MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Neurodermatitis

(UMLS:C0027822)

Definition:: An extremely variable eczematous skin disease that is presumed to be a response to prolonged vigorous scratching, rubbing, or pinching to relieve intense pruritus. It varies in intensity, severity, course, and morphologic expression in different individuals. Neurodermatitis is believed by some to be psychogenic. The circumscribed or localized form is often referred to as lichen simplex chronicus.
UMLS ID:: C0027822
MeSH ID:: D009450

Classification:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.800.174.660|C17.800.815.660

Synonym(s)

Neurodermatitis

DERMATITIS NEURODERMATITIS

Lichen Simplex Chronicus

NEURODERMATITIS

neurodermatitis

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	rofecoxib	FAERS: 19		OFFSIDES US FAERS
2	Alendronate	FAERS: 15		US FAERS
3	Aripiprazole	FAERS: 14		SIDER US FAERS
4	valdecoxib	FAERS: 9		OFFSIDES US FAERS
5	pimecrolimus	FAERS: 6		OFFSIDES US FAERS
6	Ceftriaxone	FAERS: 5		US FAERS
7	Norgestrel	FAERS: 5 Canada Vigilance: 1		Canada Vigilance OFFSIDES US FAERS
8	Scopolamine	FAERS: 5		US FAERS
9	Ciprofloxacin	FAERS: 4		US FAERS
10	Donepezil	FAERS: 4		US FAERS
11	Fingolimod Hydrochloride	FAERS: 4 Canada Vigilance: 1		Canada Vigilance US FAERS
12	Tacrolimus	FAERS: 4		US FAERS
13	Dimethyl Fumarate	FAERS: 3		US FAERS
14	Donepezil	FAERS: 3		SIDER US FAERS
15	Nitrofurantoin	FAERS: 3 Canada Vigilance: 1		Canada Vigilance US FAERS
16	Risperidone	FAERS: 3		US FAERS
17	Venlafaxine Hydrochloride	FAERS: 3		US FAERS
18	tesamorelin	FAERS: 3		US FAERS
19	Atorvastatin	FAERS: 2		US FAERS
20	Estradiol	FAERS: 2		OFFSIDES US FAERS
21	Finasteride	FAERS: 2		US FAERS
22	Isotretinoin	FAERS: 2		US FAERS
23	Lenalidomide	FAERS: 2		OFFSIDES US FAERS
24	Linezolid	FAERS: 2		OFFSIDES US FAERS
25	Lisdexamfetamine Dimesylate	FAERS: 2		US FAERS
26	Olanzapine	FAERS: 2		US FAERS
27	Thalidomide	FAERS: 2		US FAERS
28	Venlafaxine Hydrochloride	FAERS: 2		US FAERS
29	apremilast	FAERS: 2		US FAERS
30	gadoversetamide	FAERS: 2		OFFSIDES US FAERS
31	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	FAERS: 1		US FAERS
32	AN2728	FAERS: 1		US FAERS
33	Anastrozole	FAERS: 1		OFFSIDES US FAERS
34	Azathioprine	FAERS: 1		US FAERS
35	Ceftriaxone	FAERS: 1		US FAERS
36	Cyclophosphamide	FAERS: 1		US FAERS
37	Gabapentin	FAERS: 1		US FAERS
38	Glatiramer Acetate	FAERS: 1		US FAERS
39	Ibandronic Acid	FAERS: 1		US FAERS
40	Imatinib Mesylate	FAERS: 1		OFFSIDES US FAERS
41	Imatinib Mesylate	FAERS: 1		US FAERS
