MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Prostatic Neoplasms, Castration-Resistant

(UMLS:C3658267)

Definition:: Tumors or cancer of the PROSTATE which can grow in the presence of low or residual amount of androgen hormones such as TESTOSTERONE.
UMLS ID:: C3658267
MeSH ID:: D064129

Classification 1:

Name:

Neoplasms
MeSH Tree Number(s):: C04.588.945.440.770.500

Classification 2:

Name:

Male Urogenital Diseases
MeSH Tree Number(s):: C12.294.260.750.500|C12.294.565.625.500|C12.758.409.750.500

Synonym(s)

Prostatic Neoplasms, Castration-Resistant

Associated Drug(s)

	Name	Reference(s)	Data Source
1	3-hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene	18985049 25062956	CTD
2	Abiraterone Acetate	18985049	CTD
3	Docetaxel	18500220	CTD
4	Dutasteride	18500220	CTD
5	Hydrocortisone	18500220	CTD
6	Ketoconazole	18500220 18985049 25062956	CTD
7	MDV 3100	View details 24740322 25062956 25908785 30185663	CTD
8	Niclosamide	28500234	CTD
9	Prednisone	18500220	CTD
10	SP2509	29581250	CTD
11	abiraterone	25062956 25908785 30185663	CTD
12	apalutamide	25062956	CTD
13	bicalutamide	21308717 28500234	CTD
14	orteronel	25062956	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Penile Neoplasms	42.2%
2	Testicular Neoplasms	29.7%
3	Epididymitis	23%
4	Penile Diseases	23%
5	Spermatic Cord Torsion	23%
6	Hemospermia	23%
7	Testicular Hydrocele	23%
8	Benign prostatic hypertrophy	21.4%
9	prostatitis	21.4%
10	Prostatic Adenoma	21.4%
11	Benign Prostatic Hyperplasia	21.4%
12	Prostatic Hypertrophy	21.4%
13	Prostatic Hyperplasia	21.4%
14	Urologic Neoplasms	20%
15	Testicular Diseases	19.4%
16	Varicocele	19.4%
17	Infertility	19.2%
18	Spermatocele	19.2%
19	Urologic Diseases	15.3%
20	Sexually Transmitted Diseases	14.9%
21	Cryptorchidism	14.8%
22	Hypospadias	14.8%
23	Genital Herpes	14.4%
24	Genital Neoplasms, Male	14.3%
25	Balanitis	13.6%
26	Phimosis	13.6%
27	Priapism	13.6%
28	Urogenital Abnormalities	13.2%
29	Leydig Cell Tumor	13.1%
30	Prostatic Diseases	13.1%
31	Bladder Neoplasm	12.4%
32	Kidney Neoplasm	12.4%
33	Ureteral Neoplasms	12.4%
34	Urethral Neoplasms	12.4%
35	Prostatic Neoplasms	12.2%
36	Premature Ejaculation	11.5%
37	Erectile dysfunction	11.5%
38	Orchitis	11.4%
39	Dyspareunia	9.8%
40	Genital Neoplasms, Female	9.5%
41	Azoospermia	9%
42	Oligospermia	9%
43	Impotence, Vasculogenic	9%
44	Asthenozoospermia	9%
45	Teratozoospermia	9%
46	Aspermia	9%
47	Abdominal Neoplasms	8.9%
48	Head and Neck Neoplasms	8.9%
49	Soft Tissue Neoplasms	8.9%
50	Thoracic Neoplasms	8.9%
51	Bladder Exstrophy	8.8%
52	Epispadias	8.8%
53	Tuberculosis, Renal	8.7%
54	Urinary Bladder Diseases	8.2%
55	Kidney Diseases	8.2%
56	Ureteral Diseases	8.2%
