MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Atypical Hemolytic Uremic Syndrome

(UMLS:C2931788)

Definition:: An hereditary hemolytic uremic syndrome associated with variations in the gene that encodes COMPLEMENT FACTOR H, or the related proteins CFHR1 and CFHR3. Disease often progresses to CHRONIC KIDNEY FAILURE without the prodromal symptoms of ENTEROCOLITIS and DIARRHEA that characterize typical hemolytic uremic syndrome.
UMLS ID:: C2931788
MeSH ID:: D065766

Classification 1:

Name:

Male Urogenital Diseases
MeSH Tree Number(s):: C12.777.419.936.463.500

Classification 2:

Name:

Female Urogenital Diseases and Pregnancy Complications
MeSH Tree Number(s):: C13.351.968.419.936.463.500

Classification 3:

Name:

Hemic and Lymphatic Diseases
MeSH Tree Number(s):: C15.378.071.141.610.500|C15.378.140.855.925.500.500

Synonym(s)

Atypical Hemolytic Uremic Syndrome

Atypical haemolytic uraemic syndrome

Atypical hemolytic uremic syndrome

Non-diarrhea-associated Hemolytic Uremic Syndrome

aHUS - atypical hemolytic uremic syndrome

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	gemcitabine		19816959	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Anuria	21.1%
2	Nephrolithiasis	21.1%
3	Azotemia	21.1%
4	Disseminated Intravascular Coagulation	19.7%
5	Protein S Deficiency	19.7%
6	Hydronephrosis	19.3%
7	Hyperoxaluria	19.3%
8	Kidney Cortex Necrosis	19.3%
9	Kidney Papillary Necrosis	19.3%
10	Nephritis	19.3%
11	Nephrosclerosis	19.3%
12	Nephrosis	19.3%
13	Perinephritis	19.3%
14	Kidney Failure	19.3%
15	Oxalosis	19.3%
16	Renal Insufficiency	19.3%
17	Thrombocythemia, Essential	18.9%
18	Thrombasthenia	18.5%
19	Hemoglobinuria, Paroxysmal	18.3%
20	Tuberculosis, Renal	17.1%
21	Blood Coagulation Disorders	17%
22	Bone Marrow Diseases	17%
23	Hemorrhagic Disorders	17%
24	Leukocyte Disorders	17%
25	Methemoglobinemia	17%
26	Pancytopenia	17%
27	Polycythemia	17%
28	Sulfhemoglobinemia	17%
29	Thrombophilia	17%
30	Erythrocytosis	17%
31	Diabetes Insipidus	16.8%
32	Hepatorenal Syndrome	16.8%
33	Thrombocytosis	16.8%
34	Pregnancy Complications, Hematologic	16.7%
35	Diabetic Nephropathy	16.7%
36	Renal hypertension	16.7%
37	Renal Artery Obstruction	16.7%
38	Renal Artery Stenosis	16.7%
39	Nephrocalcinosis	16.6%
40	Urinary Bladder Diseases	15.9%
41	Ureteral Diseases	15.9%
42	Urethral Diseases	15.9%
43	Urination Disorders	15.9%
44	Urolithiasis	15.9%
45	Anemia, Macrocytic	15.5%
46	Kidney Neoplasm	15.2%
47	Antithrombin III Deficiency	14.8%
48	Protein C Deficiency	14.8%
49	Transfusion Reaction	14.7%
50	Hypotensive Transfusion Reaction	14.7%
51	Hematologic Neoplasms	14.4%
52	Urinary tract infection	13.8%
53	Purpura, Thrombotic Thrombocytopenic	13.2%
54	Bone Marrow Neoplasms	13.2%
