MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Neuroblastoma

(UMLS:C0027819)

Definition:: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
UMLS ID:: C0027819
MeSH ID:: D009447

Classification:

Name:

Neoplasms
MeSH Tree Number(s):: C04.557.465.625.600.590.650.550|C04.557.470.670.590.650.550|C04.557.580.625.600.590.650.550

Synonym(s)

Neuroblastoma

Cancer of early nerve cells

NB - Neuroblastoma

NEUROBLASTOMA

NEUROBLASTOMA, MALIGNANT

Neural Crest Tumor, Malignant

Neuroblastoma (Schwannian Stroma-Poor)

Neuroblastoma (Schwannian Stroma-poor)

Neuroblastoma NOS

10.

Neuroblastoma, NOS

11.

neuroblastoma

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Isotretinoin	FAERS: 19	View details 7707116 8214363 17368321 18353067 18839433 19492317	CTD US FAERS
2	Letrozole	FAERS: 6		OFFSIDES US FAERS
3	Imatinib Mesylate	FAERS: 4		US FAERS
4	Thalidomide	FAERS: 4		US FAERS
5	Crizotinib	FAERS: 3	22266870 22588779 22789543	CTD US FAERS
6	Methylprednisolone	FAERS: 3		US FAERS
7	Tacrolimus	FAERS: 3 Canada Vigilance: 1		Canada Vigilance US FAERS
8	Deferasirox	FAERS: 2		OFFSIDES US FAERS
9	Lithium Carbonate	FAERS: 2		US FAERS
10	Paroxetine	FAERS: 2		US FAERS
11	4-Aminopyridine	FAERS: 1		US FAERS
12	Arsenic Trioxide	FAERS: 1		US FAERS
13	Bosentan	FAERS: 1		US FAERS
14	Carboplatin	FAERS: 1	15768383	CTD US FAERS
15	Fentanyl	FAERS: 1		US FAERS
16	Imatinib Mesylate	FAERS: 1		US FAERS
17	Lenalidomide	FAERS: 1		US FAERS
18	Modafinil	FAERS: 1		US FAERS
19	Teriparatide	FAERS: 1		US FAERS
20	Topiramate	FAERS: 1		US FAERS
21	Zoledronic Acid	FAERS: 1		US FAERS
22	aliskiren	FAERS: 1		US FAERS
23	ceritinib	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
24	nitisinone	FAERS: 1		US FAERS
25	pazopanib	FAERS: 1		US FAERS
26	venetoclax	FAERS: 1		US FAERS
27	1,3-butadiene		15814359	CTD
28	4-oxofenretinide		16540676	CTD
29	ABT-737		23341456	CTD
30	Acridine Orange		16814760	CTD
31	Bortezomib		18534018	CTD
32	Busulfan		14595385	CTD OFFSIDES
33	Celecoxib		15492235	CTD
34	Cyclophosphamide		View details 476599 857581 3688893 8761367 15176712 16115947 18353067	CTD
35	Dacarbazine		857581 3688893	CTD
36	Decitabine		7507741	CTD
37	Diclofenac		15492235	CTD
38	Doxorubicin		15555623 18353067	CTD
39	Etoposide		View details 3335892 3813490 15768383 18353067	CTD OFFSIDES
40	Fulvestrant		27366082	CTD
41	ICE protocol 1		15176712	CTD
42	ICE protocol 3		8913079	CTD
43	Ifosfamide		2910509 3688893 3819813	CTD OFFSIDES
44	Irinotecan		8761367	CTD
45	Leuprolide			OFFSIDES
46	MLN 8237		22588779	CTD
47	Melphalan		2327660 14595385 18353067	CTD
48	Mesna		3819813	CTD OFFSIDES
49	NVP-TAE684		22588779	CTD
50	Phenobarbital			OFFSIDES
51	Phenytoin		1623454	CTD
52	Platinum		16314621 16814760	CTD
53	Temozolomide	Canada Vigilance: 1	15176712	CTD Canada Vigilance
54	Thiotepa		8761367	CTD
