MetaADEDB 2.0 @ LMMD
MYELODYSPLASTIC SYNDROME
(UMLS:C3463824)
Definition:
Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into ACUTE MYELOID LEUKEMIA.
UMLS ID:
C3463824
MeSH ID:
D009190
Classification:
Name:
Hemic and Lymphatic Diseases
MeSH Tree Number(s):
C15.378.190.625
Synonym(s)
1.
MYELODYSPLASTIC SYNDROME
2.
Dysmyelopoietic Syndrome
3.
Dysmyelopoietic syndrome
4.
Hematopoeitic - Myelodysplastic Syndrome (MDS)
5.
MDS
6.
MDS - Myelodysplastic syndrome
7.
MYELOID DYSPLASIA
8.
Myelodysplasia
9.
Myelodysplastic Neoplasm
10.
Myelodysplastic Syndrome
11.
Myelodysplastic Syndrome/Neoplasm
12.
Myelodysplastic Syndromes
Associated Drug(s)
NameNumber of ReportsReference(s)Data Source
1LenalidomideFAERS: 958
Canada Vigilance: 17		Canada Vigilance
SIDER
US FAERS
2DeferasiroxFAERS: 266
Canada Vigilance: 4		Canada Vigilance
US FAERS
3AzacitidineFAERS: 212
Canada Vigilance: 48		Canada Vigilance
US FAERS
4ThalidomideFAERS: 83SIDER
US FAERS
5eltrombopagFAERS: 55US FAERS
6olaparibFAERS: 55
Canada Vigilance: 1		Canada Vigilance
US FAERS
7Imatinib MesylateFAERS: 51US FAERS
8Imatinib MesylateFAERS: 31US FAERS
9PCI 32765FAERS: 28
Canada Vigilance: 1		Canada Vigilance
US FAERS
10Ruxolitinib phosphateFAERS: 26US FAERS
11Sodium iodide I 131FAERS: 22US FAERS
12TeriparatideFAERS: 21US FAERS
134-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamideFAERS: 20US FAERS
14CytarabineFAERS: 19US FAERS
15CyclophosphamideFAERS: 18SIDER
US FAERS
16MethotrexateFAERS: 18US FAERS
17anagrelideFAERS: 18US FAERS
18TemozolomideFAERS: 17SIDER
US FAERS
19DecitabineFAERS: 16US FAERS
20AlendronateFAERS: 15US FAERS
21AzathioprineFAERS: 15US FAERS
22Bendamustine HydrochlorideFAERS: 14US FAERS
23Zoledronic AcidFAERS: 13
Canada Vigilance: 4		Canada Vigilance
US FAERS
24ClopidogrelFAERS: 12
Canada Vigilance: 1		Canada Vigilance
US FAERS
25fludarabine phosphateFAERS: 12US FAERS
26venetoclaxFAERS: 12US FAERS
27CladribineFAERS: 11SIDER
US FAERS
28CyclosporineFAERS: 11US FAERS
29AtorvastatinFAERS: 10US FAERS
30RivaroxabanFAERS: 10US FAERS
31BortezomibFAERS: 9US FAERS
32BosentanFAERS: 9US FAERS
33DabigatranFAERS: 9US FAERS
34DasatinibFAERS: 9US FAERS
35HydroxyureaFAERS: 9US FAERS
36SorafenibFAERS: 9US FAERS
37TerbinafineFAERS: 9US FAERS
38VoriconazoleFAERS: 9US FAERS
39eltrombopagFAERS: 9
Canada Vigilance: 1		Canada Vigilance
US FAERS
40HydroxychloroquineFAERS: 8US FAERS
41SunitinibFAERS: 8US FAERS
42CapecitabineFAERS: 7US FAERS
43ClozapineFAERS: 7
Canada Vigilance: 2		Canada Vigilance
US FAERS
44Erlotinib HydrochlorideFAERS: 7US FAERS
45LetrozoleFAERS: 7US FAERS
46MDV 3100FAERS: 7US FAERS
47OctreotideFAERS: 7US FAERS
48apixabanFAERS: 7US FAERS
49carfilzomibFAERS: 7US FAERS
50niraparibFAERS: 7US FAERS
51DiclofenacFAERS: 6US FAERS
52RamiprilFAERS: 6
Canada Vigilance: 1		Canada Vigilance
US FAERS
53Sildenafil CitrateFAERS: 6US FAERS
54WarfarinFAERS: 6US FAERS
55idelalisibFAERS: 6US FAERS
56rucaparibFAERS: 6US FAERS
