MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Hemolytic-Uremic Syndrome

(UMLS:C0019061)

Definition:: A syndrome that is associated with microvascular diseases of the KIDNEY, such as RENAL CORTICAL NECROSIS. It is characterized by hemolytic anemia (ANEMIA, HEMOLYTIC); THROMBOCYTOPENIA; and ACUTE RENAL FAILURE.
UMLS ID:: C0019061
MeSH ID:: D006463

Classification 1:

Name:

Male Urogenital Diseases
MeSH Tree Number(s):: C12.777.419.936.463

Classification 2:

Name:

Female Urogenital Diseases and Pregnancy Complications
MeSH Tree Number(s):: C13.351.968.419.936.463

Classification 3:

Name:

Hemic and Lymphatic Diseases
MeSH Tree Number(s):: C15.378.071.141.610|C15.378.140.855.925.500

Synonym(s)

Hemolytic-Uremic Syndrome

GASSER SYNDROME

Gasser's syndrome

HAEMOLYTIC-URAEMIC SYNDROME

HEMOLYTIC UREMIC SYNDROME

HEMOLYTIC-UREMIC SYNDROME

HUS

HUS (hemolytic uremic syndrome)

HUS - Haemolytic uraemic syndrome

10.

HUS - Hemolytic uremic syndrome

11.

Haemolytic uraemic syndrome

12.

Haemolytic uraemic syndrome, NOS

13.

Haemolytic-uraemic syndrome

14.

Hemolytic Uremic Syndrome

15.

Hemolytic uremic syndrome

16.

Hemolytic uremic syndrome, NOS

17.

