MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Hyperpigmentation

(UMLS:C0162834)

Definition:: Excessive pigmentation of the skin, usually as a result of increased epidermal or dermal melanin pigmentation, hypermelanosis. Hyperpigmentation can be localized or generalized. The condition may arise from exposure to light, chemicals or other substances, or from a primary metabolic imbalance.
UMLS ID:: C0162834
MeSH ID:: D017495

Classification:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.800.621.430

Synonym(s)

Hyperpigmentation

Cutaneous hyperpigmentation

Dermal hyperpigmentation

HYPERPIGMENTATION

Hyperpigmentation disorder

Hyperpigmentation of skin

Hyperpigmentation of skin, NOS

Hyperpigmentation of the skin

Hyperpigmentation, NOS

10.

Hyperpigmented lesion

11.

Hyperpigmented skin

12.

Increased skin pigmentation

13.

Patchy darkened skin

14.

Skin Hyperpigmentation

15.

Skin hyperpigmentation

Associated Drug(s)

	Name	Reference(s)	Data Source
1	1-phenylazo-2-naphthol	1402006	CTD
2	2',5'-dideoxyadenosine	26443706	CTD
3	Acetylcysteine		OFFSIDES
4	Ambroxol		OFFSIDES
5	Amifostine		OFFSIDES
6	Amlodipine		OFFSIDES
7	Amlodipine		OFFSIDES
8	Ampicillin		OFFSIDES
9	Arsenicals	16476755	CTD
10	Ascorbic Acid		OFFSIDES
11	Aspirin-oxycodone hydrochloride-oxycodone terephthalate combination		OFFSIDES
12	Azathioprine		OFFSIDES
13	Azelaic acid	20804622 21637899	CTD
14	Beclomethasone		OFFSIDES
15	Bexarotene		OFFSIDES
16	Bimatoprost		OFFSIDES
17	Bisacodyl		OFFSIDES
18	Bleomycin		OFFSIDES
19	Bosentan		OFFSIDES
20	Bromhexine		OFFSIDES
21	Bumetanide		OFFSIDES
22	Calcitriol		OFFSIDES
23	Capecitabine	12564432 17669305	CTD OFFSIDES
24	Carbamazepine		OFFSIDES
25	Carbimazole		OFFSIDES
26	Carnitine		OFFSIDES
27	Carvedilol		OFFSIDES
28	Cephalexin		OFFSIDES
29	Chloroquine	9523387 11245140	CTD
30	Chondroitin Sulfates		OFFSIDES
31	Cinacalcet		OFFSIDES
32	Clonazepam		OFFSIDES
33	Clopidogrel		OFFSIDES
34	Clotrimazole		OFFSIDES
35	Cloxacillin		OFFSIDES
36	Colchicine		OFFSIDES
37	Colestipol		OFFSIDES
38	Colforsin	26443706	CTD
39	Cyclophosphamide		OFFSIDES
40	Cyclosporine		OFFSIDES
41	Dacarbazine		OFFSIDES
42	Daunorubicin		OFFSIDES
43	Dexamethasone	12564432	CTD
44	Digoxin		OFFSIDES
45	Dimethindene		OFFSIDES
46	Disopyramide		OFFSIDES
47	Docetaxel	12564432	CTD OFFSIDES
48	Docusate sodium		OFFSIDES
49	Doxazosin		OFFSIDES
50	Doxorubicin		OFFSIDES
51	Doxycycline		OFFSIDES
52	Dronabinol		OFFSIDES
53	Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination	18156608	CTD
54	Enalapril		OFFSIDES
