MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Anemia, Hemolytic

(UMLS:C0002878)

Definition:: A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red blood cells (ERYTHROCYTES).
UMLS ID:: C0002878
MeSH ID:: D000743

Classification:

Name:

Hemic and Lymphatic Diseases
MeSH Tree Number(s):: C15.378.071.141

Synonym(s)

Anemia, Hemolytic

ANEMIA HEMOLYTIC

Anaemia;haemolytic

HEMOLYTIC ANEMIA

Haemolytic anaemia

Haemolytic anaemia, NOS

Hemolytic Anemia

Hemolytic anemia

Hemolytic anemia, NOS

10.

Increased hemolysis

11.

anemia; hemolytic

12.

haemolytic anaemia

Associated Drug(s)

	Name	Reference(s)	Data Source
1	1,2-naphthoquinone	17265417	CTD
2	1,4-naphthoquinone	17265417	CTD
3	2-amino-1,4-naphthoquinone imine	16045903	CTD
4	2-dimethylamino-1,4-naphthoquinone	17265417	CTD
5	2-methylamino-1,4-naphthoquinone	17265417	CTD
6	4-amino-4'-hydroxylaminodiphenylsulfone	7616443	CTD
7	4-chloro-3-nitroaniline	19683565	CTD
8	4-dichlorobenzene	19369838	CTD
9	Acetaminophen	82726 2716023 4749897	CTD
10	Ajmaline	4062136 6219361	CTD
11	Aminosalicylic Acid	5058584	CTD
12	Amiodarone	1759074	CTD
13	Amoxicillin	3939067 16425853 20516363	CTD
14	Ampicillin	4124995 4850156 5694079	CTD
15	Artesunate	25071004	CTD
16	Aspirin	View details 2502894 4124995 4852166 6239255	CTD
17	Auranofin	366858	CTD
18	Benzocaine	2933656	CTD
19	Bilirubin	10644400	CTD
20	Bleomycin	9572663	CTD
21	Bortezomib	16832816	CTD
22	Carbamazepine	6441416 9855327 18055338	CTD
23	Carbenicillin	4124995	CTD
24	Carbidopa	466061	CTD
25	Carboplatin	15188759 17381629	CTD
26	Cefadroxil	8952318	CTD
27	Cefamandole	3970014	CTD
28	Cefazolin	96555	CTD
29	Cefoperazone	20046091	CTD
30	Cefotaxime	2316002	CTD
31	Cefotetan	View details 1445986 1554932 1557810 1557811 1585910 8658540 10411803 10815791 10871459 10975934 11129837 14965871 15373671 16493619	CTD
32	Cefoxitin	6641504 10204595 17381629	CTD
33	Ceftazidime	17381629	CTD
34	Ceftizoxime	20046091	CTD
35	Ceftriaxone	View details 8745031 10407998 10554824 11089773 12031011 12089751 12451362 15024441 15225244 15857541 16491410 16602117 17381629 18613898 19083297 19829151 20931689	CTD
36	Cefuroxime	12915840	CTD
37	Cephalothin	View details 96555 816141 958099 4998514	CTD
38	Chlorambucil	2816917	CTD
39	Chloroquine	4794122	CTD
40	Chlorpromazine	876939 3925683 7471027	CTD
41	Chlorpropamide	3766527 5458054	CTD
42	Cimetidine	9059066 19874564	CTD
43	Ciprofloxacin	12911170 18791946 20127091	CTD
44	Cladribine	16398735	CTD
45	Clofazimine	19274991 20140364	CTD
46	Cloxacillin	4124995	CTD
47	Cocaine	8766259 10620564	CTD
48	Cyclophosphamide	6027686	CTD
49	Cyclosporine	1611201 19602210 23619107	CTD
50	Dapsone	View details 454569 2266352 2510435 3425586 3800520 4151976 4657112 5441766 6231576 7065565 7198620 7752092 7973902 8341116 10028001 12030789 16212642 16639690 18971091 19274991 19954390 20140364	CTD
51	Dermazin	1760119	CTD
52	Dextropropoxyphene	2716023	CTD
53	Diatrizoate Meglumine	7313758	CTD
54	Diclofenac	View details 1703888 2025580 8235782 8321735 8982039 11051389 14750454 14984563 15038209 16432863 17381629	CTD
55	Diethylstilbestrol	2712071	CTD
56	Diflunisal	2967101	CTD