57AmlodipineFAERS: 5US FAERS
58AnastrozoleFAERS: 5US FAERS
59CelecoxibFAERS: 5US FAERS
60DeferoxamineFAERS: 5US FAERS
61DoxorubicinFAERS: 5SIDER
US FAERS
62EsomeprazoleFAERS: 5US FAERS
63LeflunomideFAERS: 5US FAERS
64PregabalinFAERS: 5US FAERS
65SunitinibFAERS: 5US FAERS
66ValsartanFAERS: 5
Canada Vigilance: 2		Canada Vigilance
US FAERS
67exemestaneFAERS: 5US FAERS
68Carbidopa, levodopa, and entacaponeFAERS: 4US FAERS
69CarboplatinFAERS: 4SIDER
US FAERS
70CilostazolFAERS: 4US FAERS
71IrinotecanFAERS: 4US FAERS
72LinezolidFAERS: 4US FAERS
73MercaptopurineFAERS: 4
Canada Vigilance: 1		Canada Vigilance
US FAERS
74PioglitazoneFAERS: 4US FAERS
75TelmisartanFAERS: 4US FAERS
76Valproic AcidFAERS: 4SIDER
US FAERS
77Venlafaxine HydrochlorideFAERS: 4US FAERS
78palbociclibFAERS: 4US FAERS
79posaconazoleFAERS: 4SIDER
US FAERS
80Arsenic TrioxideFAERS: 3US FAERS
81ChlorambucilFAERS: 3SIDER
US FAERS
82Erlotinib HydrochlorideFAERS: 3US FAERS
83EtoposideFAERS: 3US FAERS
84GlyburideFAERS: 3US FAERS
85GoserelinFAERS: 3US FAERS
86OctreotideFAERS: 3US FAERS
87PemetrexedFAERS: 3US FAERS
88Raloxifene HydrochlorideFAERS: 3US FAERS
89RisperidoneFAERS: 3US FAERS
90RivastigmineFAERS: 3US FAERS
91RosiglitazoneFAERS: 3US FAERS
92Tiotropium BromideFAERS: 3US FAERS
93TretinoinFAERS: 3US FAERS
94gemcitabineFAERS: 3US FAERS
95glimepirideFAERS: 3US FAERS
96liposomal amphotericin BFAERS: 3US FAERS
97rofecoxibFAERS: 3US FAERS
98tofacitinibFAERS: 3US FAERS
99AmiodaroneFAERS: 2US FAERS
100AmiodaroneFAERS: 2US FAERS
101AmoxicillinFAERS: 2US FAERS
102AripiprazoleFAERS: 2US FAERS
103CarbamazepineFAERS: 2US FAERS
104CiprofloxacinFAERS: 2US FAERS
105ClomipheneFAERS: 2US FAERS
106DantroleneFAERS: 2US FAERS
107DoxycyclineFAERS: 2US FAERS
108Fingolimod HydrochlorideFAERS: 2US FAERS
109GefitinibFAERS: 2US FAERS
110LCZ 696FAERS: 2US FAERS
111LamivudineFAERS: 2US FAERS
112LamotrigineFAERS: 2US FAERS
113LatanoprostFAERS: 2
Canada Vigilance: 1		Canada Vigilance
US FAERS
114LeuprolideFAERS: 2US FAERS
115LevetiracetamFAERS: 2US FAERS
116LiraglutideFAERS: 2US FAERS
117LopinavirFAERS: 2US FAERS
118LosartanFAERS: 2US FAERS
119LosartanFAERS: 2US FAERS
120MelphalanFAERS: 2US FAERS
121MetforminFAERS: 2US FAERS
122MethotrexateFAERS: 2US FAERS
123MinoxidilFAERS: 2US FAERS
124MitoxantroneFAERS: 2US FAERS
125NiacinFAERS: 2US FAERS
126OmeprazoleFAERS: 2US FAERS
127PaclitaxelFAERS: 2SIDER
US FAERS
128PrednisoloneFAERS: 2US FAERS
129Quetiapine FumarateFAERS: 2US FAERS
130Risedronic AcidFAERS: 2US FAERS
131Senna ExtractFAERS: 2US FAERS
132SertralineFAERS: 2US FAERS
133SimvastatinFAERS: 2US FAERS
134Sitagliptin PhosphateFAERS: 2US FAERS
135TadalafilFAERS: 2US FAERS
136TicagrelorFAERS: 2US FAERS
137aclidinium bromideFAERS: 2US FAERS
138alfuzosinFAERS: 2US FAERS
139aliskirenFAERS: 2US FAERS
140ambrisentanFAERS: 2US FAERS
141apremilastFAERS: 2US FAERS
142bosutinibFAERS: 2US FAERS
143carbidopa, levodopa drug combinationFAERS: 2US FAERS
