MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Hypereosinophilic syndrome

(UMLS:C1540912)

UMLS ID:: C1540912
MeSH ID:: D017681

Classification:

Name:

Hemic and Lymphatic Diseases
MeSH Tree Number(s):: C15.378.553.231.549

Synonym(s)

Hypereosinophilic syndrome

HES - hypereosinophilic syndrome

Hypereosinophilic Syndrome

Hypereosinophilic syndrome/chronic eosinophilic leukemia

hypereosinophilic syndrome

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Allopurinol	FAERS: 10		US FAERS
2	Doxycycline	FAERS: 9		US FAERS
3	Imatinib Mesylate	FAERS: 7	20169542 28347583	CTD US FAERS
4	Ibuprofen	FAERS: 3		US FAERS
5	Orlistat	FAERS: 3		OFFSIDES US FAERS
6	Rivaroxaban	FAERS: 3		US FAERS
7	Triamcinolone Acetonide	FAERS: 3		US FAERS
8	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	FAERS: 2		US FAERS
9	Lenalidomide	FAERS: 2		US FAERS
10	Mefloquine	FAERS: 2		US FAERS
11	Prednisone	FAERS: 2	20169542 28347583	CTD US FAERS
12	Sorafenib	FAERS: 2		US FAERS
13	Amoxicillin	FAERS: 1		US FAERS
14	Cladribine	FAERS: 1		US FAERS
15	Cyclosporine	FAERS: 1		US FAERS
16	Leflunomide	FAERS: 1		US FAERS
17	Paroxetine	FAERS: 1		US FAERS
18	Piroxicam	FAERS: 1		US FAERS
19	Pregabalin	FAERS: 1		US FAERS
20	Rabeprazole	FAERS: 1		US FAERS
21	Ruxolitinib phosphate	FAERS: 1		US FAERS
22	Triamcinolone	FAERS: 1		US FAERS
23	apixaban	FAERS: 1		US FAERS
24	fexofenadine	FAERS: 1		US FAERS
25	Carbamazepine			OFFSIDES
26	Clobazam			OFFSIDES
27	Hydron;carbonate			OFFSIDES
28	Imatinib Mesylate			OFFSIDES
29	Lovastatin			OFFSIDES
30	Mefloquine			OFFSIDES
31	Perindopril			OFFSIDES
32	Piperacillin			OFFSIDES
33	Primidone			OFFSIDES
34	S 1108			OFFSIDES
35	Sevelamer			OFFSIDES
36	Tretinoin		16778211	CTD
37	Vancomycin		16407668	CTD
38	Vitamin A			OFFSIDES
39	Warfarin		20169542 28347583	CTD
40	azosemide			OFFSIDES
41	quazepam			OFFSIDES
42	tetrazepam			OFFSIDES
43	tizanidine			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Leukopenia	34.4%
2	Leukostasis	34.4%
3	Anemia	25.4%
4	Blood Coagulation Disorders	25.4%
5	Blood Platelet Disorders	25.4%
6	Bone Marrow Diseases	25.4%
7	Hemorrhagic Disorders	25.4%
8	Methemoglobinemia	25.4%
9	Pancytopenia	25.4%
10	Polycythemia	25.4%
11	Sulfhemoglobinemia	25.4%
12	Thrombophilia	25.4%
13	Erythrocytosis	25.4%
14	Eosinophilia-Myalgia Syndrome	25%
15	Leukocytosis	23.6%
16	Pelger-Huet Anomaly	23.6%
17	Pleocytosis	23.6%
18	Agranulocytosis	22.6%
19	Lymphocytosis	22.6%
20	Disseminated Intravascular Coagulation	22.3%
21	Protein S Deficiency	22.3%
22	Leukemoid Reaction	21.5%
23	Thrombocythemia, Essential	18.6%
24	Transfusion Reaction	18.1%
25	Hypotensive Transfusion Reaction	18.1%
26	Eosinophilic Granuloma	17.6%
27	Pregnancy Complications, Hematologic	17.2%
28	Hematologic Neoplasms	17.2%
29	Neutropenia	16.8%
30	Lymphatic Diseases	16.4%
31	Thrombocytosis	16.3%
32	Infectious Mononucleosis	15.8%
33	Thrombasthenia	15.8%
34	Antithrombin III Deficiency	15.8%
35	Protein C Deficiency	15.8%
36	Lymphopenia	15.6%
37	Job Syndrome	15.2%
38	Bone Marrow Neoplasms	14.9%
39	Anemia, Hemolytic	14.8%
40	Anemia, Macrocytic	14.8%
41	Hypoproteinemia	14.8%
42	Thrombocytopenia	14.8%
43	MYELODYSPLASTIC SYNDROME	14.8%
44	Vitamin K Deficiency	14.7%
45	Febrile Neutropenia	13.9%
46	Afibrinogenemia	13.7%
47	Factor VII Deficiency	13.7%
48	Factor X Deficiency	13.7%
49	Factor XII Deficiency	13.7%
50	Hemophilia A	13.7%
51	Activated Protein C Resistance	13.7%
52	Factor II deficiency	13.7%
53	Factor VIII Deficiency	13.7%
54	Factor V deficiency	13.7%
