MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Transfusion Reaction

(UMLS:C0274435)

Definition:: Complications of BLOOD TRANSFUSION. Included adverse reactions are common allergic and febrile reactions; hemolytic (delayed and acute) reactions; and other non-hemolytic adverse reactions such as infections and adverse immune reactions related to immunocompatibility.
UMLS ID:: C0274435
MeSH ID:: D065227

Classification 1:

Name:

Hemic and Lymphatic Diseases
MeSH Tree Number(s):: C15.378.962

Classification 2:

Name:

Immune System Diseases
MeSH Tree Number(s):: C20.920

Synonym(s)

Transfusion Reaction

Adverse effect;transfusion

Blood transfusion reaction

Blood transfusion reaction, NOS

Complication of blood transfusion

Complication of blood transfusion, NOS

TRANSFUSION REACTION

Transfusion reaction

Transfusion reaction, NOS

10.

Transfusion reaction, unspecified

11.

blood complication transfusion

12.

blood complications transfusion

13.

blood complications transfusions

14.

blood reaction transfusion

15.

blood reactions transfusion

16.

blood transfusion complication

17.

blood transfusion complications

18.

blood transfusion reaction

19.

blood transfusion reactions

20.

complication of blood transfusion

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Lenalidomide	FAERS: 11	SIDER US FAERS
2	Temozolomide	FAERS: 9	OFFSIDES US FAERS
3	niraparib	FAERS: 9	US FAERS
4	Alendronate	FAERS: 8	US FAERS
5	Deferasirox	FAERS: 8	US FAERS
6	Thalidomide	FAERS: 4	US FAERS
7	PCI 32765	FAERS: 3	US FAERS
8	Zoledronic Acid	FAERS: 3	US FAERS
9	rofecoxib	FAERS: 3	US FAERS
10	Bosentan	FAERS: 2	US FAERS
11	Dabigatran	FAERS: 2	US FAERS
12	Dasatinib	FAERS: 2	US FAERS
13	Decitabine	FAERS: 2	OFFSIDES SIDER US FAERS
14	Isotretinoin	FAERS: 2	US FAERS
15	Sertraline	FAERS: 2	US FAERS
16	ambrisentan	FAERS: 2	US FAERS
17	venetoclax	FAERS: 2	US FAERS
18	Aspirin-oxycodone hydrochloride-oxycodone terephthalate combination	FAERS: 1	US FAERS
19	Azacitidine	FAERS: 1	OFFSIDES SIDER US FAERS
20	Bortezomib	FAERS: 1	SIDER US FAERS
21	Cefotetan	FAERS: 1	US FAERS
22	Clofarabine	FAERS: 1	OFFSIDES US FAERS
23	Cytarabine	FAERS: 1	US FAERS
24	Docetaxel	FAERS: 1	US FAERS
25	Erlotinib Hydrochloride	FAERS: 1	US FAERS
26	Etoposide	FAERS: 1	OFFSIDES US FAERS
27	Finasteride	FAERS: 1	US FAERS
28	Methotrexate	FAERS: 1	US FAERS
29	Methoxsalen	FAERS: 1	US FAERS
30	Methylprednisolone Hemisuccinate	FAERS: 1	US FAERS
31	Modafinil	FAERS: 1	US FAERS
32	NuvaRing	FAERS: 1	US FAERS
33	Ondansetron	FAERS: 1	US FAERS
34	Piperacillin, Tazobactam Drug Combination	FAERS: 1	US FAERS
