MetaADEDB 2.0 @ LMMD
Vitamin E
(GVJHHUAWPYXKBD-IEOSBIPESA-N)
Structure
SMILES
C[C@@H](CCC[C@]1(C)CCc2c(O1)c(C)c(c(c2C)O)C)CCC[C@@H](CCCC(C)C)C
Type(s)
Approved; Nutraceutical; Vet_approved
Molecular Formula:
C29H50O2
Molecular Weight:
430.706
Log P:
8.8402
Hydrogen Bond Acceptor:
2
Hydrogen Bond Donor:
1
TPSA:
29.46
CAS Number(s):
59-02-9; 1406-18-4; 2074-53-5; 10191-41-0; 18920-62-2; 21590
Synonym(s)
1.
Vitamin E
External Link(s)
MeSHD014810
PubChem Compound14985
ChEBI18145
CHEMBLCHEMBL47
DrugBankDB00163
DrugCentral4280
KEGGcpd:C02477
ZINC4095858
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Burning sensationFAERS: 1OFFSIDES
US FAERS
2ErythemaFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
3Lip swellingFAERS: 1US FAERS
4Medication ErrorFAERS: 1US FAERS
5AMYOTROPHIC LATERAL SCLEROSIS 18967745CTD
6Abdominal Pain16260695CTD
OFFSIDES
7Abdominal discomfortOFFSIDES
8Abdominal strangulated herniaOFFSIDES
9Acid refluxOFFSIDES
10Acne Vulgaris6455256CTD
11Acute kidney injury

View details

3353995
8891671
9763232
19766176
 		CTD
12Adenocarcinoma9200147CTD
OFFSIDES
13Alcohol consumptionOFFSIDES
14Anal discomfortOFFSIDES
15Androgenetic AlopeciaOFFSIDES
16Anemia, Hemolytic968551
5094252		CTD
17Anemia, Macrocytic4214104CTD
18Anemia, Sickle Cell15997260CTD
19Anemia1893952
7103234
12662204		CTD
20Angina Pectoris9822095
15562867		CTD
21AngioedemaOFFSIDES
22Anorexia946274CTD
23Anticonvulsant drug level below therapeuticOFFSIDES
24Anticonvulsant drug level increasedOFFSIDES
25Anxiety Disorders19472364CTD
26ApathyOFFSIDES
27Apparent life threatening eventOFFSIDES
28Arsenic Poisoning16217243CTD
29Arteriosclerosis10052017CTD
30ArthritisOFFSIDES
31ArthropathyOFFSIDES
32Arthropod biteOFFSIDES
33Artificial crown procedureOFFSIDES
34AstheniaCanada Vigilance: 116260695CTD
OFFSIDES
Canada Vigilance
35Asthenozoospermia15304303
25046308		CTD
36Ataxia with vitamin E deficiency9760855
10896705
15681888		CTD
37Ataxia3681102
10453775		CTD
38Atherosclerosis

View details

12675867
12680623
16303615
18435936
 		CTD
OFFSIDES
39Atrial FlutterOFFSIDES
40Atrophic vulvovaginitisOFFSIDES
41AuraOFFSIDES
42AutomatismOFFSIDES
43Benign Prostatic HyperplasiaOFFSIDES
44Bilirubin conjugated increasedOFFSIDES
45Biopsy breast abnormalOFFSIDES
46Bird Diseases11913585CTD
47BlepharopachynsisOFFSIDES
48Blood 1,25-dihydroxycholecalciferol decreasedOFFSIDES
49Blood cholesterol abnormalOFFSIDES
50Blood glucose abnormalOFFSIDES
51Blood iron decreasedOFFSIDES
52Blood triglycerides increasedOFFSIDES
53Blood uric acidOFFSIDES
54Blurred visionOFFSIDES
55Body Weight Changes23633841CTD
56Bone density decreasedOFFSIDES
57Bone erosionOFFSIDES
58Bone painOFFSIDES
59Brain ConcussionOFFSIDES
60Brain Diseases20305954
20490610		CTD
61Brain Infarction14512146CTD
62Brain Injuries14645467
19941068		CTD
63Brain Ischemia21051774CTD
64BronchitisOFFSIDES
65BronchopneumoniaOFFSIDES
66BursitisOFFSIDES
67Calcinosis3754046
6468435
11913585		CTD
68Carcinoma 256, Walker19781538CTD
69Cardiomegaly17447016
23523949		CTD
70Cardiovascular Abnormalities20068362CTD
71Cardiovascular Diseases19769483CTD
72Cataract operationOFFSIDES
73CataractOFFSIDES
74Catheter placementOFFSIDES
75CellulitisOFFSIDES
76Cerebellar Diseases9760855CTD
77Cerebral ArteriosclerosisOFFSIDES
78Cervicobrachial syndromeOFFSIDES
79Chemical and Drug Induced Liver Injury

