MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Heavy Chain Disease

(UMLS:C0018852)

Definition:: A disorder of immunoglobulin synthesis in which large quantities of abnormal heavy chains are excreted in the urine. The amino acid sequences of the N-(amino-) terminal regions of these chains are normal, but they have a deletion extending from part of the variable domain through the first domain of the constant region, so that they cannot form cross-links to the light chains. The defect arises through faulty coupling of the variable (V) and constant (C) region genes.
UMLS ID:: C0018852
MeSH ID:: D006362

Classification 1:

Name:

Hemic and Lymphatic Diseases
MeSH Tree Number(s):: C15.378.147.780.490|C15.604.515.435

Classification 2:

Name:

Immune System Diseases
MeSH Tree Number(s):: C20.683.780.490

Synonym(s)

Heavy Chain Disease

BALLARD DISEASE

Heavy chain disease

Heavy chain disease, NOS

SELIGMANN DISEASE

heavy chain disease

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Methotrexate	FAERS: 5		US FAERS
2	Methotrexate	FAERS: 2		US FAERS

Similar ADE(s)

	Name	Semantic Similarity
1	Monoclonal Gammopathy of Undetermined Significance	42.3%
2	Waldenstrom Macroglobulinemia	37%
3	Agammaglobulinemia	34.6%
4	Cryoglobulinemia	32.9%
5	Multiple Myeloma	30%
6	POEMS Syndrome	28.6%
7	Tumor Lysis Syndrome	28.5%
8	Protein S Deficiency	28.2%
9	Sezary Syndrome	26.5%
10	Infectious Mononucleosis	26.4%
11	Sarcoidosis	25.6%
12	Hypergammaglobulinemia	24.3%
13	Lymphoma	24%
14	Autoimmune Lymphoproliferative Syndrome	23.7%
15	Antithrombin III Deficiency	22.2%
16	Protein C Deficiency	22.2%
17	Transfusion Reaction	21.7%
18	Hypotensive Transfusion Reaction	21.7%
19	Disseminated Intravascular Coagulation	21.5%
20	Granuloma	20.8%
21	Hypoproteinemia	20.7%
22	Thrombocythemia, Essential	19.7%
23	Adenitis	19.3%
24	Histiocytosis	19.3%
25	Lymphadenitis	19.3%
26	Lymphangitis	19.3%
27	Lymphedema	19.3%
28	Splenic Diseases	19.3%
29	Thymus Hyperplasia	19.3%
30	Pseudolymphoma	19.3%
31	Lymphadenopathy	19.3%
32	Primary amyloidosis	18.9%
33	Anemia	17.6%
34	Blood Coagulation Disorders	17.6%
35	Blood Platelet Disorders	17.6%
36	Bone Marrow Diseases	17.6%
37	Hemorrhagic Disorders	17.6%
38	Leukocyte Disorders	17.6%
39	Methemoglobinemia	17.6%
40	Pancytopenia	17.6%
41	Polycythemia	17.6%
42	Sulfhemoglobinemia	17.6%
43	Thrombophilia	17.6%
44	Erythrocytosis	17.6%
45	Hodgkin Disease	17.5%
46	Lymphoma, Non-Hodgkin	17.5%
47	Leukemia, T-Cell	17.4%
48	Leukemia, B-Cell	17.4%
49	Schnitzler Syndrome	17.2%
50	Lymphangiectasis, Intestinal	16.6%
51	Thrombasthenia	16.5%
52	Lymphocele	15.6%
53	Lymphoproliferative Disorders	15.6%
54	Lymphatic Abnormalities	15.6%
55	Thymus Neoplasms	15.4%
56	Sarcoidosis, Pulmonary	15.1%
57	Composite Lymphoma	15%
58	Lymphangioleiomyomatosis	14.9%
59	Afibrinogenemia	14.6%
60	Factor VII Deficiency	14.6%
61	Factor X Deficiency	14.6%
62	Factor XII Deficiency	14.6%
63	Hemophilia A	14.6%
64	Activated Protein C Resistance	14.6%
65	Factor II deficiency	14.6%
66	Factor VIII Deficiency	14.6%
67	Factor V deficiency	14.6%
68	Factor XI Deficiency	14.6%
69	Hypoprothrombinemias	14.6%
70	Thrombocytosis	14.5%
71	Bone Marrow Neoplasms	14.4%
72	Lymphoma, Follicular	14.3%
73	T-Cell Lymphoma	14.3%
74	Mantle cell lymphoma	14.3%
