MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Polycythemia Vera

(UMLS:C0032463)

Definition:: A myeloproliferative disorder of unknown etiology, characterized by abnormal proliferation of all hematopoietic bone marrow elements and an absolute increase in red cell mass and total blood volume, associated frequently with splenomegaly, leukocytosis, and thrombocythemia. Hematopoiesis is also reactive in extramedullary sites (liver and spleen). In time myelofibrosis occurs.
UMLS ID:: C0032463
MeSH ID:: D011087

Classification 1:

Name:

Neoplasms
MeSH Tree Number(s):: C04.588.448.200.500

Classification 2:

Name:

Hemic and Lymphatic Diseases
MeSH Tree Number(s):: C15.378.190.250.500|C15.378.190.636.753|C15.378.400.200.500

Synonym(s)

Polycythemia Vera

ERYTHREMIA

Erythraemia

Erythremia

OSLER-VAQUEZ DISEASE

Osler's disease

Osler-Vaquez

Osler-Vaquez syndrome

POLYCYTHEMIA VERA

10.

POLYCYTHEMIA, SPLENOMEGALIC

11.

PPP - Primary proliferative polycythaemia

12.

PPP - Primary proliferative polycythemia

13.

PRV - Polycythaemia rubra vera

14.

PRV - Polycythemia rubra vera

15.

16.

Polycythaemia rubra vera

17.

