MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Mixed Connective Tissue Disease

(UMLS:C0026272)

Definition:: A syndrome with overlapping clinical features of systemic lupus erythematosus, scleroderma, polymyositis, and Raynaud's phenomenon. The disease is differentially characterized by high serum titers of antibodies to ribonuclease-sensitive extractable (saline soluble) nuclear antigen and a "speckled" epidermal nuclear staining pattern on direct immunofluorescence.
UMLS ID:: C0026272
MeSH ID:: D008947

Classification:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.300.540

Synonym(s)

Mixed Connective Tissue Disease

CONNECTIVE TISSUE DISEASE MIXED

Connective tissue disease overlap syndrome

Connective tissue disease, mixed form

MCTD

MCTD - Mixed connective tissue disease

MCTD SYNDROME

MIXED CONNECTIVE TISSUE DISEASE

Mixed collagen vascular disease

10.

Mixed collagen vascular disease, NOS

11.

Mixed connective tissue disease

12.

Mixed connective tissue disease, NOS

13.

Sharp's syndrome

14.

collagen disease mixed vascular

15.

connective disease mixed tissue

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Dimethyl Fumarate	FAERS: 4		US FAERS
2	ambrisentan	FAERS: 4		US FAERS
3	rofecoxib	FAERS: 4		OFFSIDES US FAERS
4	Dasatinib	FAERS: 3		US FAERS
5	4-hydroxybutyric acid	FAERS: 2		US FAERS
6	Celecoxib	FAERS: 2		US FAERS
7	Norgestrel	FAERS: 2		US FAERS
8	Telmisartan	FAERS: 2		US FAERS
9	Topiramate	FAERS: 2		US FAERS
10	2-(Tert-butylamino)-1-(3-chlorophenyl)propan-1-one;hydron;chloride	FAERS: 1		US FAERS
11	Azithromycin	FAERS: 1		US FAERS
12	Bosentan	FAERS: 1		OFFSIDES US FAERS
13	Cabergoline	FAERS: 1		US FAERS
14	Interferon alpha-2	FAERS: 1		US FAERS
15	Liraglutide	FAERS: 1		US FAERS
16	Nitrofurantoin	FAERS: 1		US FAERS
17	Qlaira	FAERS: 1		US FAERS
18	Sodium Morrhuate	FAERS: 1		US FAERS
19	Spironolactone	FAERS: 1		US FAERS
20	Terbinafine	FAERS: 1		US FAERS
21	Teriparatide	FAERS: 1		US FAERS
22	Zoledronic Acid	FAERS: 1		US FAERS
23	macitentan	FAERS: 1		US FAERS
24	treprostinil	FAERS: 1		US FAERS
25	Allopurinol			OFFSIDES
26	Amphetamine			OFFSIDES
27	Atovaquone			OFFSIDES
28	Calcium Citrate			OFFSIDES
29	Cefoxitin			OFFSIDES
30	Chlorhexidine			OFFSIDES
31	Ciprofloxacin			OFFSIDES
32	Cortisone			OFFSIDES
33	Econazole			OFFSIDES
34	Ertapenem			OFFSIDES
35	Etoricoxib			OFFSIDES
36	Gabapentin			OFFSIDES
37	Hydroxychloroquine		12427911	CTD
38	Ibuprofen			SIDER
39	Leflunomide			OFFSIDES
40	Meperidine			OFFSIDES
41	Methotrexate	Canada Vigilance: 1		Canada Vigilance
42	Methotrexate			OFFSIDES
