MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Splenic Rupture

(UMLS:C0038000)

Definition:: Rupture of the SPLEEN due to trauma or disease.
UMLS ID:: C0038000
MeSH ID:: D013161

Classification 1:

Name:

Hemic and Lymphatic Diseases
MeSH Tree Number(s):: C15.604.744.742

Classification 2:

Name:

Wounds and Injuries
MeSH Tree Number(s):: C26.017.680|C26.761.555

Synonym(s)

Splenic Rupture

Disruption of spleen

Fragmentation of spleen

Pulped spleen

RUPTURE OF SPLEEN

Rupture of spleen

Rupture;spleen

Ruptured spleen

SPLEEN RUPTURE

10.

SPLEEN, RUPTURE

11.

Splenic rupture

12.

rupture of spleen

13.

rupture spleen

14.

rupture splenic

15.

rupture; spleen

16.

ruptured spleen

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Rivaroxaban	FAERS: 64 Canada Vigilance: 3	Canada Vigilance US FAERS
2	Dabigatran	FAERS: 47 Canada Vigilance: 1	Canada Vigilance US FAERS
3	Ruxolitinib phosphate	FAERS: 15	US FAERS
4	PCI 32765	FAERS: 13 Canada Vigilance: 4	Canada Vigilance US FAERS
5	Imatinib Mesylate	FAERS: 10	US FAERS
6	reviparin	FAERS: 9	US FAERS
7	apixaban	FAERS: 8	US FAERS
8	Lenalidomide	FAERS: 7 Canada Vigilance: 1	Canada Vigilance US FAERS
9	Thalidomide	FAERS: 6	US FAERS
10	ponatinib	FAERS: 5	US FAERS
11	Azacitidine	FAERS: 4	US FAERS
12	Bosentan	FAERS: 4	US FAERS
13	Diazepam	FAERS: 4	US FAERS
14	Dimethyl Fumarate	FAERS: 4	US FAERS
15	Fingolimod Hydrochloride	FAERS: 3	US FAERS
16	Tiotropium Bromide	FAERS: 3	US FAERS
17	Warfarin	FAERS: 3	US FAERS
18	Warfarin	FAERS: 3	US FAERS
19	ambrisentan	FAERS: 3	US FAERS
20	rofecoxib	FAERS: 3	US FAERS
21	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	FAERS: 2	US FAERS
22	Alprazolam	FAERS: 2	US FAERS
23	Bortezomib	FAERS: 2	US FAERS
24	Cilostazol	FAERS: 2	US FAERS
25	Cinacalcet	FAERS: 2	US FAERS
26	Clopidogrel	FAERS: 2	US FAERS
27	Deferasirox	FAERS: 2	US FAERS
28	Duloxetine Hydrochloride	FAERS: 2	US FAERS
29	INCB018424	FAERS: 2	US FAERS
30	Imatinib Mesylate	FAERS: 2	US FAERS
31	Isotretinoin	FAERS: 2	US FAERS
32	Losartan	FAERS: 2	US FAERS
33	Olanzapine	FAERS: 2	US FAERS
34	Omeprazole	FAERS: 2	US FAERS
35	Rosuvastatin Calcium	FAERS: 2	US FAERS
36	Sitagliptin Phosphate	FAERS: 2	US FAERS
37	Testosterone	FAERS: 2	US FAERS
38	Varenicline	FAERS: 2	US FAERS
39	Zoledronic Acid	FAERS: 2	US FAERS
40	atovaquone, proguanil drug combination	FAERS: 2 Canada Vigilance: 2	Canada Vigilance US FAERS
41	4-hydroxybutyric acid	FAERS: 1	US FAERS
42	Amphetamine	FAERS: 1	US FAERS
43	Aspirin	FAERS: 1	US FAERS
44	Budesonide	FAERS: 1	US FAERS
45	Canagliflozin	FAERS: 1	US FAERS
46	Dasatinib	FAERS: 1	US FAERS
47	Decitabine	FAERS: 1	US FAERS
48	F8 protein, human	FAERS: 1	US FAERS
49	Febuxostat	FAERS: 1	US FAERS
50	Fondaparinux	FAERS: 1	US FAERS
51	Fondaparinux	FAERS: 1	US FAERS
52	Gabapentin	FAERS: 1	US FAERS
53	Ibandronic Acid	FAERS: 1	US FAERS
54	LCZ 696	FAERS: 1	US FAERS
55	Levofloxacin	FAERS: 1	US FAERS
56	Naltrexone	FAERS: 1	US FAERS
57	Naproxen	FAERS: 1	US FAERS
58	Oxcarbazepine	FAERS: 1	US FAERS
59	Oxymetholone	FAERS: 1	US FAERS
60	Propofol	FAERS: 1	US FAERS
61	Ramipril	FAERS: 1	US FAERS
62	Rivastigmine	FAERS: 1	US FAERS
63	Sertraline	FAERS: 1	US FAERS
64	Sildenafil Citrate	FAERS: 1	US FAERS
65	Sirolimus	FAERS: 1	US FAERS
66	Sumatriptan	FAERS: 1	US FAERS
67	Teriparatide	FAERS: 1	US FAERS
68	Topiramate	FAERS: 1	US FAERS
69	Tramadol	FAERS: 1	US FAERS
70	Vemurafenib	FAERS: 1	US FAERS
71	anagrelide	FAERS: 1	US FAERS
72	carbidopa, levodopa drug combination	FAERS: 1	US FAERS
73	ceritinib	FAERS: 1	US FAERS
74	edoxaban	FAERS: 1	US FAERS
75	idelalisib	FAERS: 1	US FAERS
76	ledipasvir, sofosbuvir drug combination	FAERS: 1	US FAERS
77	macitentan	FAERS: 1	US FAERS
78	niraparib	FAERS: 1	US FAERS
79	temsirolimus	FAERS: 1	US FAERS
80	Pregabalin		SIDER
81	trans		SIDER

