MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Erdheim-Chester Disease

(UMLS:C0878675)

Definition:: A rare form of non-Langerhans-cell histiocytosis (HISTIOCYTOSIS, NON-LANGERHANS-CELL) with onset in middle age. The systemic disease is characterized by infiltration of lipid-laden macrophages, multinucleated giant cells, an inflammatory infiltrate of lymphocytes and histiocytes in the bone marrow, and a generalized sclerosis of the long bones.
UMLS ID:: C0878675
MeSH ID:: D031249

Classification:

Name:

Hemic and Lymphatic Diseases
MeSH Tree Number(s):: C15.604.250.410.224

Synonym(s)

Erdheim-Chester Disease

Erdheim-Chester disease

Erdheim-Chester syndrome

Lipid granulomatosis

Lipogranulomatosis

Polyostotic Sclerosing Histiocytosis

Polyostotic sclerosing histiocytosis

chester disease erdheim

erdheim chester disease

10.

erdheim-chester disease

11.

lipogranulomatosis

12.

polyostotic sclerosing histiocytosis

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Dexamethasone	FAERS: 1	US FAERS
2	Fingolimod Hydrochloride	FAERS: 1	US FAERS
3	Warfarin	FAERS: 1	US FAERS

Similar ADE(s)

	Name	Semantic Similarity
1	Lymphohistiocytosis, Hemophagocytic	48.4%
2	Adenitis	25.4%
3	Lymphadenitis	25.4%
4	Lymphangitis	25.4%
5	Lymphedema	25.4%
6	Splenic Diseases	25.4%
7	Thymus Hyperplasia	25.4%
8	Pseudolymphoma	25.4%
9	Lymphadenopathy	25.4%
10	Histiocytic Disorders, Malignant	23.6%
11	Histiocytosis, Langerhans-Cell	23.1%
12	Lymphocele	17.2%
13	Lymphoproliferative Disorders	17.2%
14	Lymphatic Abnormalities	17.2%
15	Thymus Neoplasms	16.9%
16	Malignant histiocytosis	15.2%
17	Histiocytic sarcoma	15.2%
18	Lymphangiectasis, Intestinal	14.9%
19	Elephantiasis	14.8%
20	Hypersplenism	14.8%
21	Sarcoidosis	14.8%
22	Elephantiasis Nostras Verrucosa	14.8%
23	Mucocutaneous Lymph Node Syndrome	12.6%
24	Granuloma	10.1%
25	Splenic Infarction	10.1%
26	Splenic Neoplasms	10.1%
27	Agammaglobulinemia	10.1%
28	Tumor Lysis Syndrome	9.9%
29	Heavy Chain Disease	9%
30	Eosinophilic Granuloma	8.8%
31	Anemia	8.5%
32	Blood Coagulation Disorders	8.5%
33	Blood Platelet Disorders	8.5%
34	Bone Marrow Diseases	8.5%
35	Hemorrhagic Disorders	8.5%
36	Leukocyte Disorders	8.5%
37	Methemoglobinemia	8.5%
38	Pancytopenia	8.5%
39	Polycythemia	8.5%
40	Sulfhemoglobinemia	8.5%
41	Thrombophilia	8.5%
42	Erythrocytosis	8.5%
43	Infectious Mononucleosis	7.9%
44	Splenic Rupture	7.7%
45	Lymphoma	7.6%
46	Disseminated Intravascular Coagulation	7.4%
47	Protein S Deficiency	7.4%
48	Thymoma	7.4%
49	Sezary Syndrome	6.6%
50	Sarcoidosis, Pulmonary	6.5%
51	Niemann-Pick Disease, Type C	6.4%
52	Thrombocythemia, Essential	6.2%
53	Autoimmune Lymphoproliferative Syndrome	6.1%
54	Waldenstrom Macroglobulinemia	6.1%
55	Transfusion Reaction	6%
56	Hypotensive Transfusion Reaction	6%
57	Pregnancy Complications, Hematologic	5.7%
