MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Adrenocortical carcinoma

(UMLS:C0206686)

Definition:: A malignant neoplasm of the ADRENAL CORTEX. Adrenocortical carcinomas are unencapsulated anaplastic (ANAPLASIA) masses sometimes exceeding 20 cm or 200 g. They are more likely to be functional than nonfunctional, and produce ADRENAL CORTEX HORMONES that may result in hypercortisolism (CUSHING SYNDROME); HYPERALDOSTERONISM; and/or VIRILISM.
UMLS ID:: C0206686
MeSH ID:: D018268

Classification 1:

Name:

Neoplasms
MeSH Tree Number(s):: C04.557.470.200.025.152|C04.588.322.078.265.750

Classification 2:

Name:

Endocrine System Diseases
MeSH Tree Number(s):: C19.053.098.265.750|C19.053.347.500.750|C19.344.078.265.750

Synonym(s)

Adrenocortical carcinoma

ADRENAL CARCINOMA

ADRENAL CORTEX CANCER, CARCINOMA

Adenocarcinoma, Adrenocortical, Malignant

Adrenal Cortex Adenocarcinoma

Adrenal Cortex Cancer

Adrenal Cortex Carcinoma

Adrenal Cortical Adenocarcinoma

Adrenal Cortical Carcinoma

10.

Adrenal carcinoma

11.

Adrenal cortical adenocarcinoma

12.

