.3%
90	Cutaneous Fistula	20.3%
91	Nephrogenic Fibrosing Dermopathy	20.3%
92	Nephrogenic Systemic Fibrosis	20.3%
93	Exanthema Subitum	19.9%
94	Erythema Induratum	19.9%
95	Panniculitis	19.9%
96	Urticaria Pigmentosa	19.8%
97	Ectodermal Dysplasia	19.4%
98	Aplasia Cutis Congenita	19.4%
99	Skin Diseases, Infectious	18.8%
100	Dermatitis, Irritant	18.4%
101	Acne Conglobata	18.4%
102	Mastocytosis	18.2%
103	Piedra	17.9%
104	Candidiasis, Chronic Mucocutaneous	17.9%
105	Cutaneous Candidiasis	17.9%
106	Ichthyosis, X-Linked	17.6%
107	carbuncle	17.6%
108	Sjogren-Larsson Syndrome	17.6%
109	Tinea Pedis	17.1%
110	Chromoblastomycosis	17.1%
111	Dermatophytosis	17.1%
112	Sporotrichosis	17.1%
113	Tinea	17.1%
114	Tinea Versicolor	17.1%
115	Trichophytosis	17.1%
116	Hyalohyphomycosis	17.1%
117	Granuloma Annulare	16.9%
118	Dermatitis, Occupational	16.9%
119	Dermatitis, Allergic Contact	16.6%
120	Papillon-Lefevre Disease	16.5%
121	Hyperkeratosis, Epidermolytic	16.5%
122	Skin Diseases, Bacterial	16.5%
123	Behcet Syndrome	15.4%
124	Blastomycosis	15.2%
125	Central Nervous System Bacterial Infections	15.1%
126	Diaper Rash	14.7%
127	Bacteremia	14.6%
128	Anhidrosis	14.4%
129	Cholesteatoma	14.4%
130	Pressure Ulcer	14.4%
131	Folliculitis	14.4%
132	Foot Dermatoses	14.4%
133	Gynecomastia	14.4%
134	Hypertrichosis	14.4%
135	Hypohidrosis	14.4%
136	Hypotrichosis	14.4%
137	Leg Ulcer	14.4%
138	Miliaria	14.4%
139	Parakeratosis	14.4%
140	Parapsoriasis	14.4%
141	Pityriasis	14.4%
142	Psoriasis	14.4%
143	Hidradenitis	14.4%
144	Onycholysis	14.4%
145	Miliaria Rubra	14.4%
146	Hyperpigmentation	14.4%
147	Lichenoid Eruptions	14.4%
148	Chloracne	14.4%
149	Albinism	14.3%
150	Collagen Diseases	14.1%
151	Mixed Connective Tissue Disease	14.1%
152	Mucinoses	14.1%
153	Mesenteric Panniculitis	14.1%
154	Panniculitis, Peritoneal	14.1%
155	Erythema	13.7%
156	Bacterial Endocarditis	13.4%
157	Joint Tuberculosis	13.2%
158	Tuberculosis, Osteoarticular	13.2%
159	Bone Tuberculosis	13.2%
160	Gram-Negative Bacterial Infections	13.1%
161	Acantholysis	13%
162	Breast Cyst	13%
163	Actinic keratosis	13%
164	Pemphigoid, Benign Mucous Membrane	13%
165	Pemphigus	13%
166	Sunburn	13%
167	Borrelia Infections	13%
168	Leptospirosis	13%
169	Cartilage Diseases	12.9%
170	Rheumatism	12.9%
171	Chondromalacia	12.9%
172	Argyria	12.9%
173	Hirsutism	12.9%
174	Lactation Disorder	12.9%
175	Mastitis	12.9%
176	Urticaria	12.9%
177	Adiposis Dolorosa	12.8%
178	Pruritus Vulvae	12.8%
179	Mastocytoma	12.8%
180	Pruritus Ani	12.8%
181	Lupus Erythematosus, Systemic	12.7%
182	Overlap syndrome	12.7%
183	Fusariosis	12.3%
184	Connective Tissue Diseases	11.9%
185	Syphilis	11.8%
186	Mucocutaneous Lymph Node Syndrome	11.7%
187	Drug Eruptions	11.6%