View details

946274
3509882
6524888
9537283
12635103
17927767
20305954
20803752
21628957
21791388
30057697
 		CTD
80Chemotherapeutic drug level increasedOFFSIDES
81Chest PainOFFSIDES
82Choking sensationOFFSIDES
83ChokingOFFSIDES
84Cholestasis946274CTD
85Chromosome Breakage26332274CTD
86Chronic Obstructive Airway DiseaseOFFSIDES
87Chronic sinusitisOFFSIDES
88Clostridium colitisOFFSIDES
89Cognition Disorders19464315
21447382		CTD
90Cold sweatOFFSIDES
91Colorectal Neoplasms9359698CTD
92ConfabulationOFFSIDES
93Congenital heart diseaseOFFSIDES
94Craniofacial Abnormalities19769572CTD
95Cystitis15232716CTD
96CystoceleOFFSIDES
97DehydrationOFFSIDES
98DemyelinationOFFSIDES
99Dental cariesOFFSIDES
100DermatitisCanada Vigilance: 3Canada Vigilance
101DiabetesOFFSIDES
102Diabetes Mellitus, Experimental12736908CTD
103Diabetic Retinopathy18779489CTD
104DiarrheaOFFSIDES
105Diastolic dysfunctionOFFSIDES
106DiplopiaOFFSIDES
107Disease Progression23859036CTD
108Disease recurrenceOFFSIDES
109Distal intestinal obstruction syndromeOFFSIDES
110DiverticulosisOFFSIDES
111DizzinessCanada Vigilance: 2Canada Vigilance
OFFSIDES
112Drug Eruptions11792017CTD
113Drug administered at inappropriate siteOFFSIDES
114Drug administration errorOFFSIDES
115Drug withdrawal headacheOFFSIDES
116Dry skinOFFSIDES
117Dyslipidemias16487912CTD
118DysmorphismOFFSIDES
119DyspareuniaOFFSIDES
120DyspepsiaOFFSIDES
121DysphoniaOFFSIDES
122Eales disease9068938CTD
123EczemaCanada Vigilance: 1Canada Vigilance
OFFSIDES
124Embolic cerebral infarctionOFFSIDES
125Embolic strokeOFFSIDES
126Emotional distressOFFSIDES
127Endodontic procedureOFFSIDES
128Endometrial HyperplasiaOFFSIDES
129Endometrial hypertrophyOFFSIDES
130Eosinophilia11913585CTD
131Epileptic auraOFFSIDES
132EpistaxisOFFSIDES
133Erectile dysfunctionOFFSIDES
134Erosive gastritisOFFSIDES
135Esophageal Neoplasms22223226CTD
136Eustachian tube disorderOFFSIDES
137Exfoliative rashCanada Vigilance: 1Canada Vigilance
138Eye InfectionOFFSIDES
139Eye inflammationCanada Vigilance: 1Canada Vigilance
OFFSIDES
140Eyelid Diseases11018306CTD
141Facial NeuralgiaOFFSIDES
142Factor VIII DeficiencyOFFSIDES
143FatigueOFFSIDES
144Fatty Liver, Alcoholic4735055CTD
145Fatty Liver23348005CTD
146Feeling ColdOFFSIDES
147Feeling abnormalOFFSIDES
148Fetal Growth Retardation11018306CTD
149Fever16844102CTD
150FibromyalgiaOFFSIDES
151Fibrosis16260695CTD
152FlatulenceOFFSIDES
153Fluid overloadOFFSIDES
154Food PoisoningOFFSIDES
155FormicationOFFSIDES
156GamblingOFFSIDES
157Gastrointestinal Diseases9199886
30003487		CTD
158General symptomOFFSIDES
159Glioma23859036CTD
160Glomerulonephritis10353404CTD
161Growth Disorders20068362CTD
162HIV Infections9764785CTD
163HeadacheCanada Vigilance: 211841391
16260695		CTD
Canada Vigilance
164Heart Diseases16418954CTD
165Heart failure