Adrenal cortical carcinoma

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Carbamazepine	FAERS: 2		US FAERS
2	Sorafenib	FAERS: 2		US FAERS
3	Axitinib	FAERS: 1		US FAERS
4	Clozapine	FAERS: 1		US FAERS
5	Mifepristone	FAERS: 1	19289534	CTD US FAERS
6	Mitotane	FAERS: 1	View details 1320517 1517795 2954144 3441014 4739370 6094274 8098948 11106117 11572034 12015757 17675396 18854392 22156929 23179081 23330457 23585556 25542188	CTD OFFSIDES US FAERS
7	Norgestrel	FAERS: 1		US FAERS
8	pomalidomide	FAERS: 1		US FAERS
9	Acetylcysteine			OFFSIDES
10	Aminoglutethimide		11572034	CTD
11	Decitabine		20231622	CTD
12	Doxorubicin		11572034 12015757 17675396	CTD
13	Etoposide		11572034 12015757 17675396	CTD
14	Ketoconazole		11572034	CTD
15	Nicardipine			OFFSIDES
16	Paclitaxel		22156929	CTD
17	Streptozocin		11106117	CTD
18	Vincristine		12015757	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Parathyroid Neoplasms	25.7%
2	Thyroid Neoplasm	25.7%
3	Thyroid carcinoma	25.7%
4	Multiple Endocrine Neoplasia	21%
5	Cystadenocarcinoma	20.1%
6	Mucoepidermoid Carcinoma	20.1%
7	Carcinoma, Lobular	19.3%
8	Pancreatic Neoplasm	18.3%
9	Testicular Neoplasms	17.9%
10	ovarian neoplasm	17.6%
11	Carcinoma, Pancreatic Ductal	17.5%
12	Adenoid Cystic Carcinoma	17.1%
13	Adenocarcinoma, Clear Cell	17.1%
14	Cholangiocarcinoma	17.1%
15	Carcinoma, Ovarian Epithelial	16.7%
16	Basal cell carcinoma	16.5%
17	Carcinoma, Papillary	16.5%
18	Squamous cell carcinoma	16.5%
19	Carcinoma, Basal Cell	16.5%
20	Carcinoid Tumor	16%
21	Pituitary Adenoma	15.6%
22	Pituitary Neoplasms	15.6%
23	Prolactinoma	15.5%
24	Growth Hormone-Secreting Pituitary Adenoma	15.5%
25	Choriocarcinoma	15.4%
26	Carcinoma, Ehrlich Tumor	15.3%
27	Carcinoma, Lewis Lung	15.3%
28	Thyroid Nodule	15.1%
29	Gonadal Disorders	15%
30	Parathyroid Diseases	15%
31	Thyroid Diseases	15%
32	Adrenal Gland Neoplasms	13.4%
33	Gastrinoma	13.4%
34	Glucagonoma	13.4%
35	Vipoma	13%
36	Bone Diseases, Endocrine	13%
37	Neoplasms, Neuroepithelial	12.9%
38	Gliomatosis cerebri	12.9%
39	Diabetes Mellitus	12.9%
40	Carcinoma in Situ	12.8%
41	Carcinoma, Transitional Cell	12.8%
42	Carcinoma, Large Cell	12.8%
43	Carcinoma, Small Cell	12.8%
44	Pituitary Diseases	12.8%
45	Klatskin Tumor	12.8%
46	Multiple Endocrine Neoplasia Type 1	12%
47	Malignant Carcinoid Syndrome	11.9%
48	Carcinoma, Endometrioid	11.9%
49	granulosa cell tumor	11.4%
50	Dwarfism	11.3%
51	Cushing Syndrome	11.3%
52	Hyperaldosteronism	11.3%
53	Hypoaldosteronism	11.3%
54	Cystadenoma	11%
55	Mesothelioma	11%
56	Bowen's Disease	11%
57	Adrenal Cortex Diseases	10.9%
58	Endocrine Gland Neoplasms	10.8%
59	Adenoma	10.8%
60	Renal Cell Carcinoma	10.5%
61	Papillary Renal Cell Carcinoma	10.5%
62	Acanthoma	10.1%
63	Addison Disease	9.8%
64	Primary Adrenal Insufficiency	9.8%
65	Abdominal Neoplasms	9.8%
