MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Dermatitis, Irritant

(UMLS:C0162823)

Definition:: A non-allergic contact dermatitis caused by prolonged exposure to irritants and not explained by delayed hypersensitivity mechanisms.
UMLS ID:: C0162823
MeSH ID:: D017453

Classification:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.800.174.255.400|C17.800.815.255.400

Synonym(s)

Dermatitis, Irritant

ICD - Irritant contact dermatitis

Irritant Contact Dermatitis

Irritant contact dermatitis

Irritant contact dermatitis, unspecified cause

Non-allergic contact dermatitis

Primary irritant dermatitis

contact dermatitis irritant

contact; dermatitis, irritant

10.

dermatitis contact irritant

11.

dermatitis irritants

12.

dermatitis; contact, irritant

13.

dermatitis; irritant

14.

irritant contact dermatitis

15.

irritant dermatitis

16.

irritant; dermatitis

17.

primary irritant dermatitis

Associated Drug(s)

	Name	Reference(s)	Data Source
1	2,4-hexadienal	22906572	CTD
2	4-Aminobenzoic Acid	22381623	CTD
3	Benzoic Acid	7673705	CTD
4	Benzyl Alcohol	22906572	CTD
5	Calcium Compounds	22906572	CTD
6	Clobetasol	11851881	CTD
7	Clofibrate	11851881	CTD
8	Diclofenac	21319177	CTD
9	Formaldehyde	17408435	CTD
10	Hydrochloric Acid	22906572	CTD
11	Ibuprofen	21319177	CTD
12	Indomethacin	21319177	CTD
13	Linoleic Acid	11851881	CTD
14	N,N-dimethylaminoisopropanol	22906572	CTD
15	Naproxen	21319177	CTD
16	Neostigmine	21319177	CTD
17	Piperazine	22906572	CTD
18	Sodium Bicarbonate	22906572	CTD
19	Sodium Dodecyl Sulfate	7673705 22381623 22906572	CTD
20	Tetradecanoylphorbol Acetate	11851881 21319177 25818598	CTD
21	Toluene 2,4-Diisocyanate	22003193	CTD
22	Tretinoin	8236244	CTD
23	furfuryl alcohol	22003193	CTD
24	linalool	22906572	CTD
25	n-dodecane	19152832	CTD
26	n-tetradecane	19152832	CTD
27	nonane	19152832	CTD
28	o-Phthalaldehyde	20176622	CTD
29	pirinixic acid	11851881	CTD
30	potassium hydroxide	22906572	CTD
31	sodium sulfate	22906572	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Eczema	49.2%
2	Intertrigo	49.2%
3	Neurodermatitis	49.2%
4	Dermatitis, Occupational	48.6%
5	Dermatitis, Allergic Contact	46.8%
6	Perioral Dermatitis	39.3%
7	Dermatitis, Photoallergic	38.7%
8	Dermatitis, Atopic	36.8%
9	Pyoderma Gangrenosum	35.5%
10	Lupus Erythematosus, Cutaneous	33.9%
11	Panniculitis	33.9%
12	Systemic Scleroderma	33.9%
13	Morphea	33.9%
14	Breast Diseases	33.3%
15	Exanthema	33.3%
16	Facial Dermatoses	33.3%
17	Hair Diseases	33.3%
18	Hand Dermatoses	33.3%
19	keratoacanthoma	33.3%
20	Keratosis	33.3%
21	Nail Diseases	33.3%
22	Photosensitivity Disorders	33.3%
23	Prurigo	33.3%
24	Pyoderma	33.3%
25	Rosacea	33.3%
26	Sebaceous Gland Diseases	33.3%
27	Skin Diseases, Vesiculobullous	33.3%
28	Skin Ulcer	33.3%
29	Sweat Gland Diseases	33.3%
30	Skin Diseases, Papulosquamous	33.3%
31	Skin Diseases, Vascular	33.3%
32	Acneiform Eruptions	33.3%
33	Ocular Rosacea	33.3%
34	Subcorneal pustular dermatosis	33.3%
35	Erythematotelangiectatic Rosacea	33.3%
36	Papulopustular Rosacea	33.3%
37	Chronic Actinic Dermatitis	33.3%
38	Dermatitis Herpetiformis	32%
