MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Chloasma

(UMLS:C0025218)

UMLS ID:: C0025218
MeSH ID:: D008548

Classification:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.800.621.430.530

Synonym(s)

Chloasma

CHLOASMA

Chloasma, NOS

Facial melanosis

MELASMA

Melasma

Melasma, NOS

chloasma

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Norgestrel	FAERS: 54	OFFSIDES SIDER US FAERS
2	Ortho Evra	FAERS: 35	US FAERS
3	NuvaRing	FAERS: 8	US FAERS
4	Finasteride	FAERS: 7	US FAERS
5	Estradiol	FAERS: 5	SIDER US FAERS
6	Isotretinoin	FAERS: 5	US FAERS
7	Medroxyprogesterone Acetate	FAERS: 5 Canada Vigilance: 1	Canada Vigilance US FAERS
8	Norethindrone acetate and ethinyl estradiol	FAERS: 5	US FAERS
9	Metronidazole	FAERS: 4	US FAERS
10	apremilast	FAERS: 4	US FAERS
11	Estrogens, Conjugated (USP)	FAERS: 3	US FAERS
12	Tri-Luma	FAERS: 3	US FAERS
13	norgestimate, ethinyl estradiol drug combination	FAERS: 3	US FAERS
14	4-hydroxybutyric acid	FAERS: 2	US FAERS
15	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	FAERS: 2	US FAERS
16	Deoxycholic Acid	FAERS: 2	US FAERS
17	Fingolimod Hydrochloride	FAERS: 2	US FAERS
18	Nicotine	FAERS: 2	US FAERS
19	Pregabalin	FAERS: 2	US FAERS
20	etonogestrel	FAERS: 2	SIDER US FAERS
21	rofecoxib	FAERS: 2	US FAERS
22	2-(Tert-butylamino)-1-(3-chlorophenyl)propan-1-one;hydron;chloride	FAERS: 1	US FAERS
23	3-ingenyl angelate	FAERS: 1	US FAERS
24	Adapalene, Benzoyl Peroxide Drug Combination	FAERS: 1	US FAERS
25	Adapalene	FAERS: 1	US FAERS
26	Anastrozole	FAERS: 1	US FAERS
27	Atenolol	FAERS: 1	US FAERS
28	Bimatoprost	FAERS: 1	US FAERS
29	Copper	FAERS: 1	US FAERS
30	Desogestrel	FAERS: 1	US FAERS
31	Doxorubicin	FAERS: 1	US FAERS
32	Dutasteride	FAERS: 1	US FAERS
33	Estradiol acetate	FAERS: 1	US FAERS
34	Lamotrigine	FAERS: 1	US FAERS
35	MDV 3100	FAERS: 1	US FAERS
36	Meloxicam	FAERS: 1	US FAERS
37	Minocycline	FAERS: 1	US FAERS
38	Norethindrone	FAERS: 1	SIDER US FAERS
39	Paroxetine	FAERS: 1	US FAERS
40	Raloxifene Hydrochloride	FAERS: 1	US FAERS
41	Tamoxifen	FAERS: 1	US FAERS
42	beyaz	FAERS: 1	US FAERS
43	drospirenone and ethinyl estradiol combination	FAERS: 1	US FAERS
44	fexofenadine	FAERS: 1	US FAERS
45	iodixanol	FAERS: 1	US FAERS
46	linaclotide	FAERS: 1	US FAERS
47	teriflunomide	FAERS: 1	US FAERS
48	Calcium Citrate		OFFSIDES
49	Clomipramine		SIDER
50	Desogestrel		SIDER
51	Diane	Canada Vigilance: 1	Canada Vigilance
52	Estriol		SIDER
53	Estrone		SIDER
54	Ethinyl Estradiol-Norgestrel Combination	Canada Vigilance: 1	Canada Vigilance
55	Letrozole		OFFSIDES
56	Lovastatin	Canada Vigilance: 1	Canada Vigilance
57	Medroxyprogesterone		SIDER
58	Mefenamic Acid		OFFSIDES
59	Nafarelin		SIDER
60	Norethindrone Acetate	Canada Vigilance: 1	Canada Vigilance
61	Norinyl	Canada Vigilance: 2	Canada Vigilance
62	Omeprazole		OFFSIDES
63	Oracon	Canada Vigilance: 1	Canada Vigilance
64	Phenytoin		OFFSIDES
65	Progesterone		SIDER
66	Topiramate		SIDER
67	Trisequens		SIDER
68	estradiol, estriol drug combination		SIDER
69	pimecrolimus		OFFSIDES
70	tazarotene		OFFSIDES
71	tibolone		SIDER