66	Head and Neck Neoplasms	9.8%
67	leukemia	9.8%
68	Neoplasms, Germ Cell and Embryonal	9.8%
69	Soft Tissue Neoplasms	9.8%
70	Thoracic Neoplasms	9.8%
71	Germ Cell Cancer	9.8%
72	Hamartoma	9.4%
73	Neoplasms, Hormone-Dependent	9.4%
74	Neoplasms, Multiple Primary	9.4%
75	Paraneoplastic Syndromes	9.4%
76	Precancerous Conditions	9.4%
77	Neoplasms, Second Primary	9.4%
78	Neuroectodermal Tumors	9.3%
79	Carcinoid Heart Disease	8.9%
80	insulinoma	8.7%
81	Digestive System Neoplasms	8.7%
82	Eye Neoplasms	8.7%
83	Nervous System Neoplasms	8.7%
84	Meningioma	8.6%
85	Cervical Intraepithelial Neoplasia	8.5%
86	Nelson Syndrome	8.5%
87	Bone neoplasms	8.5%
88	Skin Neoplasms	8.5%
89	Hematologic Neoplasms	8.5%
90	Histiocytic Disorders, Malignant	8.4%
91	Splenic Neoplasms	8.4%
92	Cyst	8.2%
93	Neoplastic Processes	8.2%
94	Neoplastic Syndromes, Hereditary	8.2%
95	Pregnancy Complications, Neoplastic	8.2%
96	Euthyroid Sick Syndromes	8.2%
97	Goiter	8.2%
98	Hyperparathyroidism	8.2%
99	Hyperthyroidism	8.2%
100	Hyperthyroxinemia	8.2%
101	Hypogonadism	8.2%
102	Hypoparathyroidism	8.2%
103	Hypothyroidism	8.2%
104	Delayed Puberty	8.2%
105	Precocious Puberty	8.2%
106	Thyroiditis	8.2%
107	Hypogonadotropic hypogonadism	8.2%
108	Testotoxicosis	8.2%
109	Secondary hypothyroidism	8.2%
110	Primary Hyperthyroidism	8.2%
111	Primary Hypothyroidism	8.2%
112	Basal Cell Nevus Syndrome	8.1%
113	Neoplasms, Experimental	8.1%
114	Medulloblastoma	8.1%
115	Adenoma, Acidophil	8%
116	Ganglioneuroma	8%
117	Glioma	8%
118	Malignant Glioma	8%
119	Congenital Hypothyroidism	7.9%
120	Paraneoplastic Encephalomyelitis	7.9%
121	Leydig Cell Tumor	7.8%
122	Trophoblastic Neoplasms	7.8%
123	Leukemia, Experimental	7.8%
124	Mammary Neoplasms, Experimental	7.8%
125	Carcinoma 256, Walker	7.7%
126	Lymphoma	7.4%
127	Carcinosarcoma	7.4%
128	Hemangiosarcoma	7.4%
129	lymphangiosarcoma	7.4%
130	Peritoneal Neoplasms	7.4%
131	Corpus Luteum Cyst	7.3%
132	Ovarian Cysts	7.3%
133	melanoma	7.2%
134	Nasopharyngeal carcinoma	7.2%
135	Composite Lymphoma	7.2%
136	Neoplasms, Radiation-Induced	7.1%
137	Testicular Diseases	7.1%
138	Adrenocortical carcinoma	7.1%
139	Retinoblastoma	7%
140	Dermoid Cyst	7%
141	Ovarian Diseases	7%
142	Empty Sella Syndrome	7%
143	Hyperpituitarism	7%
144	Hypopituitarism	7%
145	Hypophysitis	7%
146	Leukemia, Radiation-Induced	7%
147	Adenofibroma	6.9%
148	Fibroadenoma	6.9%
149	Melanoma, Experimental	6.8%
150	Graves Disease	6.6%
151	Thymoma	6.5%
152	Hepatocellular Adenoma	6.5%
153	Leukemia, Plasma Cell	6.5%
154	Tuberous Sclerosis	6.4%
155	Papilloma	6.4%
156	Pseudomyxoma Peritonei	6.4%
157	Papillomatosis	6.4%
158	Adenomatosis, Pulmonary	6.4%
159	Adenomatous Polyps	6.4%
160	Gestational Diabetes	6.2%
161	Latent Autoimmune Diabetes in Adults	6.2%
162	Diabetes Insipidus	6.1%
163	Diabetes Mellitus, Experimental	6.1%