Hemolytic-uremic syndrome

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Amoxicillin	20813025	CTD
2	Ampicillin	2306432 8903184	CTD
3	Aspirin	2413037 4116173	CTD
4	Atorvastatin	16780456	CTD
5	Bleomycin	View details 1699855 2482985 6203452 7679450 9572663 10435899	CTD
6	Bupropion	12544732	CTD
7	Ciprofloxacin	12022900	CTD
8	Clarithromycin	20813025	CTD
9	Clopidogrel	View details 10809043 10949205 11604563 15162901 15310726	CTD
10	Cocaine	7679450	CTD
11	Cyclosporine	View details 1721362 7679450 11140243 11604563 16388419	CTD
12	Dipyridamole	2413037	CTD
13	Epirubicin	9572663	CTD
14	Erythromycin	20813025	CTD
15	Estramustine	9949296	CTD
16	Ethinyl Estradiol-Norgestrel Combination	2080604	CTD
17	Etoposide	10435899	CTD
18	Everolimus	17951952	CTD
19	Fluorouracil	6313552 6401771 12119460	CTD
20	Hydrochloric Acid	6218601	CTD
21	Ibuprofen	17915621	CTD
22	Ketorolac Tromethamine	8443483	CTD
23	Leucovorin	12119460	CTD
24	Medroxyprogesterone Acetate	6429463	CTD
25	Mercuric Chloride	6218601	CTD
26	Metronidazole	2306432 3173180	CTD
27	Mitomycin	View details 1519930 2104558 2112726 2114657 2493141 2658095 2934584 3085480 3101142 3108839 3142062 3876775 3927871 6210069 6313552 6401771 6437662 6870446 7491579 7679450 7917560 8061399 8215482 8222875 8483557 8712831 9016902 9152802 9660541 10178695 10761566 10892085 11219485 11604563 12053072 12119460 12166705 12421219 12588957 12813674 15340761 15384034 16388419 18591164	CTD
28	Prednisolone	11037870 18427761	CTD
29	Quinine	View details 1415380 1611088 1898704 7679450 7977300 8160939 9202872 10923967 11604563 11747383 12013332 12432194 12682720 12759685 14671503 16388419 16780456 20799358	CTD
30	Sirolimus	15625544 17288963	CTD
31	Tacrolimus	View details 7679450 9811409 10328486 10561115 10616519 10831087 11100278 11140243 12644073 14696762 15219059 15388824 17123120 17951952 18534145 18689275 20009155 20813025	CTD
32	Tamoxifen	7917560 8260241	CTD
33	Ticlopidine	11604563 16388419	CTD
34	Vinblastine	7679450 8483557	CTD
35	Vincristine	View details 1699855 2482985 6846975 11037870	CTD
36	Vitamin B 12	7842113 8060203	CTD
37	chloroacetic acid	17538244	CTD
38	gemcitabine	View details 9932169 10528696 10965557 12324937 14501391 15340761 15790464 15895229 16142487 17929123 18427761 18557535 19116715 20119714	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Azotemia	28.3%
2	Anuria	25.5%
3	Nephrolithiasis	25.5%
4	Hemoglobinuria, Paroxysmal	24.1%
5	Hydronephrosis	23.4%
6	Hyperoxaluria	23.4%
7	Kidney Cortex Necrosis	23.4%
8	Kidney Papillary Necrosis	23.4%
9	Nephritis	23.4%
10	Nephrosclerosis	23.4%
11	Nephrosis	23.4%
12	Perinephritis	23.4%
13	Kidney Failure	23.4%
14	Oxalosis	23.4%
15	Renal Insufficiency	23.4%
16	Thrombocythemia, Essential	23%
17	Disseminated Intravascular Coagulation	23%
18	Protein S Deficiency	23%
19	Thrombasthenia	21.7%
20	Diabetes Insipidus	20.3%
21	Hepatorenal Syndrome	20.3%
22	Tuberculosis, Renal	20.3%
23	Diabetic Nephropathy	20.1%
24	Renal hypertension	20.1%