Similar ADE(s)

	Name	Semantic Similarity
1	Breast Diseases	25.4%
2	Dermatitis	25.4%
3	Exanthema	25.4%
4	Facial Dermatoses	25.4%
5	Hair Diseases	25.4%
6	Hand Dermatoses	25.4%
7	keratoacanthoma	25.4%
8	Keratosis	25.4%
9	Nail Diseases	25.4%
10	Photosensitivity Disorders	25.4%
11	Prurigo	25.4%
12	Pyoderma	25.4%
13	Rosacea	25.4%
14	Sebaceous Gland Diseases	25.4%
15	Skin Diseases, Vesiculobullous	25.4%
16	Skin Ulcer	25.4%
17	Sweat Gland Diseases	25.4%
18	Skin Diseases, Papulosquamous	25.4%
19	Skin Diseases, Vascular	25.4%
20	Acneiform Eruptions	25.4%
21	Ocular Rosacea	25.4%
22	Subcorneal pustular dermatosis	25.4%
23	Erythematotelangiectatic Rosacea	25.4%
24	Papulopustular Rosacea	25.4%
25	Chronic Actinic Dermatitis	25.4%
26	Argyria	23.1%
27	Lupus Erythematosus, Cutaneous	23%
28	Panniculitis	23%
29	Systemic Scleroderma	23%
30	Morphea	23%
31	Vitiligo	22.6%
32	Pyoderma Gangrenosum	22.3%
33	Urticaria Pigmentosa	21.8%
34	Acne Vulgaris	19.8%
35	Contact Dermatitis	19.8%
36	Eczema	19.8%
37	Erythema Multiforme	19.8%
38	Intertrigo	19.8%
39	Neurodermatitis	19.8%
40	Rhinophyma	19.8%
41	Perioral Dermatitis	19.8%
42	Acne	19.8%
43	Foot Diseases	18.1%
44	Xeroderma Pigmentosum	17.8%
45	Skin Abnormalities	17.2%
46	Skin Diseases, Infectious	17.2%
47	Skin Neoplasms	17.2%
48	Lipomatosis	16.9%
49	Pruritus	16.9%
50	Erythema	16.9%
51	Necrolytic Migratory Erythema	16.9%
52	Cutaneous Fistula	16.9%
53	Nephrogenic Fibrosing Dermopathy	16.9%
54	Nephrogenic Systemic Fibrosis	16.9%
55	Connective Tissue Diseases	16.4%
56	Foot Ulcer	16.3%
57	Dermatitis Herpetiformis	15.1%
58	Dermatitis, Atopic	14.9%
59	Epidermolysis Bullosa	14.9%
60	Acrodermatitis	14.9%
61	Sebaceous Gland Neoplasms	14.9%
62	Porokeratosis	14.9%
63	Gianotti-Crosti Syndrome	14.9%
64	Keratoderma, Palmoplantar	14.9%
65	Anhidrosis	14.8%
66	Cholesteatoma	14.8%
67	Pressure Ulcer	14.8%
68	Folliculitis	14.8%
69	Foot Dermatoses	14.8%
70	Gynecomastia	14.8%
71	Hypertrichosis	14.8%
72	Hypohidrosis	14.8%
73	Hypotrichosis	14.8%
74	Leg Ulcer	14.8%
75	Miliaria	14.8%
76	Parakeratosis	14.8%
77	Parapsoriasis	14.8%
78	Pityriasis	14.8%
79	Psoriasis	14.8%
80	Sweet Syndrome	14.8%
81	Hidradenitis	14.8%
82	Onycholysis	14.8%
83	Miliaria Rubra	14.8%
84	Lichenoid Eruptions	14.8%
85	Chloracne	14.8%
86	Dermatitis, Phototoxic	14.5%
87	Pityriasis Lichenoides et Varioliformis Acuta	14.5%
