MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Primary Myelofibrosis

(UMLS:C0001815)

Definition:: A de novo myeloproliferation arising from an abnormal stem cell. It is characterized by the replacement of bone marrow by fibrous tissue, a process that is mediated by CYTOKINES arising from the abnormal clone.
UMLS ID:: C0001815
MeSH ID:: D055728

Classification:

Name:

Hemic and Lymphatic Diseases
MeSH Tree Number(s):: C15.378.190.636.765

Synonym(s)

Primary Myelofibrosis

Agnogenic Myeloid Metaplasia

Agnogenic myeloid metaplasia

Aleukemic myelosis

Chronic Idiopathic Myelofibrosis

Chronic idiopathic myelofibrosis

Idiopathic Bone Marrow Fibrosis

Idiopathic Myelofibrosis

MOS

10.

MYELOFIBROSIS

11.

MYELOFIBROSIS AND MYELOID METAPLASIA

12.

MYELOID METAPLASIA

13.

MYELOID METAPLASIA AGNOGENIC

14.

MYELOID METAPLASIA PRIMARY MYELOFIBROSIS

15.

MYELOID METAPLASIA, AGNOGENIC

16.

MYELOSCLEROSIS

17.

MYELOSIS NON-LEUKEMIC

18.

MYELOSIS, ALEUKEMIC

19.

Megakaryocytic myelosclerosis

20.

Myelofibrosis as a result of myeloproliferative disease

21.

