MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Job Syndrome

(UMLS:C3887645)

Definition:: Primary immunodeficiency syndrome characterized by recurrent infections and hyperimmunoglobulinemia E. Most cases are sporadic. Of the rare familial forms, the dominantly inherited subtype has additional connective tissue, dental and skeletal involvement that the recessive type does not share.
UMLS ID:: C3887645
MeSH ID:: D007589

Classification 1:

Name:

Hemic and Lymphatic Diseases
MeSH Tree Number(s):: C15.378.553.774.600

Classification 2:

Name:

Immune System Diseases
MeSH Tree Number(s):: C20.673.774.600

Synonym(s)

Job Syndrome

Buckley's syndrome

DERMATITIS, ATOPIC, WITH IMPAIRED NEUTROPHIL CHEMOTAXIS

HIE syndrome

Hyper IgE syndrome

Hyperimmunoglobulin E Syndrome

Hyperimmunoglobulin E [IgE] syndrome

Hyperimmunoglobulin E syndrome

JOB SYNDROME

10.

Job syndrome

11.

Job's syndrome

12.

Job-Buckley syndrome

13.

Quie-Hill syndrome

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Pentoxifylline		1976392	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Chronic granulomatous disease	38.2%
2	Lymphopenia	26.7%
3	Eosinophilia	23.1%
4	Leukopenia	23.1%
5	Leukostasis	23.1%
6	Transfusion Reaction	22.1%
7	Hypotensive Transfusion Reaction	22.1%
8	Agammaglobulinemia	20.1%
9	Disseminated Intravascular Coagulation	17.9%
10	Protein S Deficiency	17.9%
11	Leukocytosis	17.6%
12	Pelger-Huet Anomaly	17.6%
13	Pleocytosis	17.6%
14	Anemia	16.9%
15	Blood Coagulation Disorders	16.9%
16	Blood Platelet Disorders	16.9%
17	Bone Marrow Diseases	16.9%
18	Hemorrhagic Disorders	16.9%
19	Methemoglobinemia	16.9%
20	Pancytopenia	16.9%
21	Polycythemia	16.9%
22	Sulfhemoglobinemia	16.9%
23	Thrombophilia	16.9%
24	Erythrocytosis	16.9%
25	Leukemoid Reaction	16.3%
26	Thrombocythemia, Essential	15.5%
27	Wiskott-Aldrich Syndrome	15.4%
28	Infectious Mononucleosis	15.4%
29	Agranulocytosis	15.2%
30	Lymphocytosis	15.2%
31	Hypereosinophilic syndrome	15.2%
32	Thrombasthenia	13.2%
33	Antithrombin III Deficiency	13.2%
34	Protein C Deficiency	13.2%
35	Pregnancy Complications, Hematologic	12.8%
36	Hematologic Neoplasms	12.8%
37	Paraproteinemias	12.6%
38	Thrombocytosis	12.3%
39	HIV Infections	12%
40	Bone Marrow Neoplasms	11.9%
41	Vitamin K Deficiency	11.8%
42	Autoimmune Diseases	11.8%
43	Hypersensitivity	11.8%
44	Immunoproliferative Disorders	11.8%
45	Immune reconstitution syndrome	11.8%
46	Immune Reconstitution Inflammatory Syndrome	11.8%
47	Afibrinogenemia	11.5%
48	Factor VII Deficiency	11.5%
49	Factor X Deficiency	11.5%
50	Factor XII Deficiency	11.5%
51	Hemophilia A	11.5%
52	Activated Protein C Resistance	11.5%
53	Factor II deficiency	11.5%
54	Factor VIII Deficiency	11.5%
55	Factor V deficiency	11.5%
56	Factor XI Deficiency	11.5%
57	Hypoprothrombinemias	11.5%
58	Neutropenia	11.4%
59	Monoclonal Gammopathy of Undetermined Significance	10.9%
60	Autoimmune thrombocytopenia	10.7%
61	Immune thrombocytopenic purpura	10.7%
62	Lymphatic Diseases	10.6%
63	Hypergammaglobulinemia	10.2%
64	Transfusion-Related Acute Lung Injury	10%
65	Anemia, Hemolytic	9.9%
66	Anemia, Macrocytic	9.9%
67	Hypoproteinemia	9.9%
68	Thrombocytopenia	9.9%
69	MYELODYSPLASTIC SYNDROME	9.9%
70	HTLV-I Infections	9.8%
