MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Monoclonal Gammopathy of Undetermined Significance

(UMLS:C0026470)

Definition:: Conditions characterized by the presence of M protein (Monoclonal protein) in serum or urine without clinical manifestations of plasma cell dyscrasia.
UMLS ID:: C0026470
MeSH ID:: D008998

Classification 1:

Name:

Hemic and Lymphatic Diseases
MeSH Tree Number(s):: C15.378.147.542.640|C15.378.147.780.570

Classification 2:

Name:

Immune System Diseases
MeSH Tree Number(s):: C20.683.460.640|C20.683.780.640

Synonym(s)

Monoclonal Gammopathy of Undetermined Significance

Asymptomatic monoclonal gammopathy

BENIGN MONOCLONAL HYPERGAMMAGLOBUMINEMIA

Benign Monoclonal Gammopathy

Benign monoclonal gammopathy

GAMMOPATHY MONOCLONAL BENIGN

GAMMOPATHY MONOCLONAL UNCERTAIN SIGNIFICANCE

Hypergammaglobulinaemia benign monoclonal

MGUS

10.

MGUS - Monoclonal gammopathy of uncertain significance

11.

Monoclonal Gammopathy of Undetermined Significance (MGUS)

12.

Monoclonal Gammopathy of Unknown Significance

13.

Monoclonal gammopathy of uncertain significance

14.

Monoclonal gammopathy of undetermined significance

15.

Monoclonal gammopathy of undetermined significance (MGUS)

16.