Similar ADE(s)

	Name	Semantic Similarity
1	Frostbite	29%
2	Hypersplenism	24.1%
3	Hip Fractures	23%
4	Crush syndrome	22.5%
5	Femoral Fractures	22.5%
6	Tibial Fractures	22.5%
7	Athletic Injuries	21.8%
8	Hand Injuries	21.8%
9	Soft Tissue Injuries	21.8%
10	Sprain	21.8%
11	Sprains and Strains	21.8%
12	Tendon Injuries	21.8%
13	Laceration	21.8%
14	Wounds, Penetrating	21.8%
15	Heat Cramps	21.8%
16	Chilblains	19.4%
17	Splenic Infarction	19.4%
18	Splenic Neoplasms	19.4%
19	Spinal Fractures	19.4%
20	Hip Dislocation	18.6%
21	Shoulder Dislocation	18.6%
22	Hip Dysplasia	18.6%
23	Uterine Rupture	18.3%
24	Trauma, Nervous System	17.9%
25	Bites and Stings	17.4%
26	Extravasation of Diagnostic and Therapeutic Materials	17.4%
27	Vascular System Injuries	17.4%
28	Tympanic Membrane Perforation	17.4%
29	Tooth Injuries	17.4%
30	Asphyxia	17.1%
31	Esophageal Perforation	17.1%
32	Shock, Traumatic	17.1%
33	Self Mutilation	17%
34	Iliotibial Band Syndrome	16.4%
35	Uterine Perforation	16.3%
36	Adenitis	15.8%
37	Histiocytosis	15.8%
38	Lymphadenitis	15.8%
39	Lymphangitis	15.8%
40	Lymphedema	15.8%
41	Thymus Hyperplasia	15.8%
42	Pseudolymphoma	15.8%
43	Lymphadenopathy	15.8%
44	Aortic Rupture	15.5%
45	Spinal Cord Injuries	14.3%
46	Eye Burns	14.1%
47	Drowning	14.1%
48	Human Bite	14%
49	Contusions	14%
50	Decompression Sickness	14%
51	Finger Injuries	14%
52	Flail Chest	14%
53	Fractures, Closed	14%
54	Pathological fracture	14%
55	Heart Injuries	14%
56	Heat Exhaustion	14%
57	Heat Stroke	14%
58	Knee Injuries	14%
59	Foot Injuries	14%
60	Decapitation	14%
61	Ankle Fracture	14%
62	Avulsion fracture	14%
63	Compression fracture	14%
64	Osteoporotic Fractures	14%
65	Lymphangiectasis, Intestinal	13.6%
66	Lymphocele	12.7%
67	Lymphoproliferative Disorders	12.7%
68	Lymphatic Abnormalities	12.7%
69	Thymus Neoplasms	12.5%
70	Radiation injury	11.9%
71	Brain Concussion	11.4%
72	Craniocerebral Trauma	11.3%
73	Tendinitis	11.3%
74	Lung Injury	11.3%
75	Tendinopathy	11.3%
76	Foreign-Body Reaction	11.1%
77	Insect Bites and Stings	11.1%
78	Paralysis, Obstetric	11.1%
79	Sunburn	11.1%
80	Tooth Avulsion	11.1%
81	Conus Medullaris Syndrome	11.1%
82	Near Drowning	11%
83	Osteoradionecrosis	11%
84	Rupture	10.9%
85	Elephantiasis	10.3%
86	Mucocutaneous Lymph Node Syndrome	10.3%
87	Pseudarthrosis	10.3%
88	Sarcoidosis	10.3%
89	Smoke Inhalation Injury	10.3%
90	Elephantiasis Nostras Verrucosa	10.3%
91	Brain Contusion	10%
92	Neoplasms, Radiation-Induced	9.5%
93	Splenic Rupture	9.3%
94	Peripheral Nerve Injuries	9.3%
95	Medial Tibial Stress Syndrome	9.3%
96	Agammaglobulinemia	9.2%
97	Central Cord Syndrome	9.1%
98	Heavy Chain Disease	8.5%
99	Granuloma	8.3%
100	Histiocytic Disorders, Malignant	8.3%
101	Facial Injuries	8.2%
102	Granuloma, Foreign-Body	8.2%
103	Histiocytosis, Langerhans-Cell	8.2%