55	Topotecan		15176712	CTD
56	Troglitazone		16820965	CTD
57	Vincristine		857581 4294312 18353067	CTD
58	Vindesine		7038420 7438126	CTD
59	WP 744		15555623	CTD
60	bisphenol A		27366082	CTD
61	dexamethasone 21-phosphate			OFFSIDES
62	fludarabine phosphate			OFFSIDES
63	fludarabine			OFFSIDES
64	nutlin 3		22260869	CTD
65	tryptanthrine		23500671	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Medulloblastoma	43.1%
2	Ganglioneuroma	38.3%
3	Glioma	38.3%
4	Malignant Glioma	38.3%
5	Craniopharyngioma	30.5%
6	Neuroectodermal Tumor, Melanotic	30.5%
7	Neuroendocrine Tumors	30.5%
8	leukemia	30.4%
9	melanoma	24.7%
10	Retinoblastoma	24.6%
11	Histiocytic Disorders, Malignant	24.4%
12	Astrocytoma	22.8%
13	Ependymoma	22.8%
14	oligodendroglioma	22.8%
15	Ganglioglioma	22.8%
16	gliosarcoma	22.8%
17	Anaplastic astrocytoma	22.8%
18	Anaplastic Oligodendroglioma	22.8%
19	Adenoma	22.7%
20	Carcinoma	22.7%
21	Epithelioma	22.7%
22	Meningioma	22.7%
23	Adenoma, Acidophil	22.4%
24	Chordoma	22.3%
25	Teratoma	22.3%
26	Germinoma	22.3%
27	Teratocarcinoma	22.3%
28	Trophoblastic Neoplasms	22.1%
29	Hamartoma	20.5%
30	Neoplasms, Hormone-Dependent	20.5%
31	Neoplasms, Multiple Primary	20.5%
32	Paraneoplastic Syndromes	20.5%
33	Precancerous Conditions	20.5%
34	Neoplasms, Second Primary	20.5%
35	Lymphoma	20.4%
36	Neoplasms, Germ Cell and Embryonal	20.3%
37	Germ Cell Cancer	20.3%
38	Neoplasms, Glandular and Epithelial	20%
39	Basal cell carcinoma	19.7%
40	Carcinoma, Papillary	19.7%
41	Squamous cell carcinoma	19.7%
42	Cystadenoma	19.7%
43	Mesothelioma	19.7%
44	Carcinoma, Basal Cell	19.7%
45	Carcinosarcoma	19.2%
46	Hemangiosarcoma	19.2%
47	lymphangiosarcoma	19.2%
48	Carcinoid Tumor	18.9%
49	Neurilemmoma	18.7%
50	Carcinoma, Ehrlich Tumor	18.1%
51	Carcinoma, Lewis Lung	18.1%
52	Composite Lymphoma	17.9%
53	Dermoid Cyst	17.8%
54	Leukemia, Experimental	17.3%
55	Paraganglioma	17%
56	Neuroectodermal Tumors	16.9%
57	Cyst	16.6%
58	Neoplastic Processes	16.6%
59	Neoplastic Syndromes, Hereditary	16.6%
60	Pregnancy Complications, Neoplastic	16.6%
61	Neoplasms, Experimental	16.4%
62	Leukemia, Plasma Cell	16%
63	Melanoma, Experimental	15.9%
64	Carcinoma 256, Walker	15.6%
65	Ameloblastoma	15.5%
66	Angiokeratoma	15.5%
67	Hemangioma	15.5%
68	hemangiopericytoma	15.5%
69	Lymphangioma	15.5%
70	Mesenchymoma	15.5%
71	Nevus	15.5%
72	Hepatoblastoma	15.5%
73	Mixed Tumor, Mullerian	15.5%
74	Angiofibroma	15.5%
75	Sarcoma	15.5%
76	Cystadenocarcinoma	15.5%
77	Mucoepidermoid Carcinoma	15.5%
78	Glioblastoma	15.2%
79	Glioblastoma Multiforme	15.2%
80	Leukemia, Radiation-Induced	15.1%
81	Neoplasms, Neuroepithelial	14.4%
82	Gliomatosis cerebri	14.4%
83	Hutchinson's Melanotic Freckle	14.2%
84	Melanoma, Amelanotic	14.2%
85	Carcinoma, Lobular	14.2%
86	Acanthoma	14.1%
87	Choriocarcinoma	13.9%
88	Neoplasms, Radiation-Induced	13.7%
