MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Anemia, Megaloblastic

(UMLS:C0002888)

Definition:: A disorder characterized by the presence of ANEMIA, abnormally large red blood cells (megalocytes or macrocytes), and MEGALOBLASTS.
UMLS ID:: C0002888
MeSH ID:: D000749

Classification:

Name:

Hemic and Lymphatic Diseases
MeSH Tree Number(s):: C15.378.071.252.196

Synonym(s)

Anemia, Megaloblastic

ANAEMIA MEGALOBLASTIC

ANEMIA MEGALOBLASTIC

Anaemia megaloblastic

Anaemia;megaloblastic

MEGALOBLASTIC

MEGALOBLASTIC ANEMIA

Megaloblastic Anemia

Megaloblastic anaemia

10.

Megaloblastic anaemia, NOS

11.

Megaloblastic anemia

12.

Megaloblastic anemia, NOS

13.

anemia megaloblastic

14.

anemia; megaloblastic

15.

megaloblastic

16.

megaloblastic anaemia

17.

megaloblastic anemia

Associated Drug(s)

	Name	Reference(s)	Data Source
1	6-thioguanylic acid	6704287	CTD
2	Acyclovir	6130274	CTD
3	Ascorbic Acid	16353713	CTD
4	Azathioprine	View details 273109 5131885 6704287 7191017 9535611	CTD
5	Chlorambucil	15656036	CTD
6	Chloroquine	18057166	CTD
7	Colchicine	15656036	CTD
8	Cyclophosphamide	15656036	CTD
9	Fluorouracil	5917383 11129139	CTD
10	Folic Acid	View details 601569 1922593 2535199 4169978 4175396 4264432 4627864 4729182 5618821 6021848 8349867 14227437 16353713 19110522	CTD
11	Leucovorin	View details 4005162 8124920 21310276 21310277	CTD
12	Lithium Carbonate	7246823	CTD
13	Maloprim	View details 63088 828128 1256293 3628888 5141843 7280928 7741386	CTD
14	Medroxyprogesterone Acetate	6520357	CTD
15	Metformin	7388472 12772378	CTD
16	Methotrexate	View details 3947544 4005162 5917383 6018206 8124920 8349867 10458822	CTD
17	Niacin	16353713	CTD
18	Nitrofurantoin	869654	CTD
19	Norethindrone Acetate	974714	CTD
20	Norinyl	974714	CTD
21	Pentamidine	11801480	CTD
22	Phenformin	12772378	CTD
23	Phenobarbital	4627864	CTD
24	Phenytoin	1147459 4169978 4627864	CTD
25	Prednisolone	19110522	CTD
26	Primidone	View details 2535199 4169978 4627864 5618821	CTD
27	Proguanil	18057166	CTD
28	Pyrazinamide	4731775	CTD
29	Sulfasalazine	View details 2872667 2905757 8568395 10434561 19110522	CTD
30	Tetracycline	4268307	CTD
31	Triamterene	313333 5455994 16187172	CTD
32	Trimethoprim, Sulfamethoxazole Drug Combination	View details 63088 593952 828128 4729182 6972183 9145363	CTD
33	Uridine	1036874	CTD
34	Vitamin B 12	View details 3057748 4169978 4627864 5984971 6685839 9001810 11182287 12772378 15559613 16353713 19556642	CTD
35	azaribine	1036874	CTD
36	cobamamide	3057748	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Anemia, Hemolytic	34.4%
2	Blood Coagulation Disorders	25.4%
3	Blood Platelet Disorders	25.4%
4	Bone Marrow Diseases	25.4%
5	Hemorrhagic Disorders	25.4%
6	Leukocyte Disorders	25.4%
7	Methemoglobinemia	25.4%
8	Pancytopenia	25.4%
9	Polycythemia	25.4%
10	Sulfhemoglobinemia	25.4%
11	Thrombophilia	25.4%
12	Erythrocytosis	25.4%
13	Anemia, Neonatal	23.6%
14	Disseminated Intravascular Coagulation	22.3%
15	Protein S Deficiency	22.3%
16	Hemoglobinuria, Paroxysmal	21.5%
17	Anemia, Diamond-Blackfan	18.7%
18	Thrombocythemia, Essential	18.6%
19	Transfusion Reaction	18.1%
20	Hypotensive Transfusion Reaction	18.1%
21	Pregnancy Complications, Hematologic	17.2%
22	Hematologic Neoplasms	17.2%
23	Lymphatic Diseases	16.4%
24	Thrombocytosis	16.3%
25	Thrombasthenia	15.8%
26	Antithrombin III Deficiency	15.8%
27	Protein C Deficiency	15.8%
28	Bone Marrow Neoplasms	14.9%
29	Eosinophilia	14.8%
30	Hypoproteinemia	14.8%
31	Leukopenia	14.8%
32	Thrombocytopenia	14.8%
33	Leukostasis	14.8%
34	MYELODYSPLASTIC SYNDROME	14.8%
35	Vitamin K Deficiency	14.7%
36	Afibrinogenemia	13.7%
37	Factor VII Deficiency	13.7%
38	Factor X Deficiency	13.7%
39	Factor XII Deficiency	13.7%
40	Hemophilia A	13.7%
41	Activated Protein C Resistance	13.7%
42	Factor II deficiency	13.7%
