MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Histiocytosis, Langerhans-Cell

(UMLS:C0019621)

Definition:: A group of disorders resulting from the abnormal proliferation of and tissue infiltration by LANGERHANS CELLS which can be detected by their characteristic Birbeck granules (X bodies), or by monoclonal antibody staining for their surface CD1 ANTIGENS. Langerhans-cell granulomatosis can involve a single organ, or can be a systemic disorder.
UMLS ID:: C0019621
MeSH ID:: D006646

Classification 1:

Name:

Respiratory Tract Diseases
MeSH Tree Number(s):: C08.381.483.375

Classification 2:

Name:

Hemic and Lymphatic Diseases
MeSH Tree Number(s):: C15.604.250.400

Synonym(s)

Histiocytosis, Langerhans-Cell

Chronic differentiated progressive histiocytosis

Chronic disseminated histiocytosis X

Chronic histiocytosis X

Chronic idiopathic xanthomatosis

Classic Multifocal Langerhans Cell Histiocytosis

Differentiated progressive histiocytosis

EOSINOPHILIC GRANULOMA, MULTIFOCAL

Generalized histiocytosis of bones

10.

HISTIOCYTOSIS X II

11.

Hand-Schueller-Christian syndrome

12.

Hand-Schuller-Christian Disease

13.