89	Chondrosarcoma	13.3%
90	leiomyosarcoma	13.3%
91	liposarcoma	13.3%
92	synovial sarcoma	13.3%
93	Angiomyolipoma	13.3%
94	Clear Cell Sarcoma of Soft Tissue	13.3%
95	Alveolar Soft Part Sarcoma	13.3%
96	Sarcoma, Myeloid	13.3%
97	Multiple Endocrine Neoplasia	13.2%
98	Plasmacytoma	12.5%
99	Malignant histiocytosis	12.5%
100	Histiocytic sarcoma	12.5%
101	Sarcoma, Experimental	12.4%
102	Thymoma	12.3%
103	Adenocarcinoma	12.3%
104	Carcinoma in Situ	12.3%
105	Carcinoma, Transitional Cell	12.3%
106	Papilloma	12.3%
107	Pseudomyxoma Peritonei	12.3%
108	Papillomatosis	12.3%
109	Adenomatosis, Pulmonary	12.3%
110	Adenomatous Polyps	12.3%
111	Carcinoma, Large Cell	12.3%
112	Carcinoma, Small Cell	12.3%
113	Adenofibroma	12.2%
114	Fibroadenoma	12.2%
115	Dysgerminoma	11.9%
116	Neuroma	11.9%
117	Seminoma	11.9%
118	Malignant Carcinoid Syndrome	11.7%
119	Endometrial Stromal Sarcoma	11.6%
120	Optic Nerve Glioma	11.5%
121	Bowen's Disease	11.4%
122	Leukemia L1210	10.9%
123	Leukemia P388	10.9%
124	Paraneoplastic Encephalomyelitis	10.5%
125	Fibrosarcoma	10.4%
126	Osteosarcoma	10.4%
127	Tuberous Sclerosis	10.4%
128	Hodgkin Disease	10.4%
129	Lymphoma, Non-Hodgkin	10.4%
130	Pheochromocytoma	10.4%
131	Mammary Neoplasms, Experimental	10.3%
132	Abdominal Neoplasms	10.1%
133	Erythroplasia	10.1%
134	Follicular cyst	10.1%
135	Head and Neck Neoplasms	10.1%
136	Mucocele	10.1%
137	Pilonidal Cyst	10.1%
138	Soft Tissue Neoplasms	10.1%
139	Thoracic Neoplasms	10.1%
140	Thyroglossal Cyst	10.1%
141	Synovial Cyst	10.1%
142	Aberrant Crypt Foci	10.1%
143	Nephroblastoma	10%
144	Lymphangioleiomyomatosis	9.6%
145	Primary amyloidosis	9%
146	Malignant Fibrous Histiocytoma	9%
147	Basal Cell Nevus Syndrome	8.8%
148	Hepatocellular Adenoma	8.7%
149	Digestive System Neoplasms	8.5%
150	Endocrine Gland Neoplasms	8.5%
151	Eye Neoplasms	8.5%
152	Nervous System Neoplasms	8.5%
153	Lymphomatoid Granulomatosis	8.5%
154	Phyllodes Tumor	8.3%
155	Hemangioendothelioma	8.3%
156	Lipoma	8.3%
157	Myoma	8.3%
158	Myxoma	8.3%
159	Angiolipoma	8.3%
160	Myelolipoma	8.3%
161	Neoplasms, Bone Tissue	8.3%
162	Neoplasms, Fibrous Tissue	8.3%
163	Smooth Muscle Tumor	8.3%
164	Desmoplastic Small Round Cell Tumor	8.3%
165	Chondroma	8.3%
166	Enchondroma	8.3%
167	Bone neoplasms	8.3%
168	Leukoplakia	8.3%
169	Lymphocele	8.3%
170	Pancreatic Cyst	8.3%
171	Skin Neoplasms	8.3%
172	Hematologic Neoplasms	8.3%
173	Barrett Esophagus	8.1%
174	Breast Cyst	8.1%
175	Actinic keratosis	8.1%
176	Mediastinal Cyst	8.1%
177	Neoplasm Invasiveness	8.1%
178	Neoplasm Metastasis	8.1%
179	Neoplasm Recurrence, Local	8.1%
180	Parovarian Cyst	8.1%
181	Pericardial Cyst	8.1%
182	Splenic Neoplasms	8.1%
183	Thymic Cyst	8.1%
184	Carcinogenesis	8.1%
185	Myxoid cyst	8.1%
186	Metastasis	8.1%
187	Sarcoma 180	8%
188	neurofibroma	7.9%
189	Mesoblastic Nephroma	7.6%
190	Prolactinoma	7.6%
