MetaADEDB 2.0 @ LMMD
Ascorbic Acid
(CIWBSHSKHKDKBQ-JLAZNSOCSA-N)
Structure
SMILES
OC[C@@H]([C@H]1OC(=O)C(=C1O)O)O
Type(s)
Approved; Nutraceutical
ATC code(s)
A11GA01; A11GB01; G01AD03; S01XA15
Molecular Formula:
C6H8O6
Molecular Weight:
176.124
Log P:
-1.4074
Hydrogen Bond Acceptor:
6
Hydrogen Bond Donor:
4
TPSA:
107.22
CAS Number(s):
50-81-7; 299-36-5; 6730-29-6; 53262-66-1; 89924-69-6; 178101-88-7
Synonym(s)
1.
Ascorbic Acid
2.
Vitamin C
3.
Ascorbic Acid, Monosodium Salt
4.
Ferrous Ascorbate
5.
Hybrin
6.
L-Ascorbic Acid
7.
Magnesium Ascorbate
8.
Magnesium Ascorbicum
9.
Magnesium di-L-Ascorbate
10.
Magnorbin
11.
Sodium Ascorbate
12.
Acid, Ascorbic
13.
Acid, L-Ascorbic
14.
Ascorbate, Ferrous
15.
Ascorbate, Magnesium
16.
Ascorbate, Sodium
17.
L Ascorbic Acid
18.
Magnesium di L Ascorbate
19.
di-L-Ascorbate, Magnesium
External Link(s)
MeSHD001205
PubChem Compound54670067
BindingDB50090256
ChEBI29073
CHEMBLCHEMBL40274
CHEMBL196
DrugBankDB00126
DrugCentral4072
IUPHAR/BPS Guide to PHARMACOLOGY4781
4532
KEGGcpd:C00072
dr:D00018
Therapeutic Target DatabaseD06NNE
D07AHW
D0U4HT
ZINC100006770
100019304
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Acute kidney injuryFAERS: 6
Canada Vigilance: 3		18714631
30606963		CTD
Canada Vigilance
US FAERS
2Crystal nephropathyFAERS: 5
Canada Vigilance: 2		Canada Vigilance
US FAERS
3VomitingFAERS: 3
Canada Vigilance: 1		Canada Vigilance
US FAERS
4ChillsFAERS: 2
Canada Vigilance: 1		Canada Vigilance
US FAERS
5PainFAERS: 2OFFSIDES
US FAERS
6Renal painFAERS: 2US FAERS
7Abdominal PainFAERS: 1
Canada Vigilance: 3		Canada Vigilance
OFFSIDES
US FAERS
8AlopeciaFAERS: 1OFFSIDES
US FAERS
9ArthrodesisFAERS: 1US FAERS
10Blood glucose false positiveFAERS: 1US FAERS
11Burkholderia test positiveFAERS: 1US FAERS
12Cerebrovascular accidentFAERS: 1US FAERS
13ChokingFAERS: 1US FAERS
14ChromaturiaFAERS: 1US FAERS
15Diabetes mellitus inadequate controlFAERS: 1US FAERS
16DizzinessFAERS: 1OFFSIDES
SIDER
US FAERS
17Dry skinFAERS: 1OFFSIDES
US FAERS
18Electrocardiogram T wave peakedFAERS: 1US FAERS
19FatigueFAERS: 117497326CTD
OFFSIDES
US FAERS
20General physical health deteriorationFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
21HyperoxalaemiaFAERS: 1US FAERS
22HyperoxaluriaFAERS: 154676
54776
18042297		CTD
US FAERS
23Intentional product misuseFAERS: 1US FAERS
24Intercepted product dispensing errorFAERS: 1US FAERS
25Irritable Bowel SyndromeFAERS: 1US FAERS
26NauseaFAERS: 1
Canada Vigilance: 4		17497326CTD
OFFSIDES
Canada Vigilance
US FAERS
27OliguriaFAERS: 1US FAERS
28Oropharyngeal painFAERS: 1US FAERS
29OverdoseFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
30OxalosisFAERS: 1US FAERS
31Pharmaceutical product complaintFAERS: 1US FAERS
32Poor quality sleepFAERS: 1OFFSIDES
US FAERS
33Post inflammatory pigmentation changeFAERS: 1US FAERS