25	Renal Artery Obstruction	20.1%
26	Renal Artery Stenosis	20.1%
27	Nephrocalcinosis	20%
28	Thrombocytosis	19.9%
29	Blood Coagulation Disorders	18.6%
30	Bone Marrow Diseases	18.6%
31	Hemorrhagic Disorders	18.6%
32	Leukocyte Disorders	18.6%
33	Methemoglobinemia	18.6%
34	Pancytopenia	18.6%
35	Polycythemia	18.6%
36	Sulfhemoglobinemia	18.6%
37	Thrombophilia	18.6%
38	Erythrocytosis	18.6%
39	Anemia, Macrocytic	18.4%
40	Kidney Neoplasm	18.3%
41	Pregnancy Complications, Hematologic	18.2%
42	Purpura, Thrombotic Thrombocytopenic	18.1%
43	Urinary Bladder Diseases	17.8%
44	Ureteral Diseases	17.8%
45	Urethral Diseases	17.8%
46	Urination Disorders	17.8%
47	Urolithiasis	17.8%
48	Antithrombin III Deficiency	17.7%
49	Protein C Deficiency	17.7%
50	Pyelonephritis	17.3%
51	Anemia, Sickle Cell	17%
52	Thalassemia	17%
53	Thrombocytopenic purpura	16.8%
54	Transfusion Reaction	16.1%
55	Hypotensive Transfusion Reaction	16.1%
56	Kidney Calculi	16%
57	Anemia, Diamond-Blackfan	15.9%
58	Ureterolithiasis	15.8%
59	Hematologic Neoplasms	15.7%
60	AIDS-Associated Nephropathy	15.6%
61	Anemia, Neonatal	15.6%
62	Glomerulonephritis	15.5%
63	Nephritis, Interstitial	15.5%
64	Lipoid nephrosis	15.5%
65	Nephrotic Syndrome	15.5%
66	Pyelitis	15.5%
67	Pyonephrosis	15.5%
68	Nephrogenic Diabetes Insipidus	15.5%
69	Congenital Nephrogenic Diabetes Insipidus	15.5%
70	Acute kidney injury	15.5%
71	Urinary tract infection	15.4%
72	Bone Marrow Neoplasms	15.3%
73	Vitamin K Deficiency	15.2%
74	Afibrinogenemia	15.2%
75	Factor VII Deficiency	15.2%
76	Factor X Deficiency	15.2%
77	Factor XII Deficiency	15.2%
78	Hemophilia A	15.2%
79	Activated Protein C Resistance	15.2%
80	Factor II deficiency	15.2%
81	Factor VIII Deficiency	15.2%
82	Factor V deficiency	15.2%
83	Factor XI Deficiency	15.2%
84	Hypoprothrombinemias	15.2%
85	Autoimmune thrombocytopenia	15.1%
86	Immune thrombocytopenic purpura	15.1%
87	Multicystic Dysplastic Kidney	15.1%
88	Pyelocystitis	13.9%
89	Hypertension, Renovascular	13.3%
90	Bladder neck obstruction	13.1%
91	Renal Osteodystrophy	12.7%
92	Renal rickets	12.7%
93	Polycythemia Vera	12.7%
94	Sickle Cell Trait	12.6%
95	Glycosuria, Renal	12.2%
96	Anemia, Megaloblastic	11.9%
97	Lymphatic Diseases	11.7%
98	Polycystic Kidney Diseases	11.7%
99	Bladder Exstrophy	11.7%
100	Epispadias	11.7%
101	Renal Aminoacidurias	11.6%
102	Fanconi Syndrome	11.6%
103	Pseudohypoaldosteronism	11.6%
104	Liddle Syndrome	11.6%
105	Balkan Nephropathy	11.6%
106	Focal glomerulosclerosis	11.6%
107	Kidney Failure, Chronic	11.6%
108	Ureteral Calculi	11.4%
109	Leukemoid Reaction	11.2%
110	Wiskott-Aldrich Syndrome	11.2%
111	Urogenital Abnormalities	11%
112	Mesoblastic Nephroma	10.9%
113	Renal Cell Carcinoma	10.9%
114	Papillary Renal Cell Carcinoma	10.9%
115	Eosinophilia	10.6%
116	Hypoproteinemia	10.6%
117	Leukopenia	10.6%
118	Leukostasis	10.6%
119	MYELODYSPLASTIC SYNDROME	10.6%
120	Cystitis	10.5%
121	Ureteral obstruction	10.5%
122	Ureterocele	10.5%
123	Urethral Obstruction	10.5%
124	Urethritis	10.5%