42	Lamotrigine	FAERS: 1		US FAERS
43	Leflunomide	FAERS: 1		US FAERS
44	Methadone	FAERS: 1		US FAERS
45	Moxifloxacin	FAERS: 1		US FAERS
46	Nafarelin	FAERS: 1		US FAERS
47	Paliperidone Palmitate	FAERS: 1		US FAERS
48	Paroxetine	FAERS: 1		US FAERS
49	Pregabalin	FAERS: 1		US FAERS
50	Quetiapine Fumarate	FAERS: 1		US FAERS
51	Sertraline	FAERS: 1		US FAERS
52	Solifenacin Succinate	FAERS: 1		US FAERS
53	Sunitinib	FAERS: 1		US FAERS
54	Teriparatide	FAERS: 1		US FAERS
55	Tinidazole	FAERS: 1		US FAERS
56	Valproic Acid	FAERS: 1		US FAERS
57	Valproic Acid	FAERS: 1		US FAERS
58	Vemurafenib	FAERS: 1		US FAERS
59	apixaban	FAERS: 1		US FAERS
60	ledipasvir, sofosbuvir drug combination	FAERS: 1		US FAERS
61	saxagliptin	FAERS: 1		US FAERS
62	sofosbuvir-velpatasvir drug combination	FAERS: 1		US FAERS
63	telithromycin	FAERS: 1		US FAERS
64	ziprasidone	FAERS: 1		US FAERS
65	Adapalene			OFFSIDES
66	Amoxicillin			OFFSIDES
67	Atomoxetine Hydrochloride			OFFSIDES
68	Bethanechol			OFFSIDES
69	Bortezomib			OFFSIDES
70	Budesonide			OFFSIDES
71	Bupropion			OFFSIDES
72	Busulfan			OFFSIDES
73	Calcium Chloride			OFFSIDES
74	Carbamazepine			SIDER
75	Cetirizine			OFFSIDES
76	Cinacalcet			OFFSIDES
77	Clobetasol			OFFSIDES
78	Clomipramine		11465569	CTD
79	Clopidogrel			OFFSIDES
80	Clotrimazole			OFFSIDES
81	Dapsone			OFFSIDES
82	Dermazin			OFFSIDES
83	Dicyclomine			OFFSIDES
84	Digoxin			OFFSIDES
85	Docusate sodium			OFFSIDES
86	Doxepin			OFFSIDES
87	Doxycycline			OFFSIDES
88	Erythromycin			OFFSIDES
89	Etoricoxib			OFFSIDES
90	Famciclovir			OFFSIDES
91	Fenofibrate			OFFSIDES
92	Fludrocortisone			OFFSIDES
93	Fosinopril			OFFSIDES
94	Gatifloxacin			OFFSIDES
95	Glucovance			OFFSIDES
96	Goserelin			OFFSIDES
97	Hydrochlorothiazide			OFFSIDES
98	Hydromorphone			OFFSIDES
99	Hydroxyzine			OFFSIDES
100	Imipramine			OFFSIDES
101	Letrozole			OFFSIDES
102	Lithium Carbonate			OFFSIDES
103	Lithium			OFFSIDES
104	Methocarbamol			OFFSIDES
105	Methylphenidate			OFFSIDES
106	Minoxidil			OFFSIDES
107	Nabumetone			OFFSIDES
108	Norethindrone Acetate			OFFSIDES
109	Norethindrone			OFFSIDES
110	Ofloxacin			OFFSIDES
111	Olopatadine Hydrochloride			OFFSIDES
112	Pamidronate			OFFSIDES
113	Perindopril			OFFSIDES
114	Pheniramine			OFFSIDES
115	Phosphates			OFFSIDES
116	Progesterone			OFFSIDES
117	Rilmenidine			OFFSIDES
118	Sevelamer			OFFSIDES
119	Sevelamer			OFFSIDES
120	Sirolimus			OFFSIDES
121	Tamoxifen			OFFSIDES
122	Terbinafine			OFFSIDES
123	Thiethylperazine			OFFSIDES
124	Tobramycin			OFFSIDES
125	Tranylcypromine			OFFSIDES
126	Tranylcypromine			OFFSIDES
127	Tretinoin			OFFSIDES
