MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Tumor Lysis Syndrome

(UMLS:C0041364)

Definition:: A syndrome resulting from cytotoxic therapy, occurring generally in aggressive, rapidly proliferating lymphoproliferative disorders. It is characterized by combinations of hyperuricemia, lactic acidosis, hyperkalemia, hyperphosphatemia and hypocalcemia.
UMLS ID:: C0041364
MeSH ID:: D015275

Classification 1:

Name:

Hemic and Lymphatic Diseases
MeSH Tree Number(s):: C15.604.515.880

Classification 2:

Name:

Immune System Diseases
MeSH Tree Number(s):: C20.683.515.950

Synonym(s)

Tumor Lysis Syndrome

TUMOR LYSIS SYNDROME

TUMOUR LYSIS SYNDROME

Tumor lysis syndrome

Tumour lysis syndrome

tumor lysis syndrome

tumour lysis syndrome

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Bendamustine Hydrochloride	16313266	CTD
2	Bortezomib	15449188 18463870	CTD
3	Cyclophosphamide	16313266	CTD
4	Cytarabine	21239698	CTD
5	Etoposide	6582781	CTD
6	Fluorouracil	7503095	CTD
7	Flutamide	15017238	CTD
8	Goserelin	15017238	CTD
9	Hydroxyurea	12708945	CTD
10	Leucovorin	7503095	CTD
11	Melphalan	18463870	CTD
12	Methylprednisolone	12653264	CTD
13	Mitoxantrone	21239698	CTD
14	alvocidib	17906454 21239698	CTD
15	fludarabine	16313266	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Sezary Syndrome	39.8%
2	Lymphoma	37.8%
3	Autoimmune Lymphoproliferative Syndrome	35.2%
4	Infectious Mononucleosis	33.1%
5	Sarcoidosis	31.1%
6	Heavy Chain Disease	28.5%
7	Hodgkin Disease	27.6%
8	Lymphoma, Non-Hodgkin	27.6%
9	Leukemia, T-Cell	27.5%
10	Leukemia, B-Cell	27.5%
11	Agammaglobulinemia	25.7%
12	Granuloma	23.7%
13	Plasmacytoma	23.3%
14	Composite Lymphoma	23.1%
15	Lymphangioleiomyomatosis	22.8%
16	Lymphoma, Follicular	22.7%
17	T-Cell Lymphoma	22.7%
18	Mantle cell lymphoma	22.7%
19	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	22.7%
20	Leukemia, Large Granular Lymphocytic	22.7%
21	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	22.7%
22	Primary amyloidosis	22.1%
23	Adenitis	20.5%
24	Histiocytosis	20.5%
25	Lymphadenitis	20.5%
26	Lymphangitis	20.5%
27	Lymphedema	20.5%
28	Splenic Diseases	20.5%
29	Thymus Hyperplasia	20.5%
30	Pseudolymphoma	20.5%
31	Lymphadenopathy	20.5%
32	Lymphoma, T-Cell, Cutaneous	20.3%
33	Lymphoma, AIDS-Related	20.3%
34	Enteropathy-Associated T-Cell Lymphoma	20.3%
35	Primary Effusion Lymphoma	20.3%
36	Mycosis Fungoides	19.1%
37	Lymphomatoid Papulosis	19.1%
38	Plasmablastic lymphoma	19.1%
39	Waldenstrom Macroglobulinemia	19%
40	Multiple Myeloma	19%
41	Paraproteinemias	18.6%
42	Sarcoidosis, Pulmonary	17.4%
43	Lymphomatoid Granulomatosis	17.2%
44	Monoclonal Gammopathy of Undetermined Significance	16.5%
45	Lymphangiectasis, Intestinal	16%
46	Lymphocele	15.5%
47	Lymphatic Abnormalities	15.5%
48	Thymus Neoplasms	15.3%
49	Hypergammaglobulinemia	15.1%
50	Burkitt Lymphoma	14.6%
51	Transfusion Reaction	14.3%
52	Hypotensive Transfusion Reaction	14.3%
53	Leukemia, Plasma Cell	13.8%
54	Elephantiasis	13.3%
55	Hypersplenism	13.3%
56	Elephantiasis Nostras Verrucosa	13.3%
57	Mucocutaneous Lymph Node Syndrome	12.2%
58	Autoimmune Diseases	11.9%
59	Hypersensitivity	11.9%
60	Immunologic Deficiency Syndromes	11.9%
61	Immune reconstitution syndrome	11.9%
62	Immune Reconstitution Inflammatory Syndrome	11.9%
