MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Lentigo

(UMLS:C0023321)

Definition:: Small circumscribed melanoses resembling, but differing histologically from, freckles. The concept includes senile lentigo ('liver spots') and nevoid lentigo (nevus spilus, lentigo simplex) and may also occur in association with multiple congenital defects or congenital syndromes (e.g., Peutz-Jeghers syndrome).
UMLS ID:: C0023321
MeSH ID:: D007911

Classification:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.800.621.430.530.550

Synonym(s)

Lentigo

LENTIGINES

LENTIGO

Lentiginosis

Lentigo, NOS

lentiginosis

lentigo

lentigos

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Fingolimod Hydrochloride	FAERS: 74 Canada Vigilance: 1		Canada Vigilance US FAERS
2	Tacrolimus	FAERS: 16		US FAERS
3	Voriconazole	FAERS: 8		US FAERS
4	Alendronate	FAERS: 7		US FAERS
5	Sunitinib	FAERS: 4		OFFSIDES US FAERS
6	Isotretinoin	FAERS: 3		US FAERS
7	Finasteride	FAERS: 2		US FAERS
8	Imatinib Mesylate	FAERS: 2		US FAERS
9	Methylprednisolone Acetate	FAERS: 2		US FAERS
10	Warfarin	FAERS: 2		US FAERS
11	Atorvastatin	FAERS: 1		US FAERS
12	Clonazepam	FAERS: 1		US FAERS
13	Clozapine	FAERS: 1		US FAERS
14	Cyclosporine	FAERS: 1		US FAERS
15	Erlotinib Hydrochloride	FAERS: 1		US FAERS
16	Exenatide	FAERS: 1		US FAERS
17	Lamotrigine	FAERS: 1		US FAERS
18	Lenalidomide	FAERS: 1		US FAERS
19	Mefloquine	FAERS: 1		US FAERS
20	Minoxidil	FAERS: 1		US FAERS
21	Norgestrel	FAERS: 1		US FAERS
22	Omeprazole	FAERS: 1		US FAERS
23	Ortho Evra	FAERS: 1		US FAERS
24	Oxcarbazepine	FAERS: 1		US FAERS
25	Quetiapine Fumarate	FAERS: 1		US FAERS
26	Sildenafil Citrate	FAERS: 1		US FAERS
27	Sorafenib	FAERS: 1		US FAERS
28	Tretinoin	FAERS: 1	8601654	CTD OFFSIDES US FAERS
29	Verapamil	FAERS: 1		US FAERS
30	etonogestrel	FAERS: 1		US FAERS
31	exemestane	FAERS: 1		OFFSIDES US FAERS
32	Ciclopirox			OFFSIDES
33	Ciclopirox			OFFSIDES
34	Dioctyl Sulfosuccinic Acid			OFFSIDES
35	Doxepin			OFFSIDES
36	Dutasteride			OFFSIDES
37	Epinephrine			OFFSIDES
38	Famotidine			OFFSIDES
39	Mometasone Furoate			OFFSIDES
40	Mupirocin			OFFSIDES
41	Naloxone			OFFSIDES
42	NuvaRing			OFFSIDES
43	Octreotide			OFFSIDES
44	Pamidronate			OFFSIDES
45	Phenazopyridine			OFFSIDES
46	Sirolimus			OFFSIDES
47	Tranexamic Acid			OFFSIDES
48	Trichloroacetic Acid		8601654	CTD
49	zafirlukast			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Acanthosis Nigricans	49.2%
2	Breast Diseases	22.7%
3	Dermatitis	22.7%
4	Exanthema	22.7%
5	Facial Dermatoses	22.7%
6	Hair Diseases	22.7%
7	Hand Dermatoses	22.7%
8	keratoacanthoma	22.7%
9	Keratosis	22.7%
10	Nail Diseases	22.7%
11	Photosensitivity Disorders	22.7%
12	Prurigo	22.7%
13	Pyoderma	22.7%
14	Rosacea	22.7%
15	Sebaceous Gland Diseases	22.7%
16	Skin Diseases, Vesiculobullous	22.7%
17	Skin Ulcer	22.7%
18	Sweat Gland Diseases	22.7%
19	Skin Diseases, Papulosquamous	22.7%
20	Skin Diseases, Vascular	22.7%
21	Acneiform Eruptions	22.7%
22	Ocular Rosacea	22.7%
23	Subcorneal pustular dermatosis	22.7%
24	Erythematotelangiectatic Rosacea	22.7%
25	Papulopustular Rosacea	22.7%
26	Chronic Actinic Dermatitis	22.7%
27	Lupus Erythematosus, Cutaneous	20.6%