43	Moxifloxacin			OFFSIDES
44	Nabumetone			OFFSIDES
45	Pamidronate			OFFSIDES
46	Pentoxifylline		12427911	CTD
47	Prednisone acetate			OFFSIDES
48	Raloxifene Hydrochloride			OFFSIDES
49	Sertraline			OFFSIDES
50	Simethicone			OFFSIDES
51	Sitagliptin Phosphate			OFFSIDES
52	Sulfasalazine			OFFSIDES
53	Sulindac		8256166	CTD
54	Thalidomide			OFFSIDES
55	Vancomycin			OFFSIDES
56	anagrelide			OFFSIDES
57	cefuroxime axetil			OFFSIDES
58	cevimeline			OFFSIDES
59	chlorhexidine gluconate			OFFSIDES
60	tegaserod			OFFSIDES
61	valdecoxib			OFFSIDES
62	zolmitriptan			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Collagen Diseases	42.9%
2	Mucinoses	42.9%
3	Lupus Erythematosus, Cutaneous	38.1%
4	Panniculitis	38.1%
5	Systemic Scleroderma	38.1%
6	Morphea	38.1%
7	Scleromyxedema	31%
8	Cartilage Diseases	30%
9	Rheumatism	30%
10	Chondromalacia	30%
11	Panniculitis, Lupus Erythematosus	29.3%
12	Lupus Erythematosus, Systemic	28.6%
13	Overlap syndrome	28.6%
14	Lupus Erythematosus, Discoid	27.3%
15	Scleroderma, Limited	27.3%
16	Cutis Laxa	25.9%
17	Dermatomyositis	21.8%
18	Mesenteric Panniculitis	20.9%
19	Panniculitis, Peritoneal	20.9%
20	Tietze's Syndrome	20.9%
21	Orbital Cellulitis	20.9%
22	Myxoid cyst	20.9%
23	Myxedema	20.5%
24	Dupuytren Contracture	20.4%
25	Necrobiosis Lipoidica Diabeticorum	18.1%
26	Granuloma Annulare	17.6%
27	Cellulitis	16.3%
28	Osteochondritis	15.8%
29	Polymyalgia Rheumatica	15.8%
30	Osteogenesis Imperfecta	15.4%
31	Pyoderma Gangrenosum	15.3%
32	Pseudoxanthoma Elasticum	15.2%
33	Keloid	15%
34	Breast Diseases	14.3%
35	Dermatitis	14.3%
36	Exanthema	14.3%
37	Facial Dermatoses	14.3%
38	Hair Diseases	14.3%
39	Hand Dermatoses	14.3%
40	keratoacanthoma	14.3%
41	Keratosis	14.3%
42	Nail Diseases	14.3%
43	Photosensitivity Disorders	14.3%
44	Prurigo	14.3%
45	Pyoderma	14.3%
46	Rosacea	14.3%
47	Sebaceous Gland Diseases	14.3%
48	Skin Diseases, Vesiculobullous	14.3%
49	Skin Ulcer	14.3%
50	Sweat Gland Diseases	14.3%
51	Skin Diseases, Papulosquamous	14.3%
52	Skin Diseases, Vascular	14.3%
53	Acneiform Eruptions	14.3%
54	Ocular Rosacea	14.3%
55	Subcorneal pustular dermatosis	14.3%
56	Erythematotelangiectatic Rosacea	14.3%
57	Papulopustular Rosacea	14.3%
58	Chronic Actinic Dermatitis	14.3%
59	Erythema Induratum	14.1%
60	Acne Vulgaris	13.6%
61	Contact Dermatitis	13.6%
62	Eczema	13.6%
63	Erythema Multiforme	13.6%
64	Intertrigo	13.6%
65	Neurodermatitis	13.6%
66	Rhinophyma	13.6%
67	Perioral Dermatitis	13.6%
68	Acne	13.6%
69	Rheumatoid Arthritis	12.5%
70	Rheumatoid Nodule	12.5%
71	Juvenile arthritis	12.5%
72	Dermatitis, Phototoxic	12.4%
