MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Bowen's Disease

(UMLS:C0006079)

Definition:: A persistent progressive non-elevated red scaly or crusted plaque which is due to an intradermal carcinoma and is potentially malignant. Atypical squamous cells proliferate through the whole thickness of the epidermis. The lesions may occur anywhere on the skin surface or on mucosal surfaces. The cause most frequently found is trivalent arsenic compounds. Freezing, cauterization or diathermy coagulation is often effective. (From Rook et al., Textbook of Dermatology, 4th ed, pp2428-9)
UMLS ID:: C0006079
MeSH ID:: D001913

Classification:

Name:

Neoplasms
MeSH Tree Number(s):: C04.557.470.200.400.130|C04.557.470.700.400.130

Synonym(s)

Bowen's Disease

BD - Bowen's disease

BOWEN DISEASE

Bowen Disease

Bowen Disease of the Skin

Bowen disease

Bowen's Disease of the Skin

Bowen's disease

Bowen's disease of skin

10.

Disease;Bowens

11.

Intraepidermal Squamous Cell Carcinoma, Bowen Type

12.

Intraepidermal squamous cell carcinoma, Bowen's type

13.

SCC - Intraepidermal squamous cell carcinoma - Bowen's type

14.

bowen disease

15.

bowen's disease

16.

bowens disease

17.