55	Anemia, Neonatal	13.1%
56	Ureterolithiasis	13.1%
57	Vitamin K Deficiency	13.1%
58	AIDS-Associated Nephropathy	12.9%
59	Anemia, Sickle Cell	12.7%
60	Thalassemia	12.7%
61	Thrombocytopenic purpura	12.5%
62	Afibrinogenemia	12.4%
63	Factor VII Deficiency	12.4%
64	Factor X Deficiency	12.4%
65	Factor XII Deficiency	12.4%
66	Hemophilia A	12.4%
67	Activated Protein C Resistance	12.4%
68	Factor II deficiency	12.4%
69	Factor VIII Deficiency	12.4%
70	Factor V deficiency	12.4%
71	Factor XI Deficiency	12.4%
72	Hypoprothrombinemias	12.4%
73	Kidney Calculi	12%
74	Multicystic Dysplastic Kidney	11.9%
75	Glomerulonephritis	11.5%
76	Nephritis, Interstitial	11.5%
77	Lipoid nephrosis	11.5%
78	Nephrotic Syndrome	11.5%
79	Pyelitis	11.5%
80	Pyonephrosis	11.5%
81	Nephrogenic Diabetes Insipidus	11.5%
82	Congenital Nephrogenic Diabetes Insipidus	11.5%
83	Acute kidney injury	11.5%
84	Anemia, Diamond-Blackfan	11.5%
85	Pyelonephritis	11.5%
86	Lymphatic Diseases	11.1%
87	Autoimmune thrombocytopenia	11%
88	Immune thrombocytopenic purpura	11%
89	Renal Osteodystrophy	10.6%
90	Renal rickets	10.6%
91	Bladder neck obstruction	10.4%
92	Urogenital Abnormalities	10.3%
93	Bladder Exstrophy	10%
94	Epispadias	10%
95	Hypertension, Renovascular	9.9%
96	Polycythemia Vera	9.9%
97	Pyelocystitis	9.6%
98	Glycosuria, Renal	9.1%
99	Eosinophilia	9.1%
100	Hypoproteinemia	9.1%
101	Leukopenia	9.1%
102	Leukostasis	9.1%
103	MYELODYSPLASTIC SYNDROME	9.1%
104	Anemia, Megaloblastic	9%
105	Wiskott-Aldrich Syndrome	9%
106	Agammaglobulinemia	8.9%
107	Leukemoid Reaction	8.8%
108	Blood Platelet Disorders	8.7%
109	Polycystic Kidney Diseases	8.7%
110	Cystitis	8.7%
111	Ureteral obstruction	8.7%
112	Ureterocele	8.7%
113	Urethral Obstruction	8.7%
114	Urethritis	8.7%
115	Vesico-Ureteral Reflux	8.7%
116	Urinary Retention	8.7%
117	Renal Aminoacidurias	8.7%
118	Fanconi Syndrome	8.7%
119	Pseudohypoaldosteronism	8.7%
120	Liddle Syndrome	8.7%
121	Ureteral Calculi	8.5%
122	Zellweger Syndrome	8.4%
123	Sickle Cell Trait	8.4%
124	Anemia	8.3%
125	Mesoblastic Nephroma	8.1%
126	Renal Cell Carcinoma	8.1%
127	Papillary Renal Cell Carcinoma	8.1%
128	Urinary Bladder Fistula	8.1%
129	Bladder Neoplasm	8.1%
130	Ureteral Neoplasms	8.1%
131	Urethral Neoplasms	8.1%
132	Leukocytosis	7.7%
133	Paraproteinemias	7.7%
134	Pelger-Huet Anomaly	7.7%
135	Pleocytosis	7.7%
136	Renal tubular acidosis	7.7%
137	Infectious Mononucleosis	7.7%
138	Balkan Nephropathy	7.6%
139	Focal glomerulosclerosis	7.6%
140	Kidney Failure, Chronic	7.6%
141	Bacteriuria	7.5%
142	Glycosuria	7.5%
143	Hematuria	7.5%
144	Oliguria	7.5%
145	Polyuria	7.5%
146	Proteinuria	7.5%
147	Pyuria	7.5%
148	Urinary Calculi	7.5%
149	Cystocele	7.4%
150	Urinary Incontinence	7.4%
151	Waldenstrom Macroglobulinemia	6.9%
152	Nephroblastoma	6.9%
