MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Cholangiocarcinoma

(UMLS:C0206698)

Definition:: A malignant tumor arising from the epithelium of the BILE DUCTS.
UMLS ID:: C0206698
MeSH ID:: D018281

Classification:

Name:

Neoplasms
MeSH Tree Number(s):: C04.557.470.200.025.450

Synonym(s)

Cholangiocarcinoma

Bile duct cancer

CHOLANGIOCARCINOMA, MALIGNANT

Cholangiocar.- intra/extrahepatic

Cholangiocarcinoma of biliary tract

Cholangiocarcinoma, intrahepatic and extrahepatic bile ducts (adenocarcinoma)

Cholangiocellular Carcinoma

Cholangiocellular carcinoma

Cholangiosarcoma

10.

cholangiocarcinoma

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Paclitaxel	FAERS: 8		US FAERS
2	Prednisolone	FAERS: 8		US FAERS
3	ledipasvir, sofosbuvir drug combination	FAERS: 6		US FAERS
4	Sitagliptin Phosphate	FAERS: 5		US FAERS
5	Imatinib Mesylate	FAERS: 4		US FAERS
6	ambrisentan	FAERS: 4		US FAERS
7	Dimethyl Fumarate	FAERS: 3		US FAERS
8	Imatinib Mesylate	FAERS: 3		US FAERS
9	Lenalidomide	FAERS: 3		US FAERS
10	Octreotide	FAERS: 3		US FAERS
11	Rivaroxaban	FAERS: 3		US FAERS
12	Sildenafil Citrate	FAERS: 3		US FAERS
13	Atorvastatin	FAERS: 2		US FAERS
14	Bosentan	FAERS: 2		US FAERS
15	Capecitabine	FAERS: 2		US FAERS
16	Carbamazepine	FAERS: 2		US FAERS
17	Dasatinib	FAERS: 2		US FAERS
18	Exenatide	FAERS: 2		US FAERS
19	Liraglutide	FAERS: 2		US FAERS
20	Prednisone	FAERS: 2		US FAERS
21	Rosiglitazone	FAERS: 2		US FAERS
22	carbidopa, levodopa drug combination	FAERS: 2		US FAERS
23	sofosbuvir-velpatasvir drug combination	FAERS: 2		US FAERS
24	(2S)-2,3,4,4-Tetraformyl-2-[[4-[2-(2-formyltetrazol-5-yl)phenyl]phenyl]methyl-pentanoylamino]-3-methyl-5-oxopentanoic acid	FAERS: 1		US FAERS
25	Clozapine	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
26	Crizotinib	FAERS: 1		US FAERS
27	Dabigatran	FAERS: 1		US FAERS
28	Dabigatran	FAERS: 1		US FAERS
29	Duloxetine Hydrochloride	FAERS: 1		US FAERS
30	Elvitegravir, Cobicistat, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination	FAERS: 1		US FAERS
31	Esomeprazole	FAERS: 1		US FAERS
32	Everolimus	FAERS: 1		US FAERS