57	Urethral Diseases	8.2%
58	Urination Disorders	8.2%
59	Urolithiasis	8.2%
60	Mesoblastic Nephroma	8.2%
61	Nephroblastoma	8.1%
62	Prostatic Neoplasms, Castration-Resistant	8%
63	Renal Cell Carcinoma	7.7%
64	Papillary Renal Cell Carcinoma	7.7%
65	Digestive System Neoplasms	7.6%
66	Endocrine Gland Neoplasms	7.6%
67	Eye Neoplasms	7.6%
68	Nervous System Neoplasms	7.6%
69	Multicystic Dysplastic Kidney	7.6%
70	Bone neoplasms	7.5%
71	Skin Neoplasms	7.5%
72	Hematologic Neoplasms	7.5%
73	Splenic Neoplasms	7.4%
74	Anuria	7.3%
75	Ureterolithiasis	7.3%
76	Nephrolithiasis	7.3%
77	Urinary tract infection	7.1%
78	Horseshoe Kidney	7.1%
79	Urinary Bladder Fistula	6.5%
80	Hermaphroditism	6.2%
81	Parathyroid Neoplasms	6.2%
82	Peritoneal Neoplasms	6.2%
83	Disorders of Sex Development	6.2%
84	Thyroid Neoplasm	6.2%
85	Thyroid carcinoma	6.2%
86	Multiple Endocrine Neoplasia	6.1%
87	Genital Diseases, Male	6.1%
88	Bladder neck obstruction	6%
89	Hamartoma	5.7%
90	Neoplasms, Hormone-Dependent	5.7%
91	Neoplasms, Multiple Primary	5.7%
92	Paraneoplastic Syndromes	5.7%
93	Precancerous Conditions	5.7%
94	Neoplasms, Second Primary	5.7%
95	Paraneoplastic Encephalomyelitis	5.7%
96	Mammary Neoplasms, Experimental	5.6%
97	Pancreatic Neoplasm	5.6%
98	Denys-Drash Syndrome	5.5%
99	Kidney Calculi	5.2%
100	Ureteral Calculi	5.2%
101	Chlamydia Infections	5%
102	Gonorrhea	5%
103	Tracheal Neoplasms	5%
104	Retroperitoneal Neoplasms	4.9%
105	Cystitis	4.9%
106	Hydronephrosis	4.9%
107	Hyperoxaluria	4.9%
108	Kidney Cortex Necrosis	4.9%
109	Kidney Papillary Necrosis	4.9%
110	Nephritis	4.9%
111	Nephrosclerosis	4.9%
112	Nephrosis	4.9%
113	Perinephritis	4.9%
114	Kidney Failure	4.9%
115	Uremia	4.9%
116	Ureteral obstruction	4.9%
117	Ureterocele	4.9%
118	Urethral Obstruction	4.9%
119	Urethritis	4.9%
120	Vesico-Ureteral Reflux	4.9%
121	Urinary Retention	4.9%
122	Acanthoma	4.9%
123	Oxalosis	4.9%
124	Renal Insufficiency	4.9%
125	Uterine Neoplasms	4.8%
126	Vaginal Neoplasms	4.8%
127	Vulvar Neoplasms	4.8%
128	Uterine Cancer	4.8%
129	Fallopian Tube Neoplasms	4.8%
130	Cyst	4.8%
131	Neoplastic Processes	4.8%
132	Neoplastic Syndromes, Hereditary	4.8%
133	Pregnancy Complications, Neoplastic	4.8%
134	Neoplasms, Experimental	4.8%
135	Syphilis	4.5%
136	Esophageal Neoplasms	4.4%
137	Diabetes Insipidus	4.2%
138	Hepatorenal Syndrome	4.2%
139	Pyelocystitis	4.2%
140	Bacteriuria	4.2%
141	Diabetic Nephropathy	4.2%
142	Glycosuria	4.2%
143	Hematuria	4.2%
144	Renal hypertension	4.2%
145	Oliguria	4.2%
146	Polyuria	4.2%
147	Proteinuria	4.2%
148	Pyuria	4.2%
149	Renal Artery Obstruction	4.2%
150	Renal Artery Stenosis	4.2%
151	Urinary Calculi	4.2%
152	Cystocele	4.2%