144eribulinFAERS: 2US FAERS
145ledipasvir, sofosbuvir drug combinationFAERS: 2US FAERS
146liposomal doxorubicinFAERS: 2US FAERS
147montelukastFAERS: 2US FAERS
148olmesartanFAERS: 2US FAERS
149pentetreotideFAERS: 2US FAERS
150pirfenidoneFAERS: 2US FAERS
151AcitretinFAERS: 1US FAERS
152AcyclovirFAERS: 1US FAERS
153AlbuterolFAERS: 1US FAERS
154AvalideFAERS: 1US FAERS
155BromocriptineFAERS: 1US FAERS
156BusulfanFAERS: 1US FAERS
157CH5424802FAERS: 1US FAERS
158CarmustineFAERS: 1US FAERS
159CeftriaxoneFAERS: 1US FAERS
160ChloramphenicolFAERS: 1US FAERS
161CitalopramFAERS: 1US FAERS
162CitalopramFAERS: 1US FAERS
163CopiktraFAERS: 1US FAERS
164DabigatranFAERS: 1US FAERS
165DeferiproneFAERS: 1US FAERS
166DigoxinFAERS: 1US FAERS
167Dimethyl FumarateFAERS: 1US FAERS
168DroxidopaFAERS: 1US FAERS
169EpoprostenolFAERS: 1US FAERS
170EstradiolFAERS: 1US FAERS
171EverolimusFAERS: 1US FAERS
172FebuxostatFAERS: 1US FAERS
173FentanylFAERS: 1US FAERS
174FentanylFAERS: 1US FAERS
175FinasterideFAERS: 1US FAERS
176Fluticasone-Salmeterol Drug CombinationFAERS: 1US FAERS
177FulvestrantFAERS: 1US FAERS
178Glatiramer AcetateFAERS: 1US FAERS
179HhAntag691FAERS: 1US FAERS
180HydroxychloroquineFAERS: 1US FAERS
181Ibandronic AcidFAERS: 1US FAERS
182Ibandronic AcidFAERS: 1US FAERS
183ImiquimodFAERS: 1US FAERS
184Insulin GlargineFAERS: 1US FAERS
185Interleukin 1 Receptor Antagonist ProteinFAERS: 1US FAERS
186IrbesartanFAERS: 1US FAERS
187ItraconazoleFAERS: 1US FAERS
188Kombiglyze XRFAERS: 1US FAERS
189LansoprazoleFAERS: 1US FAERS
190LapatinibFAERS: 1US FAERS
191LevofloxacinFAERS: 1US FAERS
192LisinoprilFAERS: 1US FAERS
193LorazepamFAERS: 1US FAERS
194LovastatinFAERS: 1US FAERS
195Medroxyprogesterone AcetateFAERS: 1US FAERS
196Methylprednisolone HemisuccinateFAERS: 1US FAERS
197MoxifloxacinFAERS: 1US FAERS
198NateglinideFAERS: 1US FAERS
199NicotineFAERS: 1US FAERS
200PamidronateFAERS: 1US FAERS
201ParoxetineFAERS: 1US FAERS
202PipobromanFAERS: 1US FAERS
203Prasugrel HydrochlorideFAERS: 1US FAERS
204PravastatinFAERS: 1US FAERS
205ProcarbazineFAERS: 1US FAERS
206Quetiapine FumarateFAERS: 1US FAERS
207QuinaprilFAERS: 1US FAERS
208RanitidineFAERS: 1US FAERS
209Rasilez HCTFAERS: 1US FAERS
210RivastigmineFAERS: 1US FAERS
211Rosuvastatin CalciumFAERS: 1US FAERS
212SertralineFAERS: 1US FAERS
213SirolimusFAERS: 1US FAERS
214SotalolFAERS: 1US FAERS
215TamoxifenFAERS: 1US FAERS
216TamsulosinFAERS: 1US FAERS
217TenofovirFAERS: 1US FAERS
218TenofovirFAERS: 1US FAERS
219TestosteroneFAERS: 1US FAERS
220TopiramateFAERS: 1US FAERS
221TramadolFAERS: 1US FAERS
222ValacyclovirFAERS: 1US FAERS
223ValacyclovirFAERS: 1US FAERS
224ValganciclovirFAERS: 1US FAERS
225Valproic AcidFAERS: 1US FAERS
226Valproic AcidFAERS: 1US FAERS
227VemurafenibFAERS: 1US FAERS
228VincristineFAERS: 1US FAERS
229VinorelbineFAERS: 1US FAERS
230VoseviFAERS: 1US FAERS
231ZidovudineFAERS: 1US FAERS
232acalabrutinibFAERS: 1US FAERS