63	Histiocytic Disorders, Malignant	10.2%
64	Splenic Infarction	10.2%
65	Splenic Neoplasms	10.2%
66	Histiocytosis, Langerhans-Cell	10%
67	Cryoglobulinemia	9.9%
68	Lymphohistiocytosis, Hemophagocytic	9.9%
69	Schnitzler Syndrome	9.9%
70	Erdheim-Chester Disease	9.9%
71	POEMS Syndrome	8.2%
72	Splenic Rupture	8.2%
73	Disseminated Intravascular Coagulation	8%
74	Protein S Deficiency	8%
75	Thymoma	7.9%
76	Autoimmune thrombocytopenia	7.6%
77	Immune thrombocytopenic purpura	7.6%
78	Lymphopenia	7.6%
79	Malignant histiocytosis	7.4%
80	Histiocytic sarcoma	7.4%
81	Thrombocytopenic purpura	7.4%
82	Thrombocythemia, Essential	7.4%
83	Anemia	6.8%
84	Blood Coagulation Disorders	6.8%
85	Blood Platelet Disorders	6.8%
86	Bone Marrow Diseases	6.8%
87	Hemorrhagic Disorders	6.8%
88	Immune Complex Diseases	6.8%
89	Leukocyte Disorders	6.8%
90	Methemoglobinemia	6.8%
91	Pancytopenia	6.8%
92	Polycythemia	6.8%
93	Sulfhemoglobinemia	6.8%
94	Antiphospholipid Syndrome	6.8%
95	Thrombophilia	6.8%
96	Latex allergy	6.8%
97	Erythrocytosis	6.8%
98	Glomerulonephritis, Membranoproliferative	6.8%
99	Transfusion-Related Acute Lung Injury	6.7%
100	Thrombasthenia	6.1%
101	Antithrombin III Deficiency	6.1%
102	Protein C Deficiency	6.1%
103	Splenosis	6%
104	Thrombocytosis	5.8%
105	Job Syndrome	5.8%
106	Eosinophilic Granuloma	5.7%
107	Wiskott-Aldrich Syndrome	5.6%
108	Afibrinogenemia	5.5%
109	Factor VII Deficiency	5.5%
110	Factor X Deficiency	5.5%
111	Factor XII Deficiency	5.5%
112	Hemophilia A	5.5%
113	Activated Protein C Resistance	5.5%
114	Factor II deficiency	5.5%
115	Factor VIII Deficiency	5.5%
116	Factor V deficiency	5.5%
117	Factor XI Deficiency	5.5%
118	Hypoprothrombinemias	5.5%
119	Environmental Illness	5.4%
120	Bone Marrow Neoplasms	5.3%
121	Vitamin K Deficiency	5.3%
122	Lupus Erythematosus, Systemic	5.2%
123	Pregnancy Complications, Hematologic	5.2%
124	Hematologic Neoplasms	5.2%
125	Overlap syndrome	5.2%
126	Addison Disease	5.1%
127	Pemphigus	5.1%
128	Autoimmune thyroiditis	5.1%
129	Primary Adrenal Insufficiency	5.1%
130	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	5%
131	Autoimmune hepatitis	5%
132	Hemoglobinuria, Paroxysmal	4.9%
133	Leukemoid Reaction	4.9%
134	Polycythemia Vera	4.9%
135	Chronic granulomatous disease	4.6%
136	Hydrops Fetalis	4.6%
137	anaphylaxis	4.4%
138	Anemia, Hemolytic	4.4%
139	Anemia, Macrocytic	4.4%
140	Eosinophilia	4.4%
141	Food Allergy	4.4%
142	Hypoproteinemia	4.4%
143	Leukopenia	4.4%
144	Thrombocytopenia	4.4%
145	Leukostasis	4.4%
146	MYELODYSPLASTIC SYNDROME	4.4%
147	Anaphylactic shock	4.4%
148	Anemia, Diamond-Blackfan	4.3%
149	Kernicterus	4.2%
150	Latent Autoimmune Diabetes in Adults	4.1%
151	Dermatitis Herpetiformis	4.1%
152	Kounis Syndrome	4.1%
153	Purpura, Thrombotic Thrombocytopenic	4%
154	HIV Infections	4%
155	Serum Sickness	3.8%
156	Asthma, Aspirin-Induced	3.8%
157	Anemia, Sickle Cell	3.6%
158	Thalassemia	3.6%
159	Respiratory Hypersensitivity	3.5%
160	Rheumatoid Arthritis	3.4%
161	Juvenile arthritis	3.4%
162	Anemia, Neonatal	3.4%
163	Leukocytosis	3.4%
164	Pelger-Huet Anomaly	3.4%
165	Sick Building Syndrome	3.4%
166	Pleocytosis	3.4%
167	Multiple Chemical Sensitivity	3.4%
168	Graves Disease	3.4%
169	Urticaria	3.3%
170	Vasculitis, Leukocytoclastic, Cutaneous	3.3%
171	Anti-Glomerular Basement Membrane Disease	3.3%