125	Vesico-Ureteral Reflux	10.5%
126	Urinary Retention	10.5%
127	Renal tubular acidosis	10.3%
128	Agammaglobulinemia	10.3%
129	Acute Chest Syndrome	10.3%
130	Glomerulonephritis, Membranoproliferative	10.2%
131	Zellweger Syndrome	10.1%
132	Blood Platelet Disorders	9.8%
133	Urinary Bladder Fistula	9.7%
134	Bladder Neoplasm	9.7%
135	Ureteral Neoplasms	9.7%
136	Urethral Neoplasms	9.7%
137	Nephroblastoma	9.2%
138	Bacteriuria	9%
139	Glycosuria	9%
140	Hematuria	9%
141	Oliguria	9%
142	Polyuria	9%
143	Proteinuria	9%
144	Pyuria	9%
145	Urinary Calculi	9%
146	Leukocytosis	9%
147	Paraproteinemias	9%
148	Pelger-Huet Anomaly	9%
149	Pleocytosis	9%
150	Cystocele	9%
151	Urinary Incontinence	9%
152	Infectious Mononucleosis	8.9%
153	Anti-Glomerular Basement Membrane Disease	8.8%
154	Anemia	8.8%
155	Lupus Nephritis	8.8%
156	Polycystic Kidney, Autosomal Dominant	8.7%
157	Cystinuria	8.7%
158	Waldenstrom Macroglobulinemia	8.6%
159	Cryoglobulinemia	8.5%
160	Monoclonal Gammopathy of Undetermined Significance	8.5%
161	Fanconi Anemia	8.5%
162	Hyperphosphaturia	8.5%
163	Enuresis	8%
164	Hypergammaglobulinemia	7.8%
165	Transfusion-Related Acute Lung Injury	7.7%
166	Ecchymosis	7.7%
167	Petechiae	7.7%
168	Purpura	7.7%
169	Hydrops Fetalis	7.6%
170	Purpura, Hyperglobulinemic	7.5%
171	Heavy Chain Disease	7.4%
172	Anemia, Pernicious	7.2%
173	Urethral Stenosis	6.9%
174	Urethral stricture	6.9%
175	Multiple Myeloma	6.8%
176	Infertility	6.8%
177	Primary Myelofibrosis	6.7%
178	Agranulocytosis	6.7%
179	Lymphocytosis	6.7%
180	Myelofibrosis	6.7%
181	Myeloid Metaplasia	6.7%
182	Hypoalbuminemia	6.7%
183	Hypereosinophilic syndrome	6.7%
184	bone marrow fibrosis	6.7%
185	Waterhouse-Friderichsen Syndrome	6.7%
186	Hypospadias	6.4%
187	Adenitis	6.2%
188	Histiocytosis	6.2%
189	Lymphadenitis	6.2%
190	Lymphangitis	6.2%
191	Lymphedema	6.2%
192	Splenic Diseases	6.2%
193	Thymus Hyperplasia	6.2%
194	Pseudolymphoma	6.2%
195	Lymphadenopathy	6.2%
196	Denys-Drash Syndrome	6.1%
197	Genital Diseases, Male	6%
198	Albuminuria	5.9%
199	Hemoglobinuria	5.9%
200	Urge Incontinence	5.9%
201	Urologic Neoplasms	5.9%
202	Horseshoe Kidney	5.9%
203	Thrombocytopenia	5.8%
204	Lymphopenia	5.7%
205	Pregnancy Complications	5.7%
206	Job Syndrome	5.6%
207	Leukemia, Myelomonocytic, Chronic	5.6%
208	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	5.6%
209	Kernicterus	5.4%
210	Sexually Transmitted Diseases	5.3%
211	Lymphocele	5.2%
212	Lymphoproliferative Disorders	5.2%
213	Lymphatic Abnormalities	5.2%
214	Diurnal Enuresis	5.2%
215	Thymus Neoplasms	5.2%
216	Hermaphroditism	5.2%
217	Disorders of Sex Development	5.2%
218	Genital Herpes	5.1%
219	Lymphangiectasis, Intestinal	5.1%
220	Eosinophilic Granuloma	5.1%
221	Eosinophilia-Myalgia Syndrome	4.9%
222	Chronic granulomatous disease	4.9%
223	Shwartzman Phenomenon	4.9%
224	Anemia, Hemolytic	4.8%
225	Endometriosis	4.8%
226	Hemangioma, Cavernous	4.8%
227	Uterine Diseases	4.8%
228	Vaginal Diseases	4.8%
229	Vulvar Diseases	4.8%
230	Endometrioma	4.8%