188	Lipodystrophy	11.6%
189	Livedo Reticularis	11.6%
190	Malignant Atrophic Papulosis	11.6%
191	Bacterial Vaginosis	11.6%
192	Polyarteritis Nodosa	11.5%
193	Takayasu Arteritis	11.5%
194	Lice Infestations	11.4%
195	Lymph Node Tuberculosis	11.4%
196	Tuberculosis, Miliary	11.4%
197	Tuberculosis, Multidrug-Resistant	11.4%
198	Latent Tuberculosis	11.4%
199	Dupuytren Contracture	11.3%
200	Subacute Bacterial Endocarditis	11.1%
201	Lyme Neuroborreliosis	10.8%
202	Clostridium Infections	10.7%
203	Listeriosis	10.7%
204	Staphylococcal Infections	10.7%
205	Streptococcal Infections	10.7%
206	Bacillaceae Infections	10.7%
207	Clostridium difficile infection	10.7%
208	Nail-Patella Syndrome	10.7%
209	Mycoses	10.7%
210	Porphyrias, Hepatic	10.6%
211	Lyme Disease	10.6%
212	Relapsing Fever	10.6%
213	Pneumonia, Bacterial	10.5%
214	CREST Syndrome	10.5%
215	Larva Migrans	10.3%
216	Leishmaniasis	10.3%
217	Molluscum Contagiosum	10.3%
218	Lichen Planus	10.3%
219	Melanosis	10.3%
220	Chloasma	10.3%
221	Pityriasis Rosea	10.3%
222	Pityriasis Rubra Pilaris	10.3%
223	Vitiligo	10.3%
224	Lichen Nitidus	10.3%
225	Onchocerciasis	10.3%
226	Tuberculosis, Gastrointestinal	10.2%
227	Tuberculosis, Central Nervous System	10.1%
228	Leprosy	10.1%
229	Mycobacterium Infections, Nontuberculous	10.1%
230	Mycobacterium abscessus Infection	10.1%
231	Actinomycosis	9.9%
232	Corynebacterium Infections	9.9%
233	Nocardia Infections	9.9%
234	Pulmonary Nocardiosis	9.9%
235	Chlamydia Infections	9.8%
236	Gonorrhea	9.8%
237	Ulcerative stomatitis	9.8%
238	Erysipelothrix infection	9.8%
239	Neurosyphilis	9.6%
240	Central Nervous System Infection	9.6%
241	Warts	9.5%
242	Pelvic Infection	9.3%
243	Wound Infection	9.3%
244	Soft Tissue Infection	9.3%
245	Community-Acquired Infections	9.3%
246	Alopecia	9.3%
247	Sweating, Gustatory	9.3%
248	Androgenetic Alopecia	9.3%
249	Auriculotemporal Syndrome	9.3%
250	Tuberculosis, Pulmonary	9.3%
251	Varicose Ulcer	9.2%
252	Breast Neoplasms, Male	9.2%
253	Triple Negative Breast Neoplasms	9.2%
254	Galactorrhea	9.2%
255	Scleromyxedema	9.2%
256	Noonan Syndrome	8.7%
257	Eye Infection	8.4%
258	Respiratory Tract Infections	8.4%
259	Angioedema	8.3%
260	Bone Diseases, Infectious	8.3%
261	Pregnancy Complications, Infectious	8.3%
262	Acanthosis Nigricans	8.3%
263	Alopecia Areata	8.3%
264	Lentigo	8.3%
265	Arthritis, Infectious	8.3%
266	Suppuration	8.3%
267	Acute Generalized Exanthematous Pustulosis	8.3%
268	Cross Infection	8.2%
269	Septicemia	8.2%
270	Sepsis	8.2%
271	Giant Cell Arteritis	8.2%
272	Temporal Arteritis	8.2%
273	Tuberculosis, Meningeal	8.2%
274	Tietze's Syndrome	8.2%
275	Orbital Cellulitis	8.2%
276	Myxoid cyst	8.2%
277	Marfan Syndrome	8.2%
278	Myxedema	8.2%
