MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Myelofibrosis

(UMLS:C0026987)

UMLS ID:: C0026987
MeSH ID:: D055728

Classification:

Name:

Hemic and Lymphatic Diseases
MeSH Tree Number(s):: C15.378.190.636.765

Synonym(s)

Myelofibrosis

Agnogenic myeloid metaplasia

MF - Myelofibrosis

MYELOFIBROSIS

Myelofibrosis, NOS

Myelosclerosis

Myelosclerosis, NOS

bone fibrosis marrow

bone marrow fibrosis

10.

chronic idiopathic myelofibrosis

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Ruxolitinib phosphate	FAERS: 412 Canada Vigilance: 4	Canada Vigilance US FAERS
2	Lenalidomide	FAERS: 54 Canada Vigilance: 1	Canada Vigilance US FAERS
3	Thalidomide	FAERS: 41	US FAERS
4	Imatinib Mesylate	FAERS: 39	US FAERS
5	eltrombopag	FAERS: 31	US FAERS
6	Deferasirox	FAERS: 21	US FAERS
7	eltrombopag	FAERS: 21	US FAERS
8	Imatinib Mesylate	FAERS: 20	US FAERS
9	anagrelide	FAERS: 19	US FAERS
10	anagrelide	FAERS: 15	US FAERS
11	Azacitidine	FAERS: 11 Canada Vigilance: 1	Canada Vigilance US FAERS
12	Tacrolimus	FAERS: 8	US FAERS
13	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	FAERS: 5	US FAERS
14	Isotretinoin	FAERS: 5	US FAERS
15	Dasatinib	FAERS: 3	US FAERS
16	Fluvastatin	FAERS: 3	US FAERS
17	Hydroxyurea	FAERS: 3	US FAERS
18	Methotrexate	FAERS: 3	US FAERS
19	PCI 32765	FAERS: 3	US FAERS
20	Pipobroman	FAERS: 3	US FAERS
21	Valsartan	FAERS: 3	US FAERS
22	Atorvastatin	FAERS: 2 Canada Vigilance: 1	Canada Vigilance US FAERS
23	Clozapine	FAERS: 2	US FAERS
24	Hydroxychloroquine	FAERS: 2	US FAERS
25	INCB018424	FAERS: 2 Canada Vigilance: 4	Canada Vigilance US FAERS
26	Liraglutide	FAERS: 2	US FAERS
27	Sildenafil Citrate	FAERS: 2	US FAERS
28	Zoledronic Acid	FAERS: 2	US FAERS
29	exemestane	FAERS: 2	US FAERS
30	Carbamazepine	FAERS: 1	US FAERS
31	Clarithromycin	FAERS: 1	US FAERS
32	Clopidogrel	FAERS: 1	US FAERS
33	Epirubicin	FAERS: 1	US FAERS
34	Epirubicin	FAERS: 1	US FAERS
35	Epoprostenol	FAERS: 1	US FAERS
36	Esomeprazole	FAERS: 1	US FAERS
37	Estradiol	FAERS: 1	US FAERS
38	Ezetimibe, Simvastatin Drug Combination	FAERS: 1	US FAERS
39	Fentanyl	FAERS: 1	US FAERS
40	Gadolinium DTPA	FAERS: 1	US FAERS
41	Iloprost	FAERS: 1	US FAERS
42	Insulin Detemir	FAERS: 1	US FAERS
43	Irbesartan	FAERS: 1	US FAERS
44	Meloxicam	FAERS: 1	US FAERS
45	Norethindrone	FAERS: 1	US FAERS
46	Octreotide	FAERS: 1	US FAERS
47	Omeprazole	FAERS: 1	US FAERS
48	Pemetrexed	FAERS: 1	US FAERS
49	Quetiapine Fumarate	FAERS: 1	US FAERS
50	Rifaximin	FAERS: 1	US FAERS
51	Risperidone	FAERS: 1 Canada Vigilance: 1	Canada Vigilance US FAERS
52	Rosiglitazone	FAERS: 1	US FAERS
53	Tenofovir	FAERS: 1	US FAERS
54	Teriparatide	FAERS: 1	US FAERS
55	abacavir, lamivudine drug combination	FAERS: 1	US FAERS
56	ambrisentan	FAERS: 1	US FAERS
57	apixaban	FAERS: 1	US FAERS
58	atovaquone, proguanil drug combination	FAERS: 1	US FAERS
59	fludarabine phosphate	FAERS: 1	US FAERS
60	idelalisib	FAERS: 1	US FAERS
61	pomalidomide	FAERS: 1	US FAERS
62	riociguat	FAERS: 1	US FAERS
63	rofecoxib	FAERS: 1	US FAERS
64	venetoclax	FAERS: 1	US FAERS
65	Mexiletine		SIDER
66	Pantoprazole	Canada Vigilance: 1	Canada Vigilance
67	Pravastatin	Canada Vigilance: 1	Canada Vigilance
68	Pregabalin		SIDER
69	Semaxinib		SIDER