172	HTLV-I Infections	3.3%
173	Primary Myelofibrosis	3.3%
174	Agranulocytosis	3.3%
175	Anemia, Megaloblastic	3.3%
176	Lymphocytosis	3.3%
177	Myelofibrosis	3.3%
178	Myeloid Metaplasia	3.3%
179	Milk Allergy	3.3%
180	Hypoalbuminemia	3.3%
181	Wheat Hypersensitivity	3.3%
182	Hypereosinophilic syndrome	3.3%
183	bone marrow fibrosis	3.3%
184	Thrombotic Microangiopathies	3.3%
185	Hemolytic-Uremic Syndrome	3%
186	Sickle Cell Trait	2.8%
187	Purpura, Hyperglobulinemic	2.8%
188	Fanconi Anemia	2.7%
189	Neutropenia	2.7%
190	Myasthenia Gravis	2.7%
191	Uveomeningoencephalitic Syndrome	2.7%
192	Mastocytosis	2.7%
193	Drug Eruptions	2.7%
194	Ecchymosis	2.7%
195	Petechiae	2.7%
196	Purpura	2.7%
197	Granulomatosis with polyangiitis	2.6%
198	Dermatitis, Allergic Contact	2.6%
199	HIV Seropositivity	2.6%
200	Atypical Hemolytic Uremic Syndrome	2.5%
201	Leukemia, Myelomonocytic, Chronic	2.5%
202	Myasthenia Gravis, Autoimmune, Experimental	2.5%
203	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	2.5%
204	Febrile Neutropenia	2.5%
205	Mastocytosis, Systemic	2.4%
206	Stiff-Person Syndrome	2.3%
207	Polyradiculoneuropathy	2.3%
208	Polyradiculoneuritis	2.3%
209	Ataxia Telangiectasia	2.2%
210	Acquired Immunodeficiency Syndrome	2.2%
211	AIDS related complex	2.2%
212	Felty Syndrome	2.2%
213	Lupus Nephritis	2.2%
214	Acute Chest Syndrome	2.2%
215	Pulmonary Eosinophilia	2.1%
216	Eosinophilic Pneumonia	2.1%
217	Waterhouse-Friderichsen Syndrome	2.1%
218	Leukemia, Myeloid, Chronic-Phase	2%
219	Anemia, Pernicious	2%
220	Eosinophilia-Myalgia Syndrome	2%
221	Angioedema	2%
222	Multiple Sclerosis	2%
223	Shwartzman Phenomenon	2%
224	Niemann-Pick Disease, Type C	2%
225	Hemangioma, Cavernous	2%
226	Scurvy	2%
227	Purpura Fulminans	2%
228	Acute Generalized Exanthematous Pustulosis	2%
229	AIDS-Related Opportunistic Infections	1.9%
230	Vasculitis, Central Nervous System	1.9%
231	Dermatitis, Atopic	1.9%
232	HIV Wasting Syndrome	1.9%
233	Rheumatoid Vasculitis	1.9%
234	AIDS Dementia Complex	1.9%
235	AIDS-Associated Nephropathy	1.9%
236	Neuromyelitis Optica	1.8%
237	Leukoencephalitis, Acute Hemorrhagic	1.8%
238	Lupus Vasculitis, Central Nervous System	1.8%
239	Asthma	1.7%
240	Lambert-Eaton Myasthenic Syndrome	1.7%
241	Asthma, Exercise-Induced	1.7%
242	Status Asthmaticus	1.7%
243	Sicca Syndrome	1.6%
244	Sjogren's Syndrome	1.6%
245	Encephalomyelitis, Acute Disseminated	1.6%
246	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	1.6%
247	Erythema Nodosum	1.6%
248	Neuritis, Autoimmune, Experimental	1.6%
249	Dermatitis, Photoallergic	1.6%
250	HIV-Associated Lipodystrophy Syndrome	1.6%
251	Multiple Sclerosis, Chronic Progressive	1.6%
252	Multiple Sclerosis, Relapsing-Remitting	1.6%
253	Hereditary Angioedema Type III	1.5%
254	Hereditary Angioedema Types I and II	1.5%
255	Asthma, Occupational	1.4%
256	Aspergillosis, Allergic Bronchopulmonary	1.4%
257	Guillain-Barre Syndrome	1.4%
258	Farmer's Lung	1.4%
259	Angioedemas, Hereditary	1.4%
260	Hay fever	1.4%
261	Rhinitis, Allergic, Perennial	1.4%
262	Toxic Epidermal Necrolysis	1.2%
263	Stevens-Johnson Syndrome	1.2%
264	Pseudoxanthoma Elasticum	1.1%
265	Giant Cell Arteritis	1.1%
266	Temporal Arteritis	1.1%
267	Myelitis, Transverse	1%
268	Miller Fisher Syndrome	0.8%

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