33	Fingolimod Hydrochloride	FAERS: 1		US FAERS
34	Flutemetamol F-18	FAERS: 1		US FAERS
35	Glatiramer Acetate	FAERS: 1		US FAERS
36	Insulin Glargine	FAERS: 1		US FAERS
37	Irinotecan	FAERS: 1		US FAERS
38	Isotretinoin	FAERS: 1		US FAERS
39	Kombiglyze XR	FAERS: 1		US FAERS
40	LCZ 696	FAERS: 1		US FAERS
41	Lapatinib	FAERS: 1		US FAERS
42	MDV 3100	FAERS: 1		US FAERS
43	Methotrexate	FAERS: 1		US FAERS
44	Octreotide	FAERS: 1		US FAERS
45	Sitagliptin Phosphate	FAERS: 1		US FAERS
46	Sunitinib	FAERS: 1		US FAERS
47	Tacrolimus	FAERS: 1		US FAERS
48	Testosterone	FAERS: 1		US FAERS
49	Ticagrelor	FAERS: 1		US FAERS
50	Ursodeoxycholic Acid	FAERS: 1		US FAERS
51	Valsartan	FAERS: 1		US FAERS
52	Warfarin	FAERS: 1		US FAERS
53	apixaban	FAERS: 1		US FAERS
54	dofetilide	FAERS: 1		US FAERS
55	edoxaban	FAERS: 1		US FAERS
56	entecavir	FAERS: 1		US FAERS
57	gemcitabine	FAERS: 1		US FAERS
58	gemcitabine	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
59	macitentan	FAERS: 1		US FAERS
60	teriflunomide	FAERS: 1		US FAERS
61	tofacitinib	FAERS: 1		US FAERS
62	venetoclax	FAERS: 1		US FAERS
63	1,2,3-trichloropropane		16362062	CTD
64	2,2-bis(bromomethyl)-1,3-propanediol		16362062	CTD
65	2,3',4,4',5-pentachlorobiphenyl		21383778	CTD
66	2-aminofluorene		19052882	CTD
67	2-nitrotoluene		12087420	CTD
68	3,4,5,3',4'-pentachlorobiphenyl		16628245 20959002	CTD
69	Azoxymethane		3607743	CTD
70	Carmustine		7046907	CTD
71	Chlorodiphenyl (54% Chlorine)		7817132	CTD
72	Diethylnitrosamine		View details 3607743 12597444 19052882 28943392	CTD
73	Dimethylnitrosamine		3607743	CTD
74	Enfuvirtide	Canada Vigilance: 1		Canada Vigilance
75	Maraviroc			SIDER
76	Melatonin		20626588	CTD
77	Methotrexate		1849410	CTD
78	Methylene Chloride		23493378	CTD
79	Nitroglycerin		8968066	CTD
80	Pentachlorophenol		12597444	CTD
81	Phenobarbital		12597444	CTD
82	Polychlorinated Dibenzodioxins		16835633 20959002	CTD
83	Thalidomide		18291259	CTD
84	Thioacetamide		18291259 28943392	CTD
85	furan		20124500 26194646	CTD
86	methylethylnitrosamine		3607743	CTD
87	nitromethane		16362062	CTD
88	propylene dichloride		23493378 25711234 29228347	CTD
89	proxigermanium			SIDER