43	Factor VIII Deficiency	13.7%
44	Factor V deficiency	13.7%
45	Factor XI Deficiency	13.7%
46	Hypoprothrombinemias	13.7%
47	Leukemoid Reaction	12.9%
48	Anemia, Sickle Cell	12.8%
49	Thalassemia	12.8%
50	Hemolytic-Uremic Syndrome	11.9%
51	Polycythemia Vera	11.6%
52	Leukocytosis	10.1%
53	Paraproteinemias	10.1%
54	Pelger-Huet Anomaly	10.1%
55	Pleocytosis	10.1%
56	Agammaglobulinemia	10.1%
57	Fanconi Anemia	9.7%
58	Primary Myelofibrosis	9.7%
59	Agranulocytosis	9.7%
60	Lymphocytosis	9.7%
61	Myelofibrosis	9.7%
62	Myeloid Metaplasia	9.7%
63	Hypoalbuminemia	9.7%
64	Hypereosinophilic syndrome	9.7%
65	bone marrow fibrosis	9.7%
66	Thrombotic Microangiopathies	9.7%
67	Sickle Cell Trait	9.5%
68	Purpura, Thrombotic Thrombocytopenic	9.2%
69	Wiskott-Aldrich Syndrome	9.1%
70	Atypical Hemolytic Uremic Syndrome	9%
71	Adenitis	8.5%
72	Histiocytosis	8.5%
73	Lymphadenitis	8.5%
74	Lymphangitis	8.5%
75	Lymphedema	8.5%
76	Splenic Diseases	8.5%
77	Thymus Hyperplasia	8.5%
78	Pseudolymphoma	8.5%
79	Lymphadenopathy	8.5%
80	Infectious Mononucleosis	7.9%
81	Cryoglobulinemia	7.8%
82	Monoclonal Gammopathy of Undetermined Significance	7.8%
83	Hypergammaglobulinemia	7.7%
84	Transfusion-Related Acute Lung Injury	7.5%
85	Ecchymosis	7.4%
86	Petechiae	7.4%
87	Purpura	7.4%
88	Heavy Chain Disease	7.4%
89	Neutropenia	7.2%
90	Autoimmune thrombocytopenia	7.1%
91	Immune thrombocytopenic purpura	7.1%
92	Waldenstrom Macroglobulinemia	7%
93	Acute Chest Syndrome	7%
94	Lymphopenia	6.7%
95	Job Syndrome	6.5%
96	Purpura, Hyperglobulinemic	6.5%
97	Leukemia, Myelomonocytic, Chronic	6.5%
98	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	6.5%
99	Febrile Neutropenia	6%
100	Thrombocytopenic purpura	5.8%
101	Lymphocele	5.7%
102	Lymphoproliferative Disorders	5.7%
103	Lymphatic Abnormalities	5.7%
104	Multiple Myeloma	5.6%
105	Thymus Neoplasms	5.6%
106	Hydrops Fetalis	5.6%
107	Eosinophilia-Myalgia Syndrome	5%
108	Pulmonary Eosinophilia	5%
109	Eosinophilic Pneumonia	5%
110	Lymphangiectasis, Intestinal	5%
111	Elephantiasis	4.9%
112	Chronic granulomatous disease	4.9%
113	Hypersplenism	4.9%
114	Sarcoidosis	4.9%
115	Shwartzman Phenomenon	4.9%
116	Elephantiasis Nostras Verrucosa	4.9%
117	Hemangioma, Cavernous	4.9%
118	Scurvy	4.8%
119	Purpura Fulminans	4.8%
120	Waterhouse-Friderichsen Syndrome	4.8%
121	Leukemia, Myeloid, Chronic-Phase	4.8%
122	Eosinophilic Granuloma	4.4%
123	Kernicterus	4.3%
124	Mucocutaneous Lymph Node Syndrome	4.2%
125	POEMS Syndrome	3.9%
126	Granuloma	3.4%
127	Histiocytic Disorders, Malignant	3.4%
128	Splenic Infarction	3.4%
129	Splenic Neoplasms	3.4%
130	Histiocytosis, Langerhans-Cell	3.3%
131	Tumor Lysis Syndrome	3.3%
132	Lymphohistiocytosis, Hemophagocytic	3.2%
133	Erdheim-Chester Disease	3.2%
134	Splenic Rupture	2.6%
135	Lymphoma	2.5%
136	Pseudoxanthoma Elasticum	2.5%
137	Thymoma	2.5%
138	Sezary Syndrome	2.2%
139	Malignant histiocytosis	2.2%
140	Sarcoidosis, Pulmonary	2.2%
141	Histiocytic sarcoma	2.2%
142	Autoimmune Lymphoproliferative Syndrome	2%
143	Splenosis	1.6%
144	Hodgkin Disease	1.6%
145	Lymphoma, Non-Hodgkin	1.6%
146	Leukemia, T-Cell	1.6%
147	Leukemia, B-Cell	1.6%
148	Composite Lymphoma	1.3%
149	Lymphangioleiomyomatosis	1.3%
150	Lymphoma, Follicular	1.2%
151	T-Cell Lymphoma	1.2%
152	Mantle cell lymphoma	1.2%
153	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	1.2%
154	Leukemia, Large Granular Lymphocytic	1.2%
155	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	1.2%
156	Lymphoma, T-Cell, Cutaneous	1%
157	Lymphoma, AIDS-Related	1%
158	Enteropathy-Associated T-Cell Lymphoma	1%
159	Primary Effusion Lymphoma	1%
160	Mycosis Fungoides	0.9%
161	Lymphomatoid Papulosis	0.9%
162	Plasmablastic lymphoma	0.9%
163	Lymphomatoid Granulomatosis	0.8%
164	Burkitt Lymphoma	0.7%
165	Niemann-Pick Disease, Type C	0.4%

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