279	Tuberculosis, Spinal	8%
280	Homocystinuria	8%
281	Gram-Positive Bacterial Infections	8%
282	Extensively Drug-Resistant Tuberculosis	8%
283	Leishmaniasis, Cutaneous	7.9%
284	Eczema Herpeticum	7.9%
285	Human Ehrlichiosis	7.8%
286	Opportunistic Infections	7.8%
287	Meningitis, Listeria	7.7%
288	Pertussis	7.7%
289	Hordeolum	7.6%
290	Bacterial conjunctivitis	7.6%
291	Serum Sickness	7.5%
292	Variegate Porphyria	7.5%
293	Acute intermittent porphyria	7.5%
294	Porphyria Cutanea Tarda	7.5%
295	Carcinoma, Lobular	7.5%
296	Arthritis, Psoriatic	7.5%
297	Urinary tract infection	7.5%
298	Osteochondritis	7.5%
299	Polymyalgia Rheumatica	7.5%
300	Lichen Planus, Oral	7.4%
301	Osteogenesis Imperfecta	7.4%
302	Keloid	7.3%
303	Bordetella Infections	7.3%
304	Brucellosis	7.3%
305	Campylobacter infection	7.3%
306	Enterobacteriaceae Infections	7.3%
307	Pseudomonas Infections	7.3%
308	Q Fever	7.3%
309	Vibrio Infections	7.3%
310	Helicobacter Infections	7.3%
311	Neisseriaceae Infections	7.3%
312	Burkholderia Infections	7.3%
313	Flavobacteriaceae Infections	7.3%
314	Moraxellaceae Infections	7.3%
315	Burkholderia cepacia Infection	7.3%
316	Epidermodysplasia Verruciformis	7.2%
317	Herpes Labialis	7.2%
318	Human anaplasmosis	7.2%
319	Infection	7.1%
320	Sexually Transmitted Diseases	6.9%
321	Rheumatoid Arthritis	6.8%
322	Juvenile arthritis	6.8%
323	Menkes Kinky Hair Syndrome	6.8%
324	Condylomata Acuminata	6.7%
325	Lupus Nephritis	6.6%
326	Fungemia	6.6%
327	Endotoxemia	6.6%
328	Japanese Spotted Fever	6.6%
329	Mycobacterium avium-intracellulare Infection	6.5%
330	Leprosy, Multibacillary	6.5%
331	HIV-Associated Lipodystrophy Syndrome	6.4%
332	Brain Abscess	6.3%
333	Lymphogranuloma Venereum	6.3%
334	Laryngomalacia	6.3%
335	Gas Gangrene	6.2%
336	Pneumococcal Infections	6.2%
337	Scarlet Fever	6.2%
338	Tetanus	6.2%
339	Pectus carinatum	6.2%
340	Meningitis, Pneumococcal	6.1%
341	Angioedemas, Hereditary	6.1%
342	Diabetic Foot	6%
343	Diphtheria	6%
344	Panophthalmitis	5.9%
345	Ophthalmia Neonatorum	5.8%
346	Trachoma	5.8%
347	Meningitis, Bacterial	5.8%
348	Hereditary Angioedema Type III	5.8%
349	Hereditary Angioedema Types I and II	5.8%
350	Candidemia	5.8%
351	Aspergillosis	5.6%
352	Candidiasis	5.6%
353	Coccidioidomycosis	5.6%
354	Histoplasmosis	5.6%
355	Paracoccidioidomycosis	5.6%
356	Zygomycosis	5.6%
357	Phaeohyphomycosis	5.6%
358	Pneumocystis Infections	5.6%
359	Tuberculosis, Renal	5.4%
360	Rheumatoid Nodule	5.4%
361	Meningitis, Haemophilus	5.4%
362	Peutz-Jeghers Syndrome	5.3%
363	Rheumatic Fever	5%
364	Otomycosis	5%
365	Enterocolitis, Pseudomembranous	5%
366	pseudomembranous colitis	5%
367	Central Nervous System Fungal Infections	5%
368	Neuroaspergillosis	5%
369	Felty Syndrome	4.9%