71	Thrombocytopenic purpura	9.8%
72	Hemoglobinuria, Paroxysmal	9.8%
73	Polycythemia Vera	9.7%
74	Febrile Neutropenia	9.4%
75	Lymphoproliferative Disorders	9.4%
76	Eosinophilia-Myalgia Syndrome	9.3%
77	Cryoglobulinemia	8.7%
78	Pulmonary Eosinophilia	8.7%
79	Eosinophilic Pneumonia	8.7%
80	Heavy Chain Disease	8.6%
81	Multiple Myeloma	8.2%
82	Anemia, Diamond-Blackfan	8.1%
83	Purpura, Thrombotic Thrombocytopenic	7.9%
84	Waldenstrom Macroglobulinemia	7.8%
85	HIV Seropositivity	7.8%
86	Anemia, Neonatal	7.6%
87	Eosinophilic Granuloma	7.5%
88	Anemia, Sickle Cell	7.4%
89	Thalassemia	7.4%
90	Autoimmune Lymphoproliferative Syndrome	7.3%
91	Hydrops Fetalis	7.1%
92	Glomerulonephritis, Membranoproliferative	6.7%
93	Immune Complex Diseases	6.7%
94	Antiphospholipid Syndrome	6.7%
95	Latex allergy	6.7%
96	Ataxia Telangiectasia	6.7%
97	Acquired Immunodeficiency Syndrome	6.6%
98	AIDS related complex	6.6%
99	Primary Myelofibrosis	6.5%
100	Anemia, Megaloblastic	6.5%
101	Myelofibrosis	6.5%
102	Myeloid Metaplasia	6.5%
103	Hypoalbuminemia	6.5%
104	bone marrow fibrosis	6.5%
105	Thrombotic Microangiopathies	6.5%
106	Kernicterus	6.2%
107	Ecchymosis	6%
108	Petechiae	6%
109	Purpura	6%
110	Tumor Lysis Syndrome	5.8%
111	AIDS-Related Opportunistic Infections	5.8%
112	Hemolytic-Uremic Syndrome	5.6%
113	HIV Wasting Syndrome	5.6%
114	Adenitis	5.6%
115	Histiocytosis	5.6%
116	Lymphadenitis	5.6%
117	Lymphangitis	5.6%
118	Lymphedema	5.6%
119	Splenic Diseases	5.6%
120	Thymus Hyperplasia	5.6%
121	Pseudolymphoma	5.6%
122	Lymphadenopathy	5.6%
123	AIDS Dementia Complex	5.6%
124	AIDS-Associated Nephropathy	5.6%
125	Purpura, Hyperglobulinemic	5.6%
126	POEMS Syndrome	5.5%
127	Environmental Illness	5.3%
128	Sickle Cell Trait	5.2%
129	Lupus Erythematosus, Systemic	5.1%
130	Overlap syndrome	5.1%
131	Addison Disease	5%
132	Pemphigus	5%
133	Autoimmune thyroiditis	5%
134	Primary Adrenal Insufficiency	5%
135	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	5%
136	Autoimmune hepatitis	5%
137	Fanconi Anemia	4.9%
138	Leukemia, Myelomonocytic, Chronic	4.9%
139	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	4.9%
140	HIV-Associated Lipodystrophy Syndrome	4.9%
141	Sezary Syndrome	4.7%
142	Lymphoma	4.7%
143	Waterhouse-Friderichsen Syndrome	4.4%
144	Atypical Hemolytic Uremic Syndrome	4.4%
145	anaphylaxis	4.4%
146	Food Allergy	4.4%
147	Primary amyloidosis	4.4%
148	Anaphylactic shock	4.4%
149	Lymphocele	4.3%
150	Lymphatic Abnormalities	4.3%
151	Thymus Neoplasms	4.2%
152	Latent Autoimmune Diabetes in Adults	4.1%
153	Acute Chest Syndrome	4%
154	Dermatitis Herpetiformis	4%
155	Kounis Syndrome	4%
156	Lymphangiectasis, Intestinal	4%
157	Shwartzman Phenomenon	3.9%
158	Hemangioma, Cavernous	3.9%
159	Scurvy	3.9%
160	Purpura Fulminans	3.9%
161	Serum Sickness	3.8%
162	Asthma, Aspirin-Induced	3.8%
163	Leukemia, Myeloid, Chronic-Phase	3.6%
164	Anemia, Pernicious	3.6%
165	Respiratory Hypersensitivity	3.5%
166	Rheumatoid Arthritis	3.4%
167	Juvenile arthritis	3.4%
168	Sick Building Syndrome	3.4%
169	Multiple Chemical Sensitivity	3.4%
170	Mucocutaneous Lymph Node Syndrome	3.4%
171	Graves Disease	3.4%
172	Plasmacytoma	3.3%
173	Urticaria	3.3%
174	Vasculitis, Leukocytoclastic, Cutaneous	3.3%
175	Elephantiasis	3.3%
176	Hypersplenism	3.3%