231	Scurvy	4.8%
232	Purpura Fulminans	4.8%
233	Neutropenia	4.8%
234	Genital Neoplasms, Male	4.7%
235	Vesicovaginal Fistula	4.6%
236	Mucocutaneous Lymph Node Syndrome	4.5%
237	Familial Hypophosphatemic Rickets	4.3%
238	POEMS Syndrome	4.3%
239	Uterine Neoplasms	4.1%
240	Vaginal Neoplasms	4.1%
241	Vulvar Neoplasms	4.1%
242	Uterine Cancer	4.1%
243	Pulmonary Eosinophilia	4.1%
244	Eosinophilic Pneumonia	4.1%
245	Genital Neoplasms, Female	4.1%
246	Endometritis	4%
247	Leukemia, Myeloid, Chronic-Phase	4%
248	Thrombotic Microangiopathies	3.8%
249	Febrile Neutropenia	3.8%
250	Uterine Inversion	3.8%
251	Penile Neoplasms	3.7%
252	Prostatic Neoplasms	3.7%
253	Hemolytic-Uremic Syndrome	3.6%
254	Elephantiasis	3.5%
255	Hypersplenism	3.5%
256	Sarcoidosis	3.5%
257	Elephantiasis Nostras Verrucosa	3.5%
258	Dyspareunia	3.5%
259	Fallopian Tube Neoplasms	3.4%
260	Cryptorchidism	3.3%
261	Uterine Rupture	3.3%
262	Epididymitis	3.3%
263	Penile Diseases	3.3%
264	Prostatic Diseases	3.3%
265	Spermatic Cord Torsion	3.3%
266	Hemospermia	3.3%
267	Testicular Hydrocele	3.3%
268	Salpingitis	3.2%
269	Vulvovaginitis	3.2%
270	Pseudoxanthoma Elasticum	3.1%
271	Gonadal Dysgenesis	3%
272	Adrenogenital Syndrome	3%
273	Ovotesticular Disorders of Sex Development	3%
274	Granuloma	3%
275	Histiocytic Disorders, Malignant	3%
276	Splenic Infarction	3%
277	Splenic Neoplasms	3%
278	Histiocytosis, Langerhans-Cell	3%
279	Tumor Lysis Syndrome	3%
280	Polyhydramnios	2.9%
281	Obstetric Labor Complications	2.9%
282	Ectopic Pregnancy	2.9%
283	Pregnancy, Prolonged	2.9%
284	Puerperal Disorders	2.9%
285	Oligohydramnios	2.9%
286	Prenatal Injuries	2.9%
287	Endometrial Hyperplasia	2.9%
288	Pyometra	2.9%
289	Vaginitis	2.9%
290	Vulvitis	2.9%
291	Vaginal Discharge	2.9%
292	Vulvodynia	2.9%
293	Testicular Diseases	2.8%
294	Varicocele	2.8%
295	Oophoritis	2.8%
296	Endometrial Neoplasms	2.7%
297	Spermatocele	2.7%
298	ovarian neoplasm	2.7%
299	Abruptio Placentae	2.7%
300	Placenta Accreta	2.7%
301	Atypical Hemolytic Uremic Syndrome	2.7%
302	Hyperandrogenism	2.7%
303	Chorioamnionitis	2.7%
304	Splenic Rupture	2.6%
305	Sezary Syndrome	2.6%
306	Lymphoma	2.6%
307	Thymoma	2.5%
308	Fetal Diseases	2.5%
309	Pregnancy Complications, Cardiovascular	2.5%
310	Pregnancy Complications, Neoplastic	2.5%
311	Pregnancy Complications, Infectious	2.5%
312	Fetal Death	2.5%
313	Perinatal death	2.5%
314	Ovarian Diseases	2.4%
315	Morning Sickness	2.4%
316	Adnexitis	2.4%
317	Pruritus Vulvae	2.4%
318	Uterine hemorrhage	2.4%
319	Vaginal Fistula	2.4%
320	Pelvic Inflammatory Disease	2.4%
321	Uterine Prolapse	2.4%
322	Vaginal Prolapse	2.4%
323	Prostatic Neoplasms, Castration-Resistant	2.4%
324	Uterine Cervical Incompetence	2.4%
325	Carcinoma, Endometrioid	2.4%
326	Puerperal Infection	2.3%
327	Postpartum Hemorrhage	2.3%
328	Autoimmune Lymphoproliferative Syndrome	2.3%
329	Lymphohistiocytosis, Hemophagocytic	2.2%
330	Erdheim-Chester Disease	2.2%
331	Gestational Diabetes	2.1%
332	Candidiasis, Vulvovaginal	2.1%
