MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Staphylococcal Scalded Skin Syndrome

(UMLS:C0038165)

Definition:: A disease of infants due to group 2 phage type 17 staphylococci that produce an epidermolytic exotoxin. Superficial fine vesicles and bullae form and rupture easily, resulting in loss of large sheets of epidermis.
UMLS ID:: C0038165
MeSH ID:: D013206

Classification 1:

Name:

Bacterial Infections and Mycoses
MeSH Tree Number(s):: C01.252.410.868.820.770|C01.252.825.770.770|C01.539.800.720.770.770

Classification 2:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.800.838.765.770.770

Synonym(s)

Staphylococcal Scalded Skin Syndrome

Dermatitis exfoliativa neonatorum

Ritter

Ritter's disease

SCALDED SKIN SYNDROME

SCALDED SKIN SYNDROME STAPH

SSSS

SSSS - Staphylococcal scalded skin syndrome

Scalded skin syndrome

10.

Staphylococcal scalded skin syndrome

11.

Toxic epidermal necrolysis, subcorneal type

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Allopurinol	FAERS: 10	US FAERS
2	Acetaminophen	FAERS: 2	US FAERS
3	Amoxicillin	FAERS: 2	US FAERS
4	Lamotrigine	FAERS: 2	OFFSIDES US FAERS
5	Lenalidomide	FAERS: 2	US FAERS
6	Nicardipine	FAERS: 2	US FAERS
7	2-(Tert-butylamino)-1-(3-chlorophenyl)propan-1-one;hydron;chloride	FAERS: 1 Canada Vigilance: 1	Canada Vigilance US FAERS
8	Amoxicillin	FAERS: 1	US FAERS
9	Carbamazepine	FAERS: 1	US FAERS
10	Clofarabine	FAERS: 1	US FAERS
11	Duloxetine Hydrochloride	FAERS: 1	US FAERS
12	Ibuprofen	FAERS: 1	US FAERS
13	Omeprazole	FAERS: 1	US FAERS
14	Oseltamivir	FAERS: 1	US FAERS
15	PCI 32765	FAERS: 1	US FAERS
16	Zoledronic Acid	FAERS: 1	US FAERS
17	Atazanavir Sulfate		SIDER
18	Cyclophosphamide		OFFSIDES
19	Dapsone		OFFSIDES
20	Hydroxyzine		OFFSIDES
21	Melphalan		OFFSIDES
22	Oseltamivir		OFFSIDES
23	Pentamidine		OFFSIDES
24	Piperacillin		OFFSIDES
25	Temazepam		OFFSIDES
26	Tropisetron		OFFSIDES
27	calcipotriene		OFFSIDES
28	chlordiazepoxide, clidinium drug combination		OFFSIDES
29	fludarabine		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Impetigo	55%
2	Furunculosis	49.1%
3	furuncle	49.1%
4	carbuncle	40.7%
5	Erysipelas	39.2%
6	Ecthyma	37.7%
7	Erythrasma	36.9%
8	Mycetoma	36.5%
9	Hidradenitis Suppurativa	34.8%
10	Erythema Chronicum Migrans	32.9%
11	Rhinoscleroma	26.4%
12	Dermatomycoses	25.5%
13	Erythema Induratum	23%
14	Central Nervous System Bacterial Infections	22.2%
15	Gram-Negative Bacterial Infections	21.5%
16	Bacteremia	21.4%
17	Borrelia Infections	20.5%
18	Leptospirosis	20.5%
19	Bacterial Endocarditis	19%
20	Actinomycetales Infections	18.6%
21	Clostridium Infections	18.6%
22	Listeriosis	18.6%
23	Streptococcal Infections	18.6%
24	Bacillaceae Infections	18.6%
25	Clostridium difficile infection	18.6%
26	Bacterial Vaginosis	17.8%
27	Mycoses	17.4%
28	Cellulitis	16.6%
29	Lyme Disease	16.5%
30	Relapsing Fever	16.5%
31	Syphilis	16.4%
32	Candidiasis, Chronic Mucocutaneous	16.4%
33	Cutaneous Candidiasis	16.4%
34	Subacute Bacterial Endocarditis	16.2%
35	Erysipelothrix infection	16.2%