disease bowen's

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Fingolimod Hydrochloride	FAERS: 22 Canada Vigilance: 2		Canada Vigilance US FAERS
2	Ruxolitinib phosphate	FAERS: 11		US FAERS
3	Acitretin	FAERS: 6		US FAERS
4	Tacrolimus	FAERS: 6		US FAERS
5	Dimethyl Fumarate	FAERS: 5		US FAERS
6	Lenalidomide	FAERS: 5 Canada Vigilance: 1		Canada Vigilance US FAERS
7	Voriconazole	FAERS: 5		OFFSIDES US FAERS
8	Cyclosporine	FAERS: 3 Canada Vigilance: 1		Canada Vigilance US FAERS
9	Hydroxyurea	FAERS: 3		US FAERS
10	PCI 32765	FAERS: 3 Canada Vigilance: 1		Canada Vigilance US FAERS
11	Ramipril	FAERS: 3		US FAERS
12	Scopolamine	FAERS: 3		OFFSIDES US FAERS
13	tofacitinib	FAERS: 3		US FAERS
14	3-ingenyl angelate	FAERS: 2		US FAERS
15	Alendronate	FAERS: 2		US FAERS
16	Everolimus	FAERS: 2		US FAERS
17	Hydrochlorothiazide	FAERS: 2		US FAERS
18	Sirolimus	FAERS: 2		OFFSIDES US FAERS
19	apremilast	FAERS: 2		US FAERS
20	4-Aminopyridine	FAERS: 1		US FAERS
21	4-hydroxybutyric acid	FAERS: 1		US FAERS
22	Azelaic acid	FAERS: 1		US FAERS
23	Docetaxel	FAERS: 1		US FAERS
24	Doxorubicin	FAERS: 1		US FAERS
25	Imiquimod	FAERS: 1	11207687	CTD US FAERS
26	Mycophenolic Acid	FAERS: 1		US FAERS
27	Nevirapine	FAERS: 1		OFFSIDES US FAERS
28	Vemurafenib	FAERS: 1		US FAERS
29	amiloride, hydrochlorothiazide drug combination	FAERS: 1		US FAERS
30	carbidopa, levodopa drug combination	FAERS: 1		US FAERS
31	edoxaban	FAERS: 1		US FAERS
32	liposomal doxorubicin	FAERS: 1		US FAERS
33	pimecrolimus	FAERS: 1		US FAERS
34	valdecoxib	FAERS: 1		US FAERS
35	5-[[4-[2-(5-Ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione;hydron;chloride			OFFSIDES
36	Arsenicals		View details 15116095 21514422 25559853 29103775	CTD
37	Bortezomib			OFFSIDES
38	Clozapine	Canada Vigilance: 1		Canada Vigilance
39	Deamino Arginine Vasopressin			OFFSIDES
40	Diphenoxylate			OFFSIDES
41	Gabapentin			OFFSIDES
42	Galactose			OFFSIDES
43	Leflunomide			OFFSIDES
44	Maraviroc			SIDER
45	Mometasone Furoate			OFFSIDES
46	Pamidronate			OFFSIDES
47	Phenol		19293009	CTD
48	Piroxicam			OFFSIDES
49	Sodium Bicarbonate			OFFSIDES
50	Sulindac		11207687	CTD
51	Tenofovir			OFFSIDES
52	Varenicline			OFFSIDES
53	Zoledronic Acid			OFFSIDES
54	dabrafenib			SIDER
55	lewisite		1486858	CTD
56	mebeverine			OFFSIDES
57	montelukast			OFFSIDES
58	olsalazine			OFFSIDES
59	prednisolone phosphate			OFFSIDES
60	tizanidine			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Carcinoma, Papillary	52.8%
2	Basal cell carcinoma	43.2%
3	Carcinoma, Basal Cell	43.2%
4	Adenoma	37.6%
5	Adenocarcinoma	35.1%
6	Carcinoma in Situ	35.1%
7	Carcinoma, Transitional Cell	35.1%
8	Papilloma	35.1%
9	Papillomatosis	35.1%
10	Carcinoma, Large Cell	35.1%
11	Carcinoma, Small Cell	35.1%
12	Carcinoma, Ehrlich Tumor	34.4%
13	Carcinoma, Lewis Lung	34.4%
14	Cystadenocarcinoma	34.3%
15	Mucoepidermoid Carcinoma	34.3%
16	Neoplasms, Neuroepithelial	34.2%
17	Gliomatosis cerebri	34.2%
18	Cystadenoma	33.6%
19	Mesothelioma	33.6%
20	Acanthoma	30.6%
21	leukemia	29.7%
22	Neoplasms, Germ Cell and Embryonal	29.7%
23	Germ Cell Cancer	29.7%
24	Carcinoma, Lobular	25.7%
25	Neuroectodermal Tumors	24.4%
26	Adenoid Cystic Carcinoma	23.3%
27	Adenocarcinoma, Clear Cell	23.3%
28	Cholangiocarcinoma	23.3%
29	Cervical Intraepithelial Neoplasia	23.3%
30	Pseudomyxoma Peritonei	22.3%