55	Erlotinib Hydrochloride		OFFSIDES
56	Estrogens, Conjugated (USP)		OFFSIDES
57	Fludrocortisone		OFFSIDES
58	Fluorouracil	5031606	CTD
59	Fluoxetine	26443706	CTD OFFSIDES
60	Folic Acid		OFFSIDES
61	Fosinopril		OFFSIDES
62	Gemifloxacin		OFFSIDES
63	Gentamicins		OFFSIDES
64	Goserelin		OFFSIDES
65	Hydrocortisone		OFFSIDES
66	Hydroxychloroquine		OFFSIDES
67	Hydroxyurea	4643395 7499134 9256830	CTD
68	Hydroxyzine		OFFSIDES
69	Ifosfamide	6176753	CTD
70	Ipratropium		OFFSIDES
71	Isosorbide		OFFSIDES
72	Isradipine		OFFSIDES
73	Ivermectin	26443706	CTD
74	Ketoconazole		OFFSIDES
75	Labetalol		OFFSIDES
76	Lanthanum carbonate hydrate		OFFSIDES
77	Letrozole		OFFSIDES
78	Leuprolide		OFFSIDES
79	Lisinopril		OFFSIDES
80	MSH Release-Inhibiting Hormone	26443706	CTD
81	Maloprim		OFFSIDES
82	Mesna		OFFSIDES
83	Methadone		OFFSIDES
84	Methiothepin	26443706	CTD
85	Methotrexate		OFFSIDES
86	Methyldopa		OFFSIDES
87	Metolazone		OFFSIDES
88	Metronidazole		OFFSIDES
89	Midodrine		OFFSIDES
90	Minocycline		OFFSIDES
91	Minoxidil		OFFSIDES
92	Mycophenolic Acid		OFFSIDES
93	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	26443706	CTD
94	Nabumetone		OFFSIDES
95	Naloxone		OFFSIDES
96	Norepinephrine		OFFSIDES
97	Nortriptyline		OFFSIDES
98	Olmesartan Medoxomil		OFFSIDES
99	Ondansetron		OFFSIDES
100	Paclitaxel		OFFSIDES
101	Pamidronate		OFFSIDES
102	Pantoprazole		OFFSIDES
103	Pemetrexed		OFFSIDES
104	Pentoxifylline		OFFSIDES
105	Phenobarbital		OFFSIDES
106	Prednisone acetate		OFFSIDES
107	Prednisone	5031606	CTD
108	Pyridoxine		OFFSIDES
109	Reserpine	26443706	CTD
110	Rosuvastatin Calcium		OFFSIDES
111	Rosuvastatin Calcium		OFFSIDES
112	S 1108		OFFSIDES
113	Serotonin	26443706	CTD
114	Sertraline		OFFSIDES
115	Sevelamer		OFFSIDES
116	Sevelamer		OFFSIDES
117	Sodium Bicarbonate		OFFSIDES
118	Sodium ferric gluconate complex		OFFSIDES
119	Sulfate		OFFSIDES
120	Taurine	20804622	CTD
121	Testosterone		OFFSIDES
122	Thalidomide		OFFSIDES
123	Tiagabine		OFFSIDES
124	Timolol		OFFSIDES
125	Travoprost		OFFSIDES
126	Tretinoin	View details 1552056 2024983 2337528 8277035 9257379	CTD OFFSIDES
127	Trimethoprim, Sulfamethoxazole Drug Combination		OFFSIDES
128	Trimethoprim		OFFSIDES
129	Valganciclovir		OFFSIDES
130	Vancomycin		OFFSIDES
131	Verapamil		OFFSIDES
132	Vincristine		OFFSIDES
133	Vindesine		OFFSIDES
134	Vinorelbine		OFFSIDES
135	Vorinostat		OFFSIDES
136	Warfarin		OFFSIDES
137	Zolpidem		OFFSIDES
138	abacavir		OFFSIDES
139	altanserin	26443706	CTD
140	artemisic acid	23063590	CTD
141	benzanthrone	28029781	CTD
142	betamethasone-17,21-dipropionate		OFFSIDES