Hand-Schuller-Christian disease

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Pamidronate	12087588	CTD
2	Prednisone	12571475	CTD
3	Vinblastine	12571475	CTD
4	afuresertib	25075128 27804235 29768711	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Sarcoidosis, Pulmonary	30.6%
2	Pneumoconiosis	27.8%
3	Idiopathic Pulmonary Fibrosis	27.3%
4	Histiocytic Disorders, Malignant	23.7%
5	Lymphohistiocytosis, Hemophagocytic	23.1%
6	Erdheim-Chester Disease	23.1%
7	Radiation Pneumonitis	22.3%
8	Radiation Fibrosis	22.3%
9	Pneumonia	20.7%
10	Lobar Pneumonia	20.7%
11	Respiratory Distress Syndrome, Adult	20.7%
12	Pneumonitis	20.7%
13	Adenitis	20.5%
14	Atelectasis	20.5%
15	Pulmonary Hypertension	20.5%
16	Lymphadenitis	20.5%
17	Lymphangitis	20.5%
18	Lymphedema	20.5%
19	Pulmonary Alveolar Proteinosis	20.5%
20	Pulmonary Edema	20.5%
21	Pulmonary Fibrosis	20.5%
22	Splenic Diseases	20.5%
23	Thymus Hyperplasia	20.5%
24	Hamman-Rich syndrome	20.5%
25	Pseudolymphoma	20.5%
26	Lymphadenopathy	20.5%
27	Lung Diseases, Obstructive	20.5%
28	Asbestosis	20%
29	Berylliosis	20%
30	Silicosis	20%
31	Granulomatosis with polyangiitis	18.5%
32	Malignant histiocytosis	17.4%
33	Histiocytic sarcoma	17.4%
34	Pulmonary Eosinophilia	17.2%
35	Eosinophilic Pneumonia	17.2%
36	Lung Diseases, Fungal	16.7%
37	Bronchitis	16.4%
38	Respiratory Distress Syndrome, Newborn	16.4%
39	Lung Abscess	16.3%
40	Lung Neoplasms	16.3%
41	Tuberculosis, Pulmonary	16.2%
42	Lymphangiectasis, Intestinal	16%
43	Lymphocele	15.5%
44	Lymphoproliferative Disorders	15.5%
45	Lung Injury	15.5%
46	Lymphatic Abnormalities	15.5%
47	Hepatopulmonary Syndrome	15.5%
48	Anti-Glomerular Basement Membrane Disease	15.4%
49	Thymus Neoplasms	15.3%
50	Pulmonary Embolism	15.1%
51	Bronchopneumonia	14.9%
52	Bronchitis, Chronic	14.3%
53	Farmer's Lung	13.9%
54	Asthma	13.6%
55	Elephantiasis	13.3%
56	Hypersplenism	13.3%
57	Chronic Obstructive Airway Disease	13.3%
58	Middle Lobe Syndrome	13.3%
59	Pleuropneumonia	13.3%
60	Aspiration Pneumonia	13.3%
61	Sarcoidosis	13.3%
62	Acute Lung Injury	13.3%
63	Elephantiasis Nostras Verrucosa	13.3%
64	Hemoptysis	12.2%
65	Mucocutaneous Lymph Node Syndrome	12.2%
66	Acute Chest Syndrome	12.1%
67	Bronchial Diseases	11.9%
68	Pleural Diseases	11.9%
69	Respiration Disorders	11.9%
70	Thoracic Diseases	11.9%
71	Tracheal Diseases	11.9%
72	Bronchiolitis	11.3%
73	Pneumonia, Viral	11.1%
74	Agammaglobulinemia	10.8%
75	Pneumonia, Bacterial	10.8%
76	Hyaline Membrane Disease	10.6%
77	Multiple Pulmonary Nodules	10.6%
78	Cystic Fibrosis	10.5%
79	Pleurisy	10.3%
80	Tracheitis	10.3%
81	Tracheobronchomegaly	10.3%
82	Scimitar Syndrome	10.2%
83	Granuloma	10.2%
84	Persistent Fetal Circulation Syndrome	10.2%
85	Splenic Infarction	10.2%
86	Splenic Neoplasms	10.2%
87	Tumor Lysis Syndrome	10%
88	Pulmonary Aspergillosis	10%
89	Bronchopulmonary Aspergillosis	10%
90	Heavy Chain Disease	9.9%
91	Pulmonary Emphysema	9.9%
92	Pulmonary Infarction	9.9%
93	Pneumonia, Lipid	9.8%
94	Laryngeal Diseases	9.3%
95	Nose Diseases	9.3%
96	Aspergillosis, Allergic Bronchopulmonary	9%
97	Respiratory Tract Infections	8.9%
98	Infectious Mononucleosis	8.8%
99	Meconium Aspiration Syndrome	8.8%
100	Granuloma, Respiratory Tract	8.8%
101	Respiratory Hypersensitivity	8.8%
102	Respiratory Tract Fistula	8.8%
103	Transfusion-Related Acute Lung Injury	8.7%
