MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Acute Generalized Exanthematous Pustulosis

(UMLS:C0877055)

Definition:: Rare skin eruption characterized by acute formation of pustules filled with NEUTROPHILS, fever, and peripheral blood LEUKOCYTOSIS. Most cases are associated with the use of antibiotics (e.g., BETA-LACTAMS).
UMLS ID:: C0877055
MeSH ID:: D056150

Classification 1:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.800.174.600.174

Classification 2:

Name:

Immune System Diseases
MeSH Tree Number(s):: C20.543.206.380.174

Classification 3:

Name:

Chemically-Induced Disorders
MeSH Tree Number(s):: C25.100.468.380.174

Synonym(s)

Acute Generalized Exanthematous Pustulosis

AGEP - acute generalized exanthematous pustulosis

Acute generalised exanthematous pustulosis

Acute generalized exanthematous pustulosis

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Carbamazepine		12430739 15229826	CTD
2	Sulfamethoxazole		12861854	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Erythema Nodosum	45.8%
2	Serum Sickness	45.8%
3	Toxic Epidermal Necrolysis	36.7%
4	Stevens-Johnson Syndrome	36.7%
5	Asthma, Aspirin-Induced	21%
6	Dermatitis, Atopic	19.8%
7	Contact Dermatitis	19.6%
8	Eczema	19.6%
9	Intertrigo	19.6%
10	Neurodermatitis	19.6%
11	Perioral Dermatitis	19.6%
12	Dermatitis Herpetiformis	19.3%
13	Acrodermatitis	16.4%
14	Gianotti-Crosti Syndrome	16.4%
15	Dermatitis, Allergic Contact	15.7%
16	Pyoderma Gangrenosum	14.8%
17	Dermatitis, Photoallergic	13.8%
18	Lupus Erythematosus, Cutaneous	13.4%
19	Panniculitis	13.4%
20	Systemic Scleroderma	13.4%
21	Morphea	13.4%
22	Mastocytosis	13.2%
23	Dermatitis, Irritant	12.9%
24	Dermatitis, Phototoxic	12.9%
25	Phototoxicity	12.9%
26	Breast Diseases	12.4%
27	Exanthema	12.4%
28	Facial Dermatoses	12.4%
29	Hair Diseases	12.4%
30	Hand Dermatoses	12.4%
31	Immune Complex Diseases	12.4%
32	keratoacanthoma	12.4%
33	Keratosis	12.4%
34	Nail Diseases	12.4%
35	Photosensitivity Disorders	12.4%
36	Prurigo	12.4%
37	Pyoderma	12.4%
38	Rosacea	12.4%
39	Sebaceous Gland Diseases	12.4%
40	Skin Diseases, Vesiculobullous	12.4%
41	Skin Ulcer	12.4%
42	Sweat Gland Diseases	12.4%
43	Anticholinergic Syndrome	12.4%
44	Skin Diseases, Papulosquamous	12.4%
45	Skin Diseases, Vascular	12.4%
46	Acneiform Eruptions	12.4%
47	Ocular Rosacea	12.4%
48	Latex allergy	12.4%
49	Subcorneal pustular dermatosis	12.4%
50	Serotonin Syndrome	12.4%
51	Propofol Infusion Syndrome	12.4%
52	Erythematotelangiectatic Rosacea	12.4%
53	Papulopustular Rosacea	12.4%
54	Chronic Actinic Dermatitis	12.4%
55	Acne Vulgaris	11.8%
56	Erythema Multiforme	11.8%
57	Rhinophyma	11.8%
58	Urticaria	11.8%
59	Acne	11.8%
60	Chemical and Drug Induced Liver Injury	11.3%
61	Dermatitis, Occupational	11.2%
62	Epidermolysis Bullosa	11.1%
63	Xeroderma Pigmentosum	10.9%
64	Foot Diseases	10.3%
65	Environmental Illness	10.3%
66	Skin Abnormalities	10.1%
67	Skin Diseases, Infectious	10.1%
68	Skin Neoplasms	10.1%