35	Ranolazine	FAERS: 1	US FAERS
36	Risperidone	FAERS: 1	US FAERS
37	Ruxolitinib phosphate	FAERS: 1	US FAERS
38	Sodium Chloride	FAERS: 1	US FAERS
39	Warfarin	FAERS: 1	US FAERS
40	Warfarin	FAERS: 1	US FAERS
41	carfilzomib	FAERS: 1	US FAERS
42	eltrombopag	FAERS: 1	US FAERS
43	pomalidomide	FAERS: 1	US FAERS
44	ponatinib	FAERS: 1	US FAERS
45	riociguat	FAERS: 1	US FAERS
46	temsirolimus	FAERS: 1	US FAERS
47	valdecoxib	FAERS: 1	US FAERS
48	Acetylcysteine		OFFSIDES
49	Acyclovir		OFFSIDES
50	Alcohols		OFFSIDES
51	Amlodipine		OFFSIDES
52	Atorvastatin		OFFSIDES
53	Beclomethasone		OFFSIDES
54	Chlorhexidine		OFFSIDES
55	Dapsone		OFFSIDES
56	Deferoxamine		OFFSIDES
57	Duloxetine Hydrochloride		OFFSIDES
58	Epinephrine		OFFSIDES
59	Erythromycin		OFFSIDES
60	Estrogens, Conjugated (USP)		OFFSIDES
61	Fondaparinux		OFFSIDES
62	Hydrochlorothiazide		OFFSIDES
63	Hydroxyurea		OFFSIDES
64	Ibuprofen		OFFSIDES
65	Medroxyprogesterone Acetate		OFFSIDES
66	Medroxyprogesterone		OFFSIDES
67	Meperidine		OFFSIDES
68	Mesna		OFFSIDES
69	Metolazone		OFFSIDES
70	Minocycline		OFFSIDES
71	Norfloxacin		OFFSIDES
72	Oxazepam		OFFSIDES
73	Pamidronate		OFFSIDES
74	Pentamidine		OFFSIDES
75	Pramipexole		OFFSIDES
76	Ribavirin		OFFSIDES
77	Rifaximin		OFFSIDES
78	Silymarin		OFFSIDES
79	Spironolactone		OFFSIDES
80	Sulfate		OFFSIDES
81	Tamoxifen		OFFSIDES
82	Tamsulosin		OFFSIDES
83	Tetracycline		OFFSIDES
84	Timolol		OFFSIDES
85	Tranexamic Acid		OFFSIDES
86	Travoprost		OFFSIDES
87	Tretinoin		OFFSIDES
88	Triamcinolone Acetonide		OFFSIDES
89	Triamcinolone		OFFSIDES
90	Vancomycin		OFFSIDES
91	Zidovudine		OFFSIDES
92	abacavir		OFFSIDES
93	chlorhexidine gluconate		OFFSIDES
94	clindamycin phosphate		OFFSIDES
95	ferrous gluconate		OFFSIDES
96	fludarabine		OFFSIDES
97	fosamprenavir		OFFSIDES
98	liposomal amphotericin B		SIDER
99	pirbuterol		OFFSIDES
100	terconazole		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Disseminated Intravascular Coagulation	38%
2	Protein S Deficiency	38%
3	Thrombocythemia, Essential	37%
4	Anemia	30%
5	Blood Coagulation Disorders	30%
6	Blood Platelet Disorders	30%
7	Bone Marrow Diseases	30%
8	Hemorrhagic Disorders	30%
9	Leukocyte Disorders	30%
10	Methemoglobinemia	30%
11	Pancytopenia	30%
12	Polycythemia	30%
13	Sulfhemoglobinemia	30%
14	Thrombophilia	30%
15	Erythrocytosis	30%
16	Thrombasthenia	29.5%
17	Antithrombin III Deficiency	29.5%
18	Protein C Deficiency	29.5%
19	Thrombocytosis	29.2%
20	Monoclonal Gammopathy of Undetermined Significance	28.7%
21	Afibrinogenemia	27.6%
22	Factor VII Deficiency	27.6%
23	Factor X Deficiency	27.6%
24	Factor XII Deficiency	27.6%
25	Hemophilia A	27.6%
26	Activated Protein C Resistance	27.6%
