MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Thrombotic Microangiopathies

(UMLS:C2717961)

Definition:: Diseases that result in THROMBOSIS in MICROVASCULATURE. The two most prominent diseases are PURPURA, THROMBOTIC THROMBOCYTOPENIC; and HEMOLYTIC-UREMIC SYNDROME. Multiple etiological factors include VASCULAR ENDOTHELIAL CELL damage due to SHIGA TOXIN; FACTOR H deficiency; and aberrant VON WILLEBRAND FACTOR formation.
UMLS ID:: C2717961
MeSH ID:: D057049

Classification:

Name:

Hemic and Lymphatic Diseases
MeSH Tree Number(s):: C15.378.140.855.925

Synonym(s)

Thrombotic Microangiopathies

Thrombotic Microangiopathy

Thrombotic microangiopathy

microangiopathy; thrombotic

thrombotic microangiopathy

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Aminocaproic Acid	18805613	CTD
2	Aspirin	15808685	CTD
3	Cyclosporine	View details 11007689 15147429 15590127 15859940 17531780 19120084 22836123 23619107	CTD
4	Diclofenac	2716392	CTD
5	Prednisolone	17541236	CTD
6	Quinine	19260037	CTD
7	Ribavirin	18852671	CTD
8	Sirolimus	View details 12603218 12830473 14724447 15147429 16310579 16421477 17531780 19120084	CTD
9	Tacrolimus	View details 10071024 11007689 14625834 14724447 17277791 17425752 18259686 18852671 19120084	CTD
10	Verapamil	12611489	CTD
11	trandolapril	12611489	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Thrombocytosis	29.3%
2	Anemia	25.4%
3	Blood Coagulation Disorders	25.4%
4	Bone Marrow Diseases	25.4%
5	Hemorrhagic Disorders	25.4%
6	Leukocyte Disorders	25.4%
7	Methemoglobinemia	25.4%
8	Pancytopenia	25.4%
9	Polycythemia	25.4%
10	Sulfhemoglobinemia	25.4%
11	Thrombophilia	25.4%
12	Erythrocytosis	25.4%
13	Thrombocythemia, Essential	23.8%
14	Thrombasthenia	23.7%
15	Disseminated Intravascular Coagulation	22.3%
16	Protein S Deficiency	22.3%
17	Transfusion Reaction	18.1%
18	Hypotensive Transfusion Reaction	18.1%
19	Pregnancy Complications, Hematologic	17.2%
20	Hematologic Neoplasms	17.2%
21	Lymphatic Diseases	16.4%
22	Antithrombin III Deficiency	15.8%
23	Protein C Deficiency	15.8%
24	Bone Marrow Neoplasms	14.9%
25	Anemia, Hemolytic	14.8%
26	Anemia, Macrocytic	14.8%
27	Eosinophilia	14.8%
28	Hypoproteinemia	14.8%
29	Leukopenia	14.8%
30	Leukostasis	14.8%
31	MYELODYSPLASTIC SYNDROME	14.8%
32	Vitamin K Deficiency	14.7%
33	Afibrinogenemia	13.7%
34	Factor VII Deficiency	13.7%
35	Factor X Deficiency	13.7%
36	Factor XII Deficiency	13.7%
37	Hemophilia A	13.7%
38	Activated Protein C Resistance	13.7%
39	Factor II deficiency	13.7%
40	Factor VIII Deficiency	13.7%
41	Factor V deficiency	13.7%
42	Factor XI Deficiency	13.7%
43	Hypoprothrombinemias	13.7%
44	Hemoglobinuria, Paroxysmal	12.9%
45	Leukemoid Reaction	12.9%
46	Polycythemia Vera	11.6%
47	Anemia, Neonatal	10.1%
48	Leukocytosis	10.1%
49	Paraproteinemias	10.1%
50	Pelger-Huet Anomaly	10.1%
51	Pleocytosis	10.1%
52	Agammaglobulinemia	10.1%
53	Primary Myelofibrosis	9.7%
54	Agranulocytosis	9.7%
55	Anemia, Megaloblastic	9.7%
56	Lymphocytosis	9.7%
57	Myelofibrosis	9.7%
58	Myeloid Metaplasia	9.7%
59	Hypoalbuminemia	9.7%
60	Anemia, Diamond-Blackfan	9.7%
61	Hypereosinophilic syndrome	9.7%
62	bone marrow fibrosis	9.7%
63	Wiskott-Aldrich Syndrome	9.1%
64	Anemia, Sickle Cell	8.9%
65	Thalassemia	8.9%
