MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Agammaglobulinemia

(UMLS:C0001768)

Definition:: An immunologic deficiency state characterized by an extremely low level of generally all classes of gamma-globulin in the blood.
UMLS ID:: C0001768
MeSH ID:: D000361

Classification 1:

Name:

Hemic and Lymphatic Diseases
MeSH Tree Number(s):: C15.378.147.142|C15.604.515.032

Classification 2:

Name:

Immune System Diseases
MeSH Tree Number(s):: C20.673.088

Synonym(s)

Agammaglobulinemia

Agammaglobulinaemia

Agammaglobulinemia, NOS

agammaglobulinaemia

agammaglobulinemia

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Puromycin Aminonucleoside		3233791	CTD
2	Sulfasalazine		25555	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Protein S Deficiency	36%
2	Heavy Chain Disease	34.6%
3	Antithrombin III Deficiency	28.7%
4	Protein C Deficiency	28.7%
5	Monoclonal Gammopathy of Undetermined Significance	28.6%
6	Waldenstrom Macroglobulinemia	27.4%
7	Paraproteinemias	27.4%
8	Hypoproteinemia	27.1%
9	Sarcoidosis	27.1%
10	Disseminated Intravascular Coagulation	27%
11	Infectious Mononucleosis	25.8%
12	Transfusion Reaction	25.7%
13	Hypotensive Transfusion Reaction	25.7%
14	Tumor Lysis Syndrome	25.7%
15	Thrombocythemia, Essential	25.7%
16	Lymphopenia	24.5%
17	Sezary Syndrome	24.3%
18	Hypergammaglobulinemia	23%
19	Autoimmune Lymphoproliferative Syndrome	22.5%
20	Granuloma	21.9%
21	Lymphoma	21.6%
22	Thrombasthenia	21.1%
23	Wiskott-Aldrich Syndrome	20.7%
24	Adenitis	20.7%
25	Anemia	20.7%
26	Blood Coagulation Disorders	20.7%
27	Blood Platelet Disorders	20.7%
28	Bone Marrow Diseases	20.7%
29	Hemorrhagic Disorders	20.7%
30	Histiocytosis	20.7%
31	Leukocyte Disorders	20.7%
32	Lymphadenitis	20.7%
33	Lymphangitis	20.7%
34	Lymphedema	20.7%
35	Methemoglobinemia	20.7%
36	Pancytopenia	20.7%
37	Polycythemia	20.7%
38	Splenic Diseases	20.7%
39	Sulfhemoglobinemia	20.7%
40	Thymus Hyperplasia	20.7%
41	Pseudolymphoma	20.7%
42	Thrombophilia	20.7%
43	Lymphadenopathy	20.7%
44	Erythrocytosis	20.7%
45	Hypoalbuminemia	20.2%
46	Job Syndrome	20.1%
47	Cryoglobulinemia	20%
48	Afibrinogenemia	19%
49	Factor VII Deficiency	19%
50	Factor X Deficiency	19%
51	Factor XII Deficiency	19%
52	Hemophilia A	19%
53	Activated Protein C Resistance	19%
54	Factor II deficiency	19%
55	Factor VIII Deficiency	19%
56	Factor V deficiency	19%
57	Factor XI Deficiency	19%
58	Hypoprothrombinemias	19%
59	Thrombocytosis	18.8%
60	Lymphangiectasis, Intestinal	18%
61	Bone Marrow Neoplasms	18%
62	Vitamin K Deficiency	17.8%
63	Multiple Myeloma	17.8%
64	Autoimmune thrombocytopenia	17%
65	Immune thrombocytopenic purpura	17%
66	Polycythemia Vera	17%
67	Chronic granulomatous disease	16.8%
68	Lymphocele	16.7%
69	Pregnancy Complications, Hematologic	16.7%
70	Hematologic Neoplasms	16.7%
71	Lymphatic Abnormalities	16.7%
72	Thymus Neoplasms	16.4%
73	Hodgkin Disease	16.1%
74	Lymphoma, Non-Hodgkin	16.1%
75	Sarcoidosis, Pulmonary	16.1%
76	Leukemia, T-Cell	16%
77	Leukemia, B-Cell	16%
78	Hemoglobinuria, Paroxysmal	16%
79	Leukemoid Reaction	16%
80	Anemia, Diamond-Blackfan	15.1%
81	Thrombocytopenic purpura	14.4%
82	Purpura, Thrombotic Thrombocytopenic	14.3%