164	Sarcoma, Experimental	6.1%
165	Tracheal Neoplasms	5.9%
166	Nephroblastoma	5.7%
167	Astrocytoma	5.6%
168	Ependymoma	5.6%
169	oligodendroglioma	5.6%
170	Ganglioglioma	5.6%
171	gliosarcoma	5.6%
172	Anaplastic astrocytoma	5.6%
173	Anaplastic Oligodendroglioma	5.6%
174	Hermaphroditism	5.5%
175	Disorders of Sex Development	5.5%
176	Chondrosarcoma	5.5%
177	Craniopharyngioma	5.5%
178	leiomyosarcoma	5.5%
179	liposarcoma	5.5%
180	synovial sarcoma	5.5%
181	Neuroectodermal Tumor, Melanotic	5.5%
182	Angiomyolipoma	5.5%
183	Clear Cell Sarcoma of Soft Tissue	5.5%
184	Alveolar Soft Part Sarcoma	5.5%
185	Neuroendocrine Tumors	5.5%
186	Sarcoma, Myeloid	5.5%
187	Pituitary Apoplexy	5.4%
188	Ameloblastoma	5.4%
189	Angiokeratoma	5.4%
190	Chordoma	5.4%
191	Hemangioma	5.4%
192	hemangiopericytoma	5.4%
193	Lymphangioma	5.4%
194	Mesenchymoma	5.4%
195	Nevus	5.4%
196	Retroperitoneal Neoplasms	5.4%
197	Teratoma	5.4%
198	Hepatoblastoma	5.4%
199	Mixed Tumor, Mullerian	5.4%
200	Germinoma	5.4%
201	Teratocarcinoma	5.4%
202	Angiofibroma	5.4%
203	Sarcoma	5.4%
204	Esophageal Neoplasms	5.2%
205	Leukemia L1210	5.1%
206	Leukemia P388	5.1%
207	Adrenal Gland Diseases	5%
208	Endometrial Stromal Sarcoma	5%
209	Liver Neoplasms, Experimental	4.9%
210	Erythroplasia	4.9%
211	Follicular cyst	4.9%
212	Mucocele	4.9%
213	Pilonidal Cyst	4.9%
214	Thyroglossal Cyst	4.9%
215	Synovial Cyst	4.9%
216	Aberrant Crypt Foci	4.9%
217	Hyperparathyroidism, Secondary	4.8%
218	Thyrotoxicosis	4.8%
219	Hyperparathyroidism, Primary	4.8%
220	Thyroid Hormone Resistance Syndrome	4.8%
221	Waterhouse-Friderichsen Syndrome	4.8%
222	Neurilemmoma	4.8%
223	Hutchinson's Melanotic Freckle	4.8%
224	Melanoma, Amelanotic	4.8%
225	Mouth Neoplasms	4.7%
226	Central Nervous System Neoplasms	4.7%
227	Vascular Neoplasms	4.7%
228	Thymus Neoplasms	4.7%
229	Lymphomatoid Granulomatosis	4.7%
230	Genital Neoplasms, Female	4.6%
231	Plasmacytoma	4.6%
232	Malignant histiocytosis	4.6%
233	Breast Neoplasms, Male	4.6%
234	Histiocytic sarcoma	4.6%
235	Triple Negative Breast Neoplasms	4.6%
236	Adenomatous Polyposis Coli	4.6%
237	Fibrosarcoma	4.6%
238	Osteosarcoma	4.6%
239	Optic Nerve Glioma	4.5%
240	Kallmann Syndrome	4.4%
241	Polycystic Ovary Syndrome	4.4%
242	Acoustic Neuroma	4.4%
243	Glioblastoma	4.4%
244	Neuroblastoma	4.4%
245	Glioblastoma Multiforme	4.4%
246	Diabetic Foot	4.3%
247	Lymphangioleiomyomatosis	4.3%
248	Leukoplakia	4.2%
249	Lymphocele	4.2%
250	Pancreatic Cyst	4.2%
251	Barrett Esophagus	4.2%
252	Breast Cyst	4.2%
253	Diabetic Angiopathies	4.2%
254	Actinic keratosis	4.2%
255	Mediastinal Cyst	4.2%
256	Neoplasm Invasiveness	4.2%
257	Neoplasm Metastasis	4.2%
258	Neoplasm Recurrence, Local	4.2%
259	Parovarian Cyst	4.2%
260	Pericardial Cyst	4.2%
261	Thymic Cyst	4.2%
262	Carcinogenesis	4.2%
263	Autoimmune thyroiditis	4.2%
264	Myxoid cyst	4.2%