191	Growth Hormone-Secreting Pituitary Adenoma	7.6%
192	Rhabdomyosarcoma	7.6%
193	Giant Cell Tumor of Bone	7.6%
194	Acoustic Neuroma	7.3%
195	Neurofibrosarcoma	7.2%
196	Adenoid Cystic Carcinoma	7.1%
197	Adenocarcinoma, Clear Cell	7.1%
198	Cholangiocarcinoma	7.1%
199	Cervical Intraepithelial Neoplasia	7.1%
200	Waldenstrom Macroglobulinemia	7%
201	Multiple Myeloma	7%
202	Carcinoid Heart Disease	7%
203	Carcinoma, Pancreatic Ductal	7%
204	Corpus Luteum Cyst	6.8%
205	Ovarian Cysts	6.8%
206	Carcinoma, Ovarian Epithelial	6.7%
207	Leukemia, Myelomonocytic, Chronic	6.7%
208	Multiple Endocrine Neoplasia Type 1	6.7%
209	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	6.7%
210	Liver Neoplasms, Experimental	6.5%
211	Hydatidiform Mole	6.3%
212	Parathyroid Neoplasms	6.1%
213	Peritoneal Neoplasms	6.1%
214	Thyroid Neoplasm	6.1%
215	Thyroid carcinoma	6.1%
216	Dermatofibrosarcoma	6.1%
217	Dermatofibrosarcoma Protuberans	6.1%
218	Adenomatous Polyposis Coli	6.1%
219	Choledochal Cyst	5.9%
220	Peutz-Jeghers Syndrome	5.8%
221	Vipoma	5.7%
222	Mastocytosis	5.7%
223	Sturge-Weber Syndrome	5.7%
224	Gastrointestinal Stromal Tumors	5.6%
225	Hemangioma, Cavernous	5.6%
226	Leukemia, T-Cell	5.6%
227	Leukemia, B-Cell	5.6%
228	Lymphoma, Follicular	5.5%
229	T-Cell Lymphoma	5.5%
230	Mantle cell lymphoma	5.5%
231	Pancreatic Neoplasm	5.4%
232	Nasopharyngeal carcinoma	5.3%
233	Retroperitoneal Neoplasms	5.2%
234	granulosa cell tumor	5%
235	fibroma	4.7%
236	Fibromatosis	4.7%
237	Osteoblastoma	4.7%
238	Osteoma	4.7%
239	Rhabdomyoma	4.7%
240	Chondromatosis	4.7%
241	Hemangioblastoma	4.7%
242	Lymphoma, Extranodal NK-T-Cell	4.7%
243	Alveolar rhabdomyosarcoma	4.7%
244	Tracheal Neoplasms	4.7%
245	Leukoplakia, Oral	4.6%
246	Paraneoplastic Cerebellar Degeneration	4.6%
247	insulinoma	4.6%
248	Klatskin Tumor	4.5%
249	Adrenocortical carcinoma	4.4%
250	Mouth Neoplasms	4.2%
251	Central Nervous System Neoplasms	4.2%
252	Vascular Neoplasms	4.2%
253	Thymus Neoplasms	4.2%
254	Genital Neoplasms, Female	4.2%
255	Pancreatic Pseudocyst	4.2%
256	Lymphatic Metastasis	4.2%
257	Neoplasms, Unknown Primary	4.2%
258	Leukemic Infiltration	4.2%
259	Breast Neoplasms, Male	4.2%
260	Neoplasm Micrometastasis	4.2%
261	Triple Negative Breast Neoplasms	4.2%
262	Esophageal Neoplasms	4.1%
263	Limbic Encephalitis	4%
264	Renal Cell Carcinoma	3.9%
265	Papillary Renal Cell Carcinoma	3.9%
266	Denys-Drash Syndrome	3.9%
267	Mastocytoma	3.8%
268	Mastocytosis, Systemic	3.8%
269	Leukemia, Myeloid, Chronic-Phase	3.8%
270	Xeroderma Pigmentosum	3.7%
271	Lambert-Eaton Myasthenic Syndrome	3.6%
272	Testicular Neoplasms	3.6%
273	Carcinoma, Endometrioid	3.6%
274	Adrenal Gland Neoplasms	3.6%
275	Gastrointestinal Neoplasms	3.6%
276	Genital Neoplasms, Male	3.6%
277	Liver neoplasms	3.6%
278	Uveal Neoplasms	3.6%
279	Urologic Neoplasms	3.5%