143	calcipotriene		OFFSIDES
144	calcium acetate		OFFSIDES
145	cefpodoxime proxetil		OFFSIDES
146	cefpodoxime		OFFSIDES
147	cevimeline		OFFSIDES
148	chlorhexidine gluconate		OFFSIDES
149	cyanopindolol	26443706	CTD
150	dolasetron		OFFSIDES
151	flomoxef		OFFSIDES
152	gadobenic acid		OFFSIDES
153	gadodiamide		OFFSIDES
154	gadoteridol		OFFSIDES
155	gadoversetamide		OFFSIDES
156	iodixanol		OFFSIDES
157	paricalcitol		OFFSIDES
158	periciazine		OFFSIDES
159	pimecrolimus		OFFSIDES
160	repaglinide		OFFSIDES
161	reviparin		OFFSIDES
162	sodium arsenite	28470405	CTD
163	tazarotene		OFFSIDES
164	terconazole		OFFSIDES
165	tipepidine		OFFSIDES
166	valdecoxib		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Vitiligo	34.4%
2	Argyria	31.1%
3	Breast Diseases	31%
4	Dermatitis	31%
5	Exanthema	31%
6	Facial Dermatoses	31%
7	Hair Diseases	31%
8	Hand Dermatoses	31%
9	keratoacanthoma	31%
10	Keratosis	31%
11	Nail Diseases	31%
12	Photosensitivity Disorders	31%
13	Prurigo	31%
14	Pyoderma	31%
15	Rosacea	31%
16	Sebaceous Gland Diseases	31%
17	Skin Diseases, Vesiculobullous	31%
18	Skin Ulcer	31%
19	Sweat Gland Diseases	31%
20	Skin Diseases, Papulosquamous	31%
21	Skin Diseases, Vascular	31%
22	Acneiform Eruptions	31%
23	Ocular Rosacea	31%
24	Subcorneal pustular dermatosis	31%
25	Erythematotelangiectatic Rosacea	31%
26	Papulopustular Rosacea	31%
27	Chronic Actinic Dermatitis	31%
28	Urticaria Pigmentosa	30.1%
29	Pyoderma Gangrenosum	30%
30	Lupus Erythematosus, Cutaneous	27.9%
31	Panniculitis	27.9%
32	Systemic Scleroderma	27.9%
33	Morphea	27.9%
34	Acne Vulgaris	26.7%
35	Contact Dermatitis	26.7%
36	Eczema	26.7%
37	Erythema Multiforme	26.7%
38	Intertrigo	26.7%
39	Neurodermatitis	26.7%
40	Rhinophyma	26.7%
41	Perioral Dermatitis	26.7%
42	Acne	26.7%
43	Xeroderma Pigmentosum	23.9%
44	Foot Ulcer	23.1%
45	Foot Diseases	22%
46	Dermatitis, Phototoxic	22%
47	Pityriasis Lichenoides et Varioliformis Acuta	22%
48	Pityriasis Lichenoides	22%
49	Phototoxicity	22%
50	Skin Abnormalities	20.9%
51	Skin Diseases, Infectious	20.9%
52	Skin Neoplasms	20.9%
53	Lipomatosis	20.5%
54	Pruritus	20.5%
55	Erythema	20.5%
56	Necrolytic Migratory Erythema	20.5%
57	Cutaneous Fistula	20.5%
58	Nephrogenic Fibrosing Dermopathy	20.5%
59	Nephrogenic Systemic Fibrosis	20.5%
60	Dermatitis Herpetiformis	20.3%
61	Acrodermatitis	20%
62	Anhidrosis	20%
63	Cholesteatoma	20%
64	Pressure Ulcer	20%
65	Dermatitis, Atopic	20%
66	Epidermolysis Bullosa	20%
67	Folliculitis	20%
68	Foot Dermatoses	20%
69	Gynecomastia	20%
70	Hypertrichosis	20%
71	Hypohidrosis	20%
72	Hypotrichosis	20%