88	Pityriasis Lichenoides	14.5%
89	Phototoxicity	14.5%
90	Dermatomyositis	13.4%
91	Lupus Erythematosus, Discoid	13.2%
92	Scleroderma, Limited	13.2%
93	Necrobiosis Lipoidica Diabeticorum	13.2%
94	Panniculitis, Lupus Erythematosus	13.1%
95	Dermatitis, Irritant	12.9%
96	Acne Conglobata	12.9%
97	Mastocytosis	12.5%
98	Xeroderma	12.1%
99	Cutis Laxa	11.8%
100	Dermatitis, Photoallergic	11.6%
101	Erythema Induratum	10.3%
102	Dermatitis, Occupational	10.3%
103	Acantholysis	10.1%
104	Breast Cyst	10.1%
105	Actinic keratosis	10.1%
106	Pemphigoid, Benign Mucous Membrane	10.1%
107	Pemphigus	10.1%
108	Piedra	10.1%
109	Sunburn	10.1%
110	Erythema Infectiosum	10%
111	Ectodermal Dysplasia	9.9%
112	Aplasia Cutis Congenita	9.9%
113	Exanthema Subitum	9.9%
114	Hirsutism	9.9%
115	Lactation Disorder	9.9%
116	Mastitis	9.9%
117	Urticaria	9.9%
118	Adiposis Dolorosa	9.8%
119	Pruritus Vulvae	9.8%
120	Dermatitis, Allergic Contact	9.8%
121	Erythema Nodosum	9.7%
122	Mastocytoma	9.7%
123	Pruritus Ani	9.7%
124	Lichen Planus	9.7%
125	Papillon-Lefevre Disease	9.7%
126	Pityriasis Rosea	9.7%
127	Pityriasis Rubra Pilaris	9.7%
128	Lichen Nitidus	9.7%
129	Pseudoxanthoma Elasticum	9.6%
130	Diaper Rash	9.6%
131	Albinism	9.5%
132	Granuloma Annulare	9%
133	Tinea Capitis	8.7%
134	Onychomycosis	8.7%
135	Collagen Diseases	8.5%
136	Mixed Connective Tissue Disease	8.5%
137	Mucinoses	8.5%
138	Toxic Epidermal Necrolysis	8.3%
139	Stevens-Johnson Syndrome	8.3%
140	Ecthyma	8.2%
141	Dermatomycoses	7.6%
142	Mucocutaneous Lymph Node Syndrome	7.6%
143	Skin Diseases, Bacterial	7.6%
144	Drug Eruptions	7.4%
145	Lipodystrophy	7.4%
146	Livedo Reticularis	7.4%
147	Malignant Atrophic Papulosis	7.4%
148	Polyarteritis Nodosa	7.3%
149	Takayasu Arteritis	7.3%
150	Alopecia Areata	7.2%
151	Behcet Syndrome	7.1%
152	Hyperkeratosis, Epidermolytic	6.9%
153	Ichthyosis, X-Linked	6.9%
154	Sjogren-Larsson Syndrome	6.8%
155	Alopecia	6.7%
156	Sweating, Gustatory	6.7%
157	Androgenetic Alopecia	6.7%
158	Auriculotemporal Syndrome	6.7%
159	Lice Infestations	6.5%
160	Varicose Ulcer	6.5%
161	Hidradenitis Suppurativa	6.5%
162	Breast Neoplasms, Male	6.5%
163	Triple Negative Breast Neoplasms	6.5%
164	Galactorrhea	6.5%
165	Nail-Patella Syndrome	6.1%
166	Erythema Chronicum Migrans	6.1%
167	Porphyrias, Hepatic	6%
168	Cartilage Diseases	6%
169	Rheumatism	6%
170	Chondromalacia	6%
171	Lupus Erythematosus, Systemic	5.7%
