MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Pulmonary Eosinophilia

(UMLS:C0034068)

Definition:: A condition characterized by infiltration of the lung with EOSINOPHILS due to inflammation or other disease processes. Major eosinophilic lung diseases are the eosinophilic pneumonias caused by infections, allergens, or toxic agents.
UMLS ID:: C0034068
MeSH ID:: D011657

Classification 1:

Name:

Respiratory Tract Diseases
MeSH Tree Number(s):: C08.381.750

Classification 2:

Name:

Hemic and Lymphatic Diseases
MeSH Tree Number(s):: C15.378.553.231.549.750

Synonym(s)

Pulmonary Eosinophilia

Andrews syndrome

Eosinophilic asthma

PIE

PIE - Pulmonary infiltrates with eosinophilia

PNEUMONITIS, EOSINOPHILIC

PULMONARY EOSINOPHILIA

PULMONARY INFILTRATION EOSINOPHILIA

Pulmonary eosinophilia

10.

Pulmonary infiltrates with eosinophilia

11.

andrews syndrome

12.

eosinophilia; pulmonary

13.

eosinophilic pneumonia

14.

eosinophilic pneumonitis

15.

eosinophilic pulmonary reactions

16.

eosinophilic; pneumonitis

17.

pneumonitis; eosinophilic

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Daptomycin	FAERS: 15		US FAERS
2	Topiramate	FAERS: 13		US FAERS
3	Ciprofloxacin	FAERS: 11		US FAERS
4	Alendronate	FAERS: 10		US FAERS
5	Allopurinol	FAERS: 6		US FAERS
6	Daptomycin	FAERS: 6	17207858	CTD US FAERS
7	Mesalamine	FAERS: 4		SIDER US FAERS
8	Ortho Evra	FAERS: 4		US FAERS
9	Sulfasalazine	FAERS: 4		US FAERS
10	Venlafaxine Hydrochloride	FAERS: 4		US FAERS
11	Imatinib Mesylate	FAERS: 3		US FAERS
12	Meropenem	FAERS: 3		US FAERS
13	Valproic Acid	FAERS: 3		US FAERS
14	Amoxicillin	FAERS: 2		US FAERS
15	Azathioprine	FAERS: 2		US FAERS
16	Doxycycline	FAERS: 2		US FAERS
17	Doxycycline	FAERS: 2		US FAERS
18	Imatinib Mesylate	FAERS: 2		US FAERS
19	Lenalidomide	FAERS: 2		US FAERS
20	Naproxen	FAERS: 2		SIDER US FAERS
21	Rivaroxaban	FAERS: 2		US FAERS
22	montelukast	FAERS: 2		SIDER US FAERS
23	Amiodarone	FAERS: 1		US FAERS
24	Amlodipine besylate and benazepril hydrochloride	FAERS: 1		US FAERS
25	Bendamustine Hydrochloride	FAERS: 1		US FAERS
26	Captopril	FAERS: 1		SIDER US FAERS
27	Carbamazepine	FAERS: 1	6462508 9923035	CTD US FAERS
28	Ceftriaxone	FAERS: 1		US FAERS
29	Ciprofloxacin	FAERS: 1		US FAERS
30	Clarithromycin	FAERS: 1		US FAERS
31	Dabigatran	FAERS: 1		US FAERS
32	Dantrolene	FAERS: 1		US FAERS
33	Diclofenac	FAERS: 1		US FAERS
34	Fluoxetine	FAERS: 1		US FAERS
35	Hydroxychloroquine	FAERS: 1		US FAERS
36	Ibuprofen	FAERS: 1		US FAERS
37	Levofloxacin	FAERS: 1		US FAERS
38	Moxifloxacin	FAERS: 1		US FAERS
39	Nitrofurantoin	FAERS: 1		US FAERS
40	Pregabalin	FAERS: 1		US FAERS
41	Sulfamethoxazole	FAERS: 1		US FAERS
42	Tazobactam	FAERS: 1		US FAERS
43	Trihexyphenidyl	FAERS: 1		US FAERS
44	riociguat	FAERS: 1		US FAERS
45	romidepsin	FAERS: 1		US FAERS
46	testosterone 17 beta-cypionate	FAERS: 1		US FAERS
47	Acetaminophen			OFFSIDES
48	Ambroxol			OFFSIDES
49	Ascorbic Acid		14606601	CTD
50	Beclomethasone		10850854	CTD
51	Benzbromarone		20190479	CTD OFFSIDES
52	Budesonide		10850854 11734451	CTD
53	CDP 840		10850854	CTD
54	Carisoprodol			OFFSIDES
55	Chloride ion			OFFSIDES
56	Dapsone			SIDER
57	Daptomycin			SIDER
58	Dexamethasone		10850854	CTD
59	Diphenoxylate			OFFSIDES
60	Dobutamine			OFFSIDES
61	Epoprostenol			OFFSIDES
62	Fluorouracil			OFFSIDES
63	Fluticasone		10850854	CTD
64	Fosfomycin			OFFSIDES
65	Fosinopril			SIDER
66	Leucovorin			OFFSIDES
67	Lisinopril			SIDER
68	Maloprim			SIDER
69	Metoclopramide			OFFSIDES
70	Minocycline		16045429	CTD
71	Nedocromil			SIDER
72	Perindopril			SIDER
73	Piperacillin, Tazobactam Drug Combination			OFFSIDES
74	Quinapril			SIDER
75	Ramipril			SIDER
76	Rolipram		10850854	CTD
77	Toluene 2,4-Diisocyanate		14606601	CTD
78	Trazodone		8520792	CTD
79	Venlafaxine Hydrochloride			SIDER
80	Vitamin E		14606601	CTD
81	Vitamin K 1			OFFSIDES
82	balsalazide		21127763	CTD
83	benazeprilat			SIDER
84	benazepril			SIDER
85	cefditoren			SIDER
86	ferrous fumarate			OFFSIDES
87	fexofenadine			OFFSIDES
88	fosinoprilat			SIDER
89	gadoversetamide			OFFSIDES
90	moexiprilat			SIDER
91	perindoprilat			SIDER
92	piclamilast		10850854	CTD
93	quinaprilat			SIDER
94	ramiprilat			SIDER
95	rebamipide			OFFSIDES
96	tosufloxacin			OFFSIDES
97	trandolaprilat			SIDER
98	trandolapril			SIDER