27	Factor II deficiency	27.6%
28	Factor VIII Deficiency	27.6%
29	Factor V deficiency	27.6%
30	Factor XI Deficiency	27.6%
31	Hypoprothrombinemias	27.6%
32	Paraproteinemias	27.3%
33	Hemoglobinuria, Paroxysmal	26.3%
34	Leukemoid Reaction	26.3%
35	Autoimmune thrombocytopenia	25.8%
36	Immune thrombocytopenic purpura	25.8%
37	Agammaglobulinemia	25.7%
38	Polycythemia Vera	25.6%
39	Bone Marrow Neoplasms	25.4%
40	Vitamin K Deficiency	25.1%
41	Lymphopenia	24.3%
42	Wiskott-Aldrich Syndrome	24.1%
43	Anemia, Diamond-Blackfan	23.9%
44	Cryoglobulinemia	23%
45	Pregnancy Complications, Hematologic	22.2%
46	Hematologic Neoplasms	22.2%
47	Thrombocytopenic purpura	22.2%
48	Job Syndrome	22.1%
49	Anemia, Hemolytic	22%
50	Anemia, Macrocytic	22%
51	Eosinophilia	22%
52	Hypoproteinemia	22%
53	Leukopenia	22%
54	Thrombocytopenia	22%
55	Leukostasis	22%
56	MYELODYSPLASTIC SYNDROME	22%
57	Hypergammaglobulinemia	21.7%
58	Heavy Chain Disease	21.7%
59	Multiple Myeloma	21.4%
60	Purpura, Thrombotic Thrombocytopenic	21.2%
61	Autoimmune Diseases	21.1%
62	Hypersensitivity	21.1%
63	Immunologic Deficiency Syndromes	21.1%
64	Immunoproliferative Disorders	21.1%
65	Immune reconstitution syndrome	21.1%
66	Immune Reconstitution Inflammatory Syndrome	21.1%
67	Waldenstrom Macroglobulinemia	19.7%
68	Infectious Mononucleosis	19.7%
69	Lymphoproliferative Disorders	18.5%
70	Anemia, Sickle Cell	18.2%
71	Thalassemia	18.2%
72	Primary Myelofibrosis	18.1%
73	Agranulocytosis	18.1%
74	Anemia, Megaloblastic	18.1%
75	Lymphocytosis	18.1%
76	Myelofibrosis	18.1%
77	Myeloid Metaplasia	18.1%
78	Hypoalbuminemia	18.1%
79	Hypereosinophilic syndrome	18.1%
80	bone marrow fibrosis	18.1%
81	Thrombotic Microangiopathies	18.1%
82	Chronic granulomatous disease	17.5%
83	Autoimmune Lymphoproliferative Syndrome	16.7%
84	Hydrops Fetalis	16.5%
85	Anemia, Neonatal	16.4%
86	Leukocytosis	16.4%
87	Pelger-Huet Anomaly	16.4%
88	Pleocytosis	16.4%
89	Neutropenia	16.2%
90	Hemolytic-Uremic Syndrome	16.1%
91	Lymphatic Diseases	15.8%
92	Sickle Cell Trait	15.7%
93	Fanconi Anemia	15.4%
94	Febrile Neutropenia	15.2%
95	Immune Complex Diseases	15%
96	Antiphospholipid Syndrome	15%
97	Latex allergy	15%
98	Atypical Hemolytic Uremic Syndrome	14.7%
99	Purpura, Hyperglobulinemic	14.6%
100	POEMS Syndrome	14.4%
101	Tumor Lysis Syndrome	14.3%
102	Sezary Syndrome	13.6%
103	Leukemia, Myelomonocytic, Chronic	13.2%
104	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	13.2%
105	Kernicterus	13%
106	Ecchymosis	12.7%
107	Petechiae	12.7%
108	Purpura	12.7%
109	anaphylaxis	12.2%
110	Food Allergy	12.2%
111	Anaphylactic shock	12.2%
112	Pulmonary Eosinophilia	12.1%