104	Bronchiolitis Obliterans	8.6%
105	Sezary Syndrome	8.5%
106	Laryngitis	8.3%
107	Rhinitis	8.3%
108	Vocal Cord Dysfunction	8.3%
109	Splenic Rupture	8.2%
110	Bronchial Fistula	8.2%
111	Pleural Neoplasms	8.2%
112	Lymphoma	8.1%
113	Disseminated Intravascular Coagulation	8%
114	Protein S Deficiency	8%
115	Thymoma	7.9%
116	Granuloma, Laryngeal	7.8%
117	Bronchopulmonary Dysplasia	7.4%
118	Waldenstrom Macroglobulinemia	7.4%
119	Thrombocythemia, Essential	7.4%
120	Choanal Atresia	6.9%
121	Laryngocele	6.9%
122	Altitude Sickness	6.8%
123	Anemia	6.8%
124	Blood Coagulation Disorders	6.8%
125	Blood Platelet Disorders	6.8%
126	Bone Marrow Diseases	6.8%
127	Bronchospasm	6.8%
128	Bronchiectasis	6.8%
129	Chylothorax	6.8%
130	Hemorrhagic Disorders	6.8%
131	Hydropneumothorax	6.8%
132	Hydrothorax	6.8%
133	Leukocyte Disorders	6.8%
134	Methemoglobinemia	6.8%
135	Pancytopenia	6.8%
136	Pneumothorax	6.8%
137	Polycythemia	6.8%
138	Respiratory Insufficiency	6.8%
139	Sulfhemoglobinemia	6.8%
140	Tracheal Stenosis	6.8%
141	Bronchial Hyperreactivity	6.8%
142	Respiratory Depression	6.8%
143	Thrombophilia	6.8%
144	Respiratory Failure	6.8%
145	Autoimmune Lymphoproliferative Syndrome	6.8%
146	Erythrocytosis	6.8%
147	Tracheal Neoplasms	6.8%
148	Sinusitis	6.8%
149	Bronchial Neoplasms	6.7%
150	Blastomycosis	6.6%
151	Pleural Effusion, Malignant	6.6%
152	Thrombasthenia	6.1%
153	Antithrombin III Deficiency	6.1%
154	Protein C Deficiency	6.1%
155	Splenosis	6%
156	Hodgkin Disease	5.9%
157	Lymphoma, Non-Hodgkin	5.9%
158	Invasive Pulmonary Aspergillosis	5.9%
159	Primary Ciliary Dyskinesia	5.9%
160	Laryngeal neoplasm	5.9%
161	Leukemia, T-Cell	5.9%
162	Leukemia, B-Cell	5.9%
163	Thrombocytosis	5.8%
164	Afibrinogenemia	5.5%
165	Factor VII Deficiency	5.5%
166	Factor X Deficiency	5.5%
167	Factor XII Deficiency	5.5%
168	Hemophilia A	5.5%
169	Activated Protein C Resistance	5.5%
170	Factor II deficiency	5.5%
171	Factor VIII Deficiency	5.5%
172	Factor V deficiency	5.5%
173	Factor XI Deficiency	5.5%
174	Hypoprothrombinemias	5.5%
175	Transfusion Reaction	5.4%
176	Hypotensive Transfusion Reaction	5.4%
177	Laryngospasm	5.3%
178	Bone Marrow Neoplasms	5.3%
179	Asthma, Exercise-Induced	5.3%
180	Status Asthmaticus	5.3%
181	Vitamin K Deficiency	5.3%
182	Granuloma, Lethal Midline	5.2%
183	Laryngeal Edema	5.2%
184	Nose Deformities, Acquired	5.2%
185	Pregnancy Complications, Hematologic	5.2%
186	Hematologic Neoplasms	5.2%
187	Respiratory Aspiration	5.2%
188	Apnea	5.1%
189	Cheyne-Stokes Respiration	5.1%
190	Common Cold	5.1%
191	Dyspnea	5.1%
192	Hemothorax	5.1%
193	Hyperventilation	5.1%
194	Influenza	5.1%
195	Mouth Breathing	5.1%
196	Tachypnea	5.1%
197	Catarrh	5.1%
198	Severe Acute Respiratory Syndrome	5%
199	Laryngopharyngeal Reflux	5%
200	Composite Lymphoma	4.9%
201	Hemoglobinuria, Paroxysmal	4.9%
202	Leukemoid Reaction	4.9%
203	Polycythemia Vera	4.9%
204	Lymphangioleiomyomatosis	4.9%
205	Lymphoma, Follicular	4.9%
206	T-Cell Lymphoma	4.9%
207	Mantle cell lymphoma	4.9%
208	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	4.9%
209	Leukemia, Large Granular Lymphocytic	4.9%
210	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	4.9%
211	Niemann-Pick Disease, Type C	4.6%
212	Asthma, Occupational	4.6%
213	Nose Neoplasms	4.5%
214	Rhinoscleroma	4.5%
215	Airway Obstruction	4.4%