128	Triamterene			OFFSIDES
129	Varenicline			OFFSIDES
130	Vitamin A			OFFSIDES
131	Vitamin B 12			OFFSIDES
132	Vitamin D			OFFSIDES
133	Zoledronic Acid			OFFSIDES
134	betamethasone-17,21-dipropionate			OFFSIDES
135	exemestane			OFFSIDES
136	gadodiamide			OFFSIDES
137	hydrocodone tartrate, ibuprofen drug combination			OFFSIDES
138	naphthalan		2147803	CTD
139	paricalcitol			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Contact Dermatitis	66.7%
2	Eczema	66.7%
3	Intertrigo	66.7%
4	Perioral Dermatitis	53.3%
5	Dermatitis, Atopic	49.5%
6	Dermatitis, Irritant	49.2%
7	Dermatitis, Phototoxic	48.4%
8	Phototoxicity	48.4%
9	Pyoderma Gangrenosum	48%
10	Dermatitis Herpetiformis	43.2%
11	Acrodermatitis	42.7%
12	Gianotti-Crosti Syndrome	42.7%
13	Lupus Erythematosus, Cutaneous	41.4%
14	Panniculitis	41.4%
15	Systemic Scleroderma	41.4%
16	Morphea	41.4%
17	Dermatitis, Occupational	41.1%
18	Breast Diseases	40.9%
19	Exanthema	40.9%
20	Facial Dermatoses	40.9%
21	Hair Diseases	40.9%
22	Hand Dermatoses	40.9%
23	keratoacanthoma	40.9%
24	Keratosis	40.9%
25	Nail Diseases	40.9%
26	Photosensitivity Disorders	40.9%
27	Prurigo	40.9%
28	Pyoderma	40.9%
29	Rosacea	40.9%
30	Sebaceous Gland Diseases	40.9%
31	Skin Diseases, Vesiculobullous	40.9%
32	Skin Ulcer	40.9%
33	Sweat Gland Diseases	40.9%
34	Skin Diseases, Papulosquamous	40.9%
35	Skin Diseases, Vascular	40.9%
36	Acneiform Eruptions	40.9%
37	Ocular Rosacea	40.9%
38	Subcorneal pustular dermatosis	40.9%
39	Erythematotelangiectatic Rosacea	40.9%
40	Papulopustular Rosacea	40.9%
41	Chronic Actinic Dermatitis	40.9%
42	Diaper Rash	40.7%
43	Dermatitis, Photoallergic	40.2%
44	Acne Vulgaris	40%
45	Erythema Multiforme	40%
46	Rhinophyma	40%
47	Acne	40%
48	Dermatitis, Allergic Contact	39.5%
49	Pityriasis Lichenoides et Varioliformis Acuta	35.3%
50	Pityriasis Lichenoides	35.3%
51	Foot Ulcer	34.7%
52	Epidermolysis Bullosa	34.3%
53	Xeroderma Pigmentosum	32.2%
54	Foot Diseases	32.1%
55	Sebaceous Gland Neoplasms	32%
56	Porokeratosis	32%
57	Keratoderma, Palmoplantar	32%
58	Skin Abnormalities	31%
59	Skin Diseases, Infectious	31%
60	Skin Neoplasms	31%
61	Pigmentation Disorders	31%
62	Panniculitis, Lupus Erythematosus	30.8%
63	Lipomatosis	30.5%
64	Pruritus	30.5%
65	Erythema	30.5%
66	Necrolytic Migratory Erythema	30.5%
67	Cutaneous Fistula	30.5%
68	Nephrogenic Fibrosing Dermopathy	30.5%
69	Nephrogenic Systemic Fibrosis	30.5%
70	Necrobiosis Lipoidica Diabeticorum	29.8%
71	Erythema Nodosum	29.5%
72	Acne Conglobata	29.5%
73	Urticaria Pigmentosa	27.5%
74	Xeroderma	27%
75	Toxic Epidermal Necrolysis	26.9%