280	Sebaceous Gland Neoplasms	3.5%
281	Spinal Neoplasms	3.5%
282	Bone Marrow Neoplasms	3.5%
283	Polycystic Ovary Syndrome	3.5%
284	Gastrinoma	3.4%
285	Glucagonoma	3.4%
286	Opsoclonus-Myoclonus Syndrome	3.3%
287	Thyroid Nodule	3.2%
288	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	3.2%
289	Leukemia, Large Granular Lymphocytic	3.2%
290	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	3.2%
291	Lymphoma, T-Cell, Cutaneous	3.1%
292	Lymphoma, AIDS-Related	3.1%
293	Enteropathy-Associated T-Cell Lymphoma	3.1%
294	Primary Effusion Lymphoma	3.1%
295	Neuroblastoma	3.1%
296	Fibromatosis, Aggressive	2.9%
297	Fibromatosis, Abdominal	2.9%
298	Myelitis, Transverse	2.9%
299	Leydig Cell Tumor	2.9%
300	ovarian neoplasm	2.6%
301	Burkitt Lymphoma	2.4%
302	Ganglioneuroblastoma	2.4%
303	Nose Neoplasms	2.3%
304	Meningeal Neoplasms	2.2%
305	Pituitary Adenoma	2.2%
306	Pituitary Neoplasms	2.2%
307	Zollinger-Ellison syndrome	2.1%
308	Dupuytren Contracture	2%
309	Urticaria Pigmentosa	2%
310	Palatal Neoplasms	2%
311	Mycosis Fungoides	2%
312	Lymphomatoid Papulosis	2%
313	Plasmablastic lymphoma	2%
314	Ear Neoplasms	1.9%
315	Eyelid Neoplasms	1.9%
316	Lung Neoplasms	1.9%
317	Pleural Neoplasms	1.9%
318	Cell Transformation, Viral	1.9%
319	Brain Neoplasms	1.9%
320	Salivary Gland Neoplasms	1.9%
321	Spinal Cord Neoplasms	1.9%
322	Tongue Neoplasms	1.9%
323	Uterine Neoplasms	1.9%
324	Vaginal Neoplasms	1.9%
325	Vulvar Neoplasms	1.9%
326	Uterine Cancer	1.9%
327	Fallopian Tube Neoplasms	1.9%
328	Pharyngeal Neoplasms	1.7%
329	Central Nervous System Cysts	1.6%
330	Bile Duct Neoplasms	1.6%
331	gallbladder neoplasm	1.6%
332	Intestinal Neoplasms	1.6%
333	Penile Neoplasms	1.6%
334	Prostatic Neoplasms	1.6%
335	Stomach Neoplasms	1.6%
336	Polycythemia Vera	1.6%
337	Sezary Syndrome	1.5%
338	Laryngeal neoplasm	1.5%
339	Bladder Neoplasm	1.4%
340	Kidney Neoplasm	1.4%
341	Ureteral Neoplasms	1.4%
342	Urethral Neoplasms	1.4%
343	Meningeal Carcinomatosis	1.3%
344	Bronchial Neoplasms	1.1%
345	Multiple Pulmonary Nodules	1.1%
346	Supratentorial Neoplasms	1.1%
347	Endometrial Neoplasms	1.1%
348	Hypopharyngeal Neoplasms	0.9%
349	Pleural Effusion, Malignant	0.9%
350	Hypopharyngeal Cancer	0.9%
351	Parotid Neoplasms	0.9%
352	Prostatic Neoplasms, Castration-Resistant	0.9%
353	Nelson Syndrome	0.9%
354	Cecal Neoplasms	0.8%
355	Duodenal Neoplasms	0.8%
356	Nasopharyngeal Neoplasms	0.7%
357	Colorectal Neoplasms	0.7%
358	Brain Stem Neoplasms	0.7%
359	Paranasal Sinus Neoplasms	0.7%
360	Tonsillar Neoplasms	0.6%
361	Cerebellar Neoplasms	0.6%
362	Radicular Cyst	0.5%
363	Appendiceal Neoplasms	0.5%
364	Colonic Neoplasms	0.5%
365	Rectal Neoplasms	0.5%
366	Choroid Plexus Papilloma	0.5%
367	Maxillary Sinus Neoplasms	0.4%
368	Anus Neoplasms	0.3%
369	Sigmoid Neoplasms	0.3%

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