39	Acrodermatitis	31.6%
40	Gianotti-Crosti Syndrome	31.6%
41	Acne Vulgaris	29.5%
42	Erythema Multiforme	29.5%
43	Rhinophyma	29.5%
44	Acne	29.5%
45	Foot Diseases	26.3%
46	Epidermolysis Bullosa	25.5%
47	Skin Abnormalities	25.4%
48	Skin Diseases, Infectious	25.4%
49	Skin Neoplasms	25.4%
50	Pigmentation Disorders	25.4%
51	Lipomatosis	25%
52	Pruritus	25%
53	Erythema	25%
54	Necrolytic Migratory Erythema	25%
55	Cutaneous Fistula	25%
56	Nephrogenic Fibrosing Dermopathy	25%
57	Nephrogenic Systemic Fibrosis	25%
58	Foot Ulcer	24.4%
59	Xeroderma Pigmentosum	24%
60	Sebaceous Gland Neoplasms	23.7%
61	Porokeratosis	23.7%
62	Keratoderma, Palmoplantar	23.7%
63	Pityriasis Lichenoides et Varioliformis Acuta	23.2%
64	Pityriasis Lichenoides	23.2%
65	Dermatomyositis	22.2%
66	Necrobiosis Lipoidica Diabeticorum	21.9%
67	Panniculitis, Lupus Erythematosus	21.7%
68	Connective Tissue Diseases	20.9%
69	Erythema Nodosum	20.5%
70	Xeroderma	20%
71	Mastocytosis	19.9%
72	Drug Eruptions	19.7%
73	Lupus Erythematosus, Discoid	19.7%
74	Scleroderma, Limited	19.7%
75	Anhidrosis	19.6%
76	Cholesteatoma	19.6%
77	Pressure Ulcer	19.6%
78	Folliculitis	19.6%
79	Foot Dermatoses	19.6%
80	Gynecomastia	19.6%
81	Hypertrichosis	19.6%
82	Hypohidrosis	19.6%
83	Hypotrichosis	19.6%
84	Leg Ulcer	19.6%
85	Miliaria	19.6%
86	Parakeratosis	19.6%
87	Parapsoriasis	19.6%
88	Pityriasis	19.6%
89	Psoriasis	19.6%
90	Sweet Syndrome	19.6%
91	Hidradenitis	19.6%
92	Onycholysis	19.6%
93	Miliaria Rubra	19.6%
94	Hyperpigmentation	19.6%
95	Lichenoid Eruptions	19.6%
96	Chloracne	19.6%
97	Urticaria Pigmentosa	19.4%
98	Acne Conglobata	19.4%
99	Cutis Laxa	18.7%
100	Erythema Induratum	18.4%
101	Toxic Epidermal Necrolysis	17.8%
102	Stevens-Johnson Syndrome	17.8%
103	Dermatitis, Phototoxic	17.4%
104	Phototoxicity	17.4%
105	Ectodermal Dysplasia	17%
106	Aplasia Cutis Congenita	17%
107	Pseudoxanthoma Elasticum	17%
108	Dermatitis	16.7%
109	Erythema Infectiosum	16.6%
110	Exanthema Subitum	16.5%
111	Papillon-Lefevre Disease	15.5%
112	Acantholysis	15%
113	Breast Cyst	15%
114	Actinic keratosis	15%
115	Pemphigoid, Benign Mucous Membrane	15%
116	Pemphigus	15%
117	Piedra	15%
118	Sunburn	15%
119	Argyria	14.8%
120	Contact Dermatitis	14.8%
121	Hirsutism	14.8%
122	Lactation Disorder	14.8%
123	Mastitis	14.8%
124	Urticaria	14.8%
125	Adiposis Dolorosa	14.6%
126	Pruritus Vulvae	14.6%
127	Mastocytoma	14.6%
128	Pruritus Ani	14.6%
129	Tinea Capitis	14.5%
130	Onychomycosis	14.5%
131	Granuloma Annulare	14.4%
132	Ecthyma	14%
133	Lichen Planus	12.9%
134	Melanosis	12.9%
135	Chloasma	12.9%
136	Pityriasis Rosea	12.9%
137	Pityriasis Rubra Pilaris	12.9%
138	Vitiligo	12.9%
139	Lichen Nitidus	12.9%
140	Acute Generalized Exanthematous Pustulosis	12.9%
141	Ichthyosis, X-Linked	12.5%
142	Sjogren-Larsson Syndrome	12.4%
143	Behcet Syndrome	12.4%
144	Hyperkeratosis, Epidermolytic	12%
145	Dermatomycoses	12%
146	Mucocutaneous Lymph Node Syndrome	12%
147	Skin Diseases, Bacterial	12%
148	Lipodystrophy	11.8%
149	Livedo Reticularis	11.8%
150	Malignant Atrophic Papulosis	11.8%
151	Polyarteritis Nodosa	11.7%