73	Pityriasis Lichenoides et Varioliformis Acuta	12.4%
74	Pityriasis Lichenoides	12.4%
75	Phototoxicity	12.4%
76	Foot Ulcer	12.4%
77	Lupus Nephritis	11.9%
78	Noonan Syndrome	11.5%
79	Dermatitis, Irritant	11.1%
80	Acne Conglobata	11.1%
81	Laryngomalacia	10.5%
82	Anhidrosis	10.3%
83	Cholesteatoma	10.3%
84	Pressure Ulcer	10.3%
85	Dermatitis Herpetiformis	10.3%
86	Folliculitis	10.3%
87	Foot Dermatoses	10.3%
88	Gynecomastia	10.3%
89	Hypertrichosis	10.3%
90	Hypohidrosis	10.3%
91	Hypotrichosis	10.3%
92	Leg Ulcer	10.3%
93	Miliaria	10.3%
94	Parakeratosis	10.3%
95	Parapsoriasis	10.3%
96	Pityriasis	10.3%
97	Psoriasis	10.3%
98	Sweet Syndrome	10.3%
99	Hidradenitis	10.3%
100	Onycholysis	10.3%
101	Miliaria Rubra	10.3%
102	Hyperpigmentation	10.3%
103	Lichenoid Eruptions	10.3%
104	Chloracne	10.3%
105	Pectus carinatum	10.3%
106	Marfan Syndrome	10.2%
107	Acrodermatitis	10.2%
108	Sebaceous Gland Neoplasms	10.2%
109	Porokeratosis	10.2%
110	Gianotti-Crosti Syndrome	10.2%
111	Keratoderma, Palmoplantar	10.2%
112	Dermatitis, Atopic	10.1%
113	Epidermolysis Bullosa	10.1%
114	Felty Syndrome	10%
115	Foot Diseases	10%
116	Bronchomalacia	10%
117	Tracheomalacia	10%
118	Diaper Rash	9.9%
119	Dermatitis, Photoallergic	9.9%
120	Homocystinuria	9.9%
121	Skin Abnormalities	9.5%
122	Skin Diseases, Infectious	9.5%
123	Skin Neoplasms	9.5%
124	Pigmentation Disorders	9.5%
125	CREST Syndrome	9.4%
126	Lipomatosis	9.3%
127	Pruritus	9.3%
128	Erythema	9.3%
129	Necrolytic Migratory Erythema	9.3%
130	Cutaneous Fistula	9.3%
131	Nephrogenic Fibrosing Dermopathy	9.3%
132	Nephrogenic Systemic Fibrosis	9.3%
133	Urticaria Pigmentosa	9.1%
134	Xeroderma Pigmentosum	9%
135	Dermatitis, Occupational	8.8%
136	Lichen Planus	8.5%
137	Melanosis	8.5%
138	Chloasma	8.5%
139	Pityriasis Rosea	8.5%
140	Pityriasis Rubra Pilaris	8.5%
141	Vitiligo	8.5%
142	Lichen Nitidus	8.5%
143	Dermatitis, Allergic Contact	8.3%
144	Rheumatoid Vasculitis	8.3%
145	Papillon-Lefevre Disease	8.3%
146	Xeroderma	8.2%
147	Mucopolysaccharidosis III	8.1%
148	Acanthosis Nigricans	7.6%
149	Alopecia Areata	7.6%
150	Lentigo	7.6%
151	Erythema Infectiosum	7.5%
152	Exanthema Subitum	7.4%
153	Erythema Nodosum	7.3%
154	Sicca Syndrome	7.1%
155	Sjogren's Syndrome	7.1%
156	Toxic Epidermal Necrolysis	7%
157	Stevens-Johnson Syndrome	7%
158	Acantholysis	7%
159	Breast Cyst	7%
160	Actinic keratosis	7%
161	Pemphigoid, Benign Mucous Membrane	7%
162	Pemphigus	7%
163	Piedra	7%
164	Sunburn	7%
165	Tinea Capitis	6.9%
166	Onychomycosis	6.9%
167	Mastocytosis	6.8%
168	Argyria	6.8%
169	Hirsutism	6.8%
170	Lactation Disorder	6.8%
171	Mastitis	6.8%