69	Pigmentation Disorders	10.1%
70	Metabolic Side Effects of Drugs and Substances	10.1%
71	Lipomatosis	9.9%
72	Pruritus	9.9%
73	Erythema	9.9%
74	Injection Site Reaction	9.9%
75	Necrolytic Migratory Erythema	9.9%
76	Cutaneous Fistula	9.9%
77	Infusion site reaction	9.9%
78	Nephrogenic Fibrosing Dermopathy	9.9%
79	Nephrogenic Systemic Fibrosis	9.9%
80	Sebaceous Gland Neoplasms	9.8%
81	Porokeratosis	9.8%
82	Keratoderma, Palmoplantar	9.8%
83	Foot Ulcer	9.7%
84	Pityriasis Lichenoides et Varioliformis Acuta	9.7%
85	Pityriasis Lichenoides	9.7%
86	Diaper Rash	9.6%
87	Dermatomyositis	9.5%
88	Necrobiosis Lipoidica Diabeticorum	9.3%
89	Panniculitis, Lupus Erythematosus	9.3%
90	Pemphigus	9.3%
91	Xeroderma	8.5%
92	Kounis Syndrome	8.3%
93	Erythema Induratum	8.3%
94	Urticaria Pigmentosa	8.1%
95	Argyria	7.8%
96	Lupus Erythematosus, Discoid	7.8%
97	Scleroderma, Limited	7.8%
98	Acne Conglobata	7.7%
99	Cutis Laxa	7.7%
100	Autoimmune Diseases	7.7%
101	Connective Tissue Diseases	7.7%
102	Immunologic Deficiency Syndromes	7.7%
103	Immunoproliferative Disorders	7.7%
104	Poisoning	7.7%
105	Immune reconstitution syndrome	7.7%
106	Immune Reconstitution Inflammatory Syndrome	7.7%
107	Pseudoxanthoma Elasticum	7.6%
108	Akathisia, Drug-Induced	7.5%
109	Ectodermal Dysplasia	7.4%
110	Aplasia Cutis Congenita	7.4%
111	anaphylaxis	7.3%
112	Anhidrosis	7.3%
113	Cholesteatoma	7.3%
114	Pressure Ulcer	7.3%
115	Folliculitis	7.3%
116	Food Allergy	7.3%
117	Foot Dermatoses	7.3%
118	Gynecomastia	7.3%
119	Hypertrichosis	7.3%
120	Hypohidrosis	7.3%
121	Hypotrichosis	7.3%
122	Leg Ulcer	7.3%
123	Miliaria	7.3%
124	Parakeratosis	7.3%
125	Parapsoriasis	7.3%
126	Pityriasis	7.3%
127	Psoriasis	7.3%
128	Sweet Syndrome	7.3%
129	Hidradenitis	7.3%
130	Onycholysis	7.3%
131	Miliaria Rubra	7.3%
132	Hyperpigmentation	7.3%
133	Lichenoid Eruptions	7.3%
134	Chloracne	7.3%
135	Anaphylactic shock	7.3%
136	Cardiotoxicity	7.2%
137	Erythema Infectiosum	7.1%
138	Exanthema Subitum	7%
139	Lupus Erythematosus, Systemic	6.7%
140	Overlap syndrome	6.7%
141	Dyskinesia, Drug-Induced	6.6%
142	Angioedema	6.6%
143	Chemical and Drug Induced Liver Injury, Chronic	6.6%
144	Papillon-Lefevre Disease	6.5%
145	Drug abuse	6.4%
146	Substance Dependence	6.4%
147	Substance-Related Disorders	6.4%
148	Drug Dependence	6.4%
149	Tinea Capitis	6.2%
150	Onychomycosis	6.2%
151	Transfusion Reaction	6.2%
152	Hypotensive Transfusion Reaction	6.2%
153	Respiratory Hypersensitivity	6.1%
154	Ecthyma	6.1%
155	Granuloma Annulare	6%
156	Acantholysis	6%
157	Breast Cyst	6%
158	Actinic keratosis	6%
159	Pemphigoid, Benign Mucous Membrane	6%
160	Piedra	6%
161	Sick Building Syndrome	6%
162	Sunburn	6%
163	Multiple Chemical Sensitivity	6%
164	Hirsutism	5.9%
165	Lactation Disorder	5.9%
166	Mastitis	5.9%
167	Vasculitis, Leukocytoclastic, Cutaneous	5.9%
168	Adiposis Dolorosa	5.8%
169	Pruritus Vulvae	5.8%
170	Mastocytoma	5.8%
171	Pruritus Ani	5.8%
172	Ichthyosis, X-Linked	5.7%