36	Lyme Neuroborreliosis	15.8%
37	Pneumonia, Bacterial	15.5%
38	Pelvic Infection	15%
39	Wound Infection	15%
40	Soft Tissue Infection	15%
41	Community-Acquired Infections	15%
42	Chromoblastomycosis	14.9%
43	Dermatophytosis	14.9%
44	Sporotrichosis	14.9%
45	Tinea	14.9%
46	Tinea Versicolor	14.9%
47	Trichophytosis	14.9%
48	Hyalohyphomycosis	14.9%
49	Central Nervous System Infection	14.6%
50	Ulcerative stomatitis	14.5%
51	Neurosyphilis	14.4%
52	Chlamydia Infections	13.9%
53	Gonorrhea	13.9%
54	Blastomycosis	13.2%
55	Eye Infection	13%
56	Respiratory Tract Infections	13%
57	Human Ehrlichiosis	12.8%
58	Gram-Positive Bacterial Infections	12.7%
59	Bone Diseases, Infectious	12.7%
60	Pregnancy Complications, Infectious	12.7%
61	Arthritis, Infectious	12.5%
62	Suppuration	12.5%
63	Cross Infection	12.5%
64	Septicemia	12.5%
65	Sepsis	12.5%
66	Bordetella Infections	12.2%
67	Brucellosis	12.2%
68	Campylobacter infection	12.2%
69	Enterobacteriaceae Infections	12.2%
70	Pseudomonas Infections	12.2%
71	Q Fever	12.2%
72	Vibrio Infections	12.2%
73	Helicobacter Infections	12.2%
74	Neisseriaceae Infections	12.2%
75	Burkholderia Infections	12.2%
76	Flavobacteriaceae Infections	12.2%
77	Moraxellaceae Infections	12.2%
78	Burkholderia cepacia Infection	12.2%
79	Meningitis, Listeria	12%
80	Piedra	11.7%
81	Infection	11.7%
82	Pertussis	11.7%
83	Tinea Capitis	11.6%
84	Onychomycosis	11.6%
85	Actinomycosis	11.5%
86	Corynebacterium Infections	11.5%
87	Gas Gangrene	11.5%
88	Mycobacterium Infections	11.5%
89	Nocardia Infections	11.5%
90	Pneumococcal Infections	11.5%
91	Scarlet Fever	11.5%
92	Tetanus	11.5%
93	Pulmonary Nocardiosis	11.5%
94	Opportunistic Infections	11.4%
95	Human anaplasmosis	11.3%
96	Hordeolum	11%
97	Skin Diseases, Bacterial	11%
98	Bacterial conjunctivitis	11%
99	Japanese Spotted Fever	10.9%
100	Urinary tract infection	10.9%
101	Joint Tuberculosis	10.5%
102	Tuberculosis, Osteoarticular	10.5%
103	Bone Tuberculosis	10.5%
104	Pyoderma Gangrenosum	10.4%
105	Lupus Erythematosus, Cutaneous	9.9%
106	Panniculitis	9.9%
107	Systemic Scleroderma	9.9%
108	Morphea	9.9%
109	Fusariosis	9.8%
110	Meningitis, Pneumococcal	9.8%
111	Sexually Transmitted Diseases	9.8%
112	Fungemia	9.7%
113	Endotoxemia	9.6%
114	Tinea Pedis	9.2%
115	Lymphogranuloma Venereum	9.2%
116	Aspergillosis	9.1%
117	Candidiasis	9.1%
118	Coccidioidomycosis	9.1%
119	Histoplasmosis	9.1%
120	Paracoccidioidomycosis	9.1%
121	Zygomycosis	9.1%
122	Phaeohyphomycosis	9.1%
123	Pneumocystis Infections	9.1%
124	Brain Abscess	9%
125	Breast Diseases	8.8%
126	Dermatitis	8.8%
127	Exanthema	8.8%
128	Facial Dermatoses	8.8%
129	Hair Diseases	8.8%
130	Hand Dermatoses	8.8%
131	keratoacanthoma	8.8%
132	Keratosis	8.8%
133	Nail Diseases	8.8%
134	Photosensitivity Disorders	8.8%
135	Prurigo	8.8%
136	Pyoderma	8.8%
137	Rosacea	8.8%
138	Sebaceous Gland Diseases	8.8%
139	Skin Diseases, Vesiculobullous	8.8%
140	Skin Ulcer	8.8%
141	Sweat Gland Diseases	8.8%
142	Skin Diseases, Papulosquamous	8.8%
143	Skin Diseases, Vascular	8.8%
144	Acneiform Eruptions	8.8%
145	Ocular Rosacea	8.8%