73	Leg Ulcer	20%
74	Miliaria	20%
75	Parakeratosis	20%
76	Parapsoriasis	20%
77	Pityriasis	20%
78	Psoriasis	20%
79	Sebaceous Gland Neoplasms	20%
80	Sweet Syndrome	20%
81	Hidradenitis	20%
82	Onycholysis	20%
83	Miliaria Rubra	20%
84	Porokeratosis	20%
85	Lichenoid Eruptions	20%
86	Gianotti-Crosti Syndrome	20%
87	Chloracne	20%
88	Keratoderma, Palmoplantar	20%
89	Dermatitis, Irritant	19.6%
90	Acne Conglobata	19.6%
91	Connective Tissue Diseases	18.5%
92	Panniculitis, Lupus Erythematosus	18.4%
93	Necrobiosis Lipoidica Diabeticorum	17.9%
94	Lupus Erythematosus, Discoid	17.8%
95	Scleroderma, Limited	17.8%
96	Dermatitis, Photoallergic	17.5%
97	Xeroderma	16.2%
98	Dermatomyositis	16.2%
99	Diaper Rash	16.1%
100	Dermatitis, Occupational	15.5%
101	Cutis Laxa	15.3%
102	Mastocytosis	15.1%
103	Lichen Planus	14.8%
104	Pityriasis Rosea	14.8%
105	Pityriasis Rubra Pilaris	14.8%
106	Dermatitis, Allergic Contact	14.8%
107	Lichen Nitidus	14.8%
108	Papillon-Lefevre Disease	14.6%
109	Erythema Induratum	14.4%
110	Erythema Infectiosum	14.1%
111	Exanthema Subitum	14%
112	Erythema Nodosum	13.7%
113	Albinism	13.7%
114	Acantholysis	13.6%
115	Breast Cyst	13.6%
116	Actinic keratosis	13.6%
117	Pemphigoid, Benign Mucous Membrane	13.6%
118	Pemphigus	13.6%
119	Piedra	13.6%
120	Sunburn	13.6%
121	Ectodermal Dysplasia	13.3%
122	Hirsutism	13.3%
123	Lactation Disorder	13.3%
124	Mastitis	13.3%
125	Urticaria	13.3%
126	Aplasia Cutis Congenita	13.3%
127	Adiposis Dolorosa	13.2%
128	Pruritus Vulvae	13.2%
129	Mastocytoma	13.1%
130	Pruritus Ani	13.1%
131	Tinea Capitis	12.7%
132	Onychomycosis	12.7%
133	Toxic Epidermal Necrolysis	12.6%
134	Stevens-Johnson Syndrome	12.6%
135	Pseudoxanthoma Elasticum	12.6%
136	Granuloma Annulare	12.4%
137	Alopecia Areata	12.2%
138	Ecthyma	11.5%
139	Hyperkeratosis, Epidermolytic	11%
140	Collagen Diseases	10.3%
141	Mixed Connective Tissue Disease	10.3%
142	Mucinoses	10.3%
143	Dermatomycoses	10.2%
144	Mucocutaneous Lymph Node Syndrome	10.2%
145	Skin Diseases, Bacterial	10.2%
146	Alopecia	10.1%
147	Sweating, Gustatory	10.1%
148	Androgenetic Alopecia	10.1%
149	Auriculotemporal Syndrome	10.1%
150	Drug Eruptions	10%
151	Lipodystrophy	10%
152	Livedo Reticularis	10%
153	Malignant Atrophic Papulosis	10%
154	Behcet Syndrome	10%
155	Lice Infestations	9.9%
156	Varicose Ulcer	9.9%
157	Breast Neoplasms, Male	9.9%
158	Triple Negative Breast Neoplasms	9.9%
159	Polyarteritis Nodosa	9.8%
160	Takayasu Arteritis	9.8%
161	Ichthyosis, X-Linked	9.8%
162	Hidradenitis Suppurativa	9.8%
163	Galactorrhea	9.8%
164	Sjogren-Larsson Syndrome	9.8%