34Product label issueFAERS: 1US FAERS
35Product quality issueFAERS: 1US FAERS
36PruritusFAERS: 1
Canada Vigilance: 2		Canada Vigilance
US FAERS
37Reaction to drug excipientsFAERS: 1US FAERS
38Renal tubular atrophyFAERS: 1US FAERS
39TachycardiaFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
40Toxicity to various agentsFAERS: 1US FAERS
41TrichorrhexisFAERS: 1US FAERS
42Urinary tract infectionFAERS: 1US FAERS
43Viral upper respiratory tract infectionFAERS: 1US FAERS
44Wrong technique in product usage processFAERS: 1US FAERS
45AbasiaOFFSIDES
46Abdominal discomfortCanada Vigilance: 2Canada Vigilance
OFFSIDES
47Accidental exposure to product by childCanada Vigilance: 1Canada Vigilance
48AcidosisOFFSIDES
49Acute Lung Injury15612528CTD
50AgeusiaOFFSIDES
51AlbuminuriaOFFSIDES
52Aldolase increasedOFFSIDES
53Amnesia7582819CTD
54Anemia, Megaloblastic16353713CTD
55Anemia17497326CTD
56AnhedoniaOFFSIDES
57AnorexiaOFFSIDES
58AnorgasmiaOFFSIDES
59Antinuclear antibody increasedOFFSIDES
60Antiphospholipid antibodies positiveOFFSIDES
61Antiviral drug level above therapeuticOFFSIDES
62Anxiety Disorders29572072CTD
63AnxietyCanada Vigilance: 1Canada Vigilance
64AphoniaOFFSIDES
65Aphthous StomatitisOFFSIDES
66Application site painOFFSIDES
67Arsenic Poisoning20028703CTD
68ArteriosclerosisOFFSIDES
69ArthritisOFFSIDES
70ArthropathyOFFSIDES
71Ascorbic Acid Deficiency19710200CTD
72Aspiration PneumoniaOFFSIDES
73AstheniaOFFSIDES
74AtelectasisOFFSIDES
75Atrial FlutterOFFSIDES
76Atrial tachycardiaOFFSIDES
77Atrioventricular BlockOFFSIDES
78AuraOFFSIDES
79Bacterial Infections12669766CTD
80Bacterial sepsisOFFSIDES
81Bladder discomfortCanada Vigilance: 1Canada Vigilance
82Blindness1341094CTD
83Blood GlucoseOFFSIDES
84Blood creatineOFFSIDES
85Blood glucose decreasedOFFSIDES
86Blood pressure inadequately controlledOFFSIDES
87Blood sodiumOFFSIDES
88Blood thyroid stimulating hormoneOFFSIDES
89Blood triglycerides increasedOFFSIDES
90Blurred visionOFFSIDES
91Body TemperatureOFFSIDES
92Bone Diseases21281732CTD
93Bone density decreasedOFFSIDES
94Bone erosionOFFSIDES
95Bone lesionOFFSIDES
96BotulismOFFSIDES
97Brain Diseases20305954CTD
98Brain Ischemia18044087CTD
99Burning sensationCanada Vigilance: 1Canada Vigilance
100Carcinoma16345077CTD
101Cardioactive drug level increasedOFFSIDES
102Cardiomyopathies1962586
10533957		CTD
103Cardiotoxicity23194016CTD
104Cardiovascular Abnormalities20068362CTD
105Cardiovascular Diseases15531665
19769483		CTD
106Cardiovascular insufficiencyOFFSIDES
107Carotid artery occlusionOFFSIDES
108Catalepsy3088632
3703914		CTD
109Cataract operationOFFSIDES
110Cataract8698541CTD
OFFSIDES
111Central Nervous System InfectionOFFSIDES
112Cerebral ventricle dilatationOFFSIDES
113Charcot-Marie-Tooth Disease15034573CTD
114Chemical and Drug Induced Liver Injury