153	Acute Chest Syndrome	6.8%
154	Glomerulonephritis, Membranoproliferative	6.8%
155	Hypergammaglobulinemia	6.7%
156	Cryoglobulinemia	6.6%
157	Monoclonal Gammopathy of Undetermined Significance	6.6%
158	Enuresis	6.6%
159	Transfusion-Related Acute Lung Injury	6.6%
160	Ecchymosis	6.6%
161	Petechiae	6.6%
162	Purpura	6.6%
163	Hyperphosphaturia	6.3%
164	Hydrops Fetalis	6.1%
165	Infertility	6.1%
166	Heavy Chain Disease	6%
167	Purpura, Hyperglobulinemic	5.9%
168	Anti-Glomerular Basement Membrane Disease	5.9%
169	Fanconi Anemia	5.8%
170	Lupus Nephritis	5.8%
171	Polycystic Kidney, Autosomal Dominant	5.8%
172	Cystinuria	5.7%
173	Adenitis	5.7%
174	Histiocytosis	5.7%
175	Lymphadenitis	5.7%
176	Lymphangitis	5.7%
177	Lymphedema	5.7%
178	Splenic Diseases	5.7%
179	Thymus Hyperplasia	5.7%
180	Pseudolymphoma	5.7%
181	Lymphadenopathy	5.7%
182	Genital Diseases, Male	5.6%
183	Hypospadias	5.6%
184	Waterhouse-Friderichsen Syndrome	5.5%
185	Pregnancy Complications	5.5%
186	Multiple Myeloma	5.3%
187	Urologic Neoplasms	5.2%
188	Horseshoe Kidney	5.2%
189	Primary Myelofibrosis	5.2%
190	Agranulocytosis	5.2%
191	Lymphocytosis	5.2%
192	Myelofibrosis	5.2%
193	Myeloid Metaplasia	5.2%
194	Hypoalbuminemia	5.2%
195	Hypereosinophilic syndrome	5.2%
196	bone marrow fibrosis	5.2%
197	Urethral Stenosis	5.2%
198	Urethral stricture	5.2%
199	Anemia, Pernicious	4.9%
200	Lymphocele	4.8%
201	Lymphoproliferative Disorders	4.8%
202	Lymphatic Abnormalities	4.8%
203	Thrombocytopenia	4.8%
204	Sexually Transmitted Diseases	4.8%
205	Thymus Neoplasms	4.7%
206	Kernicterus	4.7%
207	Hermaphroditism	4.6%
208	Disorders of Sex Development	4.6%
209	Genital Herpes	4.6%
210	Lymphopenia	4.4%
211	Albuminuria	4.4%
212	Hemoglobinuria	4.4%
213	Urge Incontinence	4.4%
214	Job Syndrome	4.4%
215	Lymphangiectasis, Intestinal	4.4%
216	Leukemia, Myelomonocytic, Chronic	4.4%
217	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	4.4%
218	Anemia, Hemolytic	4.3%
219	Endometriosis	4.3%
220	Uterine Diseases	4.3%
221	Vaginal Diseases	4.3%
222	Vulvar Diseases	4.3%
223	Endometrioma	4.3%
224	Genital Neoplasms, Male	4.2%
225	Denys-Drash Syndrome	4.1%
226	Mucocutaneous Lymph Node Syndrome	4.1%
227	Eosinophilic Granuloma	4%
228	Diurnal Enuresis	3.9%
229	Eosinophilia-Myalgia Syndrome	3.8%
230	Chronic granulomatous disease	3.8%
231	Shwartzman Phenomenon	3.8%
232	Hemangioma, Cavernous	3.8%
233	Scurvy	3.8%
234	Purpura Fulminans	3.8%
235	Genital Neoplasms, Female	3.6%
236	Vesicovaginal Fistula	3.4%
237	Uterine Neoplasms	3.4%
238	Vaginal Neoplasms	3.4%
239	Vulvar Neoplasms	3.4%
240	Uterine Cancer	3.4%
241	Neutropenia	3.3%
242	POEMS Syndrome	3.3%
243	Uterine Inversion	3.2%
244	Endometritis	3.2%
245	Elephantiasis	3%
246	Hypersplenism	3%
247	Sarcoidosis	3%