55	Factor XI Deficiency	13.7%
56	Hypoprothrombinemias	13.7%
57	Hemoglobinuria, Paroxysmal	12.9%
58	Wiskott-Aldrich Syndrome	11.9%
59	Polycythemia Vera	11.6%
60	Chronic granulomatous disease	11.5%
61	Anemia, Neonatal	10.1%
62	Paraproteinemias	10.1%
63	Agammaglobulinemia	10.1%
64	Primary Myelofibrosis	9.7%
65	Anemia, Megaloblastic	9.7%
66	Myelofibrosis	9.7%
67	Myeloid Metaplasia	9.7%
68	Hypoalbuminemia	9.7%
69	Anemia, Diamond-Blackfan	9.7%
70	bone marrow fibrosis	9.7%
71	Thrombotic Microangiopathies	9.7%
72	Purpura, Thrombotic Thrombocytopenic	9.2%
73	Anemia, Sickle Cell	8.9%
74	Thalassemia	8.9%
75	Adenitis	8.5%
76	Histiocytosis	8.5%
77	Lymphadenitis	8.5%
78	Lymphangitis	8.5%
79	Lymphedema	8.5%
80	Splenic Diseases	8.5%
81	Thymus Hyperplasia	8.5%
82	Pseudolymphoma	8.5%
83	Lymphadenopathy	8.5%
84	Cryoglobulinemia	7.8%
85	Monoclonal Gammopathy of Undetermined Significance	7.8%
86	Hypergammaglobulinemia	7.7%
87	Transfusion-Related Acute Lung Injury	7.5%
88	Ecchymosis	7.4%
89	Petechiae	7.4%
90	Purpura	7.4%
91	Heavy Chain Disease	7.4%
92	Autoimmune thrombocytopenia	7.1%
93	Immune thrombocytopenic purpura	7.1%
94	Waldenstrom Macroglobulinemia	7%
95	Hemolytic-Uremic Syndrome	6.7%
96	Purpura, Hyperglobulinemic	6.5%
97	Leukemia, Myelomonocytic, Chronic	6.5%
98	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	6.5%
99	Sickle Cell Trait	6.3%
100	Thrombocytopenic purpura	5.8%
101	Fanconi Anemia	5.8%
102	Lymphocele	5.7%
103	Lymphoproliferative Disorders	5.7%
104	Lymphatic Abnormalities	5.7%
105	Multiple Myeloma	5.6%
106	Thymus Neoplasms	5.6%
107	Hydrops Fetalis	5.6%
108	Atypical Hemolytic Uremic Syndrome	5.2%
109	Lymphangiectasis, Intestinal	5%
110	Elephantiasis	4.9%
111	Hypersplenism	4.9%
112	Sarcoidosis	4.9%
113	Shwartzman Phenomenon	4.9%
114	Elephantiasis Nostras Verrucosa	4.9%
115	Hemangioma, Cavernous	4.9%
116	Scurvy	4.8%
117	Purpura Fulminans	4.8%
118	Waterhouse-Friderichsen Syndrome	4.8%
119	Leukemia, Myeloid, Chronic-Phase	4.8%
120	Anemia, Pernicious	4.8%
121	Acute Chest Syndrome	4.6%
122	Kernicterus	4.3%
123	Mucocutaneous Lymph Node Syndrome	4.2%
124	POEMS Syndrome	3.9%
125	Granuloma	3.4%
126	Histiocytic Disorders, Malignant	3.4%
127	Splenic Infarction	3.4%
128	Splenic Neoplasms	3.4%
129	Histiocytosis, Langerhans-Cell	3.3%
130	Tumor Lysis Syndrome	3.3%
131	Lymphohistiocytosis, Hemophagocytic	3.2%
132	Erdheim-Chester Disease	3.2%
133	Splenic Rupture	2.6%
134	Lymphoma	2.5%
135	Pseudoxanthoma Elasticum	2.5%
136	Thymoma	2.5%
137	Sezary Syndrome	2.2%
138	Malignant histiocytosis	2.2%
139	Sarcoidosis, Pulmonary	2.2%
140	Histiocytic sarcoma	2.2%
141	Autoimmune Lymphoproliferative Syndrome	2%
142	Splenosis	1.6%
143	Hodgkin Disease	1.6%
144	Lymphoma, Non-Hodgkin	1.6%
145	Leukemia, T-Cell	1.6%
146	Leukemia, B-Cell	1.6%
147	Composite Lymphoma	1.3%
148	Lymphangioleiomyomatosis	1.3%
149	Lymphoma, Follicular	1.2%
150	T-Cell Lymphoma	1.2%
151	Mantle cell lymphoma	1.2%
152	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	1.2%
153	Leukemia, Large Granular Lymphocytic	1.2%
154	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	1.2%
155	Lymphoma, T-Cell, Cutaneous	1%
156	Lymphoma, AIDS-Related	1%
157	Enteropathy-Associated T-Cell Lymphoma	1%
158	Primary Effusion Lymphoma	1%
159	Mycosis Fungoides	0.9%
160	Lymphomatoid Papulosis	0.9%
161	Plasmablastic lymphoma	0.9%
162	Lymphomatoid Granulomatosis	0.8%
163	Burkitt Lymphoma	0.7%
164	Niemann-Pick Disease, Type C	0.4%

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