31	Adenomatosis, Pulmonary	22.3%
32	Adenomatous Polyps	22.3%
33	Histiocytic Disorders, Malignant	22.3%
34	Carcinoid Tumor	21.6%
35	Adenoma, Acidophil	21%
36	Ganglioneuroma	21%
37	Glioma	21%
38	Malignant Glioma	21%
39	Adenofibroma	20.3%
40	Fibroadenoma	20.3%
41	Hamartoma	19.5%
42	Neoplasms, Hormone-Dependent	19.5%
43	Neoplasms, Multiple Primary	19.5%
44	Paraneoplastic Syndromes	19.5%
45	Precancerous Conditions	19.5%
46	Neoplasms, Second Primary	19.5%
47	Carcinosarcoma	19.4%
48	Hemangiosarcoma	19.4%
49	lymphangiosarcoma	19.4%
50	Choriocarcinoma	19.3%
51	Carcinoma	18.8%
52	Epithelioma	18.8%
53	Medulloblastoma	18.2%
54	Lymphoma	17.9%
55	Klatskin Tumor	17.4%
56	melanoma	17.3%
57	Meningioma	17.3%
58	Squamous cell carcinoma	16.8%
59	Composite Lymphoma	16.2%
60	Ameloblastoma	16.1%
61	Angiokeratoma	16.1%
62	Chordoma	16.1%
63	Hemangioma	16.1%
64	hemangiopericytoma	16.1%
65	Lymphangioma	16.1%
66	Mesenchymoma	16.1%
67	Nevus	16.1%
68	Teratoma	16.1%
69	Hepatoblastoma	16.1%
70	Mixed Tumor, Mullerian	16.1%
71	Germinoma	16.1%
72	Teratocarcinoma	16.1%
73	Angiofibroma	16.1%
74	Sarcoma	16.1%
75	Malignant Carcinoid Syndrome	16.1%
76	Trophoblastic Neoplasms	15.9%
77	Leukemia, Experimental	15.8%
78	Carcinoma 256, Walker	15.6%
79	Leukemia, Plasma Cell	15.5%
80	Cyst	14.8%
81	Neoplastic Processes	14.8%
82	Neoplastic Syndromes, Hereditary	14.8%
83	Pregnancy Complications, Neoplastic	14.8%
84	Dermoid Cyst	14.8%
85	Astrocytoma	14.6%
86	Ependymoma	14.6%
87	oligodendroglioma	14.6%
88	Ganglioglioma	14.6%
89	gliosarcoma	14.6%
90	Anaplastic astrocytoma	14.6%
91	Anaplastic Oligodendroglioma	14.6%
92	Neoplasms, Experimental	14.5%
93	Carcinoma, Ovarian Epithelial	14.4%
94	Chondrosarcoma	14.4%
95	Craniopharyngioma	14.4%
96	leiomyosarcoma	14.4%
97	liposarcoma	14.4%
98	synovial sarcoma	14.4%
99	Neuroectodermal Tumor, Melanotic	14.4%
100	Angiomyolipoma	14.4%
101	Clear Cell Sarcoma of Soft Tissue	14.4%
102	Alveolar Soft Part Sarcoma	14.4%
103	Neuroendocrine Tumors	14.4%
104	Sarcoma, Myeloid	14.4%
105	Basal Cell Nevus Syndrome	13.9%
106	Leukemia, Radiation-Induced	13.3%
107	Carcinoma, Pancreatic Ductal	13.1%
108	Retinoblastoma	13%
109	Hepatocellular Adenoma	13%
110	Melanoma, Experimental	12.5%
111	Nasopharyngeal carcinoma	12.3%
112	Plasmacytoma	12.2%
113	Malignant histiocytosis	12.1%
114	Histiocytic sarcoma	12.1%
115	Fibrosarcoma	12%
116	Osteosarcoma	12%
117	Sarcoma, Experimental	11.8%
118	Thymoma	11.7%
119	Neoplasms, Radiation-Induced	11.6%
120	Neurilemmoma	11.4%
121	Hutchinson's Melanotic Freckle	11.4%
122	Melanoma, Amelanotic	11.4%
123	Carcinoid Heart Disease	11.4%
124	Glioblastoma	11.4%
125	Neuroblastoma	11.4%
126	Glioblastoma Multiforme	11.4%
127	Leukemia L1210	11.3%
128	Leukemia P388	11.3%
129	Endometrial Stromal Sarcoma	11.2%
130	Bowen's Disease	11.1%
131	Multiple Endocrine Neoplasia	11.1%
132	Prolactinoma	11.1%
133	Growth Hormone-Secreting Pituitary Adenoma	11.1%
134	Adrenocortical carcinoma	11%
135	Malignant Fibrous Histiocytoma	10.7%
136	Abdominal Neoplasms	9.9%
137	Erythroplasia	9.9%
138	Follicular cyst	9.9%
139	Head and Neck Neoplasms	9.9%
140	Mucocele	9.9%
141	Pilonidal Cyst	9.9%
142	Soft Tissue Neoplasms	9.9%
143	Thoracic Neoplasms	9.9%
144	Thyroglossal Cyst	9.9%
145	Synovial Cyst	9.9%
146	Aberrant Crypt Foci	9.9%
147	Ganglioneuroblastoma	9.8%
148	Hodgkin Disease	9.7%