28	Panniculitis	20.6%
29	Systemic Scleroderma	20.6%
30	Morphea	20.6%
31	Argyria	19.1%
32	Pyoderma Gangrenosum	18.5%
33	Urticaria Pigmentosa	17.7%
34	Vitiligo	16.8%
35	Acne Vulgaris	16.4%
36	Contact Dermatitis	16.4%
37	Eczema	16.4%
38	Erythema Multiforme	16.4%
39	Intertrigo	16.4%
40	Neurodermatitis	16.4%
41	Rhinophyma	16.4%
42	Perioral Dermatitis	16.4%
43	Acne	16.4%
44	Foot Diseases	16.2%
45	Skin Abnormalities	15.4%
46	Skin Diseases, Infectious	15.4%
47	Skin Neoplasms	15.4%
48	Connective Tissue Diseases	15.3%
49	Lipomatosis	15.1%
50	Pruritus	15.1%
51	Erythema	15.1%
52	Necrolytic Migratory Erythema	15.1%
53	Cutaneous Fistula	15.1%
54	Nephrogenic Fibrosing Dermopathy	15.1%
55	Nephrogenic Systemic Fibrosis	15.1%
56	Xeroderma Pigmentosum	14.8%
57	Foot Ulcer	13%
58	Dermatitis Herpetiformis	12.6%
59	Dermatitis, Atopic	12.4%
60	Epidermolysis Bullosa	12.4%
61	Acrodermatitis	12.3%
62	Sebaceous Gland Neoplasms	12.3%
63	Porokeratosis	12.3%
64	Gianotti-Crosti Syndrome	12.3%
65	Keratoderma, Palmoplantar	12.3%
66	Anhidrosis	12.2%
67	Cholesteatoma	12.2%
68	Pressure Ulcer	12.2%
69	Folliculitis	12.2%
70	Foot Dermatoses	12.2%
71	Gynecomastia	12.2%
72	Hypertrichosis	12.2%
73	Hypohidrosis	12.2%
74	Hypotrichosis	12.2%
75	Leg Ulcer	12.2%
76	Miliaria	12.2%
77	Parakeratosis	12.2%
78	Parapsoriasis	12.2%
79	Pityriasis	12.2%
80	Psoriasis	12.2%
81	Sweet Syndrome	12.2%
82	Hidradenitis	12.2%
83	Onycholysis	12.2%
84	Miliaria Rubra	12.2%
85	Lichenoid Eruptions	12.2%
86	Chloracne	12.2%
87	Dermatomyositis	12%
88	Mastocytosis	11.2%
89	Lupus Erythematosus, Discoid	10.9%
90	Scleroderma, Limited	10.9%
91	Dermatitis, Phototoxic	10.8%
92	Pityriasis Lichenoides et Varioliformis Acuta	10.8%
93	Pityriasis Lichenoides	10.8%
94	Phototoxicity	10.8%
95	Necrobiosis Lipoidica Diabeticorum	10.8%
96	Panniculitis, Lupus Erythematosus	10.4%
97	Cutis Laxa	10%
98	Xeroderma	10%
99	Dermatitis, Irritant	9.6%
100	Acne Conglobata	9.6%
101	Dermatitis, Photoallergic	8.7%
102	Acantholysis	8.4%
103	Breast Cyst	8.4%
104	Actinic keratosis	8.4%
105	Pemphigoid, Benign Mucous Membrane	8.4%
106	Pemphigus	8.4%
107	Piedra	8.4%
108	Sunburn	8.4%
109	Erythema Induratum	8.3%
110	Ectodermal Dysplasia	8.3%
111	Aplasia Cutis Congenita	8.3%
112	Hirsutism	8.2%
113	Lactation Disorder	8.2%
114	Mastitis	8.2%
115	Urticaria	8.2%
116	Adiposis Dolorosa	8.1%
117	Pruritus Vulvae	8.1%
118	Pseudoxanthoma Elasticum	8.1%
119	Mastocytoma	8.1%
120	Pruritus Ani	8.1%
121	Erythema Infectiosum	8%
122	Exanthema Subitum	7.9%
123	Erythema Nodosum	7.8%
124	Dermatitis, Occupational	7.7%
125	Collagen Diseases	7.6%
126	Mixed Connective Tissue Disease	7.6%
127	Mucinoses	7.6%
128	Albinism	7.4%
129	Granuloma Annulare	7.3%
130	Dermatitis, Allergic Contact	7.3%
131	Papillon-Lefevre Disease	7.2%
132	Lichen Planus	7.2%
133	Pityriasis Rosea	7.2%
134	Pityriasis Rubra Pilaris	7.2%
135	Lichen Nitidus	7.2%
136	Tinea Capitis	6.8%
137	Onychomycosis	6.8%
138	Ecthyma	6.5%
139	Diaper Rash	6.3%
140	Dermatomycoses	6.3%
141	Mucocutaneous Lymph Node Syndrome	6.3%
142	Skin Diseases, Bacterial	6.3%
143	Toxic Epidermal Necrolysis	6.2%
144	Stevens-Johnson Syndrome	6.2%
145	Drug Eruptions	6.2%