Similar ADE(s)

	Name	Semantic Similarity
1	Pneumonia	27.7%
2	Lobar Pneumonia	27.7%
3	Respiratory Distress Syndrome, Adult	27.7%
4	Pneumonitis	27.7%
5	Atelectasis	27.4%
6	Pulmonary Hypertension	27.4%
7	Pulmonary Alveolar Proteinosis	27.4%
8	Pulmonary Edema	27.4%
9	Pulmonary Fibrosis	27.4%
10	Hamman-Rich syndrome	27.4%
11	Lung Diseases, Interstitial	27.4%
12	Lung Diseases, Obstructive	27.4%
13	Idiopathic Pulmonary Fibrosis	27.4%
14	Pneumoconiosis	25.1%
15	Bronchitis	23.4%
16	Bronchitis, Chronic	23.1%
17	Lung Diseases, Fungal	22.3%
18	Respiratory Distress Syndrome, Newborn	22%
19	Lung Abscess	21.8%
20	Lung Neoplasms	21.8%
21	Tuberculosis, Pulmonary	21.7%
22	Bronchopneumonia	21.7%
23	Lung Injury	20.8%
24	Hepatopulmonary Syndrome	20.8%
25	Pulmonary Embolism	20.3%
26	Radiation Pneumonitis	20.2%
27	Radiation Fibrosis	20.2%
28	Chronic Obstructive Airway Disease	20.1%
29	Middle Lobe Syndrome	20.1%
30	Acute Lung Injury	20.1%
31	Aspiration Pneumonia	20.1%
32	Asbestosis	20.1%
33	Berylliosis	20.1%
34	Silicosis	20.1%
35	Pleuropneumonia	20.1%
36	Leukopenia	19.6%
37	Leukostasis	19.6%
38	Asthma	19.3%
39	Eosinophilic Granuloma	18.5%
40	Bronchiolitis	17.9%
41	Histiocytosis, Langerhans-Cell	17.2%
42	Pneumonia, Viral	16.7%
43	Pulmonary Emphysema	16.6%
44	Pneumonia, Lipid	16.5%
45	Pneumonia, Bacterial	16.3%
46	Hemoptysis	16.3%
47	Sarcoidosis, Pulmonary	16.2%
48	Acute Chest Syndrome	16.1%
49	Hyaline Membrane Disease	15.9%
50	Multiple Pulmonary Nodules	15.9%
51	Anemia	15.4%
52	Blood Coagulation Disorders	15.4%
53	Blood Platelet Disorders	15.4%
54	Bone Marrow Diseases	15.4%
55	Hemorrhagic Disorders	15.4%
56	Methemoglobinemia	15.4%
57	Pancytopenia	15.4%
58	Polycythemia	15.4%
59	Sulfhemoglobinemia	15.4%
60	Thrombophilia	15.4%
61	Erythrocytosis	15.4%
62	Persistent Fetal Circulation Syndrome	15.3%
63	Bronchiolitis Obliterans	15.2%
64	Eosinophilia-Myalgia Syndrome	15.2%
65	Transfusion-Related Acute Lung Injury	15.2%
66	Pulmonary Aspergillosis	15.1%
67	Bronchopulmonary Aspergillosis	15.1%
68	Disseminated Intravascular Coagulation	15.1%
69	Protein S Deficiency	15.1%
70	Leukocytosis	14.9%
71	Pelger-Huet Anomaly	14.9%
72	Pleocytosis	14.9%
73	Pulmonary Infarction	14.9%
74	Bronchial Diseases	14.4%
75	Pleural Diseases	14.4%
76	Respiration Disorders	14.4%
77	Thoracic Diseases	14.4%
78	Tracheal Diseases	14.4%
79	Cystic Fibrosis	14%
80	Pleurisy	13.9%
81	Tracheitis	13.9%
82	Tracheobronchomegaly	13.8%
