MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Dysgerminoma

(UMLS:C0013377)

Definition:: A malignant ovarian neoplasm, thought to be derived from primordial germ cells of the sexually undifferentiated embryonic gonad. It is the counterpart of the classical seminoma of the testis, to which it is both grossly and histologically identical. Dysgerminomas comprise 16% of all germ cell tumors but are rare before the age of 10, although nearly 50% occur before the age of 20. They are generally considered of low-grade malignancy but may spread if the tumor extends through its capsule and involves lymph nodes or blood vessels. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1646)
UMLS ID:: C0013377
MeSH ID:: D004407

Classification:

Name:

Neoplasms
MeSH Tree Number(s):: C04.557.465.330.300

Synonym(s)

Dysgerminoma

DYSGERMINOMA, MALIGNANT

Disgerminoma

disgerminoma

dysgerminoma

dysgerminomas

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Bleomycin		7683015	CTD
2	Vinblastine		7683015	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Seminoma	48.4%
2	Chordoma	34.4%
3	Teratoma	34.4%
4	Teratocarcinoma	34.4%
5	Neuroectodermal Tumors	33%
6	leukemia	25.4%
7	Neoplasms, Glandular and Epithelial	25.4%
8	Neoplasms, Neuroepithelial	23.6%
9	Gliomatosis cerebri	23.6%
10	Trophoblastic Neoplasms	21.8%
11	Craniopharyngioma	21.5%
12	Neuroectodermal Tumor, Melanotic	21.5%
13	Neuroendocrine Tumors	21.5%
14	Dermoid Cyst	21.1%
15	melanoma	19.4%
16	Histiocytic Disorders, Malignant	16.9%
17	Adenoma, Acidophil	16.8%
18	Ganglioneuroma	16.8%
19	Glioma	16.8%
20	Malignant Glioma	16.8%
21	Hamartoma	16.4%
22	Neoplasms, Hormone-Dependent	16.4%
23	Neoplasms, Multiple Primary	16.4%
24	Paraneoplastic Syndromes	16.4%
25	Precancerous Conditions	16.4%
26	Neoplasms, Second Primary	16.4%
27	Carcinosarcoma	16.3%
28	Hemangiosarcoma	16.3%
29	lymphangiosarcoma	16.3%
30	Paraganglioma	16%
31	Carcinoid Tumor	15.5%
32	Neurilemmoma	15.5%
33	Medulloblastoma	15.4%
34	Adenoma	14.8%
35	Ameloblastoma	14.8%
36	Angiokeratoma	14.8%
37	Carcinoma	14.8%
38	Hemangioma	14.8%
39	hemangiopericytoma	14.8%
40	Lymphangioma	14.8%
41	Mesenchymoma	14.8%
42	Nevus	14.8%
43	Hepatoblastoma	14.8%
44	Mixed Tumor, Mullerian	14.8%
45	Angiofibroma	14.8%
46	Sarcoma	14.8%
47	Epithelioma	14.8%
48	Hutchinson's Melanotic Freckle	14.7%
49	Melanoma, Amelanotic	14.7%
50	Choriocarcinoma	13.9%
51	Astrocytoma	13.5%
52	Ependymoma	13.5%
53	oligodendroglioma	13.5%
54	Ganglioglioma	13.5%
55	gliosarcoma	13.5%
56	Anaplastic astrocytoma	13.5%
57	Anaplastic Oligodendroglioma	13.5%
58	Pheochromocytoma	13.2%
59	Basal cell carcinoma	12.9%
60	Carcinoma, Papillary	12.9%
61	Squamous cell carcinoma	12.9%
62	Chondrosarcoma	12.9%
63	Cystadenoma	12.9%
64	leiomyosarcoma	12.9%
65	liposarcoma	12.9%
66	Mesothelioma	12.9%
67	synovial sarcoma	12.9%
68	Angiomyolipoma	12.9%
69	Clear Cell Sarcoma of Soft Tissue	12.9%
70	Alveolar Soft Part Sarcoma	12.9%
71	Sarcoma, Myeloid	12.9%