75	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	14.3%
76	Pregnancy Complications, Hematologic	14.3%
77	Hematologic Neoplasms	14.3%
78	Leukemia, Large Granular Lymphocytic	14.3%
79	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	14.3%
80	Vitamin K Deficiency	14.2%
81	Hypoalbuminemia	13.9%
82	Mucocutaneous Lymph Node Syndrome	12.8%
83	Lymphoma, T-Cell, Cutaneous	12.8%
84	Lymphoma, AIDS-Related	12.8%
85	Enteropathy-Associated T-Cell Lymphoma	12.8%
86	Primary Effusion Lymphoma	12.8%
87	Polycythemia Vera	12.6%
88	Autoimmune thrombocytopenia	12.5%
89	Immune thrombocytopenic purpura	12.5%
90	Elephantiasis	12.4%
91	Hypersplenism	12.4%
92	Elephantiasis Nostras Verrucosa	12.4%
93	Wiskott-Aldrich Syndrome	12.1%
94	Mycosis Fungoides	12%
95	Lymphomatoid Papulosis	12%
96	Plasmablastic lymphoma	12%
97	Hemoglobinuria, Paroxysmal	11.8%
98	Leukemoid Reaction	11.8%
99	Lymphomatoid Granulomatosis	11.1%
100	Thrombocytopenic purpura	10.9%
101	Anemia, Hemolytic	10.7%
102	Anemia, Macrocytic	10.7%
103	Eosinophilia	10.7%
104	Leukopenia	10.7%
105	Thrombocytopenia	10.7%
106	Leukostasis	10.7%
107	MYELODYSPLASTIC SYNDROME	10.7%
108	Anemia, Diamond-Blackfan	10.7%
109	Transfusion-Related Acute Lung Injury	10.6%
110	Purpura, Thrombotic Thrombocytopenic	10.5%
111	Histiocytic Disorders, Malignant	10.1%
112	Splenic Infarction	10.1%
113	Splenic Neoplasms	10.1%
114	Lymphopenia	10%
115	Histiocytosis, Langerhans-Cell	9.9%
116	Burkitt Lymphoma	9.6%
117	Anemia, Sickle Cell	9.4%
118	Thalassemia	9.4%
119	Lymphohistiocytosis, Hemophagocytic	9%
120	Erdheim-Chester Disease	9%
121	Anemia, Neonatal	8.7%
122	Leukocytosis	8.7%
123	Pelger-Huet Anomaly	8.7%
124	Pleocytosis	8.7%
125	Autoimmune Diseases	8.7%
126	Hypersensitivity	8.7%
127	Immunologic Deficiency Syndromes	8.7%
128	Immune reconstitution syndrome	8.7%
129	Immune Reconstitution Inflammatory Syndrome	8.7%
130	Hydrops Fetalis	8.6%
131	Job Syndrome	8.6%
132	Splenic Rupture	8.5%
133	Eosinophilic Granuloma	8.3%
134	Thymoma	8.2%
135	Plasmacytoma	7.9%
136	Lymphatic Diseases	7.8%
137	Hemolytic-Uremic Syndrome	7.4%
138	Primary Myelofibrosis	7.4%
139	Agranulocytosis	7.4%
140	Anemia, Megaloblastic	7.4%
141	Lymphocytosis	7.4%
142	Myelofibrosis	7.4%
143	Myeloid Metaplasia	7.4%
144	Hypereosinophilic syndrome	7.4%
145	bone marrow fibrosis	7.4%
146	Thrombotic Microangiopathies	7.4%
147	Purpura, Hyperglobulinemic	7.3%
148	Malignant histiocytosis	7.2%
149	Histiocytic sarcoma	7.2%
150	Ecchymosis	7.2%
151	Petechiae	7.2%
152	Purpura	7.2%
153	Chronic granulomatous disease	7.1%
154	Kernicterus	7%
155	Sickle Cell Trait	7%
156	Fanconi Anemia	6.5%
157	Splenosis	6%
158	Atypical Hemolytic Uremic Syndrome	6%
159	Waterhouse-Friderichsen Syndrome	5.9%
160	Leukemia, Myelomonocytic, Chronic	5.9%
161	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	5.9%
162	Neutropenia	5.7%
163	Glomerulonephritis, Membranoproliferative	5.6%
164	Acute Chest Syndrome	5.5%
165	Immune Complex Diseases	5%
166	Antiphospholipid Syndrome	5%
167	Latex allergy	5%
168	Eosinophilia-Myalgia Syndrome	5%
169	Shwartzman Phenomenon	4.9%
170	Hemangioma, Cavernous	4.9%
171	Leukemia, Plasma Cell	4.9%
172	Scurvy	4.9%
173	Purpura Fulminans	4.9%
174	Febrile Neutropenia	4.9%
175	Pulmonary Eosinophilia	4.7%
176	Eosinophilic Pneumonia	4.7%