165	Tinea Pedis	8.9%
166	Erythema Chronicum Migrans	8.5%
167	Lichen Planus, Oral	8.4%
168	Nail-Patella Syndrome	8.2%
169	Porphyrias, Hepatic	8.1%
170	Larva Migrans	7.6%
171	Leishmaniasis	7.6%
172	Molluscum Contagiosum	7.6%
173	Angioedema	7.5%
174	Onchocerciasis	7.5%
175	Chromoblastomycosis	7.4%
176	Dermatophytosis	7.4%
177	Sporotrichosis	7.4%
178	Tinea	7.4%
179	Tinea Versicolor	7.4%
180	Trichophytosis	7.4%
181	Hyalohyphomycosis	7.4%
182	Mycetoma	7.3%
183	Cartilage Diseases	7.3%
184	Rheumatism	7.3%
185	Chondromalacia	7.3%
186	Acute Generalized Exanthematous Pustulosis	7.3%
187	Lupus Erythematosus, Systemic	7%
188	Overlap syndrome	7%
189	Scleromyxedema	6.7%
190	Leishmaniasis, Cutaneous	6.1%
191	Eczema Herpeticum	6.1%
192	Warts	6.1%
193	Fusariosis	6%
194	Candidiasis, Chronic Mucocutaneous	5.9%
195	Cutaneous Candidiasis	5.9%
196	Erysipelas	5.9%
197	Serum Sickness	5.9%
198	Staphylococcal Skin Infections	5.9%
199	Variegate Porphyria	5.9%
200	Acute intermittent porphyria	5.9%
201	Porphyria Cutanea Tarda	5.9%
202	Erythrasma	5.9%
203	Carcinoma, Lobular	5.9%
204	Arthritis, Psoriatic	5.8%
205	CREST Syndrome	5.6%
206	Hereditary Angioedema Type III	5.4%
207	Hereditary Angioedema Types I and II	5.4%
208	Dupuytren Contracture	5%
209	Angioedemas, Hereditary	5%
210	Epidermodysplasia Verruciformis	4.9%
211	Herpes Labialis	4.9%
212	Giant Cell Arteritis	4.9%
213	Temporal Arteritis	4.9%
214	Diabetic Foot	4.9%
215	Staphylococcal Scalded Skin Syndrome	4.8%
216	Mesenteric Panniculitis	4.5%
217	Panniculitis, Peritoneal	4.5%
218	Tietze's Syndrome	4.5%
219	Orbital Cellulitis	4.5%
220	Myxoid cyst	4.5%
221	Myxedema	4.4%
222	carbuncle	4.3%
223	Blastomycosis	4.2%
224	HIV-Associated Lipodystrophy Syndrome	4.2%
225	Condylomata Acuminata	4.1%
226	Furunculosis	4.1%
227	furuncle	4.1%
228	Cellulitis	4%
229	Impetigo	4%
230	Rhinoscleroma	3.8%
231	Menkes Kinky Hair Syndrome	3.5%
232	Osteochondritis	3.4%
233	Polymyalgia Rheumatica	3.4%
234	Osteogenesis Imperfecta	3.4%
235	Keloid	3.3%
236	Noonan Syndrome	2.9%
237	Rheumatoid Arthritis	2.7%
238	Juvenile arthritis	2.7%
239	Lupus Nephritis	2.6%
240	Marfan Syndrome	2.5%
241	Rheumatoid Nodule	2.5%
242	Homocystinuria	2.4%
243	Laryngomalacia	2.3%
244	Pectus carinatum	2.3%
245	Felty Syndrome	2%
246	Bronchomalacia	2%
247	Tracheomalacia	2%
248	Rheumatoid Vasculitis	1.6%
249	Mucopolysaccharidosis III	1.6%
250	Sicca Syndrome	1.4%
251	Sjogren's Syndrome	1.4%
252	Lupus Vasculitis, Central Nervous System	1.1%
253	Mucopolysaccharidosis II	1.1%

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