216	Anemia, Hemolytic	4.4%
217	Anemia, Macrocytic	4.4%
218	Choking	4.4%
219	Eosinophilia	4.4%
220	Epiglottitis	4.4%
221	Hypoproteinemia	4.4%
222	Leukopenia	4.4%
223	Mediastinitis	4.4%
224	Thrombocytopenia	4.4%
225	Leukostasis	4.4%
226	MYELODYSPLASTIC SYNDROME	4.4%
227	Paranasal Sinus Neoplasms	4.4%
228	Lymphoma, T-Cell, Cutaneous	4.4%
229	Lymphoma, AIDS-Related	4.4%
230	Enteropathy-Associated T-Cell Lymphoma	4.4%
231	Primary Effusion Lymphoma	4.4%
232	Anemia, Diamond-Blackfan	4.3%
233	Hoarseness	4.2%
234	Pharyngitis	4.2%
235	Laryngostenosis	4.1%
236	Nasal Polyps	4.1%
237	Mycosis Fungoides	4.1%
238	Lymphomatoid Papulosis	4.1%
239	Plasmablastic lymphoma	4.1%
240	Purpura, Thrombotic Thrombocytopenic	4%
241	Pertussis	4%
242	Wiskott-Aldrich Syndrome	3.9%
243	Kartagener Syndrome	3.8%
244	Hay fever	3.8%
245	Rhinitis, Allergic, Perennial	3.8%
246	Asthma, Aspirin-Induced	3.8%
247	Lymphomatoid Granulomatosis	3.7%
248	Anemia, Sickle Cell	3.6%
249	Thalassemia	3.6%
250	Voice Disorders	3.4%
251	Voice Disturbance	3.4%
252	Epistaxis	3.4%
253	Anemia, Neonatal	3.4%
254	Leukocytosis	3.4%
255	Mediastinal Cyst	3.4%
256	Paraproteinemias	3.4%
257	Pelger-Huet Anomaly	3.4%
258	Pericardial Cyst	3.4%
259	Thymic Cyst	3.4%
260	Pleocytosis	3.4%
261	Croup	3.3%
262	Mediastinal Emphysema	3.3%
263	Rhinitis, Vasomotor	3.3%
264	Hypoventilation	3.3%
265	Acidosis, Respiratory	3.3%
266	Alkalosis, Respiratory	3.3%
267	Sleep Apnea Syndromes	3.3%
268	Primary Myelofibrosis	3.3%
269	Agranulocytosis	3.3%
270	Anemia, Megaloblastic	3.3%
271	Cryoglobulinemia	3.3%
272	Lymphocytosis	3.3%
273	Monoclonal Gammopathy of Undetermined Significance	3.3%
274	Myelofibrosis	3.3%
275	Myeloid Metaplasia	3.3%
276	Hypoalbuminemia	3.3%
277	Hypereosinophilic syndrome	3.3%
278	bone marrow fibrosis	3.3%
279	Thrombotic Microangiopathies	3.3%
280	Maxillary Sinus Neoplasms	3.2%
281	Autoimmune thrombocytopenia	3.2%
282	Immune thrombocytopenic purpura	3.2%
283	Burkitt Lymphoma	3.1%
284	Hemolytic-Uremic Syndrome	3%
285	Laryngomalacia	2.9%
286	Vocal Cord Paralysis	2.9%
287	Sickle Cell Trait	2.8%
288	Purpura, Hyperglobulinemic	2.8%
289	Hypergammaglobulinemia	2.7%
290	Fanconi Anemia	2.7%
291	Neutropenia	2.7%
292	Ecchymosis	2.7%
293	Petechiae	2.7%
294	Purpura	2.7%
295	Tonsillitis	2.7%
296	Dyspnea, Paroxysmal	2.6%
297	Respiratory Paralysis	2.6%
298	Thrombocytopenic purpura	2.6%
299	Atypical Hemolytic Uremic Syndrome	2.5%
300	Lymphopenia	2.5%
301	Multiple Myeloma	2.5%
302	Job Syndrome	2.5%
303	Leukemia, Myelomonocytic, Chronic	2.5%
304	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	2.5%
305	Febrile Neutropenia	2.5%
306	Sleep Apnea, Obstructive	2.4%
307	Sleep Apnea, Central	2.4%
308	Hydrops Fetalis	2.4%
309	Aphonia	2.2%
310	Retropharyngeal Abscess	2.2%
311	Dysphonia	2.2%
312	Bronchomalacia	2.2%
313	Tracheomalacia	2.2%
314	Waterhouse-Friderichsen Syndrome	2.1%
315	Leukemia, Myeloid, Chronic-Phase	2%
316	Anemia, Pernicious	2%
317	Eosinophilia-Myalgia Syndrome	2%
318	Chronic granulomatous disease	2%
319	Shwartzman Phenomenon	2%
320	Hemangioma, Cavernous	2%
321	Scurvy	2%
322	Purpura Fulminans	2%
323	Nasopharyngitis	1.9%
324	Kernicterus	1.7%
325	POEMS Syndrome	1.6%
326	Peritonsillar Abscess	1.6%
327	Eosinophilic Granuloma	1.4%
328	Pseudoxanthoma Elasticum	1.1%

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