153	Nephrocalcinosis	4.2%
154	Urinary Incontinence	4.2%
155	Mouth Neoplasms	4.1%
156	Central Nervous System Neoplasms	4.1%
157	Vascular Neoplasms	4.1%
158	Thymus Neoplasms	4.1%
159	Neoplasms, Radiation-Induced	4.1%
160	Breast Neoplasms, Male	4%
161	Triple Negative Breast Neoplasms	4%
162	Carcinoma, Lobular	4%
163	Lymphogranuloma Venereum	3.7%
164	Enuresis	3.7%
165	Gonadal Dysgenesis	3.7%
166	Thyroid Nodule	3.7%
167	Adrenogenital Syndrome	3.7%
168	Ovotesticular Disorders of Sex Development	3.7%
169	Pyelonephritis	3.6%
170	Adrenal Gland Neoplasms	3.6%
171	Gastrointestinal Neoplasms	3.6%
172	Liver neoplasms	3.6%
173	Uveal Neoplasms	3.6%
174	Glycosuria, Renal	3.5%
175	Sebaceous Gland Neoplasms	3.5%
176	Spinal Neoplasms	3.5%
177	Bone Marrow Neoplasms	3.5%
178	Tuberous Sclerosis	3.5%
179	Multiple Endocrine Neoplasia Type 1	3.4%
180	Trophoblastic Neoplasms	3.3%
181	Leukemia, Experimental	3.3%
182	Liver Neoplasms, Experimental	3.3%
183	Carcinoma, Ehrlich Tumor	3.3%
184	Dermoid Cyst	3.3%
185	Carcinoma, Lewis Lung	3.3%
186	Carcinoma 256, Walker	3.3%
187	Thymoma	3.2%
188	Meningioma	3.2%
189	AIDS-Associated Nephropathy	3.2%
190	Glomerulonephritis	3.2%
191	Nephritis, Interstitial	3.2%
192	Lipoid nephrosis	3.2%
193	Nephrotic Syndrome	3.2%
194	Pyelitis	3.2%
195	Pyonephrosis	3.2%
196	Urethral Stenosis	3.2%
197	Nephrogenic Diabetes Insipidus	3.2%
198	Congenital Nephrogenic Diabetes Insipidus	3.2%
199	Acute kidney injury	3.2%
200	Urethral stricture	3.2%
201	Hyperandrogenism	3.2%
202	Endometrial Neoplasms	3.2%
203	Carcinoma, Pancreatic Ductal	3.2%
204	Erythroplasia	3%
205	Follicular cyst	3%
206	leukemia	3%
207	Mucocele	3%
208	Neoplasms, Germ Cell and Embryonal	3%
209	Neoplasms, Glandular and Epithelial	3%
210	Pilonidal Cyst	3%
211	Thyroglossal Cyst	3%
212	Synovial Cyst	3%
213	Germ Cell Cancer	3%
214	Aberrant Crypt Foci	3%
215	Leukemia, Radiation-Induced	2.9%
216	Leukoplakia, Oral	2.9%
217	Paraneoplastic Cerebellar Degeneration	2.8%
218	Sarcoma, Experimental	2.8%
219	Azotemia	2.8%
220	Albuminuria	2.8%
221	Hemoglobinuria	2.8%
222	Hypertension, Renovascular	2.8%
223	Urge Incontinence	2.7%
224	Nose Neoplasms	2.7%
225	ovarian neoplasm	2.7%
226	Neuroectodermal Tumors	2.7%
227	Melanoma, Experimental	2.7%
228	Renal Osteodystrophy	2.6%
229	Renal rickets	2.6%
230	Pituitary Adenoma	2.5%
231	Pituitary Neoplasms	2.5%
232	Neoplasms, Neuroepithelial	2.5%
233	Gliomatosis cerebri	2.5%
234	Limbic Encephalitis	2.5%
235	Leukoplakia	2.5%
236	Lymphocele	2.5%
237	Pancreatic Cyst	2.5%
238	Barrett Esophagus	2.5%
239	Breast Cyst	2.5%
240	Histiocytic Disorders, Malignant	2.5%
241	Actinic keratosis	2.5%
242	Mediastinal Cyst	2.5%