Polycythaemia vera

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Aspirin	16484586 17137402	CTD
2	Busulfan	4691200	CTD
3	Cytarabine	3978659	CTD
4	Dasatinib	18717827	CTD
5	Hydroxyurea	View details 8638610 12459535 19784527 19810313	CTD
6	Pipobroman	10342591 11736962	CTD
7	Uracil Mustard	3369437	CTD
8	WP1066	18245540	CTD
9	anagrelide	11034048 15531464	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Thrombocythemia, Essential	44.4%
2	Thrombocytosis	41.6%
3	Disseminated Intravascular Coagulation	37.9%
4	Protein S Deficiency	37.9%
5	Leukemoid Reaction	36.6%
6	MYELODYSPLASTIC SYNDROME	33.1%
7	Primary Myelofibrosis	32.3%
8	Myelofibrosis	32.3%
9	Myeloid Metaplasia	32.3%
10	bone marrow fibrosis	32.3%
11	Anemia	29.6%
12	Blood Coagulation Disorders	29.6%
13	Blood Platelet Disorders	29.6%
14	Hemorrhagic Disorders	29.6%
15	Leukocyte Disorders	29.6%
16	Methemoglobinemia	29.6%
17	Pancytopenia	29.6%
18	Polycythemia	29.6%
19	Sulfhemoglobinemia	29.6%
20	Thrombophilia	29.6%
21	Erythrocytosis	29.6%
22	Thrombasthenia	29.4%
23	Antithrombin III Deficiency	29.4%
24	Protein C Deficiency	29.4%
25	Hemoglobinuria, Paroxysmal	28%
26	Afibrinogenemia	25.6%
27	Factor VII Deficiency	25.6%
28	Factor X Deficiency	25.6%
29	Factor XII Deficiency	25.6%
30	Hemophilia A	25.6%
31	Activated Protein C Resistance	25.6%
32	Factor II deficiency	25.6%
33	Factor VIII Deficiency	25.6%
34	Factor V deficiency	25.6%
35	Factor XI Deficiency	25.6%
36	Hypoprothrombinemias	25.6%
37	Transfusion Reaction	25.6%
38	Hypotensive Transfusion Reaction	25.6%
39	Vitamin K Deficiency	25.1%
40	Pregnancy Complications, Hematologic	25%
41	Anemia, Diamond-Blackfan	23%
42	Bone Marrow Neoplasms	22.4%
43	Polycythemia Vera	21%
44	Leukemia, Myeloid, Chronic-Phase	20.9%
45	Leukemia, Myelomonocytic, Chronic	19.4%
46	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	19.4%
47	Wiskott-Aldrich Syndrome	19.1%
48	Purpura, Thrombotic Thrombocytopenic	18.5%
49	Lymphatic Diseases	18.2%
50	Anemia, Hemolytic	17.5%
51	Anemia, Macrocytic	17.5%
52	Eosinophilia	17.5%
53	Hypoproteinemia	17.5%
54	Leukopenia	17.5%
55	Thrombocytopenia	17.5%
56	Leukostasis	17.5%
57	Agammaglobulinemia	17%
58	Hematologic Neoplasms	16.7%
59	Anemia, Sickle Cell	16.5%
60	Thalassemia	16.5%
61	Fanconi Anemia	15.8%
62	Waldenstrom Macroglobulinemia	15.7%
63	Autoimmune thrombocytopenia	15.4%
64	Immune thrombocytopenic purpura	15.4%
65	Anemia, Neonatal	14.8%
66	Leukocytosis	14.8%
67	Paraproteinemias	14.8%
68	Pelger-Huet Anomaly	14.8%
69	Pleocytosis	14.8%
70	Infectious Mononucleosis	14.7%
71	Cryoglobulinemia	14.6%
72	Monoclonal Gammopathy of Undetermined Significance	14.6%
73	Splenic Neoplasms	13.2%
74	Thymus Neoplasms	13.2%
75	Purpura, Hyperglobulinemic	12.9%
76	Hypergammaglobulinemia	12.9%
77	Multiple Myeloma	12.7%
78	Transfusion-Related Acute Lung Injury	12.7%
79	Hemolytic-Uremic Syndrome	12.7%
80	Ecchymosis	12.6%
81	Petechiae	12.6%
82	Purpura	12.6%
83	Heavy Chain Disease	12.6%
84	Hydrops Fetalis	12.1%
85	Sickle Cell Trait	11.8%
86	Agranulocytosis	11.6%