265	Metastasis	4.2%
266	Diabetic Neuropathies	4.2%
267	Myxedema	4.2%
268	Orchitis	4.2%
269	Diabetic Amyotrophy	4.2%
270	Diabetic Autonomic Neuropathy	4.2%
271	Diabetic Cardiomyopathies	4.2%
272	Sarcoma 180	4.1%
273	Ovarian Hyperstimulation Syndrome	4.1%
274	Hyperprolactinemia	4.1%
275	Gastrointestinal Neoplasms	4.1%
276	Genital Neoplasms, Male	4.1%
277	Liver neoplasms	4.1%
278	Uveal Neoplasms	4.1%
279	Malignant Fibrous Histiocytoma	4.1%
280	Urologic Neoplasms	4.1%
281	Mesoblastic Nephroma	4.1%
282	Sebaceous Gland Neoplasms	4.1%
283	Spinal Neoplasms	4.1%
284	Bone Marrow Neoplasms	4.1%
285	Hodgkin Disease	4%
286	Lymphoma, Non-Hodgkin	4%
287	Klinefelter Syndrome	4%
288	Leukoplakia, Oral	4%
289	Paraneoplastic Cerebellar Degeneration	4%
290	Ganglioneuroblastoma	3.8%
291	Denys-Drash Syndrome	3.8%
292	Gigantism	3.7%
293	Paraganglioma	3.7%
294	Rhabdomyosarcoma	3.7%
295	Giant Cell Tumor of Bone	3.7%
296	Diabetic Nephropathy	3.6%
297	Acromegaly	3.6%
298	Anovulation	3.6%
299	Diabetic Ketoacidosis	3.6%
300	Oophoritis	3.6%
301	Primary amyloidosis	3.6%
302	Limbic Encephalitis	3.6%
303	Neurofibrosarcoma	3.5%
304	Nose Neoplasms	3.3%
305	Choledochal Cyst	3.3%
306	Cryptorchidism	3.3%
307	Lambert-Eaton Myasthenic Syndrome	3.3%
308	Peutz-Jeghers Syndrome	3.3%
309	Gonadal Dysgenesis	3.2%
310	Adrenogenital Syndrome	3.2%
311	Ovotesticular Disorders of Sex Development	3.2%
312	Adrenoleukodystrophy	3.2%
313	Phyllodes Tumor	3.2%
314	Dysgerminoma	3.2%
315	Hemangioendothelioma	3.2%
316	Hyperglycemic Hyperosmolar Nonketotic Coma	3.2%
317	Lipoma	3.2%
318	Myoma	3.2%
319	Myxoma	3.2%
320	Neuroma	3.2%
321	Seminoma	3.2%
322	Angiolipoma	3.2%
323	Myelolipoma	3.2%
324	Neoplasms, Bone Tissue	3.2%
325	Neoplasms, Fibrous Tissue	3.2%
326	Smooth Muscle Tumor	3.2%
327	Desmoplastic Small Round Cell Tumor	3.2%
328	Hashimoto Disease	3.2%
329	Chondroma	3.2%
330	Enchondroma	3.2%
331	Dermatofibrosarcoma	3.2%
332	Dermatofibrosarcoma Protuberans	3.2%
333	Opsoclonus-Myoclonus Syndrome	3%
334	Waldenstrom Macroglobulinemia	3%
335	Multiple Myeloma	3%
336	Hyperandrogenism	3%
337	Palatal Neoplasms	2.9%
338	Hydatidiform Mole	2.8%
339	Meningeal Neoplasms	2.8%
340	Leukemia, Myelomonocytic, Chronic	2.8%
341	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	2.8%
342	Myelitis, Transverse	2.8%
343	Pheochromocytoma	2.7%
344	Alveolar rhabdomyosarcoma	2.7%
345	Ear Neoplasms	2.5%
346	Eyelid Neoplasms	2.5%
347	Lung Neoplasms	2.5%
348	Pleural Neoplasms	2.5%
349	Diabetic Retinopathy	2.4%
350	Mastocytosis	2.4%
351	Sturge-Weber Syndrome	2.4%
352	Neoplasms, Glandular and Epithelial	2.4%
353	Brain Neoplasms	2.4%
354	Salivary Gland Neoplasms	2.4%
355	Spinal Cord Neoplasms	2.4%
356	Tongue Neoplasms	2.4%
357	Gastrointestinal Stromal Tumors	2.4%
358	Hemangioma, Cavernous	2.4%
359	Leukemia, T-Cell	2.4%
360	Uterine Neoplasms	2.4%