248	Elephantiasis Nostras Verrucosa	3%
249	Penile Neoplasms	3%
250	Prostatic Neoplasms	3%
251	Epididymitis	2.9%
252	Penile Diseases	2.9%
253	Prostatic Diseases	2.9%
254	Spermatic Cord Torsion	2.9%
255	Hemospermia	2.9%
256	Testicular Hydrocele	2.9%
257	Dyspareunia	2.9%
258	Familial Hypophosphatemic Rickets	2.9%
259	Cryptorchidism	2.9%
260	Thrombotic Microangiopathies	2.9%
261	Pulmonary Eosinophilia	2.8%
262	Eosinophilic Pneumonia	2.8%
263	Uterine Rupture	2.8%
264	Leukemia, Myeloid, Chronic-Phase	2.8%
265	Polyhydramnios	2.8%
266	Obstetric Labor Complications	2.8%
267	Ectopic Pregnancy	2.8%
268	Pregnancy, Prolonged	2.8%
269	Puerperal Disorders	2.8%
270	Oligohydramnios	2.8%
271	Prenatal Injuries	2.8%
272	Fallopian Tube Neoplasms	2.7%
273	Hemolytic-Uremic Syndrome	2.7%
274	Granuloma	2.6%
275	Histiocytic Disorders, Malignant	2.6%
276	Splenic Infarction	2.6%
277	Splenic Neoplasms	2.6%
278	Histiocytosis, Langerhans-Cell	2.5%
279	Tumor Lysis Syndrome	2.5%
280	Gonadal Dysgenesis	2.5%
281	Adrenogenital Syndrome	2.5%
282	Ovotesticular Disorders of Sex Development	2.5%
283	Testicular Diseases	2.5%
284	Varicocele	2.5%
285	Pseudoxanthoma Elasticum	2.5%
286	Spermatocele	2.4%
287	Abruptio Placentae	2.4%
288	Placenta Accreta	2.4%
289	Endometrial Hyperplasia	2.4%
290	Fetal Diseases	2.4%
291	Pregnancy Complications, Cardiovascular	2.4%
292	Pregnancy Complications, Neoplastic	2.4%
293	Pyometra	2.4%
294	Vaginitis	2.4%
295	Vulvitis	2.4%
296	Vaginal Discharge	2.4%
297	Vulvodynia	2.4%
298	Salpingitis	2.4%
299	Vulvovaginitis	2.4%
300	Febrile Neutropenia	2.4%
301	Chorioamnionitis	2.3%
302	Pregnancy Complications, Infectious	2.3%
303	Fetal Death	2.3%
304	Perinatal death	2.3%
305	Morning Sickness	2.3%
306	Splenic Rupture	2.2%
307	Lymphoma	2.2%
308	Thymoma	2.2%
309	ovarian neoplasm	2.2%
310	Puerperal Infection	2.1%
311	Postpartum Hemorrhage	2.1%
312	Oophoritis	2.1%
313	Sezary Syndrome	2%
314	Endometrial Neoplasms	2%
315	Ovarian Diseases	2%
316	Adnexitis	2%
317	Pruritus Vulvae	2%
318	Uterine hemorrhage	2%
319	Vaginal Fistula	2%
320	Pelvic Inflammatory Disease	2%
321	Hyperandrogenism	2%
322	Gestational Diabetes	2%
323	Uterine Prolapse	2%
324	Vaginal Prolapse	2%
325	Autoimmune Lymphoproliferative Syndrome	2%
326	Uterine Cervical Incompetence	1.9%
327	Prostatic Neoplasms, Castration-Resistant	1.8%
328	Atypical Hemolytic Uremic Syndrome	1.8%
329	Lymphohistiocytosis, Hemophagocytic	1.7%
330	Erdheim-Chester Disease	1.7%
331	Carcinoma, Endometrioid	1.7%
332	Testicular Neoplasms	1.6%
333	Balanitis	1.6%
334	Benign prostatic hypertrophy	1.6%
335	Phimosis	1.6%
336	Priapism	1.6%
337	prostatitis	1.6%
338	Prostatic Adenoma	1.6%
339	Benign Prostatic Hyperplasia	1.6%
340	Prostatic Hypertrophy	1.6%