243	Neoplasm Invasiveness	2.5%
244	Neoplasm Metastasis	2.5%
245	Neoplasm Recurrence, Local	2.5%
246	Parovarian Cyst	2.5%
247	Pericardial Cyst	2.5%
248	Thymic Cyst	2.5%
249	Carcinogenesis	2.5%
250	Myxoid cyst	2.5%
251	Metastasis	2.5%
252	Hepatocellular Adenoma	2.4%
253	Palatal Neoplasms	2.4%
254	Acoustic Neuroma	2.4%
255	Polycystic Kidney Diseases	2.4%
256	Meningeal Neoplasms	2.4%
257	Diurnal Enuresis	2.4%
258	Renal Aminoacidurias	2.4%
259	Fanconi Syndrome	2.4%
260	Pseudohypoaldosteronism	2.4%
261	Liddle Syndrome	2.4%
262	Hemolytic-Uremic Syndrome	2.4%
263	Balkan Nephropathy	2.4%
264	Focal glomerulosclerosis	2.4%
265	Kidney Failure, Chronic	2.4%
266	Retinoblastoma	2.4%
267	Lambert-Eaton Myasthenic Syndrome	2.3%
268	Turner Syndrome	2.3%
269	insulinoma	2.2%
270	Lymphomatoid Granulomatosis	2.2%
271	Vipoma	2.2%
272	Gastrinoma	2.2%
273	Glucagonoma	2.2%
274	Carcinosarcoma	2.2%
275	Hemangiosarcoma	2.2%
276	Leukemia L1210	2.2%
277	Leukemia P388	2.2%
278	lymphangiosarcoma	2.2%
279	Prolactinoma	2.2%
280	Growth Hormone-Secreting Pituitary Adenoma	2.2%
281	Renal tubular acidosis	2.1%
282	Ear Neoplasms	2.1%
283	Eyelid Neoplasms	2.1%
284	Lung Neoplasms	2.1%
285	Pleural Neoplasms	2.1%
286	Glomerulonephritis, Membranoproliferative	2.1%
287	Lymphoma	2.1%
288	Corpus Luteum Cyst	2.1%
289	Ovarian Cysts	2.1%
290	Zellweger Syndrome	2.1%
291	Opsoclonus-Myoclonus Syndrome	2.1%
292	Brain Neoplasms	2.1%
293	Salivary Gland Neoplasms	2.1%
294	Spinal Cord Neoplasms	2.1%
295	Tongue Neoplasms	2.1%
296	melanoma	2.1%
297	Composite Lymphoma	2%
298	Choriocarcinoma	2%
299	Carcinoma, Endometrioid	2%
300	Kallmann Syndrome	2%
301	granulosa cell tumor	1.9%
302	Carcinoma, Ovarian Epithelial	1.9%
303	Adenomatous Polyposis Coli	1.9%
304	Myelitis, Transverse	1.9%
305	Sarcoma 180	1.9%
306	Basal Cell Nevus Syndrome	1.9%
307	Pharyngeal Neoplasms	1.9%
308	Choledochal Cyst	1.9%
309	Central Nervous System Cysts	1.8%
310	Leukemia, Plasma Cell	1.8%
311	Peutz-Jeghers Syndrome	1.8%
312	Bile Duct Neoplasms	1.8%
313	gallbladder neoplasm	1.8%
314	Intestinal Neoplasms	1.8%
315	Stomach Neoplasms	1.8%
316	Anti-Glomerular Basement Membrane Disease	1.8%
317	Lupus Nephritis	1.8%
318	Polycythemia Vera	1.8%
319	Polycystic Kidney, Autosomal Dominant	1.8%
320	Cystinuria	1.8%
321	Atypical Hemolytic Uremic Syndrome	1.8%
322	Optic Nerve Glioma	1.8%
323	Hyperphosphaturia	1.8%
324	Klinefelter Syndrome	1.8%
325	Laryngeal neoplasm	1.7%
326	Adenoma	1.6%
327	Ameloblastoma	1.6%
328	Angiokeratoma	1.6%
329	Carcinoma	1.6%
330	Chordoma	1.6%
331	Hemangioma	1.6%
332	hemangiopericytoma	1.6%
333	Lymphangioma	1.6%
334	Mesenchymoma	1.6%
335	Nevus	1.6%
336	Teratoma	1.6%
337	Hepatoblastoma	1.6%