146	Subcorneal pustular dermatosis	8.8%
147	Erythematotelangiectatic Rosacea	8.8%
148	Papulopustular Rosacea	8.8%
149	Chronic Actinic Dermatitis	8.8%
150	Meningitis, Bacterial	8.8%
151	Staphylococcal Skin Infections	8.5%
152	Ophthalmia Neonatorum	8.4%
153	Trachoma	8.4%
154	Rheumatic Fever	8.4%
155	Xeroderma Pigmentosum	8.3%
156	Enterocolitis, Pseudomembranous	8.2%
157	pseudomembranous colitis	8.2%
158	Meningitis, Haemophilus	8.2%
159	Candidemia	8.2%
160	Dermatitis, Atopic	8.2%
161	Epidermolysis Bullosa	8.2%
162	Panophthalmitis	8.2%
163	Acne Vulgaris	8.1%
164	Contact Dermatitis	8.1%
165	Eczema	8.1%
166	Erythema Multiforme	8.1%
167	Intertrigo	8.1%
168	Neurodermatitis	8.1%
169	Rhinophyma	8.1%
170	Perioral Dermatitis	8.1%
171	Acne	8.1%
172	Rocky Mountain Spotted Fever	8.1%
173	Diphtheria	8%
174	Leprosy	8%
175	Mycobacterium Infections, Nontuberculous	8%
176	Tuberculosis	8%
177	Mycobacterium abscessus Infection	8%
178	Syphilis, Congenital	7.9%
179	Otomycosis	7.7%
180	Acinetobacter Infections	7.7%
181	Bacteroides Infections	7.7%
182	Cholera	7.7%
183	Escherichia coli Infections	7.7%
184	Haemophilus Infections	7.7%
185	Klebsiella Infections	7.7%
186	Meningococcal Infections	7.7%
187	Mycoplasma Infections	7.7%
188	Pasteurella Infections	7.7%
189	Proteus Infections	7.7%
190	Rickettsia Infections	7.7%
191	Salmonella infections	7.7%
192	Scrub Typhus	7.7%
193	Serratia Infections	7.7%
194	Ureaplasma Infections	7.7%
195	Central Nervous System Fungal Infections	7.6%
196	Foot Diseases	7.6%
197	Skin Abnormalities	7.4%
198	Skin Neoplasms	7.4%
199	Pigmentation Disorders	7.4%
200	Staphylococcal Infections	7.4%
201	Neuroaspergillosis	7.4%
202	Dermatomyositis	7.4%
203	Botulism	7.4%
204	Erythema Infectiosum	7.4%
205	Lipomatosis	7.4%
206	Pruritus	7.4%
207	Erythema	7.4%
208	Necrolytic Migratory Erythema	7.4%
209	Cutaneous Fistula	7.4%
210	Nephrogenic Fibrosing Dermopathy	7.4%
211	Nephrogenic Systemic Fibrosis	7.4%
212	Exanthema Subitum	7.3%
213	Tuberculosis, Meningeal	7.2%
214	Endophthalmitis	7.1%
215	Peritonitis	7.1%
216	Dermatitis Herpetiformis	7%
217	Osteomyelitis	7%
218	Periostitis	7%
219	Surgical Wound Infection	7%
220	Abscess	7%
221	Adnexitis	7%
222	Empyema	7%
223	Pelvic Inflammatory Disease	7%
224	Acrodermatitis	7%
225	Sebaceous Gland Neoplasms	7%
226	Porokeratosis	7%
227	Gianotti-Crosti Syndrome	7%
228	Keratoderma, Palmoplantar	7%
229	Rheumatic Heart Disease	6.8%
230	Necrobiosis Lipoidica Diabeticorum	6.7%
231	Lung Diseases, Fungal	6.7%
232	Tuberculosis, Spinal	6.5%
233	Panniculitis, Lupus Erythematosus	6.5%
234	Foot Ulcer	6.4%
235	Mastocytosis	6.3%
236	Mycobacterium avium-intracellulare Infection	6.2%
237	Lymph Node Tuberculosis	6.2%
238	Tuberculosis, Miliary	6.2%
239	Tuberculosis, Multidrug-Resistant	6.2%
240	Leprosy, Multibacillary	6.2%
241	Latent Tuberculosis	6.2%
242	Dermatitis, Phototoxic	6.2%
243	Pityriasis Lichenoides et Varioliformis Acuta	6.2%
244	Pityriasis Lichenoides	6.2%
245	Phototoxicity	6.2%
246	Xeroderma	6.2%
247	Superinfection	6.1%
248	Corneal Ulcer	6.1%