173	Sjogren-Larsson Syndrome	5.7%
174	Behcet Syndrome	5.5%
175	Hyperkeratosis, Epidermolytic	5.3%
176	Glomerulonephritis, Membranoproliferative	5%
177	Dermatomycoses	5%
178	Mucocutaneous Lymph Node Syndrome	5%
179	Skin Diseases, Bacterial	5%
180	Albinism	4.9%
181	Lipodystrophy	4.9%
182	Livedo Reticularis	4.9%
183	Malignant Atrophic Papulosis	4.9%
184	Hidradenitis Suppurativa	4.9%
185	Polyarteritis Nodosa	4.9%
186	Takayasu Arteritis	4.9%
187	Erythema Chronicum Migrans	4.8%
188	Lichen Planus	4.8%
189	Melanosis	4.8%
190	Chloasma	4.8%
191	Pityriasis Rosea	4.8%
192	Pityriasis Rubra Pilaris	4.8%
193	Vitiligo	4.8%
194	Milk Allergy	4.8%
195	Lichen Nitidus	4.8%
196	Wheat Hypersensitivity	4.8%
197	Psychoses, Substance-Induced	4.8%
198	Nail-Patella Syndrome	4.3%
199	Porphyrias, Hepatic	4.3%
200	Tinea Pedis	4.2%
201	Angioedemas, Hereditary	4.2%
202	Collagen Diseases	4.1%
203	Fluoride Poisoning	4.1%
204	Food Poisoning	4.1%
205	Gas Poisoning	4.1%
206	Mixed Connective Tissue Disease	4.1%
207	Mycotoxicosis	4.1%
208	Plant Poisoning	4.1%
209	Antiphospholipid Syndrome	4.1%
210	Mucinoses	4.1%
211	Organophosphate poisoning	4.1%
212	Hereditary Angioedema Type III	4%
213	Hereditary Angioedema Types I and II	4%
214	Alopecia	3.9%
215	Sweating, Gustatory	3.9%
216	Androgenetic Alopecia	3.9%
217	Auriculotemporal Syndrome	3.9%
218	Mushroom Poisoning	3.9%
219	Lice Infestations	3.9%
220	Varicose Ulcer	3.9%
221	Breast Neoplasms, Male	3.9%
222	Triple Negative Breast Neoplasms	3.9%
223	Mycetoma	3.9%
224	Galactorrhea	3.9%
225	Mastocytosis, Systemic	3.9%
226	Rheumatoid Arthritis	3.8%
227	Autoimmune Lymphoproliferative Syndrome	3.8%
228	Juvenile arthritis	3.8%
229	Thrombocytopenic purpura	3.7%
230	Acanthosis Nigricans	3.6%
231	Alopecia Areata	3.6%
232	Lentigo	3.6%
233	Giant Cell Arteritis	3.6%
234	Temporal Arteritis	3.6%
235	Bites and Stings	3.4%
236	Cartilage Diseases	3.4%
237	Rheumatism	3.4%
238	Chondromalacia	3.4%
239	Neurotoxicity Syndromes	3.4%
240	Lymphoproliferative Disorders	3.4%
241	Marijuana Abuse	3.4%
242	Opioid-Related Disorders	3.4%
243	Nicotine Dependence	3.4%
244	Opioid abuse	3.4%
245	Phencyclidine Abuse	3.4%
246	Substance Abuse, Intravenous	3.4%
247	Substance Withdrawal Syndrome	3.4%
248	Tobacco Use Disorder	3.4%
249	Alcohol-Related Disorders	3.4%
250	Amphetamine-Related Disorders	3.4%
251	Cocaine-Related Disorders	3.4%
252	Addison Disease	3.3%
253	Paraproteinemias	3.3%
254	Water Intoxication	3.3%
255	Arsenic Poisoning	3.3%
256	Autoimmune thyroiditis	3.3%
257	Primary Adrenal Insufficiency	3.3%
258	Larva Migrans	3.3%
259	Leishmaniasis	3.3%
260	Molluscum Contagiosum	3.3%
261	Lymphopenia	3.3%
262	Drug Overdose	3.3%
263	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	3.3%
264	Autoimmune hepatitis	3.3%
265	Autoimmune thrombocytopenia	3.3%
266	Immune thrombocytopenic purpura	3.3%
267	Onchocerciasis	3.3%
268	Chromoblastomycosis	3.2%
269	Dermatophytosis	3.2%
270	Sporotrichosis	3.2%
271	Tinea	3.2%