113	Eosinophilic Pneumonia	12.1%
114	Acute Chest Syndrome	11.9%
115	Leukemia, Myeloid, Chronic-Phase	11.7%
116	Anemia, Pernicious	11.7%
117	Primary amyloidosis	11.6%
118	Environmental Illness	11.5%
119	Glomerulonephritis, Membranoproliferative	11.5%
120	Lymphoma	11.4%
121	Lupus Erythematosus, Systemic	11.1%
122	Overlap syndrome	11.1%
123	Addison Disease	10.9%
124	Pemphigus	10.9%
125	Autoimmune thyroiditis	10.9%
126	Primary Adrenal Insufficiency	10.9%
127	Serum Sickness	10.9%
128	Milk Allergy	10.8%
129	Schnitzler Syndrome	10.8%
130	Wheat Hypersensitivity	10.8%
131	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	10.8%
132	Autoimmune hepatitis	10.8%
133	Eosinophilia-Myalgia Syndrome	10.6%
134	Shwartzman Phenomenon	10.5%
135	Hemangioma, Cavernous	10.4%
136	Scurvy	10.4%
137	Purpura Fulminans	10.3%
138	Adenitis	10%
139	Histiocytosis	10%
140	Lymphadenitis	10%
141	Lymphangitis	10%
142	Lymphedema	10%
143	Splenic Diseases	10%
144	Thymus Hyperplasia	10%
145	Pseudolymphoma	10%
146	Lymphadenopathy	10%
147	Waterhouse-Friderichsen Syndrome	10%
148	Asthma, Aspirin-Induced	9.9%
149	Eosinophilic Granuloma	9.9%
150	Hodgkin Disease	9.7%
151	Lymphoma, Non-Hodgkin	9.7%
152	Leukemia, T-Cell	9.7%
153	Leukemia, B-Cell	9.7%
154	Respiratory Hypersensitivity	9.4%
155	Sick Building Syndrome	9.1%
156	Multiple Chemical Sensitivity	9.1%
157	Plasmacytoma	8.9%
158	Urticaria	8.9%
159	Vasculitis, Leukocytoclastic, Cutaneous	8.9%
160	Lymphoma, Follicular	8.9%
161	T-Cell Lymphoma	8.9%
162	Mantle cell lymphoma	8.9%
163	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	8.9%
164	Leukemia, Large Granular Lymphocytic	8.9%
165	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	8.9%
166	HTLV-I Infections	8.8%
167	Latent Autoimmune Diabetes in Adults	8.6%
168	Dermatitis Herpetiformis	8.6%
169	Kounis Syndrome	8.6%
170	HIV Infections	8.5%
171	Lymphoma, T-Cell, Cutaneous	8.5%
172	Lymphoma, AIDS-Related	8.5%
173	Enteropathy-Associated T-Cell Lymphoma	8.5%
174	Primary Effusion Lymphoma	8.5%
175	Lymphangiectasis, Intestinal	8.5%
176	Mycosis Fungoides	8.3%
177	Lymphomatoid Papulosis	8.3%
178	Plasmablastic lymphoma	8.3%
179	Composite Lymphoma	8%
180	Lymphangioleiomyomatosis	8%
181	Mastocytosis, Systemic	7.9%
182	Myasthenia Gravis, Autoimmune, Experimental	7.6%
183	Lymphocele	7.4%
184	Lymphatic Abnormalities	7.4%
185	Elephantiasis	7.3%
186	Hypersplenism	7.3%
187	Sarcoidosis	7.3%
188	Elephantiasis Nostras Verrucosa	7.3%
189	Thymus Neoplasms	7.3%
190	Rheumatoid Arthritis	7.1%
191	Lymphomatoid Granulomatosis	7.1%
192	Myasthenia Gravis	7.1%
193	Uveomeningoencephalitic Syndrome	7.1%