83	Aspergillosis, Allergic Bronchopulmonary	13.8%
84	Scimitar Syndrome	13.6%
85	Meconium Aspiration Syndrome	12.8%
86	Bronchopulmonary Dysplasia	12.4%
87	Thrombocythemia, Essential	12.4%
88	Leukemoid Reaction	12.3%
89	Transfusion Reaction	12.1%
90	Hypotensive Transfusion Reaction	12.1%
91	Granulomatosis with polyangiitis	11.9%
92	Pregnancy Complications, Hematologic	11.7%
93	Hematologic Neoplasms	11.7%
94	Farmer's Lung	11.7%
95	Agranulocytosis	11.6%
96	Lymphocytosis	11.6%
97	Laryngeal Diseases	11.2%
98	Nose Diseases	11.2%
99	Laryngitis	11.1%
100	Rhinitis	11.1%
101	Vocal Cord Dysfunction	11.1%
102	Infectious Mononucleosis	11.1%
103	Bronchial Fistula	10.9%
104	Pleural Neoplasms	10.9%
105	Thrombasthenia	10.8%
106	Antithrombin III Deficiency	10.8%
107	Protein C Deficiency	10.8%
108	Respiratory Tract Infections	10.8%
109	Granuloma, Laryngeal	10.8%
110	Granuloma, Respiratory Tract	10.6%
111	Respiratory Hypersensitivity	10.6%
112	Respiratory Tract Fistula	10.6%
113	Lymphatic Diseases	10.2%
114	Bone Marrow Neoplasms	10%
115	Anti-Glomerular Basement Membrane Disease	10%
116	Thrombocytosis	10%
117	Pleural Effusion, Malignant	9.9%
118	Blastomycosis	9.9%
119	Vitamin K Deficiency	9.9%
120	Invasive Pulmonary Aspergillosis	9.9%
121	Sinusitis	9.5%
122	Bronchial Neoplasms	9.4%
123	Choanal Atresia	9.2%
124	Laryngocele	9.2%
125	Altitude Sickness	9.1%
126	Bronchospasm	9.1%
127	Bronchiectasis	9.1%
128	Chylothorax	9.1%
129	Hydropneumothorax	9.1%
130	Hydrothorax	9.1%
131	Pneumothorax	9.1%
132	Respiratory Insufficiency	9.1%
133	Tracheal Stenosis	9.1%
134	Bronchial Hyperreactivity	9.1%
135	Respiratory Depression	9.1%
136	Respiratory Failure	9.1%
137	Afibrinogenemia	9.1%
138	Factor VII Deficiency	9.1%
139	Factor X Deficiency	9.1%
140	Factor XII Deficiency	9.1%
141	Hemophilia A	9.1%
142	Activated Protein C Resistance	9.1%
143	Factor II deficiency	9.1%
144	Factor VIII Deficiency	9.1%
145	Factor V deficiency	9.1%
146	Factor XI Deficiency	9.1%
147	Hypoprothrombinemias	9.1%
148	Tracheal Neoplasms	9.1%
149	Lymphopenia	8.9%
150	Job Syndrome	8.7%
151	Anemia, Hemolytic	8.4%
152	Anemia, Macrocytic	8.4%
153	Hypoproteinemia	8.4%
154	Thrombocytopenia	8.4%
155	MYELODYSPLASTIC SYNDROME	8.4%
156	Laryngospasm	8%
157	Asthma, Exercise-Induced	7.9%
158	Status Asthmaticus	7.9%
159	Laryngeal neoplasm	7.9%
160	Wiskott-Aldrich Syndrome	7.9%
161	Neutropenia	7.7%
162	Hemoglobinuria, Paroxysmal	7.4%