benign monoclonal gammapathy

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Carbon Disulfide	19387005	CTD
2	Carbon Tetrachloride	19387005	CTD
3	Dieldrin	19387005	CTD
4	Norethindrone	820501	CTD
5	Norinyl	820501	CTD
6	tetrachloroisophthalonitrile	19387005	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Heavy Chain Disease	42.3%
2	Multiple Myeloma	39.5%
3	Cryoglobulinemia	39.3%
4	Protein S Deficiency	36.8%
5	POEMS Syndrome	34.4%
6	Waldenstrom Macroglobulinemia	33.6%
7	Antithrombin III Deficiency	29.6%
8	Protein C Deficiency	29.6%
9	Transfusion Reaction	28.7%
10	Hypotensive Transfusion Reaction	28.7%
11	Agammaglobulinemia	28.6%
12	Hypoproteinemia	27.6%
13	Primary amyloidosis	26.3%
14	Lymphoproliferative Disorders	25.8%
15	Disseminated Intravascular Coagulation	25.5%
16	Thrombocythemia, Essential	23.3%
17	Paraproteinemias	21.7%
18	Monoclonal Gammopathy of Undetermined Significance	21.3%
19	Anemia	20%
20	Blood Coagulation Disorders	20%
21	Blood Platelet Disorders	20%
22	Bone Marrow Diseases	20%
23	Hemorrhagic Disorders	20%
24	Leukocyte Disorders	20%
25	Methemoglobinemia	20%
26	Pancytopenia	20%
27	Polycythemia	20%
28	Sulfhemoglobinemia	20%
29	Thrombophilia	20%
30	Erythrocytosis	20%
31	Infectious Mononucleosis	19.8%
32	Thrombasthenia	19.8%
33	Hypergammaglobulinemia	18.8%
34	Hypoalbuminemia	18.3%
35	Autoimmune Lymphoproliferative Syndrome	17.6%
36	Autoimmune thrombocytopenia	17.5%
37	Immune thrombocytopenic purpura	17.5%
38	Afibrinogenemia	17.2%
39	Factor VII Deficiency	17.2%
40	Factor X Deficiency	17.2%
41	Factor XII Deficiency	17.2%
42	Hemophilia A	17.2%
43	Activated Protein C Resistance	17.2%
44	Factor II deficiency	17.2%
45	Factor VIII Deficiency	17.2%
46	Factor V deficiency	17.2%
47	Factor XI Deficiency	17.2%
48	Hypoprothrombinemias	17.2%
49	Bone Marrow Neoplasms	17%
50	Vitamin K Deficiency	16.9%
51	Pregnancy Complications, Hematologic	16.9%
52	Hematologic Neoplasms	16.9%
53	Tumor Lysis Syndrome	16.5%
54	Thrombocytosis	16.4%
55	Sezary Syndrome	16.2%
56	Wiskott-Aldrich Syndrome	15.4%
57	Thrombocytopenic purpura	15.2%
58	Polycythemia Vera	14.6%
59	Lymphoma	14.3%
60	Transfusion-Related Acute Lung Injury	14.2%
61	Autoimmune Diseases	13.7%
62	Hypersensitivity	13.7%
63	Immunologic Deficiency Syndromes	13.7%
64	Immune reconstitution syndrome	13.7%
65	Immune Reconstitution Inflammatory Syndrome	13.7%
66	Lymphopenia	13.3%
67	Plasmacytoma	13.2%
68	Hemoglobinuria, Paroxysmal	13%
69	Leukemoid Reaction	13%
70	Purpura, Thrombotic Thrombocytopenic	12.4%
71	Lymphatic Diseases	12.3%
72	Anemia, Diamond-Blackfan	12.2%
73	Anemia, Hemolytic	11.8%
74	Anemia, Macrocytic	11.8%
75	Eosinophilia	11.8%
76	Leukopenia	11.8%
77	Thrombocytopenia	11.8%
78	Leukostasis	11.8%
79	MYELODYSPLASTIC SYNDROME	11.8%
80	Hydrops Fetalis	11.7%
81	Anemia, Sickle Cell	11.1%
82	Thalassemia	11.1%
83	Job Syndrome	10.9%
84	Hodgkin Disease	10.3%
85	Lymphoma, Non-Hodgkin	10.3%
86	Leukemia, T-Cell	10.2%
87	Leukemia, B-Cell	10.2%
88	Anemia, Neonatal	10%
89	Leukocytosis	10%
90	Pelger-Huet Anomaly	10%
91	Pleocytosis	10%
92	Kernicterus	10%
93	Glomerulonephritis, Membranoproliferative	9.6%
94	Chronic granulomatous disease	9.4%
95	Composite Lymphoma	9%
96	Lymphangioleiomyomatosis	8.9%
97	Purpura, Hyperglobulinemic	8.7%
98	Hemolytic-Uremic Syndrome	8.5%
99	Ecchymosis	8.5%
100	Petechiae	8.5%
101	Purpura	8.5%
102	Leukemia, Plasma Cell	8.4%
103	Lymphoma, Follicular	8.3%
104	T-Cell Lymphoma	8.3%
105	Mantle cell lymphoma	8.3%
106	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	8.3%
107	Leukemia, Large Granular Lymphocytic	8.3%
108	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	8.3%
109	Immune Complex Diseases	8%
110	Antiphospholipid Syndrome	8%
111	Latex allergy	8%
112	Sickle Cell Trait	7.9%
113	Primary Myelofibrosis	7.8%
114	Agranulocytosis	7.8%
115	Anemia, Megaloblastic	7.8%
116	Lymphocytosis	7.8%
117	Myelofibrosis	7.8%
118	Myeloid Metaplasia	7.8%
119	Hypereosinophilic syndrome	7.8%
120	bone marrow fibrosis	7.8%
121	Thrombotic Microangiopathies	7.8%
122	Waterhouse-Friderichsen Syndrome	7.5%
123	Lymphoma, T-Cell, Cutaneous	7.4%
124	Lymphoma, AIDS-Related	7.4%
125	Enteropathy-Associated T-Cell Lymphoma	7.4%
126	Primary Effusion Lymphoma	7.4%
127	Fanconi Anemia	7.3%
128	Mycosis Fungoides	6.9%
129	Lymphomatoid Papulosis	6.9%
130	Environmental Illness	6.9%
131	Plasmablastic lymphoma	6.9%
132	Lupus Erythematosus, Systemic	6.7%
133	Overlap syndrome	6.7%
134	Addison Disease	6.7%
135	Adenitis	6.7%
136	Histiocytosis	6.7%