338	Mixed Tumor, Mullerian	1.6%
339	Germinoma	1.6%
340	Teratocarcinoma	1.6%
341	Angiofibroma	1.6%
342	Sarcoma	1.6%
343	Epithelioma	1.6%
344	Basal cell carcinoma	1.6%
345	Carcinoma, Papillary	1.6%
346	Squamous cell carcinoma	1.6%
347	Chondrosarcoma	1.6%
348	Craniopharyngioma	1.6%
349	Cystadenoma	1.6%
350	leiomyosarcoma	1.6%
351	liposarcoma	1.6%
352	Mesothelioma	1.6%
353	synovial sarcoma	1.6%
354	Neuroectodermal Tumor, Melanotic	1.6%
355	Angiomyolipoma	1.6%
356	Clear Cell Sarcoma of Soft Tissue	1.6%
357	Alveolar Soft Part Sarcoma	1.6%
358	Neuroendocrine Tumors	1.6%
359	Sarcoma, Myeloid	1.6%
360	Carcinoma, Basal Cell	1.6%
361	Meningeal Carcinomatosis	1.6%
362	Adenoma, Acidophil	1.6%
363	Ganglioneuroma	1.6%
364	Glioma	1.6%
365	Malignant Glioma	1.6%
366	Medulloblastoma	1.6%
367	Adrenocortical carcinoma	1.4%
368	Bronchial Neoplasms	1.4%
369	Endometrial Stromal Sarcoma	1.4%
370	Multiple Pulmonary Nodules	1.4%
371	Supratentorial Neoplasms	1.4%
372	Carcinoid Tumor	1.4%
373	Neurilemmoma	1.4%
374	Hutchinson's Melanotic Freckle	1.4%
375	Melanoma, Amelanotic	1.4%
376	Pancreatic Pseudocyst	1.4%
377	Plasmacytoma	1.4%
378	Malignant histiocytosis	1.3%
379	Lymphatic Metastasis	1.3%
380	Neoplasms, Unknown Primary	1.3%
381	Leukemic Infiltration	1.3%
382	Histiocytic sarcoma	1.3%
383	Neoplasm Micrometastasis	1.3%
384	Cystadenocarcinoma	1.3%
385	Fibrosarcoma	1.3%
386	Osteosarcoma	1.3%
387	Mucoepidermoid Carcinoma	1.3%
388	Xeroderma Pigmentosum	1.2%
389	Hypopharyngeal Neoplasms	1.2%
390	Pleural Effusion, Malignant	1.2%
391	Hypopharyngeal Cancer	1.2%
392	Lymphangioleiomyomatosis	1.2%
393	Parotid Neoplasms	1.2%
394	Adenofibroma	1.2%
395	Fibroadenoma	1.2%
396	Malignant Fibrous Histiocytoma	1.2%
397	Nelson Syndrome	1.2%
398	Hodgkin Disease	1.2%
399	Lymphoma, Non-Hodgkin	1.2%
400	Polycystic Ovary Syndrome	1.2%
401	Hydatidiform Mole	1.1%
402	Astrocytoma	1.1%
403	Ependymoma	1.1%
404	oligodendroglioma	1.1%
405	Ganglioglioma	1.1%
406	gliosarcoma	1.1%
407	Anaplastic astrocytoma	1.1%
408	Anaplastic Oligodendroglioma	1.1%
409	Nasopharyngeal carcinoma	1.1%
410	Cecal Neoplasms	1.1%
411	Duodenal Neoplasms	1.1%
412	Bowen's Disease	1.1%
413	Paraganglioma	1.1%
414	Rhabdomyosarcoma	1.1%
415	Giant Cell Tumor of Bone	1.1%
416	Brain Stem Neoplasms	1%
417	Malignant Carcinoid Syndrome	1%
418	Primary amyloidosis	1%
419	Nasopharyngeal Neoplasms	1%
420	Neurofibrosarcoma	1%
421	Adenocarcinoma	1%
422	Carcinoma in Situ	1%
423	Carcinoma, Transitional Cell	1%
424	Colorectal Neoplasms	1%
425	Phyllodes Tumor	1%
426	Dysgerminoma	1%
427	Hemangioendothelioma	1%
428	Lipoma	1%
429	Myoma	1%
430	Myxoma	1%
431	Neuroma	1%
432	Papilloma	1%