87	Anemia, Megaloblastic	11.6%
88	Lymphocytosis	11.6%
89	Hypoalbuminemia	11.6%
90	Hypereosinophilic syndrome	11.6%
91	Thrombotic Microangiopathies	11.6%
92	Thrombocytopenic purpura	11.6%
93	Waterhouse-Friderichsen Syndrome	11.2%
94	Lymphocele	11.1%
95	Atypical Hemolytic Uremic Syndrome	9.9%
96	Abdominal Neoplasms	9.9%
97	Adenitis	9.9%
98	Bone Marrow Diseases	9.9%
99	Head and Neck Neoplasms	9.9%
100	Histiocytosis	9.9%
101	Lymphadenitis	9.9%
102	Lymphangitis	9.9%
103	Lymphedema	9.9%
104	Soft Tissue Neoplasms	9.9%
105	Splenic Diseases	9.9%
106	Thoracic Neoplasms	9.9%
107	Thymus Hyperplasia	9.9%
108	Pseudolymphoma	9.9%
109	Lymphadenopathy	9.9%
110	Lymphopenia	9.8%
111	Job Syndrome	9.7%
112	Acute Chest Syndrome	9.6%
113	Hemangioma, Cavernous	9.3%
114	Kernicterus	8.9%
115	Eosinophilic Granuloma	8.7%
116	Neutropenia	8.7%
117	Digestive System Neoplasms	8.5%
118	Endocrine Gland Neoplasms	8.5%
119	Eye Neoplasms	8.5%
120	Nervous System Neoplasms	8.5%
121	Eosinophilia-Myalgia Syndrome	8.5%
122	Lymphangiectasis, Intestinal	8.4%
123	Chronic granulomatous disease	8.4%
124	Shwartzman Phenomenon	8.4%
125	Thymoma	8.4%
126	Bone neoplasms	8.3%
127	Lymphoproliferative Disorders	8.3%
128	Skin Neoplasms	8.3%
129	Lymphatic Abnormalities	8.3%
130	Scurvy	8.3%
131	Purpura Fulminans	8.3%
132	Histiocytic Disorders, Malignant	7.7%
133	Parathyroid Neoplasms	7.5%
134	Peritoneal Neoplasms	7.5%
135	Thyroid Neoplasm	7.5%
136	Thyroid carcinoma	7.5%
137	Pulmonary Eosinophilia	7.4%
138	Eosinophilic Pneumonia	7.4%
139	POEMS Syndrome	7.3%
140	Febrile Neutropenia	7.2%
141	Anemia, Pernicious	7.2%
142	Multiple Endocrine Neoplasia	7.1%
143	Mucocutaneous Lymph Node Syndrome	7.1%
144	Pancreatic Neoplasm	6.7%
145	Paraneoplastic Encephalomyelitis	6.7%
146	Lymphoma	6.6%
147	Mammary Neoplasms, Experimental	6.6%
148	Tracheal Neoplasms	6.2%
149	Hamartoma	6.1%
150	Neoplasms, Hormone-Dependent	6.1%
151	Neoplasms, Multiple Primary	6.1%
152	Paraneoplastic Syndromes	6.1%
153	Precancerous Conditions	6.1%
154	Neoplasms, Second Primary	6.1%
155	Acanthoma	5.9%
156	Elephantiasis	5.8%
157	Hypersplenism	5.8%
158	Retroperitoneal Neoplasms	5.8%
159	Sarcoidosis	5.8%
160	Elephantiasis Nostras Verrucosa	5.8%
161	Esophageal Neoplasms	5.5%
162	Pseudoxanthoma Elasticum	5.4%
163	Cyst	5.1%
164	Neoplastic Processes	5.1%
165	Neoplastic Syndromes, Hereditary	5.1%
166	Pregnancy Complications, Neoplastic	5.1%
167	Neoplasms, Experimental	5.1%
168	Carcinoma, Lobular	5.1%
169	Testicular Neoplasms	5%
170	Granuloma	4.9%
171	Mouth Neoplasms	4.9%
172	Splenic Infarction	4.9%
173	Central Nervous System Neoplasms	4.9%
174	Vascular Neoplasms	4.9%
175	Genital Neoplasms, Female	4.9%
176	Histiocytosis, Langerhans-Cell	4.9%
177	Tumor Lysis Syndrome	4.9%
178	Thyroid Nodule	4.9%
179	Composite Lymphoma	4.9%
180	Sezary Syndrome	4.9%
181	Malignant histiocytosis	4.9%
182	Breast Neoplasms, Male	4.9%
183	Histiocytic sarcoma	4.9%
184	Triple Negative Breast Neoplasms	4.9%
185	Multiple Endocrine Neoplasia Type 1	4.3%
186	Neoplasms, Radiation-Induced	4.3%