172	Overlap syndrome	5.7%
173	Tinea Pedis	5.6%
174	Larva Migrans	5%
175	Leishmaniasis	5%
176	Molluscum Contagiosum	5%
177	Lichen Planus, Oral	5%
178	Angioedema	5%
179	Onchocerciasis	4.9%
180	Scleromyxedema	4.9%
181	Chromoblastomycosis	4.9%
182	Dermatophytosis	4.9%
183	Sporotrichosis	4.9%
184	Tinea	4.9%
185	Tinea Versicolor	4.9%
186	Trichophytosis	4.9%
187	Hyalohyphomycosis	4.9%
188	Mycetoma	4.9%
189	Acute Generalized Exanthematous Pustulosis	4.8%
190	Dupuytren Contracture	4.1%
191	Warts	4.1%
192	Candidiasis, Chronic Mucocutaneous	3.9%
193	Cutaneous Candidiasis	3.9%
194	Erysipelas	3.9%
195	Serum Sickness	3.9%
196	Staphylococcal Skin Infections	3.9%
197	Variegate Porphyria	3.9%
198	Acute intermittent porphyria	3.9%
199	Porphyria Cutanea Tarda	3.9%
200	Erythrasma	3.9%
201	Carcinoma, Lobular	3.9%
202	Arthritis, Psoriatic	3.9%
203	CREST Syndrome	3.7%
204	Giant Cell Arteritis	3.7%
205	Temporal Arteritis	3.7%
206	Leishmaniasis, Cutaneous	3.6%
207	Eczema Herpeticum	3.6%
208	Fusariosis	3.6%
209	Mesenteric Panniculitis	3.4%
210	Panniculitis, Peritoneal	3.4%
211	Tietze's Syndrome	3.4%
212	Orbital Cellulitis	3.4%
213	Myxoid cyst	3.4%
214	Cellulitis	3.3%
215	Myxedema	3.3%
216	Hereditary Angioedema Type III	3%
217	Hereditary Angioedema Types I and II	3%
218	Angioedemas, Hereditary	3%
219	Epidermodysplasia Verruciformis	2.9%
220	Herpes Labialis	2.9%
221	Diabetic Foot	2.9%
222	Staphylococcal Scalded Skin Syndrome	2.9%
223	Blastomycosis	2.8%
224	HIV-Associated Lipodystrophy Syndrome	2.8%
225	Menkes Kinky Hair Syndrome	2.6%
226	Osteochondritis	2.6%
227	Polymyalgia Rheumatica	2.6%
228	Rhinoscleroma	2.5%
229	Osteogenesis Imperfecta	2.5%
230	Condylomata Acuminata	2.5%
231	Furunculosis	2.4%
232	Keloid	2.4%
233	furuncle	2.4%
234	Impetigo	2.4%
235	carbuncle	2.4%
236	Noonan Syndrome	2.4%
237	Marfan Syndrome	2.1%
238	Rheumatoid Arthritis	2%
239	Juvenile arthritis	2%
240	Homocystinuria	2%
241	Lupus Nephritis	1.9%
242	Laryngomalacia	1.7%
243	Pectus carinatum	1.7%
244	Rheumatoid Nodule	1.6%
245	Felty Syndrome	1.3%
246	Bronchomalacia	1.3%
247	Tracheomalacia	1.3%
248	Rheumatoid Vasculitis	1.1%
249	Mucopolysaccharidosis III	1.1%
250	Sicca Syndrome	0.9%
251	Sjogren's Syndrome	0.9%
252	Lupus Vasculitis, Central Nervous System	0.8%
253	Mucopolysaccharidosis II	0.7%

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