433	Pseudomyxoma Peritonei	1%
434	Seminoma	1%
435	Papillomatosis	1%
436	Angiolipoma	1%
437	Myelolipoma	1%
438	Neoplasms, Bone Tissue	1%
439	Neoplasms, Fibrous Tissue	1%
440	Smooth Muscle Tumor	1%
441	Adenomatosis, Pulmonary	1%
442	Adenomatous Polyps	1%
443	Carcinoma, Large Cell	1%
444	Carcinoma, Small Cell	1%
445	Desmoplastic Small Round Cell Tumor	1%
446	Chondroma	1%
447	Enchondroma	1%
448	Dermatofibrosarcoma	0.9%
449	Dermatofibrosarcoma Protuberans	0.9%
450	Glioblastoma	0.9%
451	Neuroblastoma	0.9%
452	Glioblastoma Multiforme	0.9%
453	Tonsillar Neoplasms	0.9%
454	Cerebellar Neoplasms	0.9%
455	Familial Hypophosphatemic Rickets	0.9%
456	Paranasal Sinus Neoplasms	0.9%
457	Choroid Plexus Papilloma	0.9%
458	Waldenstrom Macroglobulinemia	0.8%
459	Multiple Myeloma	0.8%
460	Leukemia, Myelomonocytic, Chronic	0.8%
461	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	0.8%
462	Pheochromocytoma	0.8%
463	Alveolar rhabdomyosarcoma	0.8%
464	Appendiceal Neoplasms	0.8%
465	Colonic Neoplasms	0.8%
466	Rectal Neoplasms	0.8%
467	Ganglioneuroblastoma	0.8%
468	Carcinoid Heart Disease	0.8%
469	Zollinger-Ellison syndrome	0.7%
470	Mastocytosis	0.7%
471	Sturge-Weber Syndrome	0.7%
472	Cell Transformation, Viral	0.7%
473	Gastrointestinal Stromal Tumors	0.7%
474	Hemangioma, Cavernous	0.7%
475	Leukemia, T-Cell	0.7%
476	Leukemia, B-Cell	0.7%
477	neurofibroma	0.7%
478	Lymphoma, Follicular	0.7%
479	T-Cell Lymphoma	0.7%
480	Mantle cell lymphoma	0.7%
481	Maxillary Sinus Neoplasms	0.7%
482	Adenoid Cystic Carcinoma	0.6%
483	fibroma	0.6%
484	Fibromatosis	0.6%
485	Osteoblastoma	0.6%
486	Osteoma	0.6%
487	Rhabdomyoma	0.6%
488	Chondromatosis	0.6%
489	Adenocarcinoma, Clear Cell	0.6%
490	Cholangiocarcinoma	0.6%
491	Cervical Intraepithelial Neoplasia	0.6%
492	Hemangioblastoma	0.6%
493	Lymphoma, Extranodal NK-T-Cell	0.6%
494	Anus Neoplasms	0.6%
495	Sigmoid Neoplasms	0.6%
496	Mastocytoma	0.5%
497	Mastocytosis, Systemic	0.5%
498	Leukemia, Myeloid, Chronic-Phase	0.5%
499	Fibromatosis, Aggressive	0.5%
500	Fibromatosis, Abdominal	0.5%
501	Klatskin Tumor	0.5%
502	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	0.5%
503	Leukemia, Large Granular Lymphocytic	0.5%
504	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	0.5%
505	Lymphoma, T-Cell, Cutaneous	0.5%
506	Lymphoma, AIDS-Related	0.5%
507	Enteropathy-Associated T-Cell Lymphoma	0.5%
508	Primary Effusion Lymphoma	0.5%
509	Burkitt Lymphoma	0.4%
510	Dupuytren Contracture	0.4%
511	Urticaria Pigmentosa	0.3%
512	Mycosis Fungoides	0.3%
513	Lymphomatoid Papulosis	0.3%
514	Plasmablastic lymphoma	0.3%
515	Sezary Syndrome	0.3%
516	Radicular Cyst	0.3%

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