57	Digoxin	4124995	CTD
58	Doxepin	2925599	CTD
59	Doxorubicin	6409241	CTD
60	Eicosapentaenoic Acid	12736713	CTD
61	Epirubicin	9572663	CTD
62	Ethambutol	188103	CTD
63	Ethinyl Estradiol-Norgestrel Combination	2080604	CTD
64	Etodolac	10864985 17381629	CTD
65	Fenfluramine	4706826	CTD
66	Floxacillin	3713580	CTD
67	Fluorescein	8342239	CTD
68	Fluorouracil	View details 3093413 6105503 6406059 9198664	CTD
69	Folic Acid	5774135	CTD
70	Furosemide	958099	CTD
71	Gentamicins	4124995	CTD
72	Glyburide	3115451 8562390 15126005	CTD
73	Hydralazine	20687078	CTD
74	Hydroxyurea	15558807	CTD
75	Ibuprofen	16425853 17381629	CTD
76	Indinavir	View details 9452755 10533645 10614088 11364438	CTD
77	Indomethacin	17381629	CTD
78	Isoniazid	5818564	CTD
79	Isosorbide Dinitrate	6401899	CTD
80	Lansoprazole	8997127	CTD
81	Levamisole	518426	CTD
82	Levodopa	466061	CTD
83	Lovastatin	7653497	CTD
84	Maloprim	1124444 4852166	CTD
85	Mefenamic Acid	3540922 5420190 8235782	CTD
86	Metformin	10644400 12610074	CTD
87	Methicillin	5694079	CTD
88	Methotrexate	6871106	CTD
89	Methyldopa	View details 557594 851765 901101 916211 2300859 2320485 3726712 4189111 4418166 4723818 5132639 5263208 5480713 5616039 5774135 6471436 6636654 7391634	CTD
90	Methylprednisolone	901101	CTD
91	Methysergide	5467905	CTD
92	Misoprostol	17084939	CTD
93	Mitomycin	View details 1782316 3093413 3150472 6105503 6406059 6796250 7379025	CTD
94	Mycophenolic Acid	11528156	CTD
95	N-hydroxyphenetidine	1949026	CTD
96	Nabumetone	17381629	CTD
97	Nalidixic Acid	1597360 4190560	CTD
98	Naproxen	6882485	CTD
99	Nifedipine	10733367	CTD
100	Nitrofurantoin	869654 10941490	CTD
101	Omeprazole	1992636	CTD
102	Oxcarbazepine	18356642	CTD
103	Penicillamine	49598 1154051	CTD
104	Penicillin G	View details 490820 809085 5667330 5668001 5694079 6230485	CTD
105	Pentamidine	10332545	CTD
106	Perphenazine	6859031	CTD
107	Phenazopyridine	View details 1247346 1879765 2786291 2922627 3678069 6125724 6410650 6868236 7075467 7992996 8037417 16897003 17004539	CTD
108	Phenobarbital	9855327	CTD
109	Phenytoin	1147459 9855327	CTD
110	Piperacillin, Tazobactam Drug Combination	17381629 20101875	CTD
111	Piperacillin	10223610	CTD
112	Piroxicam	3227521	CTD
113	Prednisolone	1611201 4706826 5774135	CTD
114	Prednisone	3944744 11364438	CTD
115	Primaquine	View details 4864652 5467364 11303037 15840764 15916292	CTD
116	Probenecid	4124995 17381629	CTD
117	Procainamide	417435 6858967	CTD
118	Proguanil	1124444	CTD
119	Propylthiouracil	1110434 11922496	CTD
120	Quercetin	17084956	CTD
121	Quinidine	View details 331400 644643 760860 4695590 7197395 17381629	CTD
122	Quinine	17381629 18343736	CTD
123	Ranitidine	9059066	CTD
124	Ribavirin	View details 10733558 11010742 11330434 11451176 11705128 12736713 12897097 14768501 15117320 15293138 15468613 15482540 15580403 15622486 15754628 15828854 16340643 16381245 16629641 16633111 17048050 17299014 18432160 19628158 20303990 20446436 20547162	CTD
125	Rifampin	View details 171722 188103 1504213 2293464 2609438 3796143 8184201 9175425 9428460 11798598 11820654 19224484 19274991 20140364 23069259	CTD
126	Ritodrine	7148909	CTD
127	Saridon	1949026 17082564 17698508	CTD
128	Succimer	7932916	CTD
129	Sulbactam	20046091	CTD
130	Sulfasalazine	View details 25555 30666 33552 2867466 4386139 10775222	CTD
131	Sulindac	17381629	CTD
132	Tacrolimus	View details 8629906 8701950 10743694 12753543	CTD
133	Tamoxifen	10704919	CTD
134	Tetracycline	4599404 7400406	CTD
135	Tolbutamide	838166	CTD
136	Tolmetin	17381629	CTD
137	Trimethoprim, Sulfamethoxazole Drug Combination	View details 2717509 2786291 2949369 10157546 12876641 15018178 20065266	CTD
138	Trimethoprim	20589632	CTD
139	Valproic Acid	9855327	CTD
140	Vitamin A	4684742	CTD
141	Vitamin E	968551 5094252	CTD
142	Warfarin	1147462	CTD
143	dexchlorpheniramine	6115667	CTD
144	eunalgit	2859709	CTD
145	gemcitabine	18427761 18557535 19816959	CTD
146	lawsone	17265417	CTD
147	lead nitrate	25411909	CTD
148	naphthalene	4852166	CTD
149	phenylhydrazine	View details 4341013 7184034 12006547 17082564 17084956 17698508 18687678 22908232 30140404	CTD
150	propylene dichloride	2744274 4063220	CTD
151	reviparin	8486459	CTD
152	sultamicillin	2686918 9531349	CTD
153	ticarcillin-clavulanic acid	9531349	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Anemia, Macrocytic	46.7%
2	Anemia, Megaloblastic	34.4%
3	Anemia, Neonatal	31.8%
4	Blood Coagulation Disorders	31%
5	Blood Platelet Disorders	31%
6	Bone Marrow Diseases	31%
7	Hemorrhagic Disorders	31%
8	Leukocyte Disorders	31%
9	Methemoglobinemia	31%
10	Pancytopenia	31%
11	Polycythemia	31%
12	Sulfhemoglobinemia	31%
13	Thrombophilia	31%
14	Erythrocytosis	31%
15	Disseminated Intravascular Coagulation	30%
16	Protein S Deficiency	30%
17	Anemia, Diamond-Blackfan	29.9%
18	Thrombocythemia, Essential	26.6%
19	Thrombocytosis	23.1%
20	Transfusion Reaction	22%
21	Hypotensive Transfusion Reaction	22%
22	Thrombasthenia	21.9%
23	Antithrombin III Deficiency	21.9%
24	Protein C Deficiency	21.9%
25	Pregnancy Complications, Hematologic	20.9%
26	Hematologic Neoplasms	20.9%
27	Eosinophilia	20%
28	Hypoproteinemia	20%
29	Leukopenia	20%
30	Thrombocytopenia	20%
31	Leukostasis	20%
32	Bone Marrow Neoplasms	20%
33	MYELODYSPLASTIC SYNDROME	20%
34	Vitamin K Deficiency	19.8%
35	Afibrinogenemia	19.7%
36	Factor VII Deficiency	19.7%
37	Factor X Deficiency	19.7%
38	Factor XII Deficiency	19.7%
39	Hemophilia A	19.7%
40	Activated Protein C Resistance	19.7%
41	Factor II deficiency	19.7%
42	Factor VIII Deficiency	19.7%
43	Factor V deficiency	19.7%
44	Factor XI Deficiency	19.7%
45	Hypoprothrombinemias	19.7%
46	Leukemoid Reaction	19.6%
47	Anemia, Pernicious	18.7%
48	Lymphatic Diseases	18.5%
49	Polycythemia Vera	17.5%
50	Fanconi Anemia	16.3%
51	Primary Myelofibrosis	14.8%
52	Agranulocytosis	14.8%
53	Lymphocytosis	14.8%
54	Myelofibrosis	14.8%
55	Myeloid Metaplasia	14.8%
56	Hypoalbuminemia	14.8%
57	Hypereosinophilic syndrome	14.8%
58	bone marrow fibrosis	14.8%
59	Thrombotic Microangiopathies	14.8%
60	Purpura, Thrombotic Thrombocytopenic	14.1%
61	Leukocytosis	13.6%
62	Paraproteinemias	13.6%
63	Pelger-Huet Anomaly	13.6%
64	Pleocytosis	13.6%
65	Agammaglobulinemia	13.6%
66	Wiskott-Aldrich Syndrome	13.4%
67	Neutropenia	12.2%
68	Cryoglobulinemia	11.8%
69	Monoclonal Gammopathy of Undetermined Significance	11.8%
70	Febrile Neutropenia	10.9%
71	Autoimmune thrombocytopenia	10.8%
72	Immune thrombocytopenic purpura	10.8%
73	Heavy Chain Disease	10.7%
74	Infectious Mononucleosis	10.6%
75	Waldenstrom Macroglobulinemia	10.4%
76	Adenitis	10.3%
77	Histiocytosis	10.3%
78	Hypergammaglobulinemia	10.3%
79	Lymphadenitis	10.3%
80	Lymphangitis	10.3%
81	Lymphedema	10.3%
82	Splenic Diseases	10.3%
83	Thymus Hyperplasia	10.3%
84	Pseudolymphoma	10.3%
85	Lymphadenopathy	10.3%
86	Lymphopenia	10.1%
87	Transfusion-Related Acute Lung Injury	10.1%
88	Ecchymosis	10%
89	Petechiae	10%
90	Purpura	10%
91	Job Syndrome	9.9%
92	Hemoglobinuria, Paroxysmal	9.8%
93	Leukemia, Myelomonocytic, Chronic	9.8%
94	Purpura, Hyperglobulinemic	9.8%
95	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	9.8%
96	Thrombocytopenic purpura	9.2%
97	Multiple Myeloma	8.5%
98	Pulmonary Eosinophilia	8.4%
99	Eosinophilic Pneumonia	8.4%
100	Leukemia, Myeloid, Chronic-Phase	8.1%
101	Hydrops Fetalis	8.1%
102	Anemia, Sickle Cell	7.9%
103	Thalassemia	7.9%
104	Eosinophilia-Myalgia Syndrome	7.6%
105	Chronic granulomatous disease	7.4%
106	Shwartzman Phenomenon	7.4%
107	Hemangioma, Cavernous	7.4%
108	Scurvy	7.3%
109	Purpura Fulminans	7.3%
110	Lymphocele	7%
111	Lymphoproliferative Disorders	7%
112	Lymphatic Abnormalities	7%
113	Thymus Neoplasms	6.8%
114	Waterhouse-Friderichsen Syndrome	6.8%
115	Elephantiasis	6.7%
116	Hypersplenism	6.7%
117	Lymphangiectasis, Intestinal	6.7%
118	Sarcoidosis	6.7%
119	Elephantiasis Nostras Verrucosa	6.7%
120	Eosinophilic Granuloma	6.6%
121	POEMS Syndrome	5.9%
122	Sickle Cell Trait	5.8%
123	Kernicterus	5.7%
124	Mucocutaneous Lymph Node Syndrome	5.1%
125	Lymphohistiocytosis, Hemophagocytic	4.9%
126	Erdheim-Chester Disease	4.9%
127	Hemolytic-Uremic Syndrome	4.8%
128	Granuloma	4.5%
129	Histiocytic Disorders, Malignant	4.5%
130	Splenic Infarction	4.5%
131	Splenic Neoplasms	4.5%
132	Histiocytosis, Langerhans-Cell	4.4%
133	Tumor Lysis Syndrome	4.4%
134	Atypical Hemolytic Uremic Syndrome	4.3%
135	Acute Chest Syndrome	4.3%
136	Pseudoxanthoma Elasticum	3.8%
137	Splenic Rupture	3.4%
138	Lymphoma	3.4%
139	Thymoma	3.3%
140	Sezary Syndrome	3.3%
141	Malignant histiocytosis	3.3%
142	Sarcoidosis, Pulmonary	3.3%
143	Histiocytic sarcoma	3.3%
144	Autoimmune Lymphoproliferative Syndrome	2.7%
145	Splenosis	2.5%
146	Hodgkin Disease	2.5%
147	Lymphoma, Non-Hodgkin	2.5%
148	Leukemia, T-Cell	2.4%
149	Leukemia, B-Cell	2.4%
150	Lymphoma, Follicular	2%
151	T-Cell Lymphoma	2%
152	Mantle cell lymphoma	2%
153	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	2%
154	Leukemia, Large Granular Lymphocytic	2%
155	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	2%
156	Composite Lymphoma	2%
157	Lymphangioleiomyomatosis	1.9%
158	Lymphoma, T-Cell, Cutaneous	1.8%
159	Lymphoma, AIDS-Related	1.8%
160	Enteropathy-Associated T-Cell Lymphoma	1.8%
161	Primary Effusion Lymphoma	1.8%
162	Mycosis Fungoides	1.7%
163	Lymphomatoid Papulosis	1.7%
164	Plasmablastic lymphoma	1.7%
165	Lymphomatoid Granulomatosis	1.5%
166	Burkitt Lymphoma	1.2%
167	Niemann-Pick Disease, Type C	0.7%

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