View details

21791388
23220588
24295472
30606963
 		CTD
115Chest PainCanada Vigilance: 1Canada Vigilance
OFFSIDES
116Choking sensationOFFSIDES
117Chromosome Aberrations7678149
31369745		CTD
118Chromosome Breakage30597948CTD
119Chronic Fatigue SyndromeOFFSIDES
120Chronic Obstructive Airway DiseaseOFFSIDES
121Circumstance or information capable of leading to medication errorOFFSIDES
122Citrobacter infectionOFFSIDES
123Coagulation factor VIII level increasedOFFSIDES
124Cold sweatOFFSIDES
125Common Cold17323712CTD
126Complex Regional Pain Syndromes20224742CTD
127Complication of deliveryOFFSIDES
128Conjunctival depositOFFSIDES
129Dehydration17497326CTD
OFFSIDES
130Dental cariesOFFSIDES
131DermatitisCanada Vigilance: 1Canada Vigilance
132DermatomyositisOFFSIDES
133Device dislocationOFFSIDES
134Device malfunctionOFFSIDES
135DiabetesOFFSIDES
136Diabetic Retinopathy18779489CTD
137DiarrheaOFFSIDES
138Disease Progression23859036CTD
139Distal intestinal obstruction syndromeOFFSIDES
140Diverticular perforationOFFSIDES
141DiverticulitisOFFSIDES
142DiverticulumOFFSIDES
143DrowsinessOFFSIDES
144Drug Overdose18714631CTD
145DysgeusiaOFFSIDES
146DyspepsiaCanada Vigilance: 1Canada Vigilance
OFFSIDES
147DysphoniaOFFSIDES
148DysuriaOFFSIDES
149Eales disease9068938CTD
150Economic problemOFFSIDES
151Emotional distressOFFSIDES
152Endotoxemia24239723CTD
153EpistaxisCanada Vigilance: 1Canada Vigilance
154EructationCanada Vigilance: 1Canada Vigilance
155Erythema19800932CTD
OFFSIDES
156Escherichia urinary tract infectionOFFSIDES
157Esophageal StenosisOFFSIDES
158Exaggerated startle responseOFFSIDES
159ExcoriationOFFSIDES
160Eye BurnsOFFSIDES
161Eye painOFFSIDES
162Febrile NeutropeniaOFFSIDES
163Feeding tube complicationOFFSIDES
164Feeling ColdOFFSIDES
165FibromyalgiaOFFSIDES
166FlatulenceCanada Vigilance: 2Canada Vigilance
OFFSIDES
167Fluid overloadOFFSIDES
168GamblingOFFSIDES
169General symptomOFFSIDES
170Genital erosionOFFSIDES
171Gingival HypertrophyCanada Vigilance: 1Canada Vigilance
172Glioblastoma MultiformeOFFSIDES
173Glioma23859036CTD
174Glycosuria7909430CTD
175Grip strengthOFFSIDES
176Growth Disorders20068362CTD
177HIV Infections9764785CTD
178Hallucinations8767052CTD
179HeadacheCanada Vigilance: 3Canada Vigilance
180Hepatitis COFFSIDES
181Histamine level increasedOFFSIDES
182Hungry bone syndromeOFFSIDES
183Hyperalgesia30552955CTD
184Hyperinsulinism31005848CTD
185HyperkinesiaCanada Vigilance: 1Canada Vigilance
186HyperpigmentationOFFSIDES
187Hyperplasia6681793CTD
188HypersensitivityCanada Vigilance: 1Canada Vigilance
189HypophagiaOFFSIDES
190Hypotension3706053
15612528		CTD
191Hypothyroidism12587721CTD
192IMMUNE SUPPRESSION15020195CTD
193Idiosyncratic drug reactionOFFSIDES
194Immunologic Deficiency Syndromes27020608CTD
195Incorrect dose administeredOFFSIDES
196Increased upper airway secretionOFFSIDES
197InfectionCanada Vigilance: 1Canada Vigilance
198Inflammation23692848CTD
199Infusion site mobility decreasedOFFSIDES
200Insulin Resistance31005848CTD
201Intention tremorOFFSIDES
202Intestinal ObstructionOFFSIDES
203Intraocular inflammationOFFSIDES
204IntussusceptionOFFSIDES
205Joint Range of Motion DecreasedOFFSIDES
206Joint stiffnessOFFSIDES
207Keratitis siccaOFFSIDES
208Kidney Diseases

View details

7909430
17448119
18414974
18536492
19391111
22728154
 		CTD
209Lead Poisoning, Nervous System, Childhood22056337CTD
210Left Ventricular HypertrophyOFFSIDES
211Left atrial dilatationOFFSIDES
212Ligament ruptureOFFSIDES
213Lip erosionOFFSIDES
214Liver Cirrhosis22149461
24239723		CTD
215Liver Neoplasms, Experimental18544905CTD
216Lung Neoplasms16401635CTD
217Lung diseases16863852CTD
218Lung infection pseudomonalOFFSIDES
219LymphedemaOFFSIDES
220MalaiseCanada Vigilance: 1Canada Vigilance
221Malignant neoplasm progressionOFFSIDES
222Manganese Poisoning21940818CTD
223Mercury Poisoning18536492CTD
224Micronuclei, Chromosome-Defective7992229
17169990		CTD
225Middle insomniaOFFSIDES
226Multiple MyelomaOFFSIDES
227Muscle Cramp11427639CTD
228Muscle FatigueOFFSIDES
229Muscle WeaknessOFFSIDES
230Muscle tightnessCanada Vigilance: 1Canada Vigilance
231Musculoskeletal chest painOFFSIDES
232Myocardial Infarction

View details

16444596
16635105
19466570
19494560
 		CTD
233Nasal mucosal disorderOFFSIDES
234NasopharyngitisOFFSIDES
235Necrosis

View details

10533957
15223132
15577407
19482829
21645609
22728154
 		CTD
236Neoplasms, Experimental