Similar ADE(s)

	Name	Semantic Similarity
1	Adenoid Cystic Carcinoma	49.2%
2	Adenocarcinoma, Clear Cell	49.2%
3	Cystadenocarcinoma	44.1%
4	Mucoepidermoid Carcinoma	44.1%
5	Carcinoma in Situ	36%
6	Carcinoma, Transitional Cell	36%
7	Carcinoma, Large Cell	36%
8	Carcinoma, Small Cell	36%
9	Basal cell carcinoma	35.3%
10	Carcinoma, Papillary	35.3%
11	Squamous cell carcinoma	35.3%
12	Carcinoma, Basal Cell	35.3%
13	Carcinoma, Ehrlich Tumor	29.8%
14	Carcinoma, Lewis Lung	29.8%
15	Carcinoid Tumor	29.4%
16	Adenoma	28.5%
17	Carcinoma, Lobular	28.4%
18	Choriocarcinoma	24.5%
19	Cervical Intraepithelial Neoplasia	23.8%
20	Bowen's Disease	23.3%
21	leukemia	22.7%
22	Neoplasms, Germ Cell and Embryonal	22.7%
23	Germ Cell Cancer	22.7%
24	Cystadenoma	22.5%
25	Mesothelioma	22.5%
26	Malignant Carcinoid Syndrome	21.9%
27	Neoplasms, Neuroepithelial	21.5%
28	Gliomatosis cerebri	21.5%
29	Adrenocortical carcinoma	17.1%
30	Papilloma	16.8%
31	Pseudomyxoma Peritonei	16.8%
32	Papillomatosis	16.8%
33	Adenomatosis, Pulmonary	16.8%
34	Adenomatous Polyps	16.8%
35	Neuroectodermal Tumors	16.4%
36	Hamartoma	15.3%
37	Neoplasms, Hormone-Dependent	15.3%
38	Neoplasms, Multiple Primary	15.3%
39	Paraneoplastic Syndromes	15.3%
40	Precancerous Conditions	15.3%
41	Neoplasms, Second Primary	15.3%
42	Histiocytic Disorders, Malignant	15.1%
43	Carcinoid Heart Disease	14.9%
44	Renal Cell Carcinoma	14.6%
45	Papillary Renal Cell Carcinoma	14.6%
46	Carcinoma, Endometrioid	14.4%
47	Acanthoma	14.1%
48	Adenofibroma	13.5%
49	Fibroadenoma	13.5%
50	Carcinoma, Pancreatic Ductal	13.5%
51	Adenoma, Acidophil	13.1%
52	Ganglioneuroma	13.1%
53	Glioma	13.1%
54	Malignant Glioma	13.1%
55	Carcinosarcoma	13%
56	Hemangiosarcoma	13%
57	lymphangiosarcoma	13%
58	Ameloblastoma	12.2%
59	Angiokeratoma	12.2%
60	Chordoma	12.2%
61	Hemangioma	12.2%
62	hemangiopericytoma	12.2%
63	Lymphangioma	12.2%
64	Mesenchymoma	12.2%
65	Nevus	12.2%
66	Teratoma	12.2%
67	Hepatoblastoma	12.2%
68	Mixed Tumor, Mullerian	12.2%
69	Germinoma	12.2%
70	Teratocarcinoma	12.2%
71	Angiofibroma	12.2%
72	Sarcoma	12.2%
73	Gastrinoma	11.5%
74	Glucagonoma	11.5%
75	Lymphoma	11.3%
76	Carcinoma, Ovarian Epithelial	11%
77	Vipoma	11%
78	melanoma	10.8%
79	Meningioma	10.4%
80	Medulloblastoma	10.4%
81	Cyst	10.2%
82	Neoplastic Processes	10.2%
83	Neoplastic Syndromes, Hereditary	10.2%
84	Pregnancy Complications, Neoplastic	10.2%
85	Trophoblastic Neoplasms	10%
86	Leukemia, Experimental	10%
87	Dermoid Cyst	9.9%
88	Neoplasms, Experimental	9.9%
89	Carcinoma 256, Walker	9.8%
90	Composite Lymphoma	9.8%
91	Leukemia, Plasma Cell	9.7%
92	Chondrosarcoma	9.6%
93	Craniopharyngioma	9.6%
94	leiomyosarcoma	9.6%
95	liposarcoma	9.6%