149	Lymphoma, Non-Hodgkin	9.7%
150	Lymphangioleiomyomatosis	9.6%
151	Phyllodes Tumor	9.6%
152	Dysgerminoma	9.6%
153	Hemangioendothelioma	9.6%
154	Lipoma	9.6%
155	Myoma	9.6%
156	Myxoma	9.6%
157	Neuroma	9.6%
158	Seminoma	9.6%
159	Angiolipoma	9.6%
160	Myelolipoma	9.6%
161	Neoplasms, Bone Tissue	9.6%
162	Neoplasms, Fibrous Tissue	9.6%
163	Smooth Muscle Tumor	9.6%
164	Desmoplastic Small Round Cell Tumor	9.6%
165	Chondroma	9.6%
166	Enchondroma	9.6%
167	Renal Cell Carcinoma	9.6%
168	Papillary Renal Cell Carcinoma	9.6%
169	Paraganglioma	9.5%
170	Rhabdomyosarcoma	9.5%
171	Giant Cell Tumor of Bone	9.5%
172	Paraneoplastic Encephalomyelitis	9.4%
173	Carcinoma, Endometrioid	9.3%
174	Mammary Neoplasms, Experimental	9.2%
175	Vipoma	8.8%
176	Sarcoma 180	8.8%
177	Nephroblastoma	8.5%
178	Dermatofibrosarcoma	8.3%
179	Dermatofibrosarcoma Protuberans	8.3%
180	Tuberous Sclerosis	8.2%
181	Gastrinoma	8.2%
182	Glucagonoma	8.2%
183	Primary amyloidosis	8.2%
184	Lymphomatoid Granulomatosis	8.1%
185	Digestive System Neoplasms	7.8%
186	Endocrine Gland Neoplasms	7.8%
187	Eye Neoplasms	7.8%
188	Nervous System Neoplasms	7.8%
189	Bone neoplasms	7.6%
190	Leukoplakia	7.6%
191	Lymphocele	7.6%
192	Pancreatic Cyst	7.6%
193	Skin Neoplasms	7.6%
194	Hematologic Neoplasms	7.6%
195	Neurofibrosarcoma	7.5%
196	Barrett Esophagus	7.4%
197	Breast Cyst	7.4%
198	Actinic keratosis	7.4%
199	Mediastinal Cyst	7.4%
200	Neoplasm Invasiveness	7.4%
201	Neoplasm Metastasis	7.4%
202	Neoplasm Recurrence, Local	7.4%
203	Parovarian Cyst	7.4%
204	Pericardial Cyst	7.4%
205	Splenic Neoplasms	7.4%
206	Thymic Cyst	7.4%
207	Carcinogenesis	7.4%
208	Myxoid cyst	7.4%
209	Metastasis	7.4%
210	Leukemia, Myelomonocytic, Chronic	7.2%
211	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	7.2%
212	insulinoma	7.2%
213	Adenomatous Polyposis Coli	7.2%
214	Pheochromocytoma	7.1%
215	Alveolar rhabdomyosarcoma	7.1%
216	Optic Nerve Glioma	7.1%
217	Mesoblastic Nephroma	6.8%
218	fibroma	6.3%
219	Fibromatosis	6.3%
220	Osteoblastoma	6.3%
221	Osteoma	6.3%
222	Rhabdomyoma	6.3%
223	Chondromatosis	6.3%
224	Hemangioblastoma	6.3%
225	Lymphoma, Extranodal NK-T-Cell	6.3%
226	Waldenstrom Macroglobulinemia	6.1%
227	Multiple Myeloma	6.1%
228	Multiple Endocrine Neoplasia Type 1	6%
229	Mastocytosis	5.9%
230	Sturge-Weber Syndrome	5.9%
231	Corpus Luteum Cyst	5.9%
232	Ovarian Cysts	5.9%
233	Gastrointestinal Stromal Tumors	5.8%
234	Hemangioma, Cavernous	5.8%
235	Leukemia, T-Cell	5.8%
236	Leukemia, B-Cell	5.8%
237	neurofibroma	5.8%
238	Hydatidiform Mole	5.7%
239	Lymphoma, Follicular	5.7%
240	T-Cell Lymphoma	5.7%
241	Mantle cell lymphoma	5.7%
242	Liver Neoplasms, Experimental	5.6%
243	Parathyroid Neoplasms	5.6%
244	Peritoneal Neoplasms	5.6%
245	Thyroid Neoplasm	5.6%
246	Thyroid carcinoma	5.6%
247	Acoustic Neuroma	5.4%
248	Retroperitoneal Neoplasms	5.4%
249	Choledochal Cyst	5%
250	Peutz-Jeghers Syndrome	4.9%
251	Pancreatic Neoplasm	4.8%
252	Mastocytoma	4.8%
253	granulosa cell tumor	4.8%
254	Mastocytosis, Systemic	4.8%
255	Leukemia, Myeloid, Chronic-Phase	4.8%
256	Fibromatosis, Aggressive	4.7%
257	Fibromatosis, Abdominal	4.7%
258	Tracheal Neoplasms	4.4%
259	Leukoplakia, Oral	4.3%
260	Paraneoplastic Cerebellar Degeneration	4.3%
261	Mouth Neoplasms	4.1%
262	Central Nervous System Neoplasms	4.1%
263	Vascular Neoplasms	4.1%