72	Carcinoma, Basal Cell	12.9%
73	Malignant Carcinoid Syndrome	12.9%
74	Carcinoma 256, Walker	12.8%
75	Melanoma, Experimental	12.7%
76	Meningioma	12.7%
77	Lymphoma	12.6%
78	Carcinoma, Ehrlich Tumor	12.2%
79	Carcinoma, Lewis Lung	12.2%
80	Leukemia, Plasma Cell	12.2%
81	Glioblastoma	11.9%
82	Neuroblastoma	11.9%
83	Glioblastoma Multiforme	11.9%
84	Composite Lymphoma	11.8%
85	Leukemia, Experimental	11.7%
86	Cystadenocarcinoma	11.2%
87	Fibrosarcoma	11.2%
88	Osteosarcoma	11.2%
89	Mucoepidermoid Carcinoma	11.2%
90	Ganglioneuroblastoma	11%
91	Cyst	10.8%
92	Neoplastic Processes	10.8%
93	Neoplastic Syndromes, Hereditary	10.8%
94	Pregnancy Complications, Neoplastic	10.8%
95	Neoplasms, Experimental	10.6%
96	Adenofibroma	10.4%
97	Fibroadenoma	10.4%
98	Malignant Fibrous Histiocytoma	10.4%
99	Hydatidiform Mole	10%
100	Plasmacytoma	9.9%
101	Malignant histiocytosis	9.8%
102	Leukemia L1210	9.8%
103	Leukemia P388	9.8%
104	Histiocytic sarcoma	9.8%
105	Acanthoma	9.8%
106	Adenocarcinoma	9.7%
107	Carcinoma in Situ	9.7%
108	Carcinoma, Transitional Cell	9.7%
109	Phyllodes Tumor	9.7%
110	Hemangioendothelioma	9.7%
111	Lipoma	9.7%
112	Myoma	9.7%
113	Myxoma	9.7%
114	Neuroma	9.7%
115	Papilloma	9.7%
116	Pseudomyxoma Peritonei	9.7%
117	Papillomatosis	9.7%
118	Angiolipoma	9.7%
119	Myelolipoma	9.7%
120	Neoplasms, Bone Tissue	9.7%
121	Neoplasms, Fibrous Tissue	9.7%
122	Smooth Muscle Tumor	9.7%
123	Adenomatosis, Pulmonary	9.7%
124	Adenomatous Polyps	9.7%
125	Carcinoma, Large Cell	9.7%
126	Carcinoma, Small Cell	9.7%
127	Desmoplastic Small Round Cell Tumor	9.7%
128	Chondroma	9.7%
129	Enchondroma	9.7%
130	Bowen's Disease	9.6%
131	Rhabdomyosarcoma	9.6%
132	Giant Cell Tumor of Bone	9.6%
133	Leukemia, Radiation-Induced	9.5%
134	Carcinoid Heart Disease	9.5%
135	Retinoblastoma	9.4%
136	Sarcoma, Experimental	9.1%
137	Thymoma	9%
138	Dermatofibrosarcoma	8.8%
139	Dermatofibrosarcoma Protuberans	8.8%
140	Carcinoma, Lobular	8.7%
141	Endometrial Stromal Sarcoma	8.6%
142	Abdominal Neoplasms	8.5%
143	Erythroplasia	8.5%
144	Follicular cyst	8.5%
145	Head and Neck Neoplasms	8.5%
146	Mucocele	8.5%
147	Pilonidal Cyst	8.5%
148	Soft Tissue Neoplasms	8.5%
149	Thoracic Neoplasms	8.5%
150	Thyroglossal Cyst	8.5%
151	Synovial Cyst	8.5%
152	Aberrant Crypt Foci	8.5%
153	Sarcoma 180	8.1%
154	Alveolar rhabdomyosarcoma	7.9%
155	Neoplasms, Radiation-Induced	7.9%
156	Lymphangioleiomyomatosis	7.7%
157	Multiple Endocrine Neoplasia	7.4%
158	Hodgkin Disease	7.3%
159	Lymphoma, Non-Hodgkin	7.3%
160	Adenoid Cystic Carcinoma	7.2%
161	fibroma	7.2%
162	Fibromatosis	7.2%
163	Osteoblastoma	7.2%
164	Osteoma	7.2%
165	Rhabdomyoma	7.2%
166	Chondromatosis	7.2%
167	Adenocarcinoma, Clear Cell	7.2%
168	Cholangiocarcinoma	7.2%
169	Cervical Intraepithelial Neoplasia	7.2%
170	Hemangioblastoma	7.2%
171	Lymphoma, Extranodal NK-T-Cell	7.2%
172	Paraneoplastic Encephalomyelitis	6.8%
173	Neurofibrosarcoma	6.7%
174	Mammary Neoplasms, Experimental	6.7%