66	Adenitis	8.5%
67	Histiocytosis	8.5%
68	Lymphadenitis	8.5%
69	Lymphangitis	8.5%
70	Lymphedema	8.5%
71	Splenic Diseases	8.5%
72	Thymus Hyperplasia	8.5%
73	Pseudolymphoma	8.5%
74	Lymphadenopathy	8.5%
75	Infectious Mononucleosis	7.9%
76	Cryoglobulinemia	7.8%
77	Monoclonal Gammopathy of Undetermined Significance	7.8%
78	Hypergammaglobulinemia	7.7%
79	Transfusion-Related Acute Lung Injury	7.5%
80	Ecchymosis	7.4%
81	Petechiae	7.4%
82	Purpura	7.4%
83	Heavy Chain Disease	7.4%
84	Purpura, Thrombotic Thrombocytopenic	7.2%
85	Neutropenia	7.2%
86	Waldenstrom Macroglobulinemia	7%
87	Lymphopenia	6.7%
88	Job Syndrome	6.5%
89	Purpura, Hyperglobulinemic	6.5%
90	Leukemia, Myelomonocytic, Chronic	6.5%
91	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	6.5%
92	Sickle Cell Trait	6.3%
93	Febrile Neutropenia	6%
94	Fanconi Anemia	5.8%
95	Lymphocele	5.7%
96	Lymphoproliferative Disorders	5.7%
97	Lymphatic Abnormalities	5.7%
98	Multiple Myeloma	5.6%
99	Thymus Neoplasms	5.6%
100	Hydrops Fetalis	5.6%
101	Autoimmune thrombocytopenia	5.5%
102	Immune thrombocytopenic purpura	5.5%
103	Eosinophilia-Myalgia Syndrome	5%
104	Pulmonary Eosinophilia	5%
105	Eosinophilic Pneumonia	5%
106	Lymphangiectasis, Intestinal	5%
107	Elephantiasis	4.9%
108	Chronic granulomatous disease	4.9%
109	Hypersplenism	4.9%
110	Sarcoidosis	4.9%
111	Shwartzman Phenomenon	4.9%
112	Elephantiasis Nostras Verrucosa	4.9%
113	Hemangioma, Cavernous	4.9%
114	Scurvy	4.8%
115	Purpura Fulminans	4.8%
116	Waterhouse-Friderichsen Syndrome	4.8%
117	Leukemia, Myeloid, Chronic-Phase	4.8%
118	Anemia, Pernicious	4.8%
119	Acute Chest Syndrome	4.6%
120	Eosinophilic Granuloma	4.4%
121	Kernicterus	4.3%
122	Mucocutaneous Lymph Node Syndrome	4.2%
123	POEMS Syndrome	3.9%
124	Hemolytic-Uremic Syndrome	3.8%
125	Granuloma	3.4%
126	Histiocytic Disorders, Malignant	3.4%
127	Splenic Infarction	3.4%
128	Splenic Neoplasms	3.4%
129	Thrombocytopenic purpura	3.3%
130	Histiocytosis, Langerhans-Cell	3.3%
131	Tumor Lysis Syndrome	3.3%
132	Lymphohistiocytosis, Hemophagocytic	3.2%
133	Erdheim-Chester Disease	3.2%
134	Atypical Hemolytic Uremic Syndrome	2.9%
135	Splenic Rupture	2.6%
136	Lymphoma	2.5%
137	Pseudoxanthoma Elasticum	2.5%
138	Thymoma	2.5%
139	Sezary Syndrome	2.2%
140	Malignant histiocytosis	2.2%
141	Sarcoidosis, Pulmonary	2.2%
142	Histiocytic sarcoma	2.2%
143	Autoimmune Lymphoproliferative Syndrome	2%
144	Splenosis	1.6%
145	Hodgkin Disease	1.6%
146	Lymphoma, Non-Hodgkin	1.6%
147	Leukemia, T-Cell	1.6%
148	Leukemia, B-Cell	1.6%
149	Composite Lymphoma	1.3%
150	Lymphangioleiomyomatosis	1.3%
151	Lymphoma, Follicular	1.2%
152	T-Cell Lymphoma	1.2%
153	Mantle cell lymphoma	1.2%
154	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	1.2%
155	Leukemia, Large Granular Lymphocytic	1.2%
156	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	1.2%
157	Lymphoma, T-Cell, Cutaneous	1%
158	Lymphoma, AIDS-Related	1%
159	Enteropathy-Associated T-Cell Lymphoma	1%
160	Primary Effusion Lymphoma	1%
161	Mycosis Fungoides	0.9%
162	Lymphomatoid Papulosis	0.9%
163	Plasmablastic lymphoma	0.9%
164	Lymphomatoid Granulomatosis	0.8%
165	Burkitt Lymphoma	0.7%
166	Niemann-Pick Disease, Type C	0.4%

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