104	Tumor Lysis Syndrome	8.2%
105	Enthesopathy	8.2%
106	Cardiotoxicity	8%
107	Leukemia, Radiation-Induced	7.9%
108	Radiation Pneumonitis	7.8%
109	Radiation Fibrosis	7.8%
110	Infectious Mononucleosis	7.7%
111	Lymphohistiocytosis, Hemophagocytic	7.7%
112	Erdheim-Chester Disease	7.7%
113	Sezary Syndrome	7.6%
114	Lymphoma	6.9%
115	Disseminated Intravascular Coagulation	6.8%
116	Protein S Deficiency	6.8%
117	Brain Injuries	6.8%
118	Thymoma	6.8%
119	Splenosis	6.8%
120	Abnormalities, Radiation-Induced	6.8%
121	Coma, Post-Head Injury	6.8%
122	Carpal Tunnel Syndrome	6.7%
123	Waldenstrom Macroglobulinemia	6.7%
124	Radiation Injuries, Experimental	6.7%
125	Brain Hemorrhage, Traumatic	6.6%
126	Thrombocythemia, Essential	6.5%
127	Malignant histiocytosis	6.1%
128	Sarcoidosis, Pulmonary	6.1%
129	Histiocytic sarcoma	6.1%
130	Autoimmune Lymphoproliferative Syndrome	5.9%
131	Eye Injuries	5.8%
132	Brain Injuries, Diffuse	5.6%
133	Traumatic Brain Injury	5.6%
134	Cubital Tunnel Syndrome	5.6%
135	Thrombasthenia	5.3%
136	Antithrombin III Deficiency	5.3%
137	Protein C Deficiency	5.3%
138	Anemia	5.3%
139	Blood Coagulation Disorders	5.3%
140	Blood Platelet Disorders	5.3%
141	Bone Marrow Diseases	5.3%
142	Hemorrhagic Disorders	5.3%
143	Leukocyte Disorders	5.3%
144	Methemoglobinemia	5.3%
145	Pancytopenia	5.3%
146	Polycythemia	5.3%
147	Sulfhemoglobinemia	5.3%
148	Thrombophilia	5.3%
149	Erythrocytosis	5.3%
150	Eosinophilic Granuloma	5.1%
151	Hodgkin Disease	5.1%
152	Lymphoma, Non-Hodgkin	5.1%
153	Leukemia, T-Cell	5%
154	Leukemia, B-Cell	5%
155	Vertebral Artery Dissection	5%
156	Diffuse Axonal Injury	5%
157	Pneumocephalus	4.8%
158	Afibrinogenemia	4.8%
159	Factor VII Deficiency	4.8%
160	Factor X Deficiency	4.8%
161	Factor XII Deficiency	4.8%
162	Hemophilia A	4.8%
163	Olfactory Nerve Injuries	4.8%
164	Activated Protein C Resistance	4.8%
165	Factor II deficiency	4.8%
166	Factor VIII Deficiency	4.8%
167	Factor V deficiency	4.8%
168	Factor XI Deficiency	4.8%
169	Hypoprothrombinemias	4.8%
170	Cerebrospinal Fluid Otorrhea	4.8%
171	Cerebrospinal Fluid Rhinorrhea	4.8%
172	Epilepsy, Post-Traumatic	4.8%
173	Thrombocytosis	4.8%
174	Bone Marrow Neoplasms	4.5%
175	Vitamin K Deficiency	4.5%
176	Carotid Artery Injuries	4.4%
177	Corneal Scar	4.4%
178	Transfusion Reaction	4.3%
179	Hypotensive Transfusion Reaction	4.3%
180	Composite Lymphoma	4.3%
181	Polycythemia Vera	4.3%
182	Lymphangioleiomyomatosis	4.3%
183	Pregnancy Complications, Hematologic	4.2%
184	Hematologic Neoplasms	4.2%
185	Facial Nerve Injuries	4.2%
186	Lymphoma, Follicular	4.2%
187	T-Cell Lymphoma	4.2%
188	Mantle cell lymphoma	4.2%
189	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	4.2%
190	Leukemia, Large Granular Lymphocytic	4.2%
191	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	4.2%