163	Polycythemia Vera	7.4%
164	Primary Ciliary Dyskinesia	7.1%
165	Chronic granulomatous disease	7%
166	Granuloma, Lethal Midline	6.9%
167	Laryngeal Edema	6.9%
168	Nose Deformities, Acquired	6.9%
169	Respiratory Aspiration	6.9%
170	Asthma, Occupational	6.9%
171	Apnea	6.8%
172	Cheyne-Stokes Respiration	6.8%
173	Common Cold	6.8%
174	Dyspnea	6.8%
175	Hemothorax	6.8%
176	Hyperventilation	6.8%
177	Influenza	6.8%
178	Mouth Breathing	6.8%
179	Tachypnea	6.8%
180	Catarrh	6.8%
181	Agammaglobulinemia	6.8%
182	Severe Acute Respiratory Syndrome	6.7%
183	Laryngopharyngeal Reflux	6.7%
184	Airway Obstruction	6.7%
185	Choking	6.7%
186	Epiglottitis	6.7%
187	Mediastinitis	6.7%
188	Paranasal Sinus Neoplasms	6.6%
189	Anemia, Neonatal	6.4%
190	Paraproteinemias	6.4%
191	Nose Neoplasms	6%
192	Hay fever	6%
193	Rhinitis, Allergic, Perennial	6%
194	Rhinoscleroma	6%
195	Purpura, Thrombotic Thrombocytopenic	5.9%
196	Hoarseness	5.9%
197	Anemia, Sickle Cell	5.8%
198	Thalassemia	5.8%
199	Febrile Neutropenia	5.8%
200	Asthma, Aspirin-Induced	5.7%
201	Anemia, Diamond-Blackfan	5.7%
202	Pharyngitis	5.6%
203	Laryngostenosis	5.5%
204	Nasal Polyps	5.5%
205	Maxillary Sinus Neoplasms	5.4%
206	Pertussis	5.4%
207	Kartagener Syndrome	5.3%
208	Hypergammaglobulinemia	5.2%
209	Adenitis	5.1%
210	Histiocytosis	5.1%
211	Lymphadenitis	5.1%
212	Lymphangitis	5.1%
213	Lymphedema	5.1%
214	Splenic Diseases	5.1%
215	Thymus Hyperplasia	5.1%
216	Pseudolymphoma	5.1%
217	Lymphadenopathy	5.1%
218	Mediastinal Cyst	5.1%
219	Pericardial Cyst	5.1%
220	Thymic Cyst	5.1%
221	Croup	5%
222	Mediastinal Emphysema	5%
223	Rhinitis, Vasomotor	5%
224	Hypoventilation	5%
225	Ecchymosis	5%
226	Petechiae	5%
227	Purpura	5%
228	Acidosis, Respiratory	5%
229	Alkalosis, Respiratory	5%
230	Sleep Apnea Syndromes	5%
231	Primary Myelofibrosis	5%
232	Anemia, Megaloblastic	5%
233	Myelofibrosis	5%
234	Myeloid Metaplasia	5%
235	Hypoalbuminemia	5%
236	bone marrow fibrosis	5%
237	Thrombotic Microangiopathies	5%
238	Cryoglobulinemia	5%
239	Monoclonal Gammopathy of Undetermined Significance	5%
240	Waldenstrom Macroglobulinemia	4.8%
241	Autoimmune thrombocytopenia	4.7%
242	Immune thrombocytopenic purpura	4.7%
243	Heavy Chain Disease	4.7%
244	Voice Disorders	4.6%
245	Voice Disturbance	4.6%
246	Epistaxis	4.6%
247	Purpura, Hyperglobulinemic	4.2%
248	Sleep Apnea, Obstructive	4.1%
249	Sleep Apnea, Central	4.1%
250	Hemolytic-Uremic Syndrome	4.1%
251	Tonsillitis	4%
252	Dyspnea, Paroxysmal	4%