View details

11292956
15806987
15962462
16645413
 		CTD
166Hemosiderosis4214104CTD
167Hepatitis C17420205CTD
OFFSIDES
168HiccoughOFFSIDES
169Histamine level increasedOFFSIDES
170Hyperplasia23633841CTD
171Hypersensitivity30626778CTD
172Hyperthyroidism19914224CTD
173Hypoglycemia17429802CTD
174Hypothyroidism12587721
19174171		CTD
175Hypoxia8552434CTD
176IMMUNE SUPPRESSION15020195CTD
177Iliac artery stenosisOFFSIDES
178Inappropriate affectOFFSIDES
179IncoherentOFFSIDES
180IncontinenceOFFSIDES
181InfectionOFFSIDES
182Infertility21843797CTD
183Inflammation18262176
20370442
23523949		CTD
184Infusion site mobility decreasedOFFSIDES
185Insulin Resistance23348005CTD
186Intention tremorOFFSIDES
187Intermittent ClaudicationOFFSIDES
188Intestinal FistulaOFFSIDES
189Intestinal ObstructionOFFSIDES
190Ischemia8891671CTD
191Joint sprainOFFSIDES
192Joint stiffnessOFFSIDES
193Kidney Calculi8112761CTD
194Kidney Diseases

View details

9530244
12488133
15669049
17448119
18502357
23347876
 		CTD
195Lesion excisionOFFSIDES
196Ligament ruptureOFFSIDES
197Limb discomfortOFFSIDES
198Lip exfoliationOFFSIDES
199Liver Cirrhosis, Experimental16169303CTD
200Liver diseases18377885
21787585		CTD
201Liver neoplasms7852184CTD
202Lower respiratory tract infection bacterialOFFSIDES
203Lower respiratory tract infection fungalOFFSIDES
204Lumbar radiculopathyOFFSIDES
205Lung Neoplasms11062179
11301052
16401635		CTD
206Lung diseases16863852CTD
207Lung hyperinflationOFFSIDES
208LymphomaOFFSIDES
209Melanosis16217243CTD
210Memory Disorders15364477CTD
211Micrognathism11018306CTD
212Middle insomniaOFFSIDES
213Monocyte percentage increasedOFFSIDES
214Movement Disorders10518183CTD
215Multiple MyelomaOFFSIDES
216Multiple allergiesOFFSIDES
217Muscle Cramp1457907
11427639		CTD
218Muscle FatigueOFFSIDES
219Muscle Weakness572510CTD
220Muscle necrosisOFFSIDES
221Muscular Atrophy572510CTD
222Musculoskeletal stiffnessOFFSIDES
223Myocardial Infarction

View details

9055097
15562867
16757080
17467089
19058010
19595682
20979156
 		CTD
224Myocardial Ischemia15562867CTD
225Myocarditis1926593
7256931
12924018		CTD
226NasopharyngitisOFFSIDES
227NauseaCanada Vigilance: 2946274
16260695		CTD
OFFSIDES
Canada Vigilance
228Necrosis

View details

3353995
7288501
9840616
11834455
11913585
12955582
17927767
19066852
23523949
25779342
 		CTD
229Neoplasm Metastasis19781538CTD
230Neoplasms, Experimental21869839CTD
231Neoplasms15962462CTD
232Nerve Degeneration1806894
15820619		CTD
233Nervous tensionOFFSIDES
234Neural Tube Defects11018306
12739027		CTD
235Neurotoxicity Syndromes16622646
20643751		CTD
236NoduleOFFSIDES
237Non-cardiac chest painOFFSIDES
238Occult blood positiveOFFSIDES
239Oligospermia

View details

15304303
20079796
20305954
25046308
27823922
28395332
29663635
 		CTD
240Ophthalmoplegia572510CTD
241Oral infectionOFFSIDES
242Oropharyngeal painOFFSIDES
243Osteogenesis ImperfectaOFFSIDES
244Osteolysis19781538CTD
OFFSIDES
245OsteoporosisOFFSIDES
246Ovarian Diseases23633841CTD
247Pain1566986CTD
OFFSIDES
248Pancreatic CystOFFSIDES
249Paresthesia10453775CTD
250Pericardial effusion30823661CTD
251Peripheral Nervous System Diseases

View details

572510
7814959
10453775
15642899
16622646
16939848
 		CTD
252Peripheral Vascular Diseases20174656CTD
253Peritoneal lesionOFFSIDES
254PetechiaeCanada Vigilance: 1Canada Vigilance
255Pharmaceutical product complaintOFFSIDES
256PhlebitisOFFSIDES
257Plantar erythemaOFFSIDES
258PneumothoraxOFFSIDES
259Poisoning16614824CTD
260Polycystic Ovary Syndrome26545973CTD
261Polymyalgia RheumaticaOFFSIDES
262PolyneuropathyOFFSIDES
263Poor quality drug administeredOFFSIDES
264Post procedural complicationOFFSIDES
265Pre-Eclampsia8584011CTD
266Precancerous Conditions9093712
9537283		CTD
267Procedural complicationOFFSIDES
268Prostatic Neoplasms15084515CTD
269Proteinuria

View details

7648424
7919151
9608545
14714169
19149925
20360751
 		CTD
270PruritusCanada Vigilance: 2Canada Vigilance
271Pseudoxanthoma Elasticum17845175CTD
272PsoriasisOFFSIDES
273Pulmonary Embolism15562867CTD
274Pulmonary Eosinophilia14606601CTD
275Pulmonary Fibrosis18759078CTD
276Pulmonary congestionOFFSIDES
277Pulmonary radiation injuryOFFSIDES
278Pulmonary toxicityOFFSIDES
279Purulent dischargeOFFSIDES
280Rectal ProlapseOFFSIDES
281Rectal polypOFFSIDES
282RectoceleOFFSIDES
283Reflex, Abnormal572510CTD
284Renal Insufficiency11700016
12736908		CTD
285Reperfusion Injury8891671
12910483
20609232		CTD
286Respiratory Hypersensitivity24333275CTD
287Reticulocytosis4214104CTD
288Retinal Hemorrhage3547300CTD
289Retinitis Pigmentosa16849425CTD
290Retinopathy of Prematurity3754046CTD
291RhinitisOFFSIDES
292RhinorrheaOFFSIDES
293Seizures17543232
20602035		CTD
294Sensory level abnormalOFFSIDES
295SequestrectomyOFFSIDES
296Short Bowel Syndrome3226394CTD
297SinusitisOFFSIDES
298SplenectomyOFFSIDES
299Splenomegaly4214104CTD
300SpondylolisthesisOFFSIDES
301Sputum culture positiveOFFSIDES
302StressOFFSIDES
303Tardive DyskinesiaOFFSIDES
304Temperature regulation disorderOFFSIDES
305Temporal ArteritisOFFSIDES
306Testicular Diseases27823922
29940330		CTD
307Thrombophlebitis74532
434574
15562867		CTD
308TinnitusOFFSIDES
309Tobacco Use Disorder9269585CTD
310Tobacco userOFFSIDES
311UlcerOFFSIDES
312Urinary Tract PainOFFSIDES
313Urine output increasedOFFSIDES
314Urticaria11792017CTD
315Uterine Diseases23633841CTD
316Uterine PolypOFFSIDES
317VIIth nerve paralysisOFFSIDES
318VertebroplastyOFFSIDES
319VertigoCanada Vigilance: 116260695CTD
Canada Vigilance
320Vision Disorders15753152CTD
321Visual ImpairmentCanada Vigilance: 1Canada Vigilance
322Visual disturbanceOFFSIDES
323Vitamin B 12 DeficiencyOFFSIDES
324Vitamin E Deficiency572510CTD
325VomitingCanada Vigilance: 1Canada Vigilance
326Vulvovaginal drynessOFFSIDES
327Weight Gain30057697CTD
OFFSIDES
328colonoscopyOFFSIDES
329effusionOFFSIDES
330jaundice946274
4214104		CTD
331muscle injuryOFFSIDES
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