249	Puerperal Infection	6%
250	Spondylitis	6%
251	Appendicitis	6%
252	Bacteriuria	6%
253	Pyuria	6%
254	Pyomyositis	6%
255	Invasive Pulmonary Aspergillosis	6%
256	Endotoxic shock	6%
257	Septic Shock	6%
258	Toxic Shock Syndrome	6%
259	Pseudoxanthoma Elasticum	5.8%
260	Bacterial Infections	5.7%
261	Connective Tissue Diseases	5.7%
262	Lice Infestations	5.6%
263	Cutis Laxa	5.6%
264	Staphylococcal Scalded Skin Syndrome	5.6%
265	Urticaria Pigmentosa	5.5%
266	Dysentery, Bacillary	5.5%
267	Ectodermal Dysplasia	5.4%
268	Aplasia Cutis Congenita	5.4%
269	Psittacosis	5.4%
270	Paratyphoid Fever	5.4%
271	Plague	5.4%
272	Typhoid Fever	5.4%
273	TYPHUS	5.4%
274	Yersinia pseudotuberculosis Infections	5.4%
275	Bubonic Plague	5.4%
276	Dermatitis, Photoallergic	5.4%
277	Lupus Erythematosus, Discoid	5.4%
278	Scleroderma, Limited	5.4%
279	Borderline leprosy	5.3%
280	Leprosy, Lepromatous	5.3%
281	Tuberculoid leprosy	5.3%
282	Extensively Drug-Resistant Tuberculosis	5.3%
283	Tuberculosis, Gastrointestinal	5.3%
284	Skin Diseases, Infectious	5.2%
285	Meningitis, Cryptococcal	5.2%
286	Arthritis, Reactive	5.2%
287	Tuberculosis, Central Nervous System	5.2%
288	Mucormycosis	5.1%
289	Psoas Abscess	5.1%
290	Abdominal Abscess	5.1%
291	Larva Migrans	4.9%
292	Leishmaniasis	4.9%
293	Molluscum Contagiosum	4.9%
294	Onchocerciasis	4.9%
295	Erythema Nodosum	4.8%
296	Anhidrosis	4.8%
297	Cholesteatoma	4.8%
298	Pressure Ulcer	4.8%
299	Folliculitis	4.8%
300	Foot Dermatoses	4.8%
301	Gynecomastia	4.8%
302	Hypertrichosis	4.8%
303	Hypohidrosis	4.8%
304	Hypotrichosis	4.8%
305	Leg Ulcer	4.8%
306	Miliaria	4.8%
307	Parakeratosis	4.8%
308	Parapsoriasis	4.8%
309	Pityriasis	4.8%
310	Psoriasis	4.8%
311	Sweet Syndrome	4.8%
312	Hidradenitis	4.8%
313	Onycholysis	4.8%
314	Miliaria Rubra	4.8%
315	Hyperpigmentation	4.8%
316	Lichenoid Eruptions	4.8%
317	Chloracne	4.8%
318	Dermatitis, Irritant	4.8%
319	Acne Conglobata	4.8%
320	AIDS-Related Opportunistic Infections	4.8%
321	Salmonella Infections, Animal	4.7%
322	Tuberculosis, Pulmonary	4.6%
323	Salmonella food poisoning	4.5%
324	Oral candidiasis	4.4%
325	Toxic Epidermal Necrolysis	4.3%
326	Stevens-Johnson Syndrome	4.3%
327	Warts	4.3%
328	Pulmonary Aspergillosis	4.3%
329	Bronchopulmonary Aspergillosis	4.3%
330	Diverticulitis	4.3%
331	Dermatitis, Occupational	4.3%
332	Granuloma Annulare	4.2%
333	Dermatitis, Allergic Contact	4.1%
334	Ichthyosis, X-Linked	4.1%
335	Papillon-Lefevre Disease	4.1%
336	Sjogren-Larsson Syndrome	4.1%
337	Acantholysis	4.1%
338	Breast Cyst	4.1%
339	Actinic keratosis	4.1%
340	Pemphigoid, Benign Mucous Membrane	4.1%
341	Pemphigus	4.1%
342	Sunburn	4.1%
343	Argyria	4%
344	Hirsutism	4%
345	Lactation Disorder	4%
346	Mastitis	4%
347	Urticaria	4%
348	Adiposis Dolorosa	4%
349	Pruritus Vulvae	4%
350	Mastocytoma	4%
351	Pruritus Ani	4%
352	Toxoplasmosis, Cerebral	4%
353	Behcet Syndrome	3.9%
354	Waterhouse-Friderichsen Syndrome	3.8%
355	Lung Abscess	3.8%
356	Diverticulum	3.7%
357	Diverticulosis	3.7%
358	Meningitis, Fungal	3.7%
359	Discitis	3.7%