152	Takayasu Arteritis	11.7%
153	Hidradenitis Suppurativa	11.2%
154	Collagen Diseases	11.1%
155	Mixed Connective Tissue Disease	11.1%
156	Mucinoses	11.1%
157	Albinism	11%
158	Serum Sickness	10.8%
159	Erythema Chronicum Migrans	10.8%
160	Nail-Patella Syndrome	10.1%
161	Porphyrias, Hepatic	10%
162	Alopecia	9.9%
163	Sweating, Gustatory	9.9%
164	Androgenetic Alopecia	9.9%
165	Auriculotemporal Syndrome	9.9%
166	Lice Infestations	9.8%
167	Varicose Ulcer	9.8%
168	Breast Neoplasms, Male	9.8%
169	Triple Negative Breast Neoplasms	9.8%
170	Dermatitis, Irritant	9.7%
171	Galactorrhea	9.7%
172	Tinea Pedis	9.6%
173	Acanthosis Nigricans	9.6%
174	Alopecia Areata	9.6%
175	Lentigo	9.6%
176	Cartilage Diseases	8.8%
177	Rheumatism	8.8%
178	Chondromalacia	8.8%
179	Mycetoma	8.6%
180	Lupus Erythematosus, Systemic	8.5%
181	Overlap syndrome	8.5%
182	Larva Migrans	7.9%
183	Leishmaniasis	7.9%
184	Molluscum Contagiosum	7.9%
185	Angioedema	7.9%
186	Onchocerciasis	7.9%
187	Chromoblastomycosis	7.8%
188	Dermatophytosis	7.8%
189	Sporotrichosis	7.8%
190	Tinea	7.8%
191	Tinea Versicolor	7.8%
192	Trichophytosis	7.8%
193	Hyalohyphomycosis	7.8%
194	Lichen Planus, Oral	7.4%
195	Diaper Rash	7.2%
196	Warts	6.7%
197	Dupuytren Contracture	6.6%
198	Candidiasis, Chronic Mucocutaneous	6.5%
199	Cutaneous Candidiasis	6.5%
200	Scleromyxedema	6.5%
201	Erysipelas	6.5%
202	Staphylococcal Skin Infections	6.5%
203	Giant Cell Arteritis	6.5%
204	Variegate Porphyria	6.5%
205	Acute intermittent porphyria	6.5%
206	Porphyria Cutanea Tarda	6.5%
207	Temporal Arteritis	6.5%
208	Erythrasma	6.5%
209	Carcinoma, Lobular	6.5%
210	CREST Syndrome	6.5%
211	Arthritis, Psoriatic	6.4%
212	Leishmaniasis, Cutaneous	5.8%
213	Eczema Herpeticum	5.8%
214	Fusariosis	5.8%
215	Cellulitis	5.5%
216	Mesenteric Panniculitis	5%
217	Panniculitis, Peritoneal	5%
218	Tietze's Syndrome	5%
219	Orbital Cellulitis	5%
220	Myxoid cyst	5%
221	Blastomycosis	4.9%
222	Angioedemas, Hereditary	4.9%
223	Myxedema	4.9%
224	Epidermodysplasia Verruciformis	4.9%
225	Herpes Labialis	4.9%
226	Diabetic Foot	4.9%
227	HIV-Associated Lipodystrophy Syndrome	4.8%
228	Menkes Kinky Hair Syndrome	4.8%
229	Staphylococcal Scalded Skin Syndrome	4.8%
230	Hereditary Angioedema Type III	4.8%
231	Hereditary Angioedema Types I and II	4.8%
232	Rhinoscleroma	4.5%
233	Condylomata Acuminata	4.2%
234	Furunculosis	4.2%
235	furuncle	4.2%
236	Noonan Syndrome	4.1%
237	Impetigo	4.1%
238	Peutz-Jeghers Syndrome	4.1%
239	Osteochondritis	4.1%
240	Polymyalgia Rheumatica	4.1%
241	carbuncle	4%
242	Osteogenesis Imperfecta	4%
243	Keloid	3.9%
244	Marfan Syndrome	3.7%
245	Homocystinuria	3.6%
246	Rheumatoid Arthritis	3.4%
247	Juvenile arthritis	3.4%
248	Lupus Nephritis	3.2%
249	Laryngomalacia	2.9%
250	Pectus carinatum	2.9%
251	Rheumatoid Nodule	2.6%
252	Felty Syndrome	2.2%
253	Bronchomalacia	2.2%
254	Tracheomalacia	2.2%
255	Rheumatoid Vasculitis	1.9%
256	Mucopolysaccharidosis III	1.8%
257	Sicca Syndrome	1.6%
258	Sjogren's Syndrome	1.6%
259	Lupus Vasculitis, Central Nervous System	1.5%
260	Mucopolysaccharidosis II	1.3%

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