146	Lipodystrophy	6.2%
147	Livedo Reticularis	6.2%
148	Malignant Atrophic Papulosis	6.2%
149	Polyarteritis Nodosa	6.1%
150	Takayasu Arteritis	6.1%
151	Behcet Syndrome	5.7%
152	Cartilage Diseases	5.4%
153	Rheumatism	5.4%
154	Chondromalacia	5.4%
155	Ichthyosis, X-Linked	5.4%
156	Sjogren-Larsson Syndrome	5.3%
157	Lupus Erythematosus, Systemic	5.1%
158	Overlap syndrome	5.1%
159	Nail-Patella Syndrome	5.1%
160	Porphyrias, Hepatic	5%
161	Alopecia	5%
162	Sweating, Gustatory	5%
163	Androgenetic Alopecia	5%
164	Auriculotemporal Syndrome	5%
165	Hidradenitis Suppurativa	4.9%
166	Lice Infestations	4.9%
167	Varicose Ulcer	4.9%
168	Breast Neoplasms, Male	4.9%
169	Triple Negative Breast Neoplasms	4.9%
170	Erythema Chronicum Migrans	4.8%
171	Galactorrhea	4.8%
172	Hyperkeratosis, Epidermolytic	4.8%
173	Alopecia Areata	4.8%
174	Scleromyxedema	4.1%
175	Tinea Pedis	4%
176	Larva Migrans	3.7%
177	Leishmaniasis	3.7%
178	Molluscum Contagiosum	3.7%
179	Dupuytren Contracture	3.7%
180	Angioedema	3.7%
181	Onchocerciasis	3.7%
182	Chromoblastomycosis	3.6%
183	Dermatophytosis	3.6%
184	Mycetoma	3.6%
185	Sporotrichosis	3.6%
186	Tinea	3.6%
187	Tinea Versicolor	3.6%
188	Trichophytosis	3.6%
189	Hyalohyphomycosis	3.6%
190	Acute Generalized Exanthematous Pustulosis	3.6%
191	Lichen Planus, Oral	3.3%
192	Giant Cell Arteritis	3%
193	Temporal Arteritis	3%
194	Warts	3%
195	Cellulitis	3%
196	Candidiasis, Chronic Mucocutaneous	2.9%
197	Cutaneous Candidiasis	2.9%
198	Erysipelas	2.9%
199	Serum Sickness	2.9%
200	Staphylococcal Skin Infections	2.9%
201	Variegate Porphyria	2.9%
202	Acute intermittent porphyria	2.9%
203	Porphyria Cutanea Tarda	2.9%
204	Erythrasma	2.9%
205	Carcinoma, Lobular	2.9%
206	Arthritis, Psoriatic	2.9%
207	Mesenteric Panniculitis	2.8%
208	Panniculitis, Peritoneal	2.8%
209	Tietze's Syndrome	2.8%
210	Orbital Cellulitis	2.8%
211	Myxoid cyst	2.8%
212	CREST Syndrome	2.8%
213	Myxedema	2.7%
214	Leishmaniasis, Cutaneous	2.4%
215	Eczema Herpeticum	2.4%
216	Fusariosis	2.4%
217	Menkes Kinky Hair Syndrome	2.2%
218	Noonan Syndrome	2.1%
219	Osteochondritis	2.1%
220	Polymyalgia Rheumatica	2.1%
221	Blastomycosis	2.1%
222	Osteogenesis Imperfecta	2.1%
223	HIV-Associated Lipodystrophy Syndrome	2.1%
224	Keloid	2%
225	Angioedemas, Hereditary	2%
226	Epidermodysplasia Verruciformis	1.9%
227	Herpes Labialis	1.9%
228	Diabetic Foot	1.9%
229	Staphylococcal Scalded Skin Syndrome	1.9%
230	Marfan Syndrome	1.9%
231	Rhinoscleroma	1.9%
232	Homocystinuria	1.8%
233	Hereditary Angioedema Type III	1.8%
234	Hereditary Angioedema Types I and II	1.8%
235	Rheumatoid Arthritis	1.7%
236	Juvenile arthritis	1.7%
237	Condylomata Acuminata	1.6%
238	Furunculosis	1.6%
239	furuncle	1.6%
240	Lupus Nephritis	1.6%
241	Impetigo	1.6%
242	Laryngomalacia	1.4%
243	carbuncle	1.4%
244	Pectus carinatum	1.4%
245	Rheumatoid Nodule	1.2%
246	Felty Syndrome	1%
247	Bronchomalacia	1%
248	Tracheomalacia	1%
249	Rheumatoid Vasculitis	0.8%
250	Mucopolysaccharidosis III	0.8%
251	Sicca Syndrome	0.7%
252	Sjogren's Syndrome	0.7%
253	Lupus Vasculitis, Central Nervous System	0.7%
254	Mucopolysaccharidosis II	0.5%

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