272	Tinea Versicolor	3.2%
273	Trichophytosis	3.2%
274	Hyalohyphomycosis	3.2%
275	HIV-Associated Lipodystrophy Syndrome	3.2%
276	Lichen Planus, Oral	3%
277	CREST Syndrome	2.9%
278	Asthma	2.9%
279	Warts	2.9%
280	Neonatal Abstinence Syndrome	2.8%
281	Primary amyloidosis	2.8%
282	Hypergammaglobulinemia	2.8%
283	Candidiasis, Chronic Mucocutaneous	2.8%
284	Cutaneous Candidiasis	2.8%
285	Monoclonal Gammopathy of Undetermined Significance	2.8%
286	Erysipelas	2.8%
287	Staphylococcal Skin Infections	2.8%
288	Variegate Porphyria	2.8%
289	Acute intermittent porphyria	2.8%
290	Porphyria Cutanea Tarda	2.8%
291	Latent Autoimmune Diabetes in Adults	2.8%
292	Lupus Nephritis	2.8%
293	Erythrasma	2.8%
294	Carcinoma, Lobular	2.8%
295	Agammaglobulinemia	2.8%
296	Arthritis, Psoriatic	2.8%
297	HIV Infections	2.7%
298	Alcohol-Induced Disorders, Nervous System	2.7%
299	Transfusion-Related Acute Lung Injury	2.7%
300	Dupuytren Contracture	2.7%
301	Aspergillosis, Allergic Bronchopulmonary	2.5%
302	Asthma, Exercise-Induced	2.4%
303	Cadmium poisoning	2.4%
304	Carbon Monoxide Poisoning	2.4%
305	Ciguatera Poisoning	2.4%
306	Ergotism	2.4%
307	Lead Poisoning	2.4%
308	Mercury Poisoning	2.4%
309	Status Asthmaticus	2.4%
310	Alcohol-Induced Disorders	2.4%
311	Scleromyxedema	2.4%
312	Shellfish Poisoning	2.4%
313	Leishmaniasis, Cutaneous	2.4%
314	Eczema Herpeticum	2.4%
315	Fusariosis	2.4%
316	Graves Disease	2.4%
317	Alcohol Withdrawal Delirium	2.4%
318	Cellulitis	2.4%
319	Alcohol Withdrawal Seizures	2.4%
320	Anti-Glomerular Basement Membrane Disease	2.3%
321	Felty Syndrome	2.3%
322	Psychoses, Alcoholic	2.3%
323	Menkes Kinky Hair Syndrome	2.2%
324	Blastomycosis	2.2%
325	Multiple Myeloma	2.2%
326	Asthma, Occupational	2.2%
327	Farmer's Lung	2.1%
328	Epidermodysplasia Verruciformis	2.1%
329	Herpes Labialis	2.1%
330	Hay fever	2.1%
331	Rhinitis, Allergic, Perennial	2.1%
332	Diabetic Foot	2.1%
333	Staphylococcal Scalded Skin Syndrome	2.1%
334	Rheumatoid Vasculitis	2%
335	Rhinoscleroma	2%
336	Insect Bites and Stings	2%
337	Mesenteric Panniculitis	2%
338	Panniculitis, Peritoneal	2%
339	Tietze's Syndrome	2%
340	Orbital Cellulitis	2%
341	Myxoid cyst	2%
342	Alcohol Use Disorder	2%
343	Alcoholic Intoxication	2%
344	Heroin Dependence	2%
345	Morphine Dependence	2%
346	Myxedema	2%
347	Plasmacytoma	2%
348	Tumor Lysis Syndrome	2%
349	Alcohol abuse	2%
350	Manganese Poisoning	2%
351	HTLV-I Infections	1.9%
352	Job Syndrome	1.9%
353	Salmonella food poisoning	1.9%
354	Lupus Vasculitis, Central Nervous System	1.8%
355	Kernicterus	1.8%
356	Condylomata Acuminata	1.8%
357	Noonan Syndrome	1.8%
358	Furunculosis	1.8%
359	furuncle	1.8%
360	Sicca Syndrome	1.8%
361	Sjogren's Syndrome	1.8%
362	Impetigo	1.8%
363	Peutz-Jeghers Syndrome	1.8%
364	carbuncle	1.7%
365	Osteochondritis	1.7%
366	Polymyalgia Rheumatica	1.7%
367	Marfan Syndrome	1.7%
368	Ataxia Telangiectasia	1.7%
369	Sezary Syndrome	1.7%
370	Lymphoma	1.7%
371	Myasthenia Gravis	1.7%