370	Bronchomalacia	4.9%
371	Tracheomalacia	4.9%
372	Syphilis, Congenital	4.8%
373	Borderline leprosy	4.7%
374	Leprosy, Lepromatous	4.7%
375	Tuberculoid leprosy	4.7%
376	Actinomycetales Infections	4.7%
377	Rocky Mountain Spotted Fever	4.7%
378	Endophthalmitis	4.6%
379	Peritonitis	4.6%
380	Botulism	4.6%
381	Osteomyelitis	4.6%
382	Periostitis	4.6%
383	Surgical Wound Infection	4.6%
384	Abscess	4.6%
385	Adnexitis	4.6%
386	Empyema	4.6%
387	Pelvic Inflammatory Disease	4.6%
388	Lung Diseases, Fungal	4.5%
389	Rheumatoid Vasculitis	4.5%
390	Mucopolysaccharidosis III	4.4%
391	Acinetobacter Infections	4.4%
392	Bacteroides Infections	4.4%
393	Cholera	4.4%
394	Escherichia coli Infections	4.4%
395	Haemophilus Infections	4.4%
396	Klebsiella Infections	4.4%
397	Meningococcal Infections	4.4%
398	Mycoplasma Infections	4.4%
399	Pasteurella Infections	4.4%
400	Proteus Infections	4.4%
401	Rickettsia Infections	4.4%
402	Salmonella infections	4.4%
403	Scrub Typhus	4.4%
404	Serratia Infections	4.4%
405	Ureaplasma Infections	4.4%
406	Superinfection	4.2%
407	Corneal Ulcer	4.2%
408	Sicca Syndrome	4.1%
409	Sjogren's Syndrome	4.1%
410	Puerperal Infection	4.1%
411	Spondylitis	4.1%
412	Appendicitis	4.1%
413	Bacteriuria	4.1%
414	Pyuria	4.1%
415	Pyomyositis	4.1%
416	Endotoxic shock	4.1%
417	Septic Shock	4.1%
418	Toxic Shock Syndrome	4.1%
419	Lupus Vasculitis, Central Nervous System	4.1%
420	Invasive Pulmonary Aspergillosis	4%
421	Arthritis, Reactive	3.7%
422	Meningitis, Cryptococcal	3.6%
423	Rheumatic Heart Disease	3.6%
424	Bacterial Infections	3.5%
425	Mucopolysaccharidosis II	3.5%
426	Dysentery, Bacillary	3.5%
427	AIDS-Related Opportunistic Infections	3.5%
428	Mucormycosis	3.1%
429	Psoas Abscess	3.1%
430	Abdominal Abscess	3.1%
431	Mycobacterium Infections	3%
432	Psittacosis	3%
433	Paratyphoid Fever	3%
434	Plague	3%
435	Typhoid Fever	3%
436	TYPHUS	3%
437	Yersinia pseudotuberculosis Infections	3%
438	Bubonic Plague	3%
439	Toxoplasmosis, Cerebral	3%
440	Oral candidiasis	2.8%
441	Pulmonary Aspergillosis	2.8%
442	Bronchopulmonary Aspergillosis	2.8%
443	Diverticulitis	2.7%
444	Salmonella Infections, Animal	2.7%
445	Salmonella food poisoning	2.7%
446	Waterhouse-Friderichsen Syndrome	2.6%
447	Lung Abscess	2.5%
448	Diverticulum	2.5%
449	Diverticulosis	2.5%
450	Meningitis, Fungal	2.5%
451	Discitis	2.5%
452	Mastoiditis	2.5%
453	Petrositis	2.5%
454	Candidiasis, Vulvovaginal	2.5%
455	Retropharyngeal Abscess	2.3%
456	Epidural Abscess	2.3%
457	Peritonsillar Abscess	2.2%
458	Tuberculosis	2.2%
459	Liver Abscess	1.9%
460	Lemierre Syndrome	1.9%
461	Aspergillosis, Allergic Bronchopulmonary	1.3%
462	Liver Abscess, Amebic	1.1%

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