360	Mastoiditis	3.7%
361	Petrositis	3.7%
362	Candidiasis, Vulvovaginal	3.7%
363	Albinism	3.6%
364	Mucocutaneous Lymph Node Syndrome	3.5%
365	Drug Eruptions	3.5%
366	Lipodystrophy	3.5%
367	Livedo Reticularis	3.5%
368	Malignant Atrophic Papulosis	3.5%
369	Polyarteritis Nodosa	3.4%
370	Takayasu Arteritis	3.4%
371	Hyperkeratosis, Epidermolytic	3.4%
372	Retropharyngeal Abscess	3.2%
373	Epidural Abscess	3.2%
374	Leishmaniasis, Cutaneous	3.2%
375	Eczema Herpeticum	3.2%
376	Peritonsillar Abscess	3.2%
377	Diaper Rash	3.2%
378	Nail-Patella Syndrome	3.1%
379	Porphyrias, Hepatic	3.1%
380	Tuberculosis, Renal	3%
381	Liver Abscess	3%
382	Collagen Diseases	2.9%
383	Mixed Connective Tissue Disease	2.9%
384	Mucinoses	2.9%
385	Lichen Planus	2.9%
386	Melanosis	2.9%
387	Chloasma	2.9%
388	Pityriasis Rosea	2.9%
389	Pityriasis Rubra Pilaris	2.9%
390	Vitiligo	2.9%
391	Lichen Nitidus	2.9%
392	Epidermodysplasia Verruciformis	2.8%
393	Herpes Labialis	2.8%
394	Lemierre Syndrome	2.8%
395	Cartilage Diseases	2.5%
396	Rheumatism	2.5%
397	Chondromalacia	2.5%
398	Condylomata Acuminata	2.5%
399	Lupus Erythematosus, Systemic	2.5%
400	Overlap syndrome	2.5%
401	Alopecia	2.4%
402	Sweating, Gustatory	2.4%
403	Androgenetic Alopecia	2.4%
404	Auriculotemporal Syndrome	2.4%
405	Varicose Ulcer	2.4%
406	Breast Neoplasms, Male	2.4%
407	Triple Negative Breast Neoplasms	2.4%
408	Galactorrhea	2.4%
409	Giant Cell Arteritis	2.2%
410	Temporal Arteritis	2.2%
411	Dupuytren Contracture	2.1%
412	Angioedema	2.1%
413	Acute Generalized Exanthematous Pustulosis	2.1%
414	CREST Syndrome	1.9%
415	Acanthosis Nigricans	1.9%
416	Alopecia Areata	1.9%
417	Lentigo	1.9%
418	Serum Sickness	1.8%
419	Variegate Porphyria	1.8%
420	Acute intermittent porphyria	1.8%
421	Porphyria Cutanea Tarda	1.8%
422	Aspergillosis, Allergic Bronchopulmonary	1.8%
423	Carcinoma, Lobular	1.8%
424	Arthritis, Psoriatic	1.8%
425	Menkes Kinky Hair Syndrome	1.7%
426	Lichen Planus, Oral	1.6%
427	Scleromyxedema	1.6%
428	Liver Abscess, Amebic	1.5%
429	Noonan Syndrome	1.5%
430	HIV-Associated Lipodystrophy Syndrome	1.4%
431	Mesenteric Panniculitis	1.4%
432	Panniculitis, Peritoneal	1.4%
433	Tietze's Syndrome	1.4%
434	Orbital Cellulitis	1.4%
435	Myxoid cyst	1.4%
436	Marfan Syndrome	1.4%
437	Myxedema	1.3%
438	Homocystinuria	1.3%
439	Angioedemas, Hereditary	1.2%
440	Diabetic Foot	1.2%
441	Osteochondritis	1.2%
442	Polymyalgia Rheumatica	1.2%
443	Osteogenesis Imperfecta	1.2%
444	Keloid	1.1%
445	Rheumatoid Arthritis	1%
446	Juvenile arthritis	1%
447	Hereditary Angioedema Type III	1%
448	Hereditary Angioedema Types I and II	1%
449	Lupus Nephritis	1%
450	Laryngomalacia	0.9%
451	Pectus carinatum	0.9%
452	Peutz-Jeghers Syndrome	0.9%
453	Rheumatoid Nodule	0.7%
454	Felty Syndrome	0.6%
455	Bronchomalacia	0.6%
456	Tracheomalacia	0.6%
457	Rheumatoid Vasculitis	0.5%
458	Lupus Vasculitis, Central Nervous System	0.5%
459	Mucopolysaccharidosis III	0.5%
460	Sicca Syndrome	0.5%
461	Sjogren's Syndrome	0.5%
462	Mucopolysaccharidosis II	0.4%

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