192	Corneal Perforation	4.1%
193	Hemoglobinuria, Paroxysmal	4.1%
194	Leukemoid Reaction	4.1%
195	Anemia, Diamond-Blackfan	3.8%
196	Lymphoma, T-Cell, Cutaneous	3.7%
197	Lymphoma, AIDS-Related	3.7%
198	Enteropathy-Associated T-Cell Lymphoma	3.7%
199	Primary Effusion Lymphoma	3.7%
200	Hematoma, Subdural	3.7%
201	Hematoma, Epidural, Cranial	3.7%
202	Purpura, Thrombotic Thrombocytopenic	3.6%
203	Wiskott-Aldrich Syndrome	3.5%
204	Mycosis Fungoides	3.5%
205	Lymphomatoid Papulosis	3.5%
206	Plasmablastic lymphoma	3.5%
207	Anemia, Hemolytic	3.4%
208	Anemia, Macrocytic	3.4%
209	Eosinophilia	3.4%
210	Hypoproteinemia	3.4%
211	Leukopenia	3.4%
212	Thrombocytopenia	3.4%
213	Leukostasis	3.4%
214	MYELODYSPLASTIC SYNDROME	3.4%
215	Subarachnoid Hemorrhage, Traumatic	3.3%
216	Carotid Artery, Internal, Dissection	3.3%
217	Hematoma, Subdural, Intracranial	3.3%
218	Hematoma, Subdural, Chronic	3.3%
219	Hematoma, Subdural, Acute	3.3%
220	Lymphomatoid Granulomatosis	3.2%
221	Anemia, Sickle Cell	3.1%
222	Thalassemia	3.1%
223	Autoimmune thrombocytopenia	2.9%
224	Immune thrombocytopenic purpura	2.9%
225	Cryoglobulinemia	2.9%
226	Monoclonal Gammopathy of Undetermined Significance	2.9%
227	Burkitt Lymphoma	2.8%
228	Anemia, Neonatal	2.8%
229	Leukocytosis	2.8%
230	Paraproteinemias	2.8%
231	Pelger-Huet Anomaly	2.8%
232	Pleocytosis	2.8%
233	Hemolytic-Uremic Syndrome	2.6%
234	Primary Myelofibrosis	2.6%
235	Agranulocytosis	2.6%
236	Anemia, Megaloblastic	2.6%
237	Lymphocytosis	2.6%
238	Myelofibrosis	2.6%
239	Myeloid Metaplasia	2.6%
240	Hypoalbuminemia	2.6%
241	Hypereosinophilic syndrome	2.6%
242	bone marrow fibrosis	2.6%
243	Thrombotic Microangiopathies	2.6%
244	Purpura, Hyperglobulinemic	2.5%
245	Sickle Cell Trait	2.5%
246	Fanconi Anemia	2.4%
247	Thrombocytopenic purpura	2.3%
248	Hypergammaglobulinemia	2.3%
249	Transfusion-Related Acute Lung Injury	2.3%
250	Ecchymosis	2.3%
251	Petechiae	2.3%
252	Purpura	2.3%
253	Multiple Myeloma	2.2%
254	Atypical Hemolytic Uremic Syndrome	2.2%
255	Hydrops Fetalis	2.2%
256	Neutropenia	2.1%
257	Lymphopenia	2.1%
258	Job Syndrome	2%
259	Leukemia, Myelomonocytic, Chronic	2%
260	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	2%
261	Acute Chest Syndrome	2%
262	Waterhouse-Friderichsen Syndrome	1.9%
263	Febrile Neutropenia	1.9%
264	Niemann-Pick Disease, Type C	1.9%
265	Pulmonary Eosinophilia	1.7%
266	Eosinophilic Pneumonia	1.7%
267	Eosinophilia-Myalgia Syndrome	1.7%
268	Chronic granulomatous disease	1.7%
269	Shwartzman Phenomenon	1.7%
270	Hemangioma, Cavernous	1.7%
271	Scurvy	1.7%
272	Leukemia, Myeloid, Chronic-Phase	1.7%
273	Purpura Fulminans	1.7%
274	Anemia, Pernicious	1.7%
275	Kernicterus	1.5%
276	POEMS Syndrome	1.4%
277	Pseudoxanthoma Elasticum	1%

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