172	Urticaria	6.8%
173	Adiposis Dolorosa	6.7%
174	Ectodermal Dysplasia	6.7%
175	Pruritus Vulvae	6.7%
176	Aplasia Cutis Congenita	6.7%
177	Mastocytoma	6.7%
178	Pruritus Ani	6.7%
179	Hyperkeratosis, Epidermolytic	6.5%
180	Ecthyma	6.1%
181	Alopecia	5.7%
182	Sweating, Gustatory	5.7%
183	Androgenetic Alopecia	5.7%
184	Auriculotemporal Syndrome	5.7%
185	Lice Infestations	5.6%
186	Varicose Ulcer	5.6%
187	Breast Neoplasms, Male	5.6%
188	Triple Negative Breast Neoplasms	5.6%
189	Galactorrhea	5.6%
190	Hidradenitis Suppurativa	5.5%
191	Mucopolysaccharidosis II	5.4%
192	Ichthyosis, X-Linked	5.3%
193	Behcet Syndrome	5.3%
194	Sjogren-Larsson Syndrome	5.2%
195	Dermatomycoses	5.2%
196	Mucocutaneous Lymph Node Syndrome	5.2%
197	Skin Diseases, Bacterial	5.2%
198	Tinea Pedis	5.2%
199	Lichen Planus, Oral	5.1%
200	Drug Eruptions	5.1%
201	Lipodystrophy	5.1%
202	Livedo Reticularis	5.1%
203	Malignant Atrophic Papulosis	5.1%
204	Polyarteritis Nodosa	5%
205	Takayasu Arteritis	5%
206	Lupus Vasculitis, Central Nervous System	4.9%
207	Albinism	4.6%
208	Erythema Chronicum Migrans	4.5%
209	Larva Migrans	4.3%
210	Leishmaniasis	4.3%
211	Molluscum Contagiosum	4.3%
212	Angioedema	4.2%
213	Onchocerciasis	4.2%
214	Chromoblastomycosis	4.2%
215	Dermatophytosis	4.2%
216	Nail-Patella Syndrome	4.2%
217	Sporotrichosis	4.2%
218	Tinea	4.2%
219	Tinea Versicolor	4.2%
220	Trichophytosis	4.2%
221	Hyalohyphomycosis	4.2%
222	Acute Generalized Exanthematous Pustulosis	4.1%
223	Porphyrias, Hepatic	4.1%
224	Mycetoma	4.1%
225	Leishmaniasis, Cutaneous	3.7%
226	Eczema Herpeticum	3.7%
227	Fusariosis	3.7%
228	Hereditary Angioedema Type III	3.5%
229	Hereditary Angioedema Types I and II	3.5%
230	Warts	3.4%
231	Candidiasis, Chronic Mucocutaneous	3.3%
232	Cutaneous Candidiasis	3.3%
233	Erysipelas	3.3%
234	Serum Sickness	3.3%
235	Staphylococcal Skin Infections	3.3%
236	Variegate Porphyria	3.3%
237	Acute intermittent porphyria	3.3%
238	Porphyria Cutanea Tarda	3.3%
239	Erythrasma	3.3%
240	Carcinoma, Lobular	3.3%
241	Arthritis, Psoriatic	3.3%
242	Angioedemas, Hereditary	3%
243	Epidermodysplasia Verruciformis	3%
244	Herpes Labialis	3%
245	Diabetic Foot	3%
246	Staphylococcal Scalded Skin Syndrome	2.9%
247	Peutz-Jeghers Syndrome	2.9%
248	carbuncle	2.7%
249	Condylomata Acuminata	2.5%
250	Furunculosis	2.5%
251	furuncle	2.5%
252	Giant Cell Arteritis	2.5%
253	Temporal Arteritis	2.5%
254	Impetigo	2.4%
255	Blastomycosis	2.4%
256	HIV-Associated Lipodystrophy Syndrome	2.3%
257	Rhinoscleroma	2.1%
258	Menkes Kinky Hair Syndrome	1.8%

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