83	POEMS Syndrome	14.3%
84	Composite Lymphoma	13.8%
85	Lymphangioleiomyomatosis	13.7%
86	Mucocutaneous Lymph Node Syndrome	13.6%
87	Anemia, Hemolytic	13.6%
88	Anemia, Macrocytic	13.6%
89	Elephantiasis	13.6%
90	Eosinophilia	13.6%
91	HIV Infections	13.6%
92	Hypersplenism	13.6%
93	Leukopenia	13.6%
94	Thrombocytopenia	13.6%
95	Leukostasis	13.6%
96	Elephantiasis Nostras Verrucosa	13.6%
97	Transfusion-Related Acute Lung Injury	13.6%
98	MYELODYSPLASTIC SYNDROME	13.6%
99	Lymphoma, Follicular	13.5%
100	T-Cell Lymphoma	13.5%
101	Mantle cell lymphoma	13.5%
102	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	13.4%
103	Leukemia, Large Granular Lymphocytic	13.4%
104	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	13.4%
105	Anemia, Sickle Cell	12.4%
106	Thalassemia	12.4%
107	Lymphoma, T-Cell, Cutaneous	12.2%
108	Lymphoma, AIDS-Related	12.2%
109	Enteropathy-Associated T-Cell Lymphoma	12.2%
110	Primary Effusion Lymphoma	12.2%
111	HTLV-I Infections	12.1%
112	Mycosis Fungoides	11.5%
113	Lymphomatoid Papulosis	11.5%
114	Plasmablastic lymphoma	11.5%
115	Hydrops Fetalis	11.3%
116	Anemia, Neonatal	11%
117	Histiocytic Disorders, Malignant	11%
118	Leukocytosis	11%
119	Pelger-Huet Anomaly	11%
120	Splenic Infarction	11%
121	Splenic Neoplasms	11%
122	Pleocytosis	11%
123	Histiocytosis, Langerhans-Cell	10.8%
124	Autoimmune Diseases	10.7%
125	Hypersensitivity	10.7%
126	Immunoproliferative Disorders	10.7%
127	Immune reconstitution syndrome	10.7%
128	Immune Reconstitution Inflammatory Syndrome	10.7%
129	Lymphomatoid Granulomatosis	10.5%
130	Hemolytic-Uremic Syndrome	10.3%
131	Primary Myelofibrosis	10.1%
132	Agranulocytosis	10.1%
133	Anemia, Megaloblastic	10.1%
134	Lymphocytosis	10.1%
135	Lymphohistiocytosis, Hemophagocytic	10.1%
136	Myelofibrosis	10.1%
137	Myeloid Metaplasia	10.1%
138	Erdheim-Chester Disease	10.1%
139	Hypereosinophilic syndrome	10.1%
140	bone marrow fibrosis	10.1%
141	Thrombotic Microangiopathies	10.1%
142	Eosinophilic Granuloma	10%
143	HIV Seropositivity	10%
144	Purpura, Hyperglobulinemic	9.9%
145	Sickle Cell Trait	9.9%
146	Lymphoproliferative Disorders	9.7%
147	Fanconi Anemia	9.5%
148	Splenic Rupture	9.2%
149	Burkitt Lymphoma	9.1%
150	Ecchymosis	9%
151	Kernicterus	9%
152	Petechiae	9%
153	Purpura	9%
154	Thymoma	8.9%
155	Lymphatic Diseases	8.9%
156	Atypical Hemolytic Uremic Syndrome	8.9%
157	Acquired Immunodeficiency Syndrome	8.6%
158	AIDS related complex	8.6%
159	Neutropenia	8.4%
160	Ataxia Telangiectasia	8.1%
161	Malignant histiocytosis	8.1%
162	Histiocytic sarcoma	8.1%
163	Leukemia, Myelomonocytic, Chronic	8%
164	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	8%
165	Acute Chest Syndrome	7.8%
166	AIDS-Related Opportunistic Infections	7.6%
167	Waterhouse-Friderichsen Syndrome	7.6%
168	Febrile Neutropenia	7.5%
169	HIV Wasting Syndrome	7.5%
170	AIDS Dementia Complex	7.5%
171	AIDS-Associated Nephropathy	7.5%
172	Immune Complex Diseases	6.9%
173	Antiphospholipid Syndrome	6.9%
174	Latex allergy	6.9%
175	Glomerulonephritis, Membranoproliferative	6.8%
176	Pulmonary Eosinophilia	6.8%
177	Eosinophilia-Myalgia Syndrome	6.8%
178	Eosinophilic Pneumonia	6.8%
179	Shwartzman Phenomenon	6.7%