76	Stevens-Johnson Syndrome	26.9%
77	Dermatomyositis	26.9%
78	Anhidrosis	26.7%
79	Cholesteatoma	26.7%
80	Pressure Ulcer	26.7%
81	Drug Eruptions	26.7%
82	Folliculitis	26.7%
83	Foot Dermatoses	26.7%
84	Gynecomastia	26.7%
85	Hypertrichosis	26.7%
86	Hypohidrosis	26.7%
87	Hypotrichosis	26.7%
88	Leg Ulcer	26.7%
89	Lupus Erythematosus, Discoid	26.7%
90	Miliaria	26.7%
91	Parakeratosis	26.7%
92	Parapsoriasis	26.7%
93	Pityriasis	26.7%
94	Psoriasis	26.7%
95	Sweet Syndrome	26.7%
96	Hidradenitis	26.7%
97	Onycholysis	26.7%
98	Miliaria Rubra	26.7%
99	Hyperpigmentation	26.7%
100	Lichenoid Eruptions	26.7%
101	Chloracne	26.7%
102	Scleroderma, Limited	26.7%
103	Erythema Induratum	25.7%
104	Cutis Laxa	24.3%
105	Mastocytosis	24.2%
106	Connective Tissue Diseases	23.8%
107	Papillon-Lefevre Disease	23.5%
108	Erythema Infectiosum	23.5%
109	Exanthema Subitum	23.3%
110	Ectodermal Dysplasia	22.9%
111	Aplasia Cutis Congenita	22.9%
112	Pseudoxanthoma Elasticum	22.3%
113	Tinea Capitis	21.2%
114	Onychomycosis	21.2%
115	Dermatitis	20.5%
116	Acantholysis	20.3%
117	Breast Cyst	20.3%
118	Actinic keratosis	20.3%
119	Pemphigoid, Benign Mucous Membrane	20.3%
120	Pemphigus	20.3%
121	Piedra	20.3%
122	Sunburn	20.3%
123	Argyria	20%
124	Hirsutism	20%
125	Lactation Disorder	20%
126	Mastitis	20%
127	Neurodermatitis	20%
128	Urticaria	20%
129	Granuloma Annulare	19.9%
130	Adiposis Dolorosa	19.8%
131	Pruritus Vulvae	19.8%
132	Lichen Planus	19.8%
133	Melanosis	19.8%
134	Chloasma	19.8%
135	Pityriasis Rosea	19.8%
136	Pityriasis Rubra Pilaris	19.8%
137	Vitiligo	19.8%
138	Lichen Nitidus	19.8%
139	Mastocytoma	19.8%
140	Pruritus Ani	19.8%
141	Ecthyma	19.7%
142	Acute Generalized Exanthematous Pustulosis	19.6%
143	Hyperkeratosis, Epidermolytic	19.4%
144	Ichthyosis, X-Linked	17.9%
145	Sjogren-Larsson Syndrome	17.8%
146	Behcet Syndrome	17.5%
147	Hidradenitis Suppurativa	16.9%
148	Acanthosis Nigricans	16.4%
149	Alopecia Areata	16.4%
150	Lentigo	16.4%
151	Serum Sickness	16.4%
152	Dermatomycoses	16.2%
153	Mucocutaneous Lymph Node Syndrome	16.2%
154	Skin Diseases, Bacterial	16.2%
155	Lipodystrophy	16%
156	Livedo Reticularis	16%
157	Malignant Atrophic Papulosis	16%
158	Polyarteritis Nodosa	15.8%
159	Takayasu Arteritis	15.8%
160	Albinism	15.5%
161	Tinea Pedis	15.3%
162	Erythema Chronicum Migrans	15.2%
163	Alopecia	15.1%
164	Sweating, Gustatory	15.1%
165	Androgenetic Alopecia	15.1%
166	Auriculotemporal Syndrome	15.1%
167	Lice Infestations	14.9%
168	Varicose Ulcer	14.9%
169	Breast Neoplasms, Male	14.9%
170	Triple Negative Breast Neoplasms	14.9%
171	Galactorrhea	14.8%