341	Prostatic Hyperplasia	1.6%
342	Malignant histiocytosis	1.5%
343	Sarcoidosis, Pulmonary	1.5%
344	Histiocytic sarcoma	1.5%
345	Abortion, Habitual	1.4%
346	Dystocia	1.4%
347	Eclampsia	1.4%
348	Fetal Membranes, Premature Rupture	1.4%
349	Placental Insufficiency	1.4%
350	Pre-Eclampsia	1.4%
351	Prenatal Exposure Delayed Effects	1.4%
352	HELLP Syndrome	1.4%
353	Placenta, Retained	1.4%
354	Uterine Cervicitis	1.4%
355	Leukorrhea	1.4%
356	Parametritis	1.4%
357	Turner Syndrome	1.4%
358	Candidiasis, Vulvovaginal	1.4%
359	Premature Ejaculation	1.4%
360	Erectile dysfunction	1.4%
361	Orchitis	1.3%
362	Chlamydia Infections	1.3%
363	Gonorrhea	1.3%
364	Splenosis	1.3%
365	Hodgkin Disease	1.3%
366	Lymphoma, Non-Hodgkin	1.3%
367	Leukemia, T-Cell	1.3%
368	Leukemia, B-Cell	1.3%
369	Abortion, Veterinary	1.2%
370	Pregnancy Complications, Parasitic	1.2%
371	Kallmann Syndrome	1.2%
372	Bacterial Vaginosis	1.2%
373	Lactation Disorder	1.2%
374	Mastitis	1.2%
375	Depression, Postpartum	1.2%
376	Embryo Loss	1.2%
377	Syphilis	1.2%
378	Fetal Resorption	1.2%
379	granulosa cell tumor	1.2%
380	Carcinoma, Ovarian Epithelial	1.2%
381	Hyperemesis Gravidarum	1.2%
382	Trichomonas Vaginitis	1.2%
383	Uterine Perforation	1.2%
384	Ovarian Hyperstimulation Syndrome	1.2%
385	Metrorrhagia	1.2%
386	Composite Lymphoma	1.1%
387	Lymphangioleiomyomatosis	1.1%
388	Klinefelter Syndrome	1.1%
389	Fetal Growth Retardation	1%
390	Trophoblastic Neoplasms	1%
391	Embolism, Amniotic Fluid	1%
392	Fetal Hypoxia	1%
393	Fetal Alcohol Spectrum Disorders	1%
394	Corpus Luteum Cyst	1%
395	Ovarian Cysts	1%
396	Breech Presentation	1%
397	Anovulation	1%
398	Menorrhagia	1%
399	Stillbirth	1%
400	Premature Menopause	1%
401	Azoospermia	1%
402	Oligospermia	1%
403	Impotence, Vasculogenic	1%
404	Asthenozoospermia	1%
405	Teratozoospermia	1%
406	Aspermia	1%
407	Endometrial Stromal Sarcoma	0.9%
408	Lymphogranuloma Venereum	0.9%
409	Meconium Aspiration Syndrome	0.8%
410	Lymphoma, Follicular	0.8%
411	T-Cell Lymphoma	0.8%
412	Premature Birth	0.8%
413	Mantle cell lymphoma	0.8%
414	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	0.8%
415	Leukemia, Large Granular Lymphocytic	0.8%
416	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	0.8%
417	Polycystic Ovary Syndrome	0.7%
418	Galactorrhea	0.7%
419	Leydig Cell Tumor	0.6%
420	Lymphoma, T-Cell, Cutaneous	0.6%
421	Lymphoma, AIDS-Related	0.6%
422	Enteropathy-Associated T-Cell Lymphoma	0.6%
423	Primary Effusion Lymphoma	0.6%
424	Lymphomatoid Granulomatosis	0.5%
425	Choriocarcinoma	0.5%
426	Mycosis Fungoides	0.5%
427	Lymphomatoid Papulosis	0.5%
428	Plasmablastic lymphoma	0.5%
429	Burkitt Lymphoma	0.4%
430	Niemann-Pick Disease, Type C	0.4%
431	Hydatidiform Mole	0.3%

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