372	Uveomeningoencephalitic Syndrome	1.7%
373	Neuroleptic Malignant Syndrome	1.6%
374	Osteogenesis Imperfecta	1.6%
375	Hydrops Fetalis	1.6%
376	Chronic granulomatous disease	1.6%
377	Heavy Chain Disease	1.6%
378	Binge Drinking	1.6%
379	Granulomatosis with polyangiitis	1.6%
380	Keloid	1.6%
381	Homocystinuria	1.6%
382	HIV Seropositivity	1.6%
383	Schnitzler Syndrome	1.6%
384	Myasthenia Gravis, Autoimmune, Experimental	1.4%
385	Stiff-Person Syndrome	1.4%
386	Polyradiculoneuropathy	1.4%
387	Polyradiculoneuritis	1.4%
388	Botulism	1.4%
389	Acquired Immunodeficiency Syndrome	1.4%
390	AIDS related complex	1.4%
391	Infectious Mononucleosis	1.4%
392	MPTP Poisoning	1.4%
393	Cryoglobulinemia	1.4%
394	POEMS Syndrome	1.4%
395	Cardiomyopathy, Alcoholic	1.3%
396	Pancreatitis, Alcoholic	1.3%
397	Mercury Poisoning, Nervous System	1.3%
398	Lead Poisoning, Nervous System	1.3%
399	Laryngomalacia	1.3%
400	Pectus carinatum	1.3%
401	AIDS-Related Opportunistic Infections	1.2%
402	Vasculitis, Central Nervous System	1.2%
403	HIV Wasting Syndrome	1.2%
404	Wernicke Encephalopathy	1.2%
405	AIDS Dementia Complex	1.2%
406	AIDS-Associated Nephropathy	1.2%
407	Tick Paralysis	1.2%
408	Lambert-Eaton Myasthenic Syndrome	1.1%
409	Fetal Alcohol Spectrum Disorders	1.1%
410	Waldenstrom Macroglobulinemia	1.1%
411	Wiskott-Aldrich Syndrome	1.1%
412	Multiple Sclerosis	1.1%
413	Hodgkin Disease	1.1%
414	Leukemia, Plasma Cell	1.1%
415	Lymphoma, Non-Hodgkin	1.1%
416	Rheumatoid Nodule	1.1%
417	Leukemia, T-Cell	1.1%
418	Leukemia, B-Cell	1.1%
419	Neuromyelitis Optica	1%
420	Leukoencephalitis, Acute Hemorrhagic	1%
421	Lead Poisoning, Nervous System, Childhood	1%
422	Lead Poisoning, Nervous System, Adult	1%
423	Bronchomalacia	0.9%
424	Composite Lymphoma	0.9%
425	Tracheomalacia	0.9%
426	Encephalomyelitis, Acute Disseminated	0.9%
427	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	0.9%
428	Neuritis, Autoimmune, Experimental	0.9%
429	Lymphangioleiomyomatosis	0.9%
430	Guillain-Barre Syndrome	0.8%
431	Fatty Liver, Alcoholic	0.8%
432	Hepatitis, Alcoholic	0.8%
433	Liver Cirrhosis, Alcoholic	0.8%
434	Acrodynia	0.8%
435	Multiple Sclerosis, Chronic Progressive	0.8%
436	Multiple Sclerosis, Relapsing-Remitting	0.8%
437	Lymphoma, Follicular	0.8%
438	T-Cell Lymphoma	0.8%
439	Mantle cell lymphoma	0.8%
440	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	0.8%
441	Mucopolysaccharidosis III	0.8%
442	Leukemia, Large Granular Lymphocytic	0.8%
443	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	0.8%
444	Lymphoma, T-Cell, Cutaneous	0.7%
445	Lymphoma, AIDS-Related	0.7%
446	Enteropathy-Associated T-Cell Lymphoma	0.7%
447	Primary Effusion Lymphoma	0.7%
448	Mycosis Fungoides	0.6%
449	Lymphomatoid Papulosis	0.6%
450	Plasmablastic lymphoma	0.6%
451	Myelitis, Transverse	0.6%
452	Mucopolysaccharidosis II	0.6%
453	Lymphomatoid Granulomatosis	0.6%
454	Burkitt Lymphoma	0.5%
455	Miller Fisher Syndrome	0.4%

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