177	Sarcoidosis	3.3%
178	Elephantiasis Nostras Verrucosa	3.3%
179	Anti-Glomerular Basement Membrane Disease	3.3%
180	Hodgkin Disease	3.3%
181	Lymphoma, Non-Hodgkin	3.3%
182	Milk Allergy	3.3%
183	Schnitzler Syndrome	3.3%
184	Wheat Hypersensitivity	3.3%
185	Leukemia, T-Cell	3.2%
186	Leukemia, B-Cell	3.2%
187	Composite Lymphoma	2.7%
188	Lymphangioleiomyomatosis	2.7%
189	Myasthenia Gravis	2.7%
190	Uveomeningoencephalitic Syndrome	2.7%
191	Mastocytosis	2.7%
192	Drug Eruptions	2.6%
193	Granulomatosis with polyangiitis	2.6%
194	Dermatitis, Allergic Contact	2.6%
195	Lymphoma, Follicular	2.6%
196	T-Cell Lymphoma	2.6%
197	Mantle cell lymphoma	2.6%
198	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	2.6%
199	Leukemia, Large Granular Lymphocytic	2.6%
200	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	2.6%
201	Granuloma	2.5%
202	Histiocytic Disorders, Malignant	2.5%
203	Splenic Infarction	2.5%
204	Splenic Neoplasms	2.5%
205	Histiocytosis, Langerhans-Cell	2.5%
206	Myasthenia Gravis, Autoimmune, Experimental	2.4%
207	Mastocytosis, Systemic	2.4%
208	Stiff-Person Syndrome	2.3%
209	Polyradiculoneuropathy	2.2%
210	Polyradiculoneuritis	2.2%
211	Lymphoma, T-Cell, Cutaneous	2.2%
212	Lymphoma, AIDS-Related	2.2%
213	Enteropathy-Associated T-Cell Lymphoma	2.2%
214	Primary Effusion Lymphoma	2.2%
215	Pseudoxanthoma Elasticum	2.2%
216	Felty Syndrome	2.2%
217	Lymphohistiocytosis, Hemophagocytic	2.2%
218	Erdheim-Chester Disease	2.2%
219	Lupus Nephritis	2.2%
220	Mycosis Fungoides	2.1%
221	Lymphomatoid Papulosis	2.1%
222	Plasmablastic lymphoma	2.1%
223	Splenic Rupture	2%
224	Angioedema	2%
225	Multiple Sclerosis	2%
226	Thymoma	2%
227	Leukemia, Plasma Cell	2%
228	Acute Generalized Exanthematous Pustulosis	1.9%
229	Vasculitis, Central Nervous System	1.9%
230	Lymphomatoid Granulomatosis	1.9%
231	Dermatitis, Atopic	1.9%
232	Rheumatoid Vasculitis	1.9%
233	Neuromyelitis Optica	1.8%
234	Leukoencephalitis, Acute Hemorrhagic	1.8%
235	Lupus Vasculitis, Central Nervous System	1.7%
236	Asthma	1.7%
237	Lambert-Eaton Myasthenic Syndrome	1.7%
238	Asthma, Exercise-Induced	1.6%
239	Malignant histiocytosis	1.6%
240	Sarcoidosis, Pulmonary	1.6%
241	Status Asthmaticus	1.6%
242	Sicca Syndrome	1.6%
243	Histiocytic sarcoma	1.6%
244	Sjogren's Syndrome	1.6%
245	Encephalomyelitis, Acute Disseminated	1.6%
246	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	1.6%
247	Erythema Nodosum	1.6%
248	Neuritis, Autoimmune, Experimental	1.6%
249	Dermatitis, Photoallergic	1.6%
250	Multiple Sclerosis, Chronic Progressive	1.6%
251	Multiple Sclerosis, Relapsing-Remitting	1.6%
252	Burkitt Lymphoma	1.6%
253	Hereditary Angioedema Type III	1.4%
254	Hereditary Angioedema Types I and II	1.4%
255	Asthma, Occupational	1.4%
256	Aspergillosis, Allergic Bronchopulmonary	1.4%
257	Guillain-Barre Syndrome	1.4%
258	Farmer's Lung	1.4%
259	Angioedemas, Hereditary	1.4%
260	Hay fever	1.4%
261	Rhinitis, Allergic, Perennial	1.4%
262	Splenosis	1.3%
263	Toxic Epidermal Necrolysis	1.2%
264	Stevens-Johnson Syndrome	1.2%
265	Giant Cell Arteritis	1.1%
266	Temporal Arteritis	1.1%
267	Myelitis, Transverse	1%
268	Miller Fisher Syndrome	0.8%
269	Niemann-Pick Disease, Type C	0.4%

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