233alogliptinFAERS: 1US FAERS
234atovaquone, proguanil drug combinationFAERS: 1US FAERS
235bicalutamideFAERS: 1US FAERS
236candesartan cilexetilFAERS: 1US FAERS
237desloratadineFAERS: 1US FAERS
238dofetilideFAERS: 1US FAERS
239fexofenadineFAERS: 1US FAERS
240gilteritinibFAERS: 1US FAERS
241lanreotideFAERS: 1US FAERS
242lenvatinibFAERS: 1US FAERS
243macitentanFAERS: 1US FAERS
244midostaurinFAERS: 1US FAERS
245osimertinibFAERS: 1US FAERS
246paricalcitolFAERS: 1US FAERS
247pomalidomideFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
248reviparinFAERS: 1US FAERS
249telotristat ethylFAERS: 1US FAERS
250treprostinilFAERS: 1US FAERS
251Bendamustine HydrochlorideSIDER
252DocetaxelSIDER
253DoxazosinCanada Vigilance: 1Canada Vigilance
254IdarubicinSIDER
255IfosfamideSIDER
256MitoxantroneSIDER
257RadiumSIDER
258SemaxinibSIDER
259SulfasalazineSIDER
260ThiotepaSIDER
261fludarabineSIDER
Similar ADE(s)
NameSemantic Similarity
1Thrombocytosis36.3%
2Primary Myelofibrosis34.4%
3Myelofibrosis34.4%
4Myeloid Metaplasia34.4%
5bone marrow fibrosis34.4%
6Bone Marrow Neoplasms33.3%
7Polycythemia Vera33.1%
8Thrombocythemia, Essential33.1%
9Leukemoid Reaction32.6%
10Anemia31%
11Blood Coagulation Disorders31%
12Blood Platelet Disorders31%
13Hemorrhagic Disorders31%
14Leukocyte Disorders31%
15Methemoglobinemia31%
16Pancytopenia31%
17Polycythemia31%
18Sulfhemoglobinemia31%
19Thrombophilia31%
20Erythrocytosis31%
21Disseminated Intravascular Coagulation30%
22Protein S Deficiency30%
23Leukemia, Myelomonocytic, Chronic22.8%
24Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative22.8%
25Anemia, Diamond-Blackfan22.1%
26Transfusion Reaction22%
27Hypotensive Transfusion Reaction22%
28Thrombasthenia21.9%
29Antithrombin III Deficiency21.9%
30Protein C Deficiency21.9%
31Pregnancy Complications, Hematologic20.9%
32Hematologic Neoplasms20.9%
33Anemia, Hemolytic20%
34Anemia, Macrocytic20%
35Eosinophilia20%
36Hypoproteinemia20%
37Leukopenia20%
38Thrombocytopenia20%
39Leukostasis20%
40Vitamin K Deficiency19.8%
41Afibrinogenemia19.7%
42Factor VII Deficiency19.7%
43Factor X Deficiency19.7%
44Factor XII Deficiency19.7%
45Hemophilia A19.7%
46Activated Protein C Resistance19.7%
47Factor II deficiency19.7%
48Factor VIII Deficiency19.7%
49Factor V deficiency19.7%
50Factor XI Deficiency19.7%
51Hypoprothrombinemias19.7%
52Leukemia, Myeloid, Chronic-Phase18.8%
53Lymphatic Diseases18.5%
54Fanconi Anemia16.3%
55Agranulocytosis14.8%
56Anemia, Megaloblastic14.8%
57Lymphocytosis14.8%
58Hypoalbuminemia14.8%
59Hypereosinophilic syndrome14.8%
60Thrombotic Microangiopathies14.8%
61Purpura, Thrombotic Thrombocytopenic14.1%
62Anemia, Neonatal13.6%
63Leukocytosis13.6%
64Paraproteinemias13.6%
65Pelger-Huet Anomaly13.6%
66Pleocytosis13.6%
67Agammaglobulinemia13.6%
68Wiskott-Aldrich Syndrome13.4%
69Anemia, Sickle Cell12.9%
70Thalassemia12.9%
71Neutropenia12.2%
72Cryoglobulinemia11.8%
73Monoclonal Gammopathy of Undetermined Significance11.8%