172	Collagen Diseases	13.6%
173	Mixed Connective Tissue Disease	13.6%
174	Nail-Patella Syndrome	13.6%
175	Mucinoses	13.6%
176	Porphyrias, Hepatic	13.5%
177	Mycetoma	13.1%
178	Lichen Planus, Oral	12.6%
179	Larva Migrans	12.1%
180	Leishmaniasis	12.1%
181	Molluscum Contagiosum	12.1%
182	Angioedema	12%
183	Onchocerciasis	11.9%
184	Chromoblastomycosis	11.8%
185	Dermatophytosis	11.8%
186	Sporotrichosis	11.8%
187	Tinea	11.8%
188	Tinea Versicolor	11.8%
189	Trichophytosis	11.8%
190	Hyalohyphomycosis	11.8%
191	Cartilage Diseases	10.7%
192	Rheumatism	10.7%
193	Chondromalacia	10.7%
194	Lupus Erythematosus, Systemic	10.3%
195	Overlap syndrome	10.3%
196	Warts	10.2%
197	Candidiasis, Chronic Mucocutaneous	9.9%
198	Cutaneous Candidiasis	9.9%
199	Erysipelas	9.8%
200	Leishmaniasis, Cutaneous	9.8%
201	Staphylococcal Skin Infections	9.8%
202	Variegate Porphyria	9.8%
203	Acute intermittent porphyria	9.8%
204	Porphyria Cutanea Tarda	9.8%
205	Eczema Herpeticum	9.8%
206	Erythrasma	9.8%
207	Carcinoma, Lobular	9.8%
208	CREST Syndrome	9.8%
209	Arthritis, Psoriatic	9.8%
210	Fusariosis	9.7%
211	Scleromyxedema	8.9%
212	Hereditary Angioedema Type III	8.7%
213	Hereditary Angioedema Types I and II	8.7%
214	Giant Cell Arteritis	8.7%
215	Temporal Arteritis	8.7%
216	Angioedemas, Hereditary	8.3%
217	Epidermodysplasia Verruciformis	8.2%
218	Herpes Labialis	8.2%
219	Diabetic Foot	8.2%
220	Staphylococcal Scalded Skin Syndrome	8.1%
221	Dupuytren Contracture	8%
222	Peutz-Jeghers Syndrome	7.5%
223	Blastomycosis	7.4%
224	HIV-Associated Lipodystrophy Syndrome	7.3%
225	carbuncle	7.2%
226	Condylomata Acuminata	7.1%
227	Furunculosis	7%
228	furuncle	7%
229	Impetigo	6.9%
230	Mesenteric Panniculitis	6.8%
231	Panniculitis, Peritoneal	6.8%
232	Tietze's Syndrome	6.8%
233	Orbital Cellulitis	6.8%
234	Myxoid cyst	6.8%
235	Rhinoscleroma	6.7%
236	Cellulitis	6.7%
237	Myxedema	6.7%
238	Menkes Kinky Hair Syndrome	6.5%
239	Osteochondritis	5.5%
240	Polymyalgia Rheumatica	5.5%
241	Osteogenesis Imperfecta	5.4%
242	Keloid	5.3%
243	Noonan Syndrome	5%
244	Rheumatoid Arthritis	4.5%
245	Juvenile arthritis	4.5%
246	Marfan Syndrome	4.5%
247	Lupus Nephritis	4.4%
248	Homocystinuria	4.4%
249	Rheumatoid Nodule	3.9%
250	Laryngomalacia	3.9%
251	Pectus carinatum	3.9%
252	Felty Syndrome	3.3%
253	Bronchomalacia	3.3%
254	Tracheomalacia	3.3%
255	Rheumatoid Vasculitis	2.8%
256	Mucopolysaccharidosis III	2.8%
257	Sicca Syndrome	2.5%
258	Sjogren's Syndrome	2.5%
259	Lupus Vasculitis, Central Nervous System	2%
260	Mucopolysaccharidosis II	1.9%

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