96	synovial sarcoma	9.6%
97	Neuroectodermal Tumor, Melanotic	9.6%
98	Angiomyolipoma	9.6%
99	Clear Cell Sarcoma of Soft Tissue	9.6%
100	Alveolar Soft Part Sarcoma	9.6%
101	Neuroendocrine Tumors	9.6%
102	Sarcoma, Myeloid	9.6%
103	Nasopharyngeal carcinoma	9.3%
104	Astrocytoma	9.1%
105	Ependymoma	9.1%
106	oligodendroglioma	9.1%
107	Ganglioglioma	9.1%
108	gliosarcoma	9.1%
109	Anaplastic astrocytoma	9.1%
110	Anaplastic Oligodendroglioma	9.1%
111	Basal Cell Nevus Syndrome	9%
112	Plasmacytoma	8.2%
113	Malignant histiocytosis	8.1%
114	Histiocytic sarcoma	8.1%
115	Leukemia, Radiation-Induced	8.1%
116	Fibrosarcoma	8%
117	Osteosarcoma	8%
118	Hepatocellular Adenoma	7.8%
119	Leukemia L1210	7.6%
120	Leukemia P388	7.6%
121	Abdominal Neoplasms	7.6%
122	Erythroplasia	7.6%
123	Follicular cyst	7.6%
124	Head and Neck Neoplasms	7.6%
125	Mucocele	7.6%
126	Pilonidal Cyst	7.6%
127	Soft Tissue Neoplasms	7.6%
128	Thoracic Neoplasms	7.6%
129	Thyroglossal Cyst	7.6%
130	Synovial Cyst	7.6%
131	Aberrant Crypt Foci	7.6%
132	Neoplasms, Radiation-Induced	7.4%
133	Sarcoma, Experimental	7.4%
134	Retinoblastoma	7.4%
135	Thymoma	7.3%
136	Melanoma, Experimental	7.3%
137	Phyllodes Tumor	7.2%
138	Dysgerminoma	7.2%
139	Hemangioendothelioma	7.2%
140	Lipoma	7.2%
141	Myoma	7.2%
142	Myxoma	7.2%
143	Neuroma	7.2%
144	Seminoma	7.2%
145	Angiolipoma	7.2%
146	Myelolipoma	7.2%
147	Neoplasms, Bone Tissue	7.2%
148	Neoplasms, Fibrous Tissue	7.2%
149	Smooth Muscle Tumor	7.2%
150	Desmoplastic Small Round Cell Tumor	7.2%
151	Chondroma	7.2%
152	Enchondroma	7.2%
153	Malignant Fibrous Histiocytoma	7.2%
154	Neurilemmoma	7.1%
155	Hutchinson's Melanotic Freckle	7.1%
156	Melanoma, Amelanotic	7.1%
157	Glioblastoma	7.1%
158	Neuroblastoma	7.1%
159	Glioblastoma Multiforme	7.1%
160	Endometrial Stromal Sarcoma	6.7%
161	Multiple Endocrine Neoplasia	6.6%
162	Prolactinoma	6.5%
163	Growth Hormone-Secreting Pituitary Adenoma	6.5%
164	Paraganglioma	6.3%
165	Rhabdomyosarcoma	6.3%
166	Giant Cell Tumor of Bone	6.3%
167	Ganglioneuroblastoma	6.1%
168	Hodgkin Disease	6.1%
169	Lymphoma, Non-Hodgkin	6.1%
170	Paraneoplastic Encephalomyelitis	6%
171	Sarcoma 180	5.9%
172	Mammary Neoplasms, Experimental	5.8%
173	Lymphangioleiomyomatosis	5.8%
174	Dermatofibrosarcoma	5.5%
175	Dermatofibrosarcoma Protuberans	5.5%
176	Digestive System Neoplasms	5.4%
177	Endocrine Gland Neoplasms	5.4%
178	Eye Neoplasms	5.4%
179	Nervous System Neoplasms	5.4%
180	Bone neoplasms	5.1%
181	Leukoplakia	5.1%
182	Lymphocele	5.1%
183	Pancreatic Cyst	5.1%
184	Skin Neoplasms	5.1%
185	Hematologic Neoplasms	5.1%
186	Barrett Esophagus	5%
187	Breast Cyst	5%
188	Actinic keratosis	5%
189	Mediastinal Cyst	5%
190	Neoplasm Invasiveness	5%