333	Testicular Neoplasms	2%
334	Balanitis	1.9%
335	Benign prostatic hypertrophy	1.9%
336	Phimosis	1.9%
337	Priapism	1.9%
338	prostatitis	1.9%
339	Prostatic Adenoma	1.9%
340	Benign Prostatic Hyperplasia	1.9%
341	Prostatic Hypertrophy	1.9%
342	Prostatic Hyperplasia	1.9%
343	Uterine Cervicitis	1.9%
344	Leukorrhea	1.9%
345	Parametritis	1.9%
346	Turner Syndrome	1.9%
347	Malignant histiocytosis	1.9%
348	Sarcoidosis, Pulmonary	1.9%
349	Histiocytic sarcoma	1.9%
350	Chlamydia Infections	1.8%
351	Gonorrhea	1.8%
352	granulosa cell tumor	1.7%
353	Carcinoma, Ovarian Epithelial	1.7%
354	Premature Ejaculation	1.6%
355	Erectile dysfunction	1.6%
356	Bacterial Vaginosis	1.6%
357	Kallmann Syndrome	1.6%
358	Orchitis	1.6%
359	Splenosis	1.6%
360	Abortion, Habitual	1.6%
361	Dystocia	1.6%
362	Eclampsia	1.6%
363	Fetal Membranes, Premature Rupture	1.6%
364	Hodgkin Disease	1.6%
365	Lymphoma, Non-Hodgkin	1.6%
366	Placental Insufficiency	1.6%
367	Pre-Eclampsia	1.6%
368	Prenatal Exposure Delayed Effects	1.6%
369	HELLP Syndrome	1.6%
370	Placenta, Retained	1.6%
371	Syphilis	1.6%
372	Trichomonas Vaginitis	1.6%
373	Uterine Perforation	1.6%
374	Ovarian Hyperstimulation Syndrome	1.6%
375	Leukemia, T-Cell	1.6%
376	Leukemia, B-Cell	1.6%
377	Metrorrhagia	1.6%
378	Endometrial Stromal Sarcoma	1.5%
379	Klinefelter Syndrome	1.5%
380	Composite Lymphoma	1.4%
381	Lymphangioleiomyomatosis	1.4%
382	Corpus Luteum Cyst	1.4%
383	Ovarian Cysts	1.4%
384	Abortion, Veterinary	1.4%
385	Pregnancy Complications, Parasitic	1.4%
386	Anovulation	1.4%
387	Menorrhagia	1.4%
388	Premature Menopause	1.4%
389	Lactation Disorder	1.4%
390	Mastitis	1.4%
391	Depression, Postpartum	1.4%
392	Embryo Loss	1.4%
393	Fetal Resorption	1.3%
394	Hyperemesis Gravidarum	1.3%
395	Lymphogranuloma Venereum	1.3%
396	Azoospermia	1.3%
397	Oligospermia	1.3%
398	Impotence, Vasculogenic	1.3%
399	Asthenozoospermia	1.3%
400	Teratozoospermia	1.3%
401	Aspermia	1.3%
402	Fetal Growth Retardation	1.2%
403	Trophoblastic Neoplasms	1.2%
404	Embolism, Amniotic Fluid	1.2%
405	Fetal Hypoxia	1.2%
406	Fetal Alcohol Spectrum Disorders	1.2%
407	Breech Presentation	1.2%
408	Stillbirth	1.1%
409	Lymphoma, Follicular	1.1%
410	T-Cell Lymphoma	1.1%
411	Mantle cell lymphoma	1.1%
412	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	1.1%
413	Leukemia, Large Granular Lymphocytic	1.1%
414	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	1.1%
415	Polycystic Ovary Syndrome	1%
416	Premature Birth	1%
417	Meconium Aspiration Syndrome	0.9%
418	Lymphoma, T-Cell, Cutaneous	0.9%
419	Lymphoma, AIDS-Related	0.9%
420	Enteropathy-Associated T-Cell Lymphoma	0.9%
421	Primary Effusion Lymphoma	0.9%
422	Leydig Cell Tumor	0.9%
423	Lymphomatoid Granulomatosis	0.8%
424	Galactorrhea	0.8%
425	Mycosis Fungoides	0.8%
426	Lymphomatoid Papulosis	0.8%
427	Plasmablastic lymphoma	0.8%
428	Burkitt Lymphoma	0.7%
429	Choriocarcinoma	0.6%
430	Niemann-Pick Disease, Type C	0.6%
431	Hydatidiform Mole	0.5%

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