194	Juvenile arthritis	7.1%
195	Mastocytosis	7.1%
196	Graves Disease	7.1%
197	Drug Eruptions	7%
198	Granulomatosis with polyangiitis	7%
199	Dermatitis, Allergic Contact	6.9%
200	Anti-Glomerular Basement Membrane Disease	6.9%
201	HIV Seropositivity	6.9%
202	Angioedema	6.3%
203	Multiple Sclerosis	6.3%
204	Leukemia, Plasma Cell	6.2%
205	Acute Generalized Exanthematous Pustulosis	6.2%
206	Lymphohistiocytosis, Hemophagocytic	6%
207	Erdheim-Chester Disease	6%
208	Burkitt Lymphoma	6%
209	Stiff-Person Syndrome	6%
210	Asthma, Exercise-Induced	5.9%
211	Status Asthmaticus	5.9%
212	Polyradiculoneuropathy	5.9%
213	Polyradiculoneuritis	5.9%
214	Neuromyelitis Optica	5.9%
215	Multiple Sclerosis, Chronic Progressive	5.8%
216	Multiple Sclerosis, Relapsing-Remitting	5.8%
217	Leukoencephalitis, Acute Hemorrhagic	5.8%
218	Acquired Immunodeficiency Syndrome	5.8%
219	AIDS related complex	5.8%
220	Felty Syndrome	5.7%
221	Pseudoxanthoma Elasticum	5.7%
222	Mucocutaneous Lymph Node Syndrome	5.7%
223	Lupus Nephritis	5.7%
224	Hereditary Angioedema Type III	5.6%
225	Hereditary Angioedema Types I and II	5.6%
226	Granuloma	5.5%
227	Histiocytic Disorders, Malignant	5.5%
228	Splenic Infarction	5.5%
229	Splenic Neoplasms	5.5%
230	Histiocytosis, Langerhans-Cell	5.4%
231	Asthma	5.3%
232	Encephalomyelitis, Acute Disseminated	5.2%
233	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	5.2%
234	Erythema Nodosum	5.1%
235	Neuritis, Autoimmune, Experimental	5.1%
236	Dermatitis, Photoallergic	5.1%
237	Asthma, Occupational	5.1%
238	AIDS-Related Opportunistic Infections	5%
239	Vasculitis, Central Nervous System	5%
240	Dermatitis, Atopic	5%
241	Farmer's Lung	4.9%
242	Angioedemas, Hereditary	4.9%
243	HIV Wasting Syndrome	4.9%
244	Rheumatoid Vasculitis	4.9%
245	AIDS Dementia Complex	4.9%
246	AIDS-Associated Nephropathy	4.9%
247	Lupus Vasculitis, Central Nervous System	4.9%
248	Hay fever	4.8%
249	Rhinitis, Allergic, Perennial	4.8%
250	Ataxia Telangiectasia	4.6%
251	Aspergillosis, Allergic Bronchopulmonary	4.4%
252	Malignant histiocytosis	4.4%
253	Sarcoidosis, Pulmonary	4.4%
254	Histiocytic sarcoma	4.4%
255	Guillain-Barre Syndrome	4.4%
256	Splenic Rupture	4.3%
257	Lambert-Eaton Myasthenic Syndrome	4.3%
258	Sicca Syndrome	4.3%
259	Sjogren's Syndrome	4.3%
260	HIV-Associated Lipodystrophy Syndrome	4.2%
261	Thymoma	4.2%
262	Toxic Epidermal Necrolysis	3.8%
263	Stevens-Johnson Syndrome	3.8%
264	Splenosis	3.5%
265	Giant Cell Arteritis	3.4%
266	Temporal Arteritis	3.4%
267	Myelitis, Transverse	3%
268	Miller Fisher Syndrome	2.9%
269	Niemann-Pick Disease, Type C	1.2%

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