74Febrile Neutropenia10.9%
75Autoimmune thrombocytopenia10.8%
76Immune thrombocytopenic purpura10.8%
77Heavy Chain Disease10.7%
78Hemolytic-Uremic Syndrome10.6%
79Infectious Mononucleosis10.6%
80Waldenstrom Macroglobulinemia10.4%
81Adenitis10.3%
82Histiocytosis10.3%
83Hypergammaglobulinemia10.3%
84Lymphadenitis10.3%
85Lymphangitis10.3%
86Lymphedema10.3%
87Splenic Diseases10.3%
88Thymus Hyperplasia10.3%
89Pseudolymphoma10.3%
90Lymphadenopathy10.3%
91Sickle Cell Trait10.2%
92Lymphopenia10.1%
93Transfusion-Related Acute Lung Injury10.1%
94Ecchymosis10%
95Petechiae10%
96Purpura10%
97Job Syndrome9.9%
98Hemoglobinuria, Paroxysmal9.8%
99Purpura, Hyperglobulinemic9.8%
100Thrombocytopenic purpura9.2%
101Atypical Hemolytic Uremic Syndrome9.1%
102Multiple Myeloma8.5%
103Pulmonary Eosinophilia8.4%
104Eosinophilic Pneumonia8.4%
105Hydrops Fetalis8.1%
106Anemia, Pernicious8%
107Eosinophilia-Myalgia Syndrome7.6%
108Acute Chest Syndrome7.5%
109Chronic granulomatous disease7.4%
110Shwartzman Phenomenon7.4%
111Hemangioma, Cavernous7.4%
112Scurvy7.3%
113Purpura Fulminans7.3%
114Lymphocele7%
115Lymphoproliferative Disorders7%
116Lymphatic Abnormalities7%
117Thymus Neoplasms6.8%
118Waterhouse-Friderichsen Syndrome6.8%
119Elephantiasis6.7%
120Hypersplenism6.7%
121Lymphangiectasis, Intestinal6.7%
122Sarcoidosis6.7%
123Elephantiasis Nostras Verrucosa6.7%
124Eosinophilic Granuloma6.6%
125POEMS Syndrome5.9%
126Kernicterus5.7%
127Mucocutaneous Lymph Node Syndrome5.1%
128Lymphohistiocytosis, Hemophagocytic4.9%
129Erdheim-Chester Disease4.9%
130Granuloma4.5%
131Histiocytic Disorders, Malignant4.5%
132Splenic Infarction4.5%
133Splenic Neoplasms4.5%
134Histiocytosis, Langerhans-Cell4.4%
135Tumor Lysis Syndrome4.4%
136Pseudoxanthoma Elasticum3.8%
137Splenic Rupture3.4%
138Lymphoma3.4%
139Thymoma3.3%
140Sezary Syndrome3.3%
141Malignant histiocytosis3.3%
142Sarcoidosis, Pulmonary3.3%
143Histiocytic sarcoma3.3%
144Autoimmune Lymphoproliferative Syndrome2.7%
145Splenosis2.5%
146Hodgkin Disease2.5%
147Lymphoma, Non-Hodgkin2.5%
148Leukemia, T-Cell2.4%
149Leukemia, B-Cell2.4%
150Lymphoma, Follicular2%
151T-Cell Lymphoma2%
152Mantle cell lymphoma2%
153Precursor B-Cell Lymphoblastic Leukemia-Lymphoma2%
154Leukemia, Large Granular Lymphocytic2%
155Precursor T-Cell Lymphoblastic Leukemia-Lymphoma2%
156Composite Lymphoma2%
157Lymphangioleiomyomatosis1.9%
158Lymphoma, T-Cell, Cutaneous1.8%
159Lymphoma, AIDS-Related1.8%
160Enteropathy-Associated T-Cell Lymphoma1.8%
161Primary Effusion Lymphoma1.8%
162Mycosis Fungoides1.7%
163Lymphomatoid Papulosis1.7%
164Plasmablastic lymphoma1.7%
165Lymphomatoid Granulomatosis1.5%
166Burkitt Lymphoma1.2%
167Niemann-Pick Disease, Type C0.7%
Powered by :

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120238

Copyright © 2019-2020 Laboratory of Molecular Modeling and Design, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology. All rights reserved.