253	Respiratory Paralysis	4%
254	Laryngomalacia	3.9%
255	Lymphocele	3.9%
256	Lymphoproliferative Disorders	3.9%
257	Lymphatic Abnormalities	3.9%
258	Vocal Cord Paralysis	3.9%
259	Hydrops Fetalis	3.9%
260	Thymus Neoplasms	3.8%
261	Multiple Myeloma	3.7%
262	Leukemia, Myelomonocytic, Chronic	3.7%
263	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	3.7%
264	Sickle Cell Trait	3.7%
265	Thrombocytopenic purpura	3.6%
266	Waterhouse-Friderichsen Syndrome	3.5%
267	Lymphangiectasis, Intestinal	3.3%
268	Aphonia	3.3%
269	Retropharyngeal Abscess	3.3%
270	Dysphonia	3.3%
271	Bronchomalacia	3.3%
272	Tracheomalacia	3.3%
273	Fanconi Anemia	3.3%
274	Kernicterus	3.1%
275	Mucocutaneous Lymph Node Syndrome	3.1%
276	Shwartzman Phenomenon	3%
277	Hemangioma, Cavernous	3%
278	Scurvy	3%
279	Purpura Fulminans	3%
280	Nasopharyngitis	2.9%
281	Atypical Hemolytic Uremic Syndrome	2.8%
282	Elephantiasis	2.8%
283	Hypersplenism	2.8%
284	Sarcoidosis	2.8%
285	Elephantiasis Nostras Verrucosa	2.8%
286	Peritonsillar Abscess	2.7%
287	POEMS Syndrome	2.5%
288	Leukemia, Myeloid, Chronic-Phase	2.4%
289	Anemia, Pernicious	2.4%
290	Granuloma	2.1%
291	Histiocytic Disorders, Malignant	2.1%
292	Splenic Infarction	2.1%
293	Splenic Neoplasms	2.1%
294	Tumor Lysis Syndrome	2.1%
295	Splenic Rupture	1.7%
296	Lymphoma	1.7%
297	Pseudoxanthoma Elasticum	1.7%
298	Thymoma	1.7%
299	Lymphohistiocytosis, Hemophagocytic	1.7%
300	Erdheim-Chester Disease	1.7%
301	Sezary Syndrome	1.5%
302	Autoimmune Lymphoproliferative Syndrome	1.4%
303	Malignant histiocytosis	1.2%
304	Histiocytic sarcoma	1.2%
305	Splenosis	1%
306	Hodgkin Disease	1%
307	Lymphoma, Non-Hodgkin	1%
308	Leukemia, T-Cell	1%
309	Leukemia, B-Cell	1%
310	Composite Lymphoma	0.8%
311	Lymphangioleiomyomatosis	0.8%
312	Lymphoma, Follicular	0.7%
313	T-Cell Lymphoma	0.7%
314	Mantle cell lymphoma	0.7%
315	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	0.6%
316	Leukemia, Large Granular Lymphocytic	0.6%
317	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	0.6%
318	Lymphoma, T-Cell, Cutaneous	0.5%
319	Lymphoma, AIDS-Related	0.5%
320	Enteropathy-Associated T-Cell Lymphoma	0.5%
321	Primary Effusion Lymphoma	0.5%
322	Lymphomatoid Granulomatosis	0.4%
323	Mycosis Fungoides	0.4%
324	Lymphomatoid Papulosis	0.4%
325	Plasmablastic lymphoma	0.4%
326	Burkitt Lymphoma	0.3%
327	Niemann-Pick Disease, Type C	0.3%

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