View details

19197388
19224539
19671184
21878346
22139585
24126434
 		CTD
237Neoplasms8698541
20433922		CTD
238Nephritis, Interstitial18042297CTD
239Nephrogenic Fibrosing DermopathyOFFSIDES
240Nephrolithiasis18042297
18714631		CTD
241Nerve Degeneration17959157CTD
242Nervous tensionOFFSIDES
243Nodule on extremityOFFSIDES
244NoduleOFFSIDES
245Obesity17217161CTD
246Oligospermia

View details

8671712
19429265
20305954
29663635
30140404
 		CTD
247Oral infectionOFFSIDES
248Oral mucosal erythemaCanada Vigilance: 1Canada Vigilance
249Oral mucosal exfoliationOFFSIDES
250OsteolysisOFFSIDES
251OsteomyelitisOFFSIDES
252OsteopeniaOFFSIDES
253OsteoporosisOFFSIDES
254OsteoradionecrosisOFFSIDES
255Pain of skinOFFSIDES
256Pain, Postoperative5111643CTD
257Papilloma1752781
6500233		CTD
258Pathological Conditions, Anatomical30140404CTD
259PeriarthritisOFFSIDES
260PeriodontitisOFFSIDES
261Peripheral Nervous System Diseases30552955CTD
262Peripheral Vascular Diseases20174656CTD
263Peripheral swellingCanada Vigilance: 1Canada Vigilance
264Pharyngolaryngeal PainOFFSIDES
265PingueculaOFFSIDES
266Poisoning22245848CTD
267Polycystic Ovary Syndrome26545973CTD
268PolyuriaOFFSIDES
269Precancerous Conditions1752781CTD
270Prenatal Exposure Delayed Effects27020608CTD
271Product contaminationCanada Vigilance: 1Canada Vigilance
272Product formulation issueCanada Vigilance: 1Canada Vigilance
273Productive CoughOFFSIDES
274Prostatic Neoplasms16345077CTD
275Proteinuria7919151
20360751		CTD
276Pseudoxanthoma Elasticum17845175CTD
277PsoriasisOFFSIDES
278Psychomotor skills impairedOFFSIDES
279Psychoses, Substance-Induced8767052CTD
280Pulmonary Edema15612528CTD
281Pulmonary Eosinophilia14606601CTD
282Pulmonary Fibrosis18759078CTD
283Pulmonary HypertensionOFFSIDES
284Pulmonary congestionOFFSIDES
285Pulmonary toxicityOFFSIDES
286PyelonephritisOFFSIDES
287PyuriaOFFSIDES
288Rectal ProlapseOFFSIDES
289Renal Insufficiency18042297CTD
290Respiratory depth decreasedOFFSIDES
291Retinitis Pigmentosa16849425CTD
292RhinorrheaOFFSIDES
293SclerodactyliaOFFSIDES
294ScotomaOFFSIDES
295Scurvy4538611
8698541
24162740		CTD
296Seizures

View details

17543232
18096215
20602035
20716907
20801149
 		CTD
297Septic ShockOFFSIDES
298ShockSIDER
299SinusitisOFFSIDES
300Skin IndurationOFFSIDES
301Skin hypertrophyOFFSIDES
302Skin tightnessOFFSIDES
303Soft Tissue InfectionOFFSIDES
304SomnolenceCanada Vigilance: 1Canada Vigilance
305Spinal fusion surgeryOFFSIDES
306Splenic abscessOFFSIDES
307Sputum culture positiveOFFSIDES
308Status Epilepticus17512118
18096215		CTD
309Stevens-Johnson SyndromeOFFSIDES
310Stomach Neoplasms6680729CTD
311Subcutaneous EmphysemaOFFSIDES
312Substance Withdrawal Syndrome19418264CTD
313Sudden Cardiac DeathOFFSIDES
314Sudden deathOFFSIDES
315Swelling of eyelidCanada Vigilance: 1Canada Vigilance
316SyncopeSIDER
317SynovitisOFFSIDES
318Temperature regulation disorderOFFSIDES
319Temporal ArteritisOFFSIDES
320TendinitisOFFSIDES
321Testicular Diseases25637669
29940330		CTD
322Thrombocytopenia17497326CTD
323Thrombosis26139164CTD
324Tongue erythemaCanada Vigilance: 1Canada Vigilance
325Tooth LossOFFSIDES
326Traumatic fractureOFFSIDES
327Troponin I increasedOFFSIDES
328UrticariaCanada Vigilance: 1Canada Vigilance
329Vascular encephalopathyOFFSIDES
330Venous InsufficiencyOFFSIDES
331VertebroplastyOFFSIDES
332Visual disturbanceOFFSIDES
333Vulvovaginal burning sensationOFFSIDES
334effusionOFFSIDES
335furuncleOFFSIDES
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