191	Neoplasm Metastasis	5%
192	Neoplasm Recurrence, Local	5%
193	Parovarian Cyst	5%
194	Pericardial Cyst	5%
195	Splenic Neoplasms	5%
196	Thymic Cyst	5%
197	Carcinogenesis	5%
198	Myxoid cyst	5%
199	Metastasis	5%
200	Primary amyloidosis	4.9%
201	Lymphomatoid Granulomatosis	4.9%
202	Leukemia, Myelomonocytic, Chronic	4.8%
203	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	4.8%
204	fibroma	4.8%
205	Fibromatosis	4.8%
206	Osteoblastoma	4.8%
207	Osteoma	4.8%
208	Rhabdomyoma	4.8%
209	Chondromatosis	4.8%
210	Hemangioblastoma	4.8%
211	Lymphoma, Extranodal NK-T-Cell	4.8%
212	Pheochromocytoma	4.7%
213	Alveolar rhabdomyosarcoma	4.7%
214	Nephroblastoma	4.7%
215	Tuberous Sclerosis	4.6%
216	Neurofibrosarcoma	4.4%
217	insulinoma	4.1%
218	Retroperitoneal Neoplasms	4.1%
219	Adenomatous Polyposis Coli	4%
220	Mesoblastic Nephroma	3.9%
221	Optic Nerve Glioma	3.8%
222	Mastocytosis	3.7%
223	Sturge-Weber Syndrome	3.7%
224	Corpus Luteum Cyst	3.7%
225	Ovarian Cysts	3.7%
226	Gastrointestinal Stromal Tumors	3.7%
227	Hemangioma, Cavernous	3.6%
228	Leukemia, T-Cell	3.6%
229	Leukemia, B-Cell	3.6%
230	neurofibroma	3.6%
231	Hydatidiform Mole	3.6%
232	Lymphoma, Follicular	3.6%
233	T-Cell Lymphoma	3.6%
234	Mantle cell lymphoma	3.6%
235	Fibromatosis, Aggressive	3.6%
236	Fibromatosis, Abdominal	3.6%
237	Multiple Endocrine Neoplasia Type 1	3.5%
238	Waldenstrom Macroglobulinemia	3.5%
239	Multiple Myeloma	3.5%
240	Parathyroid Neoplasms	3.4%
241	Peritoneal Neoplasms	3.4%
242	Thyroid Neoplasm	3.4%
243	Thyroid carcinoma	3.4%
244	Liver Neoplasms, Experimental	3.3%
245	Mastocytoma	3.2%
246	Mastocytosis, Systemic	3.2%
247	Leukemia, Myeloid, Chronic-Phase	3.2%
248	Choledochal Cyst	3.1%
249	Acoustic Neuroma	3%
250	Peutz-Jeghers Syndrome	3%
251	Pancreatic Neoplasm	2.8%
252	Mouth Neoplasms	2.8%
253	Central Nervous System Neoplasms	2.8%
254	Vascular Neoplasms	2.8%
255	Thymus Neoplasms	2.8%
256	granulosa cell tumor	2.8%
257	Genital Neoplasms, Female	2.7%
258	Pancreatic Pseudocyst	2.7%
259	Lymphatic Metastasis	2.7%
260	Neoplasms, Unknown Primary	2.7%
261	Leukemic Infiltration	2.7%
262	Breast Neoplasms, Male	2.7%
263	Neoplasm Micrometastasis	2.7%
264	Triple Negative Breast Neoplasms	2.7%
265	Tracheal Neoplasms	2.7%
266	Leukoplakia, Oral	2.6%
267	Paraneoplastic Cerebellar Degeneration	2.6%
268	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	2.4%
269	Leukemia, Large Granular Lymphocytic	2.4%
270	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	2.4%
271	Lymphoma, T-Cell, Cutaneous	2.4%
272	Lymphoma, AIDS-Related	2.4%
273	Enteropathy-Associated T-Cell Lymphoma	2.4%
274	Primary Effusion Lymphoma	2.4%
275	Esophageal Neoplasms	2.2%