361	Vaginal Neoplasms	2.4%
362	Vulvar Neoplasms	2.4%
363	Uterine Cancer	2.4%
364	Leukemia, B-Cell	2.4%
365	Fallopian Tube Neoplasms	2.4%
366	neurofibroma	2.4%
367	Lymphoma, Follicular	2.4%
368	T-Cell Lymphoma	2.4%
369	Mantle cell lymphoma	2.4%
370	Pancreatic Pseudocyst	2.3%
371	Lymphatic Metastasis	2.3%
372	Neoplasms, Unknown Primary	2.3%
373	Leukemic Infiltration	2.3%
374	Neoplasm Micrometastasis	2.3%
375	Xeroderma Pigmentosum	2.3%
376	Pharyngeal Neoplasms	2.2%
377	Central Nervous System Cysts	2.2%
378	Bile Duct Neoplasms	2.2%
379	gallbladder neoplasm	2.2%
380	Intestinal Neoplasms	2.2%
381	Penile Neoplasms	2.2%
382	Prostatic Neoplasms	2.2%
383	Stomach Neoplasms	2.2%
384	Polycythemia Vera	2.1%
385	Turner Syndrome	2.1%
386	fibroma	2.1%
387	Fibromatosis	2.1%
388	Osteoblastoma	2.1%
389	Osteoma	2.1%
390	Rhabdomyoma	2.1%
391	Chondromatosis	2.1%
392	Hemangioblastoma	2.1%
393	Lymphoma, Extranodal NK-T-Cell	2.1%
394	Laryngeal neoplasm	2%
395	Bladder Neoplasm	1.9%
396	Kidney Neoplasm	1.9%
397	Ureteral Neoplasms	1.9%
398	Urethral Neoplasms	1.9%
399	Mastocytoma	1.8%
400	Meningeal Carcinomatosis	1.8%
401	Mastocytosis, Systemic	1.8%
402	Leukemia, Myeloid, Chronic-Phase	1.8%
403	Bronchial Neoplasms	1.6%
404	Multiple Pulmonary Nodules	1.6%
405	Renal Osteodystrophy	1.6%
406	Renal rickets	1.6%
407	Supratentorial Neoplasms	1.6%
408	Fibromatosis, Aggressive	1.6%
409	Fibromatosis, Abdominal	1.6%
410	Endometrial Neoplasms	1.6%
411	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	1.6%
412	Leukemia, Large Granular Lymphocytic	1.6%
413	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	1.6%
414	Lymphoma, T-Cell, Cutaneous	1.6%
415	Lymphoma, AIDS-Related	1.6%
416	Enteropathy-Associated T-Cell Lymphoma	1.6%
417	Primary Effusion Lymphoma	1.6%
418	Hypopharyngeal Neoplasms	1.4%
419	Pleural Effusion, Malignant	1.4%
420	Hypopharyngeal Cancer	1.4%
421	Parotid Neoplasms	1.4%
422	Prostatic Neoplasms, Castration-Resistant	1.4%
423	Zollinger-Ellison syndrome	1.4%
424	Carcinoma	1.3%
425	Epithelioma	1.3%
426	Cecal Neoplasms	1.3%
427	Duodenal Neoplasms	1.3%
428	Burkitt Lymphoma	1.3%
429	Dupuytren Contracture	1.2%
430	Cell Transformation, Viral	1.2%
431	Urticaria Pigmentosa	1.2%
432	Brain Stem Neoplasms	1.2%
433	Mycosis Fungoides	1.2%
434	Lymphomatoid Papulosis	1.2%
435	Plasmablastic lymphoma	1.2%
436	Nasopharyngeal Neoplasms	1.2%
437	Colorectal Neoplasms	1.2%
438	Paranasal Sinus Neoplasms	1.1%
439	Tonsillar Neoplasms	1.1%
440	Cerebellar Neoplasms	1.1%
441	Choroid Plexus Papilloma	1%
442	Sezary Syndrome	1%
443	Appendiceal Neoplasms	1%
444	Colonic Neoplasms	1%
445	Rectal Neoplasms	1%
446	Maxillary Sinus Neoplasms	0.8%
447	Adenocarcinoma	0.8%
448	Anus Neoplasms	0.7%
449	Sigmoid Neoplasms	0.7%
450	Radicular Cyst	0.5%

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120234