175	Leukemia, Myelomonocytic, Chronic	6.5%
176	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	6.5%
177	Acoustic Neuroma	6.4%
178	Vipoma	6.2%
179	Lymphomatoid Granulomatosis	6.2%
180	Digestive System Neoplasms	6%
181	Endocrine Gland Neoplasms	6%
182	Eye Neoplasms	6%
183	Nervous System Neoplasms	6%
184	Fibromatosis, Aggressive	6%
185	Fibromatosis, Abdominal	6%
186	Klatskin Tumor	6%
187	Primary amyloidosis	5.9%
188	Bone neoplasms	5.7%
189	Leukoplakia	5.7%
190	Lymphocele	5.7%
191	Pancreatic Cyst	5.7%
192	Skin Neoplasms	5.7%
193	Hematologic Neoplasms	5.7%
194	Optic Nerve Glioma	5.7%
195	Nephroblastoma	5.6%
196	Barrett Esophagus	5.6%
197	Breast Cyst	5.6%
198	Actinic keratosis	5.6%
199	Mediastinal Cyst	5.6%
200	Neoplasm Invasiveness	5.6%
201	Neoplasm Metastasis	5.6%
202	Neoplasm Recurrence, Local	5.6%
203	Parovarian Cyst	5.6%
204	Pericardial Cyst	5.6%
205	Splenic Neoplasms	5.6%
206	Thymic Cyst	5.6%
207	Carcinogenesis	5.6%
208	Myxoid cyst	5.6%
209	Metastasis	5.6%
210	Hepatocellular Adenoma	5.2%
211	Tuberous Sclerosis	5.1%
212	Basal Cell Nevus Syndrome	5.1%
213	Mastocytosis	5%
214	Sturge-Weber Syndrome	5%
215	Carcinoma, Pancreatic Ductal	5%
216	Retroperitoneal Neoplasms	4.9%
217	Gastrointestinal Stromal Tumors	4.9%
218	Hemangioma, Cavernous	4.9%
219	Mastocytoma	4.9%
220	Leukemia, T-Cell	4.8%
221	Leukemia, B-Cell	4.8%
222	Mesoblastic Nephroma	4.8%
223	neurofibroma	4.8%
224	Mastocytosis, Systemic	4.8%
225	Lymphoma, Follicular	4.8%
226	T-Cell Lymphoma	4.8%
227	Mantle cell lymphoma	4.8%
228	Leukemia, Myeloid, Chronic-Phase	4.8%
229	Multiple Endocrine Neoplasia Type 1	4.4%
230	Prolactinoma	4.3%
231	Growth Hormone-Secreting Pituitary Adenoma	4.3%
232	Waldenstrom Macroglobulinemia	4.2%
233	Multiple Myeloma	4.2%
234	Corpus Luteum Cyst	4.1%
235	Ovarian Cysts	4.1%
236	Parathyroid Neoplasms	4.1%
237	Peritoneal Neoplasms	4.1%
238	Thyroid Neoplasm	4.1%
239	Thyroid carcinoma	4.1%
240	Liver Neoplasms, Experimental	3.9%
241	granulosa cell tumor	3.7%
242	Carcinoma, Ovarian Epithelial	3.7%
243	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	3.6%
244	Leukemia, Large Granular Lymphocytic	3.6%
245	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	3.6%
246	Lymphoma, T-Cell, Cutaneous	3.6%
247	Lymphoma, AIDS-Related	3.6%
248	Enteropathy-Associated T-Cell Lymphoma	3.6%
249	Primary Effusion Lymphoma	3.6%
250	Adenomatous Polyposis Coli	3.5%
251	insulinoma	3.4%
252	Pancreatic Neoplasm	3.4%
253	Choledochal Cyst	3.4%
254	Tracheal Neoplasms	3.4%
255	Mouth Neoplasms	3.4%
256	Central Nervous System Neoplasms	3.4%
257	Vascular Neoplasms	3.4%
258	Thymus Neoplasms	3.4%
259	Genital Neoplasms, Female	3.3%
260	Pancreatic Pseudocyst	3.3%
261	Peutz-Jeghers Syndrome	3.3%
262	Leukoplakia, Oral	3.3%
263	Paraneoplastic Cerebellar Degeneration	3.3%
264	Lymphatic Metastasis	3.3%
265	Neoplasms, Unknown Primary	3.3%
266	Leukemic Infiltration	3.3%
267	Breast Neoplasms, Male	3.3%
268	Neoplasm Micrometastasis	3.3%