187	Carcinoma, Pancreatic Ductal	4.3%
188	Adrenal Gland Neoplasms	4.3%
189	Gastrointestinal Neoplasms	4.3%
190	Genital Neoplasms, Male	4.3%
191	Liver neoplasms	4.3%
192	Splenic Rupture	4.3%
193	Uveal Neoplasms	4.3%
194	Meningioma	4.3%
195	Urologic Neoplasms	4.2%
196	Sebaceous Gland Neoplasms	4.2%
197	Spinal Neoplasms	4.2%
198	Hodgkin Disease	4.2%
199	Lymphoma, Non-Hodgkin	4.2%
200	Lymphomatoid Granulomatosis	4.1%
201	Lymphangioleiomyomatosis	4%
202	Liver Neoplasms, Experimental	4%
203	Carcinoma 256, Walker	4%
204	Lymphohistiocytosis, Hemophagocytic	3.9%
205	Erdheim-Chester Disease	3.9%
206	Tuberous Sclerosis	3.9%
207	Carcinoma, Ehrlich Tumor	3.8%
208	Dermoid Cyst	3.8%
209	Carcinoma, Lewis Lung	3.8%
210	Trophoblastic Neoplasms	3.8%
211	Leukemia, Experimental	3.8%
212	Autoimmune Lymphoproliferative Syndrome	3.7%
213	Leukemia, T-Cell	3.7%
214	Leukemia, B-Cell	3.7%
215	Leukoplakia, Oral	3.7%
216	Paraneoplastic Cerebellar Degeneration	3.7%
217	Nose Neoplasms	3.6%
218	Acoustic Neuroma	3.6%
219	Melanoma, Experimental	3.4%
220	Palatal Neoplasms	3.4%
221	Nephroblastoma	3.4%
222	insulinoma	3.4%
223	Pituitary Adenoma	3.4%
224	Pituitary Neoplasms	3.4%
225	Vipoma	3.3%
226	Leukemia, Radiation-Induced	3.3%
227	Erythroplasia	3.3%
228	Follicular cyst	3.3%
229	leukemia	3.3%
230	Mucocele	3.3%
231	Neoplasms, Germ Cell and Embryonal	3.3%
232	Neoplasms, Glandular and Epithelial	3.3%
233	Pilonidal Cyst	3.3%
234	Thyroglossal Cyst	3.3%
235	Synovial Cyst	3.3%
236	Germ Cell Cancer	3.3%
237	Aberrant Crypt Foci	3.3%
238	Gastrinoma	3.3%
239	Glucagonoma	3.3%
240	ovarian neoplasm	3.3%
241	Sarcoma, Experimental	3.3%
242	Retinoblastoma	3.3%
243	Neuroectodermal Tumors	3.3%
244	Hepatocellular Adenoma	3.3%
245	Limbic Encephalitis	3.2%
246	Meningeal Neoplasms	3.2%
247	Sarcoidosis, Pulmonary	3.2%
248	Neoplasms, Neuroepithelial	3.2%
249	Gliomatosis cerebri	3.2%
250	Lymphoma, Follicular	3%
251	T-Cell Lymphoma	3%
252	Mantle cell lymphoma	3%
253	Lambert-Eaton Myasthenic Syndrome	3%
254	Prolactinoma	2.9%
255	Growth Hormone-Secreting Pituitary Adenoma	2.9%
256	Ear Neoplasms	2.8%
257	Eyelid Neoplasms	2.8%
258	Lung Neoplasms	2.8%
259	Pleural Neoplasms	2.8%
260	Leydig Cell Tumor	2.8%
261	Optic Nerve Glioma	2.8%
262	Brain Neoplasms	2.8%
263	Salivary Gland Neoplasms	2.8%
264	Spinal Cord Neoplasms	2.8%
265	Tongue Neoplasms	2.8%
266	Splenosis	2.8%
267	Leukoplakia	2.8%
268	Pancreatic Cyst	2.8%
269	melanoma	2.8%
270	Uterine Neoplasms	2.8%
271	Vaginal Neoplasms	2.8%
272	Vulvar Neoplasms	2.8%
273	Uterine Cancer	2.8%
274	Fallopian Tube Neoplasms	2.8%
275	Barrett Esophagus	2.7%
276	Breast Cyst	2.7%
277	Actinic keratosis	2.7%
278	Mediastinal Cyst	2.7%
279	Neoplasm Invasiveness	2.7%
280	Neoplasm Metastasis	2.7%
281	Neoplasm Recurrence, Local	2.7%
282	Parovarian Cyst	2.7%
283	Pericardial Cyst	2.7%
284	Thymic Cyst	2.7%
285	Carcinogenesis	2.7%
286	Myxoid cyst	2.7%
287	Metastasis	2.7%
288	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	2.7%
289	Leukemia, Large Granular Lymphocytic	2.7%