Myelofibrosis with myeloid metaplasia

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Ruxolitinib phosphate	FAERS: 75		US FAERS
2	INCB018424	FAERS: 2		US FAERS
3	Lenalidomide	FAERS: 1	17870158 19720904	CTD US FAERS
4	PCI 32765	FAERS: 1		US FAERS
5	anagrelide	FAERS: 1		US FAERS
6	bosutinib	FAERS: 1		US FAERS
7	Cladribine		15654901	CTD
8	Cytarabine		3428138	CTD
9	Danazol		7847311	CTD
10	Decitabine		17616702	CTD
11	Hydroxyurea		8638610	CTD
12	Melphalan		1803051	CTD
13	Penicillamine		4587169	CTD
14	Phenylbutazone		6071896	CTD
15	Prednisolone		1803051	CTD
16	Prednisone		19720904	CTD
17	Thalidomide		11972510	CTD
18	Uracil Mustard		3369437	CTD
19	trichostatin A		17616702	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Thrombocytosis	42.4%
2	Leukemoid Reaction	38.7%
3	MYELODYSPLASTIC SYNDROME	34.4%
4	Polycythemia Vera	32.3%
5	Thrombocythemia, Essential	30.3%
6	Anemia	25.4%
7	Blood Coagulation Disorders	25.4%
8	Blood Platelet Disorders	25.4%
9	Hemorrhagic Disorders	25.4%
10	Leukocyte Disorders	25.4%
11	Methemoglobinemia	25.4%
12	Pancytopenia	25.4%
13	Polycythemia	25.4%
14	Sulfhemoglobinemia	25.4%
15	Thrombophilia	25.4%
16	Erythrocytosis	25.4%
17	Bone Marrow Neoplasms	24.8%
18	Leukemia, Myeloid, Chronic-Phase	23.9%
19	Disseminated Intravascular Coagulation	22.3%
20	Protein S Deficiency	22.3%
21	Hemoglobinuria, Paroxysmal	21.5%
22	Transfusion Reaction	18.1%
23	Hypotensive Transfusion Reaction	18.1%
24	Pregnancy Complications, Hematologic	17.2%
25	Hematologic Neoplasms	17.2%
26	Lymphatic Diseases	16.4%
27	Thrombasthenia	15.8%
28	Antithrombin III Deficiency	15.8%
29	Protein C Deficiency	15.8%
30	Leukemia, Myelomonocytic, Chronic	15.1%
31	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	15.1%
32	Anemia, Hemolytic	14.8%
33	Anemia, Macrocytic	14.8%
34	Eosinophilia	14.8%
35	Hypoproteinemia	14.8%
36	Leukopenia	14.8%
37	Thrombocytopenia	14.8%
38	Leukostasis	14.8%
39	Vitamin K Deficiency	14.7%
40	Afibrinogenemia	13.7%
41	Factor VII Deficiency	13.7%
42	Factor X Deficiency	13.7%
43	Factor XII Deficiency	13.7%
44	Hemophilia A	13.7%
45	Activated Protein C Resistance	13.7%
46	Factor II deficiency	13.7%
47	Factor VIII Deficiency	13.7%
48	Factor V deficiency	13.7%
49	Factor XI Deficiency	13.7%
50	Hypoprothrombinemias	13.7%
51	Anemia, Diamond-Blackfan	13.5%
52	Anemia, Neonatal	10.1%
53	Leukocytosis	10.1%
54	Paraproteinemias	10.1%
55	Pelger-Huet Anomaly	10.1%
56	Pleocytosis	10.1%
57	Agammaglobulinemia	10.1%
58	Fanconi Anemia	9.7%
59	Agranulocytosis	9.7%
60	Anemia, Megaloblastic	9.7%
61	Lymphocytosis	9.7%
62	Hypoalbuminemia	9.7%
63	Hypereosinophilic syndrome	9.7%
64	Thrombotic Microangiopathies	9.7%
65	Purpura, Thrombotic Thrombocytopenic	9.2%
66	Wiskott-Aldrich Syndrome	9.1%
67	Anemia, Sickle Cell	8.9%
68	Thalassemia	8.9%
69	Adenitis	8.5%
70	Histiocytosis	8.5%
71	Lymphadenitis	8.5%
72	Lymphangitis	8.5%
73	Lymphedema	8.5%
74	Splenic Diseases	8.5%
75	Thymus Hyperplasia	8.5%
76	Pseudolymphoma	8.5%
77	Lymphadenopathy	8.5%
78	Infectious Mononucleosis	7.9%
79	Cryoglobulinemia	7.8%
80	Monoclonal Gammopathy of Undetermined Significance	7.8%
81	Hypergammaglobulinemia	7.7%
82	Transfusion-Related Acute Lung Injury	7.5%
83	Ecchymosis	7.4%
84	Petechiae	7.4%
85	Purpura	7.4%
86	Heavy Chain Disease	7.4%
87	Neutropenia	7.2%
88	Autoimmune thrombocytopenia	7.1%
89	Immune thrombocytopenic purpura	7.1%
90	Waldenstrom Macroglobulinemia	7%
91	Hemolytic-Uremic Syndrome	6.7%
92	Lymphopenia	6.7%
93	Job Syndrome	6.5%
94	Purpura, Hyperglobulinemic	6.5%
95	Sickle Cell Trait	6.3%
96	Febrile Neutropenia	6%
97	Thrombocytopenic purpura	5.8%
98	Lymphocele	5.7%
99	Lymphoproliferative Disorders	5.7%
100	Lymphatic Abnormalities	5.7%
101	Multiple Myeloma	5.6%
102	Thymus Neoplasms	5.6%
103	Hydrops Fetalis	5.6%
104	Atypical Hemolytic Uremic Syndrome	5.2%
105	Eosinophilia-Myalgia Syndrome	5%
106	Pulmonary Eosinophilia	5%
107	Eosinophilic Pneumonia	5%
108	Lymphangiectasis, Intestinal	5%
109	Elephantiasis	4.9%
110	Chronic granulomatous disease	4.9%
111	Hypersplenism	4.9%
112	Sarcoidosis	4.9%
113	Shwartzman Phenomenon	4.9%
114	Elephantiasis Nostras Verrucosa	4.9%
115	Hemangioma, Cavernous	4.9%
116	Scurvy	4.8%
117	Purpura Fulminans	4.8%
118	Waterhouse-Friderichsen Syndrome	4.8%
119	Anemia, Pernicious	4.8%
120	Acute Chest Syndrome	4.6%
121	Eosinophilic Granuloma	4.4%
122	Kernicterus	4.3%
123	Mucocutaneous Lymph Node Syndrome	4.2%
124	POEMS Syndrome	3.9%
125	Granuloma	3.4%
126	Histiocytic Disorders, Malignant	3.4%
127	Splenic Infarction	3.4%
128	Splenic Neoplasms	3.4%
129	Histiocytosis, Langerhans-Cell	3.3%
130	Tumor Lysis Syndrome	3.3%
131	Lymphohistiocytosis, Hemophagocytic	3.2%
132	Erdheim-Chester Disease	3.2%
133	Splenic Rupture	2.6%
134	Lymphoma	2.5%
135	Pseudoxanthoma Elasticum	2.5%
136	Thymoma	2.5%
137	Sezary Syndrome	2.2%
138	Malignant histiocytosis	2.2%
139	Sarcoidosis, Pulmonary	2.2%
140	Histiocytic sarcoma	2.2%
141	Autoimmune Lymphoproliferative Syndrome	2%
142	Splenosis	1.6%
143	Hodgkin Disease	1.6%
144	Lymphoma, Non-Hodgkin	1.6%
145	Leukemia, T-Cell	1.6%
146	Leukemia, B-Cell	1.6%
147	Composite Lymphoma	1.3%
148	Lymphangioleiomyomatosis	1.3%
149	Lymphoma, Follicular	1.2%
150	T-Cell Lymphoma	1.2%
151	Mantle cell lymphoma	1.2%
152	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	1.2%
153	Leukemia, Large Granular Lymphocytic	1.2%
154	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	1.2%
155	Lymphoma, T-Cell, Cutaneous	1%
156	Lymphoma, AIDS-Related	1%
157	Enteropathy-Associated T-Cell Lymphoma	1%
158	Primary Effusion Lymphoma	1%
159	Mycosis Fungoides	0.9%
160	Lymphomatoid Papulosis	0.9%
161	Plasmablastic lymphoma	0.9%
162	Lymphomatoid Granulomatosis	0.8%
163	Burkitt Lymphoma	0.7%
164	Niemann-Pick Disease, Type C	0.4%

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