137	Lymphadenitis	6.7%
138	Lymphangitis	6.7%
139	Lymphedema	6.7%
140	Pemphigus	6.7%
141	Splenic Diseases	6.7%
142	Thymus Hyperplasia	6.7%
143	Pseudolymphoma	6.7%
144	Lymphadenopathy	6.7%
145	Autoimmune thyroiditis	6.7%
146	Primary Adrenal Insufficiency	6.7%
147	Atypical Hemolytic Uremic Syndrome	6.6%
148	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	6.6%
149	Autoimmune hepatitis	6.6%
150	Lymphomatoid Granulomatosis	6.5%
151	Leukemia, Myelomonocytic, Chronic	6.5%
152	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	6.5%
153	Acute Chest Syndrome	6.4%
154	Schnitzler Syndrome	5.9%
155	Asthma, Aspirin-Induced	5.9%
156	Neutropenia	5.9%
157	Eosinophilic Granuloma	5.9%
158	Burkitt Lymphoma	5.8%
159	Latent Autoimmune Diabetes in Adults	5.7%
160	Dermatitis Herpetiformis	5.7%
161	Serum Sickness	5.7%
162	Kounis Syndrome	5.7%
163	HIV Infections	5.7%
164	Eosinophilia-Myalgia Syndrome	5.7%
165	Lymphangiectasis, Intestinal	5.7%
166	Shwartzman Phenomenon	5.6%
167	Lymphocele	5.6%
168	Lymphatic Abnormalities	5.6%
169	Hemangioma, Cavernous	5.6%
170	Scurvy	5.6%
171	Purpura Fulminans	5.6%
172	Thymus Neoplasms	5.6%
173	anaphylaxis	5.3%
174	Food Allergy	5.3%
175	Anaphylactic shock	5.3%
176	Rheumatoid Arthritis	5%
177	Juvenile arthritis	5%
178	Graves Disease	5%
179	Pulmonary Eosinophilia	5%
180	Eosinophilic Pneumonia	5%
181	Anti-Glomerular Basement Membrane Disease	4.9%
182	Febrile Neutropenia	4.9%
183	Leukemia, Myeloid, Chronic-Phase	4.9%
184	Anemia, Pernicious	4.9%
185	Mucocutaneous Lymph Node Syndrome	4.8%
186	Respiratory Hypersensitivity	4.5%
187	Sick Building Syndrome	4.4%
188	Multiple Chemical Sensitivity	4.4%
189	Urticaria	4.4%
190	Vasculitis, Leukocytoclastic, Cutaneous	4.4%
191	HTLV-I Infections	4.4%
192	Elephantiasis	3.9%
193	Hypersplenism	3.9%
194	Sarcoidosis	3.9%
195	Elephantiasis Nostras Verrucosa	3.9%
196	Milk Allergy	3.9%
197	Myasthenia Gravis, Autoimmune, Experimental	3.9%
198	Wheat Hypersensitivity	3.9%
199	Myasthenia Gravis	3.8%
200	Uveomeningoencephalitic Syndrome	3.8%
201	Mastocytosis	3.8%
202	Drug Eruptions	3.8%
203	Granulomatosis with polyangiitis	3.7%
204	Dermatitis, Allergic Contact	3.7%
205	HIV Seropositivity	3.7%
206	Ataxia Telangiectasia	3.6%
207	Pseudoxanthoma Elasticum	3.6%
208	Stiff-Person Syndrome	3.4%
209	Polyradiculoneuropathy	3.3%
210	Polyradiculoneuritis	3.3%
211	Granuloma	3.3%
212	Histiocytic Disorders, Malignant	3.3%
213	Splenic Infarction	3.3%
214	Splenic Neoplasms	3.3%
215	Acquired Immunodeficiency Syndrome	3.3%
216	AIDS related complex	3.3%
217	Histiocytosis, Langerhans-Cell	3.3%
218	Felty Syndrome	3.3%
219	Lupus Nephritis	3.3%
220	Mastocytosis, Systemic	3.3%
221	Lupus Vasculitis, Central Nervous System	3%
222	Neuromyelitis Optica	3%
223	Leukoencephalitis, Acute Hemorrhagic	3%
224	AIDS-Related Opportunistic Infections	3%
225	Vasculitis, Central Nervous System	3%
226	Dermatitis, Atopic	2.9%
227	HIV Wasting Syndrome	2.9%
228	Rheumatoid Vasculitis	2.9%
229	AIDS Dementia Complex	2.9%
230	AIDS-Associated Nephropathy	2.9%
231	Splenic Rupture	2.9%
232	Angioedema	2.8%
233	Multiple Sclerosis	2.8%
234	Thymoma	2.8%
235	Acute Generalized Exanthematous Pustulosis	2.8%
236	Lambert-Eaton Myasthenic Syndrome	2.7%
237	Sicca Syndrome	2.6%
238	Sjogren's Syndrome	2.6%
239	Lymphohistiocytosis, Hemophagocytic	2.6%
240	Erdheim-Chester Disease	2.6%
241	HIV-Associated Lipodystrophy Syndrome	2.6%
242	Asthma	2.5%
243	Encephalomyelitis, Acute Disseminated	2.5%
244	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	2.5%
245	Erythema Nodosum	2.4%
246	Neuritis, Autoimmune, Experimental	2.4%
247	Dermatitis, Photoallergic	2.4%
248	Asthma, Exercise-Induced	2.3%
249	Status Asthmaticus	2.3%
250	Multiple Sclerosis, Chronic Progressive	2.3%
251	Multiple Sclerosis, Relapsing-Remitting	2.3%
252	Aspergillosis, Allergic Bronchopulmonary	2.2%
253	Guillain-Barre Syndrome	2.2%
254	Malignant histiocytosis	2.2%
255	Sarcoidosis, Pulmonary	2.2%
256	Histiocytic sarcoma	2.2%
257	Asthma, Occupational	2.1%
258	Hereditary Angioedema Type III	2.1%
259	Hereditary Angioedema Types I and II	2.1%
260	Farmer's Lung	2.1%
261	Angioedemas, Hereditary	2.1%
262	Hay fever	2%
263	Rhinitis, Allergic, Perennial	2%
264	Toxic Epidermal Necrolysis	2%
265	Stevens-Johnson Syndrome	2%
266	Splenosis	1.9%
267	Giant Cell Arteritis	1.8%
268	Temporal Arteritis	1.8%
269	Myelitis, Transverse	1.6%
270	Miller Fisher Syndrome	1.4%
271	Niemann-Pick Disease, Type C	0.7%

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