276	Limbic Encephalitis	2.2%
277	Adrenal Gland Neoplasms	2.1%
278	Gastrointestinal Neoplasms	2.1%
279	Genital Neoplasms, Male	2.1%
280	Liver neoplasms	2.1%
281	Uveal Neoplasms	2.1%
282	Urologic Neoplasms	2.1%
283	Sebaceous Gland Neoplasms	2.1%
284	Spinal Neoplasms	2.1%
285	Bone Marrow Neoplasms	2.1%
286	Polycystic Ovary Syndrome	2%
287	Thyroid Nodule	2%
288	Denys-Drash Syndrome	1.9%
289	Lambert-Eaton Myasthenic Syndrome	1.9%
290	Testicular Neoplasms	1.9%
291	Leydig Cell Tumor	1.9%
292	Dupuytren Contracture	1.9%
293	Urticaria Pigmentosa	1.8%
294	Mycosis Fungoides	1.8%
295	Lymphomatoid Papulosis	1.8%
296	Plasmablastic lymphoma	1.8%
297	Xeroderma Pigmentosum	1.7%
298	Opsoclonus-Myoclonus Syndrome	1.7%
299	Meningeal Neoplasms	1.6%
300	Burkitt Lymphoma	1.6%
301	Myelitis, Transverse	1.5%
302	ovarian neoplasm	1.4%
303	Nose Neoplasms	1.3%
304	Ear Neoplasms	1.3%
305	Eyelid Neoplasms	1.3%
306	Lung Neoplasms	1.3%
307	Pleural Neoplasms	1.3%
308	Cell Transformation, Viral	1.2%
309	Brain Neoplasms	1.2%
310	Salivary Gland Neoplasms	1.2%
311	Spinal Cord Neoplasms	1.2%
312	Tongue Neoplasms	1.2%
313	Uterine Neoplasms	1.2%
314	Vaginal Neoplasms	1.2%
315	Vulvar Neoplasms	1.2%
316	Uterine Cancer	1.2%
317	Sezary Syndrome	1.2%
318	Fallopian Tube Neoplasms	1.2%
319	Palatal Neoplasms	1.2%
320	Pituitary Adenoma	1.1%
321	Pituitary Neoplasms	1.1%
322	Meningeal Carcinomatosis	1.1%
323	Zollinger-Ellison syndrome	1%
324	Pharyngeal Neoplasms	1%
325	Central Nervous System Cysts	1%
326	Bile Duct Neoplasms	1%
327	gallbladder neoplasm	1%
328	Intestinal Neoplasms	1%
329	Penile Neoplasms	1%
330	Prostatic Neoplasms	1%
331	Stomach Neoplasms	1%
332	Polycythemia Vera	1%
333	Laryngeal neoplasm	0.9%
334	Bronchial Neoplasms	0.8%
335	Bladder Neoplasm	0.8%
336	Kidney Neoplasm	0.8%
337	Ureteral Neoplasms	0.8%
338	Urethral Neoplasms	0.8%
339	Multiple Pulmonary Nodules	0.8%
340	Supratentorial Neoplasms	0.8%
341	Endometrial Neoplasms	0.8%
342	Hypopharyngeal Neoplasms	0.7%
343	Pleural Effusion, Malignant	0.7%
344	Hypopharyngeal Cancer	0.7%
345	Parotid Neoplasms	0.6%
346	Prostatic Neoplasms, Castration-Resistant	0.6%
347	Nelson Syndrome	0.6%
348	Brain Stem Neoplasms	0.6%
349	Cecal Neoplasms	0.5%
350	Duodenal Neoplasms	0.5%
351	Choroid Plexus Papilloma	0.5%
352	Tonsillar Neoplasms	0.5%
353	Cerebellar Neoplasms	0.5%
354	Nasopharyngeal Neoplasms	0.5%
355	Colorectal Neoplasms	0.5%
356	Paranasal Sinus Neoplasms	0.4%
357	Radicular Cyst	0.4%
358	Appendiceal Neoplasms	0.4%
359	Colonic Neoplasms	0.4%
360	Rectal Neoplasms	0.4%
361	Maxillary Sinus Neoplasms	0.3%
362	Anus Neoplasms	0.3%
363	Sigmoid Neoplasms	0.3%

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