58	Hematologic Neoplasms	5.7%
59	Thrombocytosis	5.4%
60	Thrombasthenia	5.3%
61	Antithrombin III Deficiency	5.3%
62	Protein C Deficiency	5.3%
63	Bone Marrow Neoplasms	5%
64	Anemia, Hemolytic	4.9%
65	Anemia, Macrocytic	4.9%
66	Eosinophilia	4.9%
67	Hypoproteinemia	4.9%
68	Leukopenia	4.9%
69	Thrombocytopenia	4.9%
70	Splenosis	4.9%
71	Leukostasis	4.9%
72	MYELODYSPLASTIC SYNDROME	4.9%
73	Vitamin K Deficiency	4.9%
74	Hodgkin Disease	4.9%
75	Lymphoma, Non-Hodgkin	4.9%
76	Leukemia, T-Cell	4.8%
77	Leukemia, B-Cell	4.8%
78	Afibrinogenemia	4.6%
79	Factor VII Deficiency	4.6%
80	Factor X Deficiency	4.6%
81	Factor XII Deficiency	4.6%
82	Hemophilia A	4.6%
83	Activated Protein C Resistance	4.6%
84	Factor II deficiency	4.6%
85	Factor VIII Deficiency	4.6%
86	Factor V deficiency	4.6%
87	Factor XI Deficiency	4.6%
88	Hypoprothrombinemias	4.6%
89	Hemoglobinuria, Paroxysmal	4.3%
90	Leukemoid Reaction	4.3%
91	Composite Lymphoma	3.9%
92	Polycythemia Vera	3.9%
93	Lymphangioleiomyomatosis	3.9%
94	Lymphoma, Follicular	3.6%
95	T-Cell Lymphoma	3.6%
96	Mantle cell lymphoma	3.6%
97	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	3.6%
98	Leukemia, Large Granular Lymphocytic	3.6%
99	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	3.6%
100	Anemia, Neonatal	3.4%
101	Leukocytosis	3.4%
102	Paraproteinemias	3.4%
103	Pelger-Huet Anomaly	3.4%
104	Pleocytosis	3.4%
105	Primary Myelofibrosis	3.2%
106	Agranulocytosis	3.2%
107	Anemia, Megaloblastic	3.2%
108	Lymphocytosis	3.2%
109	Myelofibrosis	3.2%
110	Myeloid Metaplasia	3.2%
111	Hypoalbuminemia	3.2%
112	Anemia, Diamond-Blackfan	3.2%
113	Hypereosinophilic syndrome	3.2%
114	bone marrow fibrosis	3.2%
115	Thrombotic Microangiopathies	3.2%
116	Purpura, Thrombotic Thrombocytopenic	3.1%
117	Wiskott-Aldrich Syndrome	3%
118	Lymphoma, T-Cell, Cutaneous	3%
119	Lymphoma, AIDS-Related	3%
120	Enteropathy-Associated T-Cell Lymphoma	3%
121	Primary Effusion Lymphoma	3%
122	Anemia, Sickle Cell	3%
123	Thalassemia	3%
124	Mycosis Fungoides	2.7%
125	Lymphomatoid Papulosis	2.7%
126	Plasmablastic lymphoma	2.7%
127	Cryoglobulinemia	2.6%
128	Monoclonal Gammopathy of Undetermined Significance	2.6%
129	Hypergammaglobulinemia	2.6%
130	Transfusion-Related Acute Lung Injury	2.5%
131	Ecchymosis	2.5%
132	Petechiae	2.5%
133	Purpura	2.5%
134	Lymphomatoid Granulomatosis	2.4%
135	Neutropenia	2.4%
136	Autoimmune thrombocytopenia	2.4%
137	Immune thrombocytopenic purpura	2.4%
138	Hemolytic-Uremic Syndrome	2.2%
139	Lymphopenia	2.2%
140	Job Syndrome	2.2%
141	Purpura, Hyperglobulinemic	2.2%
142	Leukemia, Myelomonocytic, Chronic	2.2%
143	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	2.2%
144	Sickle Cell Trait	2.1%
145	Burkitt Lymphoma	2%
146	Febrile Neutropenia	2%
147	Thrombocytopenic purpura	1.9%
148	Fanconi Anemia	1.9%
149	Multiple Myeloma	1.9%
150	Hydrops Fