MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Leukostasis

(UMLS:C0282548)

Definition:: Abnormal intravascular leukocyte aggregation and clumping often seen in leukemia patients. The brain and lungs are the two most commonly affected organs. This acute syndrome requires aggressive cytoreductive modalities including chemotherapy and/or leukophoresis. It is differentiated from LEUKEMIC INFILTRATION which is a neoplastic process where leukemic cells invade organs.
UMLS ID:: C0282548
MeSH ID:: D018921

Classification:

Name:

Hemic and Lymphatic Diseases
MeSH Tree Number(s):: C15.378.553.560

Synonym(s)

Leukostasis

Leukostasis syndrome

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Deferasirox	FAERS: 3		US FAERS
2	Lenalidomide	FAERS: 2		OFFSIDES US FAERS
3	Acyclovir	FAERS: 1		US FAERS
4	Arsenic Trioxide	FAERS: 1		US FAERS
5	Imatinib Mesylate	FAERS: 1		US FAERS
6	Imatinib Mesylate	FAERS: 1		US FAERS
7	Thalidomide	FAERS: 1		US FAERS
8	Acebutolol			OFFSIDES
9	Azacitidine			OFFSIDES
10	Bendamustine Hydrochloride			OFFSIDES
11	Cladribine			OFFSIDES
12	Cytarabine			OFFSIDES
13	Erythromycin			OFFSIDES
14	Etoposide			OFFSIDES
15	Hydroxyurea			OFFSIDES
16	Oxygen		28294475	CTD
17	Sodium Bicarbonate			OFFSIDES
18	Streptozocin		10485912	CTD
19	Temozolomide			OFFSIDES
20	Troglitazone		12468449	CTD
21	plerixafor octahydrochloride			SIDER
22	tanshinone II A sodium sulfonate		28294475	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Eosinophilia	46.7%
2	Leukopenia	46.7%
3	Agranulocytosis	34.4%
4	Lymphocytosis	34.4%
5	Hypereosinophilic syndrome	34.4%
6	Leukemoid Reaction	32.6%
7	Leukocytosis	31.8%
8	Pelger-Huet Anomaly	31.8%
9	Pleocytosis	31.8%
10	Anemia	31%
11	Blood Coagulation Disorders	31%
12	Blood Platelet Disorders	31%
13	Bone Marrow Diseases	31%
14	Hemorrhagic Disorders	31%
15	Methemoglobinemia	31%
16	Pancytopenia	31%
17	Polycythemia	31%
18	Sulfhemoglobinemia	31%
19	Thrombophilia	31%
20	Erythrocytosis	31%
21	Disseminated Intravascular Coagulation	30%
22	Protein S Deficiency	30%
23	Neutropenia	28.5%
24	Thrombocythemia, Essential	26.6%
25	Febrile Neutropenia	25.5%
26	Lymphopenia	23.6%
27	Thrombocytosis	23.1%
28	Job Syndrome	23.1%
29	Transfusion Reaction	22%
30	Hypotensive Transfusion Reaction	22%
31	Thrombasthenia	21.9%
32	Antithrombin III Deficiency	21.9%
33	Protein C Deficiency	21.9%
34	Infectious Mononucleosis	21.2%
35	Pregnancy Complications, Hematologic	20.9%
36	Hematologic Neoplasms	20.9%
37	Anemia, Hemolytic	20%
38	Anemia, Macrocytic	20%
39	Hypoproteinemia	20%
40	Thrombocytopenia	20%
41	Bone Marrow Neoplasms	20%
42	MYELODYSPLASTIC SYNDROME	20%
43	Vitamin K Deficiency	19.8%
44	Afibrinogenemia	19.7%
45	Factor VII Deficiency	19.7%
46	Factor X Deficiency	19.7%
47	Factor XII Deficiency	19.7%
48	Hemophilia A	19.7%
49	Activated Protein C Resistance	19.7%
50	Factor II deficiency	19.7%
51	Factor VIII Deficiency	19.7%
52	Factor V deficiency	19.7%
53	Factor XI Deficiency	19.7%
54	Hypoprothrombinemias	19.7%
55	Hemoglobinuria, Paroxysmal	19.6%
56	Pulmonary Eosinophilia	19.6%
57	Eosinophilic Pneumonia	19.6%
58	Lymphatic Diseases	18.5%
59	Wiskott-Aldrich Syndrome	18.1%
60	Eosinophilia-Myalgia Syndrome	17.6%
61	Polycythemia Vera	17.5%
62	Chronic granulomatous disease	17.4%
63	Anemia, Diamond-Blackfan	15.6%
64	Primary Myelofibrosis	14.8%
65	Anemia, Megaloblastic	14.8%
66	Myelofibrosis	14.8%
67	Myeloid Metaplasia	14.8%
68	Hypoalbuminemia	14.8%
69	bone marrow fibrosis	14.8%
70	Thrombotic Microangiopathies	14.8%
71	Purpura, Thrombotic Thrombocytopenic	14.1%
72	Anemia, Neonatal	13.6%
73	Paraproteinemias	13.6%
74	Agammaglobulinemia	13.6%
75	Eosinophilic Granuloma	13.3%
76	Anemia, Sickle Cell	12.9%
77	Thalassemia	12.9%
78	Cryoglobulinemia	11.8%
79	Monoclonal Gammopathy of Undetermined Significance	11.8%
80	Autoimmune thrombocytopenia	10.8%
81	Immune thrombocytopenic purpura	10.8%
82	Heavy Chain Disease	10.7%
83	Hemolytic-Uremic Syndrome	10.6%
84	Waldenstrom Macroglobulinemia	10.4%
85	Adenitis	10.3%
86	Histiocytosis	10.3%
87	Hypergammaglobulinemia	10.3%
88	Lymphadenitis	10.3%
89	Lymphangitis	10.3%
90	Lymphedema	10.3%
91	Splenic Diseases	10.3%
92	Thymus Hyperplasia	10.3%
93	Pseudolymphoma	10.3%
94	Lymphadenopathy	10.3%
95	Sickle Cell Trait	10.2%
96	Transfusion-Related Acute Lung Injury	10.1%
97	Ecchymosis	10%
98	Petechiae	10%
99	Purpura	10%
100	Fanconi Anemia	9.8%
101	Leukemia, Myelomonocytic, Chronic	9.8%
102	Purpura, Hyperglobulinemic	9.8%
103	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	9.8%
104	Thrombocytopenic purpura	9.2%
105	Atypical Hemolytic Uremic Syndrome	9.1%
106	Multiple Myeloma	8.5%
107	Leukemia, Myeloid, Chronic-Phase	8.1%
108	Hydrops Fetalis	8.1%
109	Anemia, Pernicious	8%
110	Acute Chest Syndrome	7.5%
111	Shwartzman Phenomenon	7.4%
112	Hemangioma, Cavernous	7.4%
113	Scurvy	7.3%
114	Purpura Fulminans	7.3%
115	Lymphocele	7%
116	Lymphoproliferative Disorders	7%
117	Lymphatic Abnormalities	7%
118	Thymus Neoplasms	6.8%
119	Waterhouse-Friderichsen Syndrome	6.8%
120	Elephantiasis	6.7%
121	Hypersplenism	6.7%
122	Lymphangiectasis, Intestinal	6.7%
123	Sarcoidosis	6.7%
124	Elephantiasis Nostras Verrucosa	6.7%
125	POEMS Syndrome	5.9%
126	Kernicterus	5.7%
127	Mucocutaneous Lymph Node Syndrome	5.1%
128	Lymphohistiocytosis, Hemophagocytic	4.9%
129	Erdheim-Chester Disease	4.9%
130	Granuloma	4.5%
131	Histiocytic Disorders, Malignant	4.5%
132	Splenic Infarction	4.5%
133	Splenic Neoplasms	4.5%
134	Histiocytosis, Langerhans-Cell	4.4%
135	Tumor Lysis Syndrome	4.4%
136	Pseudoxanthoma Elasticum	3.8%
137	Splenic Rupture	3.4%
138	Lymphoma	3.4%
139	Thymoma	3.3%
140	Sezary Syndrome	3.3%
141	Malignant histiocytosis	3.3%
142	Sarcoidosis, Pulmonary	3.3%
143	Histiocytic sarcoma	3.3%
144	Autoimmune Lymphoproliferative Syndrome	2.7%
145	Splenosis	2.5%
146	Hodgkin Disease	2.5%
147	Lymphoma, Non-Hodgkin	2.5%
148	Leukemia, T-Cell	2.4%
149	Leukemia, B-Cell	2.4%
150	Lymphoma, Follicular	2%
151	T-Cell Lymphoma	2%
152	Mantle cell lymphoma	2%
153	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	2%
154	Leukemia, Large Granular Lymphocytic	2%
155	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	2%
156	Composite Lymphoma	2%
157	Lymphangioleiomyomatosis	1.9%
158	Lymphoma, T-Cell, Cutaneous	1.8%
159	Lymphoma, AIDS-Related	1.8%
160	Enteropathy-Associated T-Cell Lymphoma	1.8%
161	Primary Effusion Lymphoma	1.8%
162	Mycosis Fungoides	1.7%
163	Lymphomatoid Papulosis	1.7%
164	Plasmablastic lymphoma	1.7%
165	Lymphomatoid Granulomatosis	1.5%
166	Burkitt Lymphoma	1.2%
167	Niemann-Pick Disease, Type C	0.7%

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