290	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	2.7%
291	Carcinosarcoma	2.7%
292	Hemangiosarcoma	2.7%
293	Leukemia L1210	2.7%
294	Leukemia P388	2.7%
295	lymphangiosarcoma	2.7%
296	Opsoclonus-Myoclonus Syndrome	2.7%
297	Choriocarcinoma	2.6%
298	granulosa cell tumor	2.6%
299	Carcinoma, Ovarian Epithelial	2.6%
300	Adenomatous Polyposis Coli	2.5%
301	Medulloblastoma	2.5%
302	Pharyngeal Neoplasms	2.5%
303	Central Nervous System Cysts	2.5%
304	Bile Duct Neoplasms	2.4%
305	gallbladder neoplasm	2.4%
306	Intestinal Neoplasms	2.4%
307	Penile Neoplasms	2.4%
308	Prostatic Neoplasms	2.4%
309	Stomach Neoplasms	2.4%
310	Myelitis, Transverse	2.4%
311	Sarcoma 180	2.4%
312	Mesoblastic Nephroma	2.4%
313	Meningeal Carcinomatosis	2.4%
314	Lymphoma, T-Cell, Cutaneous	2.4%
315	Lymphoma, AIDS-Related	2.4%
316	Enteropathy-Associated T-Cell Lymphoma	2.4%
317	Primary Effusion Lymphoma	2.4%
318	Basal Cell Nevus Syndrome	2.4%
319	Corpus Luteum Cyst	2.3%
320	Ovarian Cysts	2.3%
321	Leukemia, Plasma Cell	2.3%
322	Adenoma, Acidophil	2.3%
323	Ganglioneuroma	2.3%
324	Glioma	2.3%
325	Malignant Glioma	2.3%
326	Laryngeal neoplasm	2.2%
327	Bladder Neoplasm	2.2%
328	Kidney Neoplasm	2.2%
329	Ureteral Neoplasms	2.2%
330	Urethral Neoplasms	2.2%
331	Basal cell carcinoma	2.2%
332	Carcinoma, Papillary	2.2%
333	Squamous cell carcinoma	2.2%
334	Chondrosarcoma	2.2%
335	Craniopharyngioma	2.2%
336	Cystadenoma	2.2%
337	leiomyosarcoma	2.2%
338	liposarcoma	2.2%
339	Mesothelioma	2.2%
340	synovial sarcoma	2.2%
341	Neuroectodermal Tumor, Melanotic	2.2%
342	Angiomyolipoma	2.2%
343	Clear Cell Sarcoma of Soft Tissue	2.2%
344	Alveolar Soft Part Sarcoma	2.2%
345	Neuroendocrine Tumors	2.2%
346	Sarcoma, Myeloid	2.2%
347	Carcinoma, Basal Cell	2.2%
348	Adrenocortical carcinoma	2.1%
349	Bronchial Neoplasms	2.1%
350	Mycosis Fungoides	2.1%
351	Lymphomatoid Papulosis	2.1%
352	Plasmablastic lymphoma	2.1%
353	Multiple Pulmonary Nodules	2.1%
354	Choledochal Cyst	2.1%
355	Supratentorial Neoplasms	2.1%
356	Carcinoid Tumor	2.1%
357	Endometrial Neoplasms	2.1%
358	Neurilemmoma	2.1%
359	Hutchinson's Melanotic Freckle	2.1%
360	Melanoma, Amelanotic	2.1%
361	Peutz-Jeghers Syndrome	2%
362	Adenoma	1.9%
363	Ameloblastoma	1.9%
364	Angiokeratoma	1.9%
365	Carcinoma	1.9%
366	Chordoma	1.9%
367	Hemangioma	1.9%
368	hemangiopericytoma	1.9%
369	Lymphangioma	1.9%
370	Mesenchymoma	1.9%
371	Nevus	1.9%
372	Teratoma	1.9%
373	Hepatoblastoma	1.9%
374	Mixed Tumor, Mullerian	1.9%
375	Germinoma	1.9%
376	Teratocarcinoma	1.9%
377	Angiofibroma	1.9%
378	Sarcoma	1.9%
379	Epithelioma	1.9%
380	Renal Cell Carcinoma	1.9%
381	Papillary Renal Cell Carcinoma	1.9%
382	Cystadenocarcinoma	1.9%
383	Fibrosarcoma	1.9%
384	Osteosarcoma	1.9%
385	Mucoepidermoid Carcinoma	1.9%
386	Burkitt Lymphoma	1.9%
387	Hypopharyngeal Neoplasms	1.8%
388	Pleural Effusion, Malignant	1.8%
389	Hypopharyngeal Cancer	1.8%
390	Astrocytoma	1.8%
391	Ependymoma	1.8%
392	oligodendroglioma	1.8%
393	Ganglioglioma	1.8%
394	gliosarcoma	1.8%
395	Anaplastic astrocytoma	1.8%
396	Anaplastic Oligodendroglioma	1.8%