180	Splenosis	6.7%
181	Hemangioma, Cavernous	6.7%
182	Scurvy	6.6%
183	Purpura Fulminans	6.6%
184	Leukemia, Myeloid, Chronic-Phase	6.6%
185	Anemia, Pernicious	6.6%
186	HIV-Associated Lipodystrophy Syndrome	6.6%
187	Primary amyloidosis	5.7%
188	Environmental Illness	5.7%
189	Lupus Erythematosus, Systemic	5.6%
190	Overlap syndrome	5.6%
191	Addison Disease	5.5%
192	Pemphigus	5.5%
193	Autoimmune thyroiditis	5.5%
194	Primary Adrenal Insufficiency	5.5%
195	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	5.4%
196	Autoimmune hepatitis	5.4%
197	Serum Sickness	5.2%
198	anaphylaxis	5.1%
199	Food Allergy	5.1%
200	Anaphylactic shock	5.1%
201	Asthma, Aspirin-Induced	5%
202	Latent Autoimmune Diabetes in Adults	4.6%
203	Agammaglobulinemia	4.5%
204	Dermatitis Herpetiformis	4.5%
205	Kounis Syndrome	4.5%
206	Respiratory Hypersensitivity	4.2%
207	Milk Allergy	4.2%
208	Schnitzler Syndrome	4.2%
209	Wheat Hypersensitivity	4.2%
210	Sick Building Syndrome	4.1%
211	Multiple Chemical Sensitivity	4.1%
212	Plasmacytoma	4.1%
213	Urticaria	4.1%
214	Vasculitis, Leukocytoclastic, Cutaneous	4.1%
215	Pseudoxanthoma Elasticum	4%
216	Rheumatoid Arthritis	3.9%
217	Juvenile arthritis	3.9%
218	Graves Disease	3.9%
219	Anti-Glomerular Basement Membrane Disease	3.8%
220	Myasthenia Gravis, Autoimmune, Experimental	3.7%
221	Myasthenia Gravis	3.4%
222	Uveomeningoencephalitic Syndrome	3.4%
223	Mastocytosis	3.4%
224	Drug Eruptions	3.4%
225	Granulomatosis with polyangiitis	3.3%
226	Dermatitis, Allergic Contact	3.3%
227	Mastocytosis, Systemic	3.3%
228	Stiff-Person Syndrome	2.9%
229	Polyradiculoneuropathy	2.9%
230	Polyradiculoneuritis	2.9%
231	Felty Syndrome	2.9%
232	Neuromyelitis Optica	2.8%
233	Lupus Nephritis	2.8%
234	Leukoencephalitis, Acute Hemorrhagic	2.8%
235	Angioedema	2.8%
236	Multiple Sclerosis	2.8%
237	Leukemia, Plasma Cell	2.8%
238	Acute Generalized Exanthematous Pustulosis	2.8%
239	Lupus Vasculitis, Central Nervous System	2.6%
240	Vasculitis, Central Nervous System	2.5%
241	Dermatitis, Atopic	2.5%
242	Asthma, Exercise-Induced	2.5%
243	Status Asthmaticus	2.5%
244	Rheumatoid Vasculitis	2.5%
245	Multiple Sclerosis, Chronic Progressive	2.5%
246	Multiple Sclerosis, Relapsing-Remitting	2.5%
247	Niemann-Pick Disease, Type C	2.5%
248	Asthma	2.4%
249	Encephalomyelitis, Acute Disseminated	2.4%
250	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	2.4%
251	Erythema Nodosum	2.4%
252	Neuritis, Autoimmune, Experimental	2.4%
253	Dermatitis, Photoallergic	2.4%
254	Hereditary Angioedema Type III	2.3%
255	Hereditary Angioedema Types I and II	2.3%
256	Lambert-Eaton Myasthenic Syndrome	2.2%
257	Sicca Syndrome	2.2%
258	Sjogren's Syndrome	2.2%
259	Asthma, Occupational	2.2%
260	Farmer's Lung	2.2%
261	Angioedemas, Hereditary	2.2%
262	Hay fever	2.1%
263	Rhinitis, Allergic, Perennial	2.1%
264	Aspergillosis, Allergic Bronchopulmonary	2.1%
265	Guillain-Barre Syndrome	2.1%
266	Toxic Epidermal Necrolysis	1.8%
267	Stevens-Johnson Syndrome	1.8%
268	Giant Cell Arteritis	1.6%
269	Temporal Arteritis	1.6%
270	Myelitis, Transverse	1.5%
271	Miller Fisher Syndrome	1.4%

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