264	Thymus Neoplasms	4.1%
265	Genital Neoplasms, Female	4.1%
266	Pancreatic Pseudocyst	4.1%
267	Lymphatic Metastasis	4%
268	Neoplasms, Unknown Primary	4%
269	Leukemic Infiltration	4%
270	Breast Neoplasms, Male	4%
271	Neoplasm Micrometastasis	4%
272	Triple Negative Breast Neoplasms	4%
273	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	3.8%
274	Leukemia, Large Granular Lymphocytic	3.8%
275	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	3.8%
276	Lymphoma, T-Cell, Cutaneous	3.8%
277	Lymphoma, AIDS-Related	3.8%
278	Enteropathy-Associated T-Cell Lymphoma	3.8%
279	Primary Effusion Lymphoma	3.8%
280	Esophageal Neoplasms	3.7%
281	Limbic Encephalitis	3.7%
282	Denys-Drash Syndrome	3.5%
283	Adrenal Gland Neoplasms	3.4%
284	Gastrointestinal Neoplasms	3.4%
285	Genital Neoplasms, Male	3.4%
286	Liver neoplasms	3.4%
287	Uveal Neoplasms	3.4%
288	Leydig Cell Tumor	3.4%
289	Urologic Neoplasms	3.3%
290	Lambert-Eaton Myasthenic Syndrome	3.3%
291	Testicular Neoplasms	3.3%
292	Sebaceous Gland Neoplasms	3.3%
293	Spinal Neoplasms	3.3%
294	Bone Marrow Neoplasms	3.3%
295	Thyroid Nodule	3.2%
296	Polycystic Ovary Syndrome	3.2%
297	Xeroderma Pigmentosum	3%
298	Dupuytren Contracture	2.9%
299	Opsoclonus-Myoclonus Syndrome	2.9%
300	Urticaria Pigmentosa	2.9%
301	Mycosis Fungoides	2.8%
302	Lymphomatoid Papulosis	2.8%
303	Plasmablastic lymphoma	2.8%
304	Burkitt Lymphoma	2.7%
305	Myelitis, Transverse	2.6%
306	Meningeal Neoplasms	2.4%
307	ovarian neoplasm	2.3%
308	Nose Neoplasms	2.2%
309	Sezary Syndrome	2.1%
310	Pituitary Adenoma	2%
311	Pituitary Neoplasms	2%
312	Palatal Neoplasms	2%
313	Ear Neoplasms	2%
314	Eyelid Neoplasms	2%
315	Lung Neoplasms	2%
316	Pleural Neoplasms	2%
317	Cell Transformation, Viral	2%
318	Brain Neoplasms	1.9%
319	Salivary Gland Neoplasms	1.9%
320	Spinal Cord Neoplasms	1.9%
321	Tongue Neoplasms	1.9%
322	Uterine Neoplasms	1.9%
323	Vaginal Neoplasms	1.9%
324	Vulvar Neoplasms	1.9%
325	Uterine Cancer	1.9%
326	Fallopian Tube Neoplasms	1.9%
327	Zollinger-Ellison syndrome	1.8%
328	Pharyngeal Neoplasms	1.7%
329	Central Nervous System Cysts	1.6%
330	Bile Duct Neoplasms	1.6%
331	gallbladder neoplasm	1.6%
332	Intestinal Neoplasms	1.6%
333	Penile Neoplasms	1.6%
334	Prostatic Neoplasms	1.6%
335	Stomach Neoplasms	1.6%
336	Polycythemia Vera	1.6%
337	Meningeal Carcinomatosis	1.6%
338	Laryngeal neoplasm	1.5%
339	Bladder Neoplasm	1.4%
340	Kidney Neoplasm	1.4%
341	Ureteral Neoplasms	1.4%
342	Urethral Neoplasms	1.4%
343	Bronchial Neoplasms	1.3%
344	Multiple Pulmonary Nodules	1.3%
345	Supratentorial Neoplasms	1.3%
346	Endometrial Neoplasms	1.3%
347	Hypopharyngeal Neoplasms	1.1%
348	Pleural Effusion, Malignant	1.1%
349	Hypopharyngeal Cancer	1.1%
350	Parotid Neoplasms	1.1%
351	Prostatic Neoplasms, Castration-Resistant	1.1%
352	Nelson Syndrome	1.1%
353	Brain Stem Neoplasms	1%
354	Cecal Neoplasms	0.9%
355	Duodenal Neoplasms	0.9%
356	Nasopharyngeal Neoplasms	0.8%
357	Colorectal Neoplasms	0.8%
358	Tonsillar Neoplasms	0.8%
359	Cerebellar Neoplasms	0.8%
360	Choroid Plexus Papilloma	0.8%
361	Paranasal Sinus Neoplasms	0.7%
362	Radicular Cyst	0.7%
363	Appendiceal Neoplasms	0.7%
364	Colonic Neoplasms	0.7%
365	Rectal Neoplasms	0.7%
366	Maxillary Sinus Neoplasms	0.5%
367	Anus Neoplasms	0.5%
368	Sigmoid Neoplasms	0.5%

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