177	Leukemia, Myeloid, Chronic-Phase	4.5%
178	Anemia, Pernicious	4.5%
179	Environmental Illness	4.2%
180	Lupus Erythematosus, Systemic	4.1%
181	Overlap syndrome	4.1%
182	Addison Disease	4%
183	Pemphigus	4%
184	Autoimmune thyroiditis	4%
185	Primary Adrenal Insufficiency	4%
186	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	4%
187	Autoimmune hepatitis	4%
188	Latent Autoimmune Diabetes in Adults	3.4%
189	Dermatitis Herpetiformis	3.4%
190	Kounis Syndrome	3.4%
191	HIV Infections	3.3%
192	Asthma, Aspirin-Induced	3.3%
193	anaphylaxis	3.3%
194	Food Allergy	3.3%
195	Anaphylactic shock	3.3%
196	Heavy Chain Disease	3.3%
197	Serum Sickness	3.3%
198	Pseudoxanthoma Elasticum	3%
199	Rheumatoid Arthritis	2.9%
200	Juvenile arthritis	2.9%
201	Graves Disease	2.9%
202	Anti-Glomerular Basement Membrane Disease	2.8%
203	Respiratory Hypersensitivity	2.8%
204	Paraproteinemias	2.7%
205	Sick Building Syndrome	2.7%
206	Multiple Chemical Sensitivity	2.7%
207	Urticaria	2.6%
208	Vasculitis, Leukocytoclastic, Cutaneous	2.6%
209	HTLV-I Infections	2.6%
210	Milk Allergy	2.5%
211	Wheat Hypersensitivity	2.5%
212	Myasthenia Gravis	2.2%
213	Uveomeningoencephalitic Syndrome	2.2%
214	Mastocytosis	2.2%
215	Drug Eruptions	2.2%
216	Niemann-Pick Disease, Type C	2.2%
217	Granulomatosis with polyangiitis	2.2%
218	Dermatitis, Allergic Contact	2.2%
219	Myasthenia Gravis, Autoimmune, Experimental	2.2%
220	HIV Seropositivity	2.2%
221	Ataxia Telangiectasia	2%
222	Mastocytosis, Systemic	2%
223	Stiff-Person Syndrome	1.9%
224	Polyradiculoneuropathy	1.9%
225	Polyradiculoneuritis	1.9%
226	Acquired Immunodeficiency Syndrome	1.9%
227	AIDS related complex	1.9%
228	Felty Syndrome	1.9%
229	Lupus Nephritis	1.9%
230	AIDS-Related Opportunistic Infections	1.7%
231	Vasculitis, Central Nervous System	1.7%
232	Dermatitis, Atopic	1.7%
233	Angioedema	1.7%
234	Multiple Sclerosis	1.6%
235	HIV Wasting Syndrome	1.6%
236	Rheumatoid Vasculitis	1.6%
237	AIDS Dementia Complex	1.6%
238	AIDS-Associated Nephropathy	1.6%
239	Neuromyelitis Optica	1.6%
240	Acute Generalized Exanthematous Pustulosis	1.6%
241	Lupus Vasculitis, Central Nervous System	1.6%
242	Leukoencephalitis, Acute Hemorrhagic	1.6%
243	Lambert-Eaton Myasthenic Syndrome	1.5%
244	Sicca Syndrome	1.5%
245	Sjogren's Syndrome	1.5%
246	HIV-Associated Lipodystrophy Syndrome	1.4%
247	Asthma	1.4%
248	Encephalomyelitis, Acute Disseminated	1.4%
249	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	1.4%
250	Erythema Nodosum	1.4%
251	Neuritis, Autoimmune, Experimental	1.4%
252	Dermatitis, Photoallergic	1.4%
253	Asthma, Exercise-Induced	1.4%
254	Status Asthmaticus	1.4%
255	Multiple Sclerosis, Chronic Progressive	1.4%
256	Multiple Sclerosis, Relapsing-Remitting	1.4%
257	Aspergillosis, Allergic Bronchopulmonary	1.2%
258	Guillain-Barre Syndrome	1.2%
259	Hereditary Angioedema Type III	1.2%
260	Hereditary Angioedema Types I and II	1.2%
261	Asthma, Occupational	1.2%
262	Farmer's Lung	1.2%
263	Angioedemas, Hereditary	1.2%
264	Hay fever	1.2%
265	Rhinitis, Allergic, Perennial	1.2%
266	Toxic Epidermal Necrolysis	1.1%
267	Stevens-Johnson Syndrome	1.1%
268	Giant Cell Arteritis	1%
269	Temporal Arteritis	1%
270	Myelitis, Transverse	0.9%
271	Miller Fisher Syndrome	0.7%

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