397	Parotid Neoplasms	1.8%
398	Prostatic Neoplasms, Castration-Resistant	1.8%
399	Endometrial Stromal Sarcoma	1.8%
400	Nelson Syndrome	1.8%
401	Denys-Drash Syndrome	1.8%
402	Adenofibroma	1.7%
403	Fibroadenoma	1.7%
404	Malignant Fibrous Histiocytoma	1.7%
405	Brain Stem Neoplasms	1.7%
406	Malignant Carcinoid Syndrome	1.7%
407	Nasopharyngeal carcinoma	1.7%
408	Carcinoma, Endometrioid	1.7%
409	Pancreatic Pseudocyst	1.6%
410	Plasmacytoma	1.6%
411	Lymphatic Metastasis	1.6%
412	Neoplasms, Unknown Primary	1.6%
413	Leukemic Infiltration	1.6%
414	Neoplasm Micrometastasis	1.6%
415	Cecal Neoplasms	1.6%
416	Duodenal Neoplasms	1.6%
417	Hydatidiform Mole	1.6%
418	Bowen's Disease	1.6%
419	Paraganglioma	1.6%
420	Rhabdomyosarcoma	1.6%
421	Giant Cell Tumor of Bone	1.6%
422	Glioblastoma	1.6%
423	Neuroblastoma	1.6%
424	Glioblastoma Multiforme	1.6%
425	Choroid Plexus Papilloma	1.5%
426	Tonsillar Neoplasms	1.5%
427	Neurofibrosarcoma	1.5%
428	Cerebellar Neoplasms	1.5%
429	Ganglioneuroblastoma	1.5%
430	Nasopharyngeal Neoplasms	1.5%
431	Dermatofibrosarcoma	1.5%
432	Dermatofibrosarcoma Protuberans	1.5%
433	Colorectal Neoplasms	1.4%
434	Polycystic Ovary Syndrome	1.4%
435	Xeroderma Pigmentosum	1.4%
436	Carcinoid Heart Disease	1.4%
437	Paranasal Sinus Neoplasms	1.3%
438	Pheochromocytoma	1.3%
439	Alveolar rhabdomyosarcoma	1.3%
440	Appendiceal Neoplasms	1.3%
441	Colonic Neoplasms	1.3%
442	Rectal Neoplasms	1.3%
443	Adenocarcinoma	1.3%
444	Carcinoma in Situ	1.3%
445	Carcinoma, Transitional Cell	1.3%
446	Phyllodes Tumor	1.3%
447	Dysgerminoma	1.3%
448	Hemangioendothelioma	1.3%
449	Lipoma	1.3%
450	Myoma	1.3%
451	Myxoma	1.3%
452	Neuroma	1.3%
453	Papilloma	1.3%
454	Pseudomyxoma Peritonei	1.3%
455	Seminoma	1.3%
456	Papillomatosis	1.3%
457	Angiolipoma	1.3%
458	Myelolipoma	1.3%
459	Neoplasms, Bone Tissue	1.3%
460	Neoplasms, Fibrous Tissue	1.3%
461	Smooth Muscle Tumor	1.3%
462	Adenomatosis, Pulmonary	1.3%
463	Adenomatous Polyps	1.3%
464	Carcinoma, Large Cell	1.3%
465	Carcinoma, Small Cell	1.3%
466	Desmoplastic Small Round Cell Tumor	1.3%
467	Chondroma	1.3%
468	Enchondroma	1.3%
469	Primary amyloidosis	1.2%
470	Maxillary Sinus Neoplasms	1.1%
471	Anus Neoplasms	1.1%
472	Sigmoid Neoplasms	1.1%
473	Niemann-Pick Disease, Type C	1%
474	Adenoid Cystic Carcinoma	1%
475	fibroma	1%
476	Fibromatosis	1%
477	Osteoblastoma	1%
478	Osteoma	1%
479	Rhabdomyoma	1%
480	Chondromatosis	1%
481	Adenocarcinoma, Clear Cell	1%
482	Cholangiocarcinoma	1%
483	Cervical Intraepithelial Neoplasia	1%
484	Hemangioblastoma	1%
485	Lymphoma, Extranodal NK-T-Cell	1%
486	Mastocytosis	0.9%
487	Sturge-Weber Syndrome	0.9%
488	Cell Transformation, Viral	0.9%
489	Gastrointestinal Stromal Tumors	0.9%
490	neurofibroma	0.9%
491	Zollinger-Ellison syndrome	0.9%
492	Mastocytoma	0.8%
493	Mastocytosis, Systemic	0.8%
494	Fibromatosis, Aggressive	0.8%
495	Fibromatosis, Abdominal	0.8%
496	Klatskin Tumor	0.8%
497	Dupuytren Contracture	0.6%
498	Urticaria Pigmentosa	0.6%
499	Radicular Cyst	0.4%

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