269	Triple Negative Breast Neoplasms	3.3%
270	Adrenocortical carcinoma	3.2%
271	Dupuytren Contracture	3.1%
272	Gastrinoma	3.1%
273	Glucagonoma	3.1%
274	Urticaria Pigmentosa	3%
275	Mycosis Fungoides	3%
276	Lymphomatoid Papulosis	3%
277	Plasmablastic lymphoma	3%
278	Nasopharyngeal carcinoma	2.9%
279	Leydig Cell Tumor	2.9%
280	Esophageal Neoplasms	2.7%
281	Renal Cell Carcinoma	2.7%
282	Papillary Renal Cell Carcinoma	2.7%
283	Limbic Encephalitis	2.7%
284	Thyroid Nodule	2.6%
285	Carcinoma, Endometrioid	2.6%
286	Adrenal Gland Neoplasms	2.6%
287	Gastrointestinal Neoplasms	2.6%
288	Genital Neoplasms, Male	2.6%
289	Liver neoplasms	2.6%
290	Uveal Neoplasms	2.6%
291	Denys-Drash Syndrome	2.5%
292	Urologic Neoplasms	2.5%
293	Sebaceous Gland Neoplasms	2.5%
294	Spinal Neoplasms	2.5%
295	Bone Marrow Neoplasms	2.5%
296	Polycystic Ovary Syndrome	2.4%
297	Burkitt Lymphoma	2.4%
298	Lambert-Eaton Myasthenic Syndrome	2.4%
299	Testicular Neoplasms	2.4%
300	Meningeal Neoplasms	2.2%
301	Opsoclonus-Myoclonus Syndrome	2.1%
302	Sezary Syndrome	2%
303	Xeroderma Pigmentosum	1.9%
304	Myelitis, Transverse	1.8%
305	Ear Neoplasms	1.7%
306	Eyelid Neoplasms	1.7%
307	Lung Neoplasms	1.7%
308	Nose Neoplasms	1.7%
309	Pleural Neoplasms	1.7%
310	ovarian neoplasm	1.7%
311	Cell Transformation, Viral	1.6%
312	Brain Neoplasms	1.6%
313	Salivary Gland Neoplasms	1.6%
314	Spinal Cord Neoplasms	1.6%
315	Tongue Neoplasms	1.6%
316	Palatal Neoplasms	1.6%
317	Uterine Neoplasms	1.6%
318	Vaginal Neoplasms	1.6%
319	Vulvar Neoplasms	1.6%
320	Uterine Cancer	1.6%
321	Fallopian Tube Neoplasms	1.6%
322	Meningeal Carcinomatosis	1.6%
323	Pituitary Adenoma	1.5%
324	Pituitary Neoplasms	1.5%
325	Pharyngeal Neoplasms	1.4%
326	Central Nervous System Cysts	1.3%
327	Bile Duct Neoplasms	1.3%
328	gallbladder neoplasm	1.3%
329	Intestinal Neoplasms	1.3%
330	Penile Neoplasms	1.3%
331	Prostatic Neoplasms	1.3%
332	Stomach Neoplasms	1.3%
333	Polycythemia Vera	1.3%
334	Bronchial Neoplasms	1.2%
335	Zollinger-Ellison syndrome	1.2%
336	Multiple Pulmonary Nodules	1.2%
337	Supratentorial Neoplasms	1.2%
338	Endometrial Neoplasms	1.2%
339	Laryngeal neoplasm	1.1%
340	Bladder Neoplasm	1.1%
341	Kidney Neoplasm	1.1%
342	Ureteral Neoplasms	1.1%
343	Urethral Neoplasms	1.1%
344	Brain Stem Neoplasms	1%
345	Hypopharyngeal Neoplasms	1%
346	Pleural Effusion, Malignant	1%
347	Hypopharyngeal Cancer	1%
348	Parotid Neoplasms	1%
349	Prostatic Neoplasms, Castration-Resistant	1%
350	Nelson Syndrome	1%
351	Choroid Plexus Papilloma	0.9%
352	Cecal Neoplasms	0.8%
353	Duodenal Neoplasms	0.8%
354	Tonsillar Neoplasms	0.8%
355	Cerebellar Neoplasms	0.8%
356	Nasopharyngeal Neoplasms	0.7%
357	Colorectal Neoplasms	0.7%
358	Radicular Cyst	0.7%
359	Appendiceal Neoplasms	0.7%
360	Colonic Neoplasms	0.7%
361	Rectal Neoplasms	0.7%
362	Paranasal Sinus Neoplasms	0.6%
363	Anus Neoplasms	0.5%
364	Sigmoid Neoplasms	0.5%
365	Maxillary Sinus Neoplasms	0.5%

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