Similar ADE(s)

	Name	Semantic Similarity
1	Thrombocytosis	42.4%
2	Leukemoid Reaction	38.7%
3	MYELODYSPLASTIC SYNDROME	34.4%
4	Polycythemia Vera	32.3%
5	Thrombocythemia, Essential	30.3%
6	Anemia	25.4%
7	Blood Coagulation Disorders	25.4%
8	Blood Platelet Disorders	25.4%
9	Hemorrhagic Disorders	25.4%
10	Leukocyte Disorders	25.4%
11	Methemoglobinemia	25.4%
12	Pancytopenia	25.4%
13	Polycythemia	25.4%
14	Sulfhemoglobinemia	25.4%
15	Thrombophilia	25.4%
16	Erythrocytosis	25.4%
17	Bone Marrow Neoplasms	24.8%
18	Leukemia, Myeloid, Chronic-Phase	23.9%
19	Disseminated Intravascular Coagulation	22.3%
20	Protein S Deficiency	22.3%
21	Hemoglobinuria, Paroxysmal	21.5%
22	Transfusion Reaction	18.1%
23	Hypotensive Transfusion Reaction	18.1%
24	Pregnancy Complications, Hematologic	17.2%
25	Hematologic Neoplasms	17.2%
26	Lymphatic Diseases	16.4%
27	Thrombasthenia	15.8%
28	Antithrombin III Deficiency	15.8%
29	Protein C Deficiency	15.8%
30	Leukemia, Myelomonocytic, Chronic	15.1%
31	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	15.1%
32	Anemia, Hemolytic	14.8%
33	Anemia, Macrocytic	14.8%
34	Eosinophilia	14.8%
35	Hypoproteinemia	14.8%
36	Leukopenia	14.8%
37	Thrombocytopenia	14.8%
38	Leukostasis	14.8%
39	Vitamin K Deficiency	14.7%
40	Afibrinogenemia	13.7%
41	Factor VII Deficiency	13.7%
42	Factor X Deficiency	13.7%
43	Factor XII Deficiency	13.7%
44	Hemophilia A	13.7%
45	Activated Protein C Resistance	13.7%
46	Factor II deficiency	13.7%
47	Factor VIII Deficiency	13.7%
48	Factor V deficiency	13.7%
49	Factor XI Deficiency	13.7%
50	Hypoprothrombinemias	13.7%
51	Anemia, Diamond-Blackfan	13.5%
52	Anemia, Neonatal	10.1%
53	Leukocytosis	10.1%
54	Paraproteinemias	10.1%
55	Pelger-Huet Anomaly	10.1%
56	Pleocytosis	10.1%
57	Agammaglobulinemia	10.1%
58	Fanconi Anemia	9.7%
59	Agranulocytosis	9.7%
60	Anemia, Megaloblastic	9.7%
61	Lymphocytosis	9.7%
62	Hypoalbuminemia	9.7%
63	Hypereosinophilic syndrome	9.7%
64	Thrombotic Microangiopathies	9.7%
65	Purpura, Thrombotic Thrombocytopenic	9.2%
66	Wiskott-Aldrich Syndrome	9.1%
67	Anemia, Sickle Cell	8.9%
68	Thalassemia	8.9%
69	Adenitis	8.5%
70	Histiocytosis	8.5%
71	Lymphadenitis	8.5%
72	Lymphangitis	8.5%
73	Lymphedema	8.5%
74	Splenic Diseases	8.5%
75	Thymus Hyperplasia	8.5%
76	Pseudolymphoma	8.5%
77	Lymphadenopathy	8.5%
78	Infectious Mononucleosis	7.9%
79	Cryoglobulinemia	7.8%
80	Monoclonal Gammopathy of Undetermined Significance	7.8%
81	Hypergammaglobulinemia	7.7%
82	Transfusion-Related Acute Lung Injury	7.5%
83	Ecchymosis	7.4%
84	Petechiae	7.4%
85	Purpura	7.4%
86	Heavy Chain Disease	7.4%
87	Neutropenia	7.2%
88	Autoimmune thrombocytopenia	7.1%
89	Immune thrombocytopenic purpura	7.1%
90	Waldenstrom Macroglobulinemia	7%
91	Hemolytic-Uremic Syndrome	6.7%
92	Lymphopenia	6.7%
93	Job Syndrome	6.5%
94	Purpura, Hyperglobulinemic	6.5%
95	Sickle Cell Trait	6.3%
96	Febrile Neutropenia	6%
97	Thrombocytopenic purpura	5.8%
98	Lymphocele	5.7%
99	Lymphoproliferative Disorders	5.7%
100	Lymphatic Abnormalities	5.7%
101	Multiple Myeloma	5.6%
102	Thymus Neoplasms	5.6%
103	Hydrops Fetalis	5.6%
104	Atypical Hemolytic Uremic Syndrome	5.2%
105	Eosinophilia-Myalgia Syndrome	5%
106	Pulmonary Eosinophilia	5%
107	Eosinophilic Pneumonia	5%
108	Lymphangiectasis, Intestinal	5%
109	Elephantiasis	4.9%
110	Chronic granulomatous disease	4.9%
111	Hypersplenism	4.9%
112	Sarcoidosis	4.9%
113	Shwartzman Phenomenon	4.9%
114	Elephantiasis Nostras Verrucosa	4.9%
115	Hemangioma, Cavernous	4.9%
116	Scurvy	4.8%
117	Purpura Fulminans	4.8%
118	Waterhouse-Friderichsen Syndrome	4.8%
119	Anemia, Pernicious	4.8%
120	Acute Chest Syndrome	4.6%
121	Eosinophilic Granuloma	4.4%
122	Kernicterus	4.3%
123	Mucocutaneous Lymph Node Syndrome	4.2%
124	POEMS Syndrome	3.9%
125	Granuloma	3.4%
126	Histiocytic Disorders, Malignant	3.4%
127	Splenic Infarction	3.4%
128	Splenic Neoplasms	3.4%
129	Histiocytosis, Langerhans-Cell	3.3%
130	Tumor Lysis Syndrome	3.3%
131	Lymphohistiocytosis, Hemophagocytic	3.2%
132	Erdheim-Chester Disease	3.2%
133	Splenic Rupture	2.6%
134	Lymphoma	2.5%
135	Pseudoxanthoma Elasticum	2.5%
136	Thymoma	2.5%
137	Sezary Syndrome	2.2%
138	Malignant histiocytosis	2.2%
139	Sarcoidosis, Pulmonary	2.2%
140	Histiocytic sarcoma	2.2%
141	Autoimmune Lymphoproliferative Syndrome	2%
142	Splenosis	1.6%
143	Hodgkin Disease	1.6%
144	Lymphoma, Non-Hodgkin	1.6%
145	Leukemia, T-Cell	1.6%
146	Leukemia, B-Cell	1.6%
147	Composite Lymphoma	1.3%
148	Lymphangioleiomyomatosis	1.3%
149	Lymphoma, Follicular	1.2%
150	T-Cell Lymphoma	1.2%
151	Mantle cell lymphoma	1.2%
152	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	1.2%
153	Leukemia, Large Granular Lymphocytic	1.2%
154	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	1.2%
155	Lymphoma, T-Cell, Cutaneous	1%
156	Lymphoma, AIDS-Related	1%
157	Enteropathy-Associated T-Cell Lymphoma	1%
158	Primary Effusion Lymphoma	1%
159	Mycosis Fungoides	0.9%
160	Lymphomatoid Papulosis	0.9%
161	Plasmablastic lymphoma	0.9%
162	Lymphomatoid Granulomatosis	0.8%
163	Burkitt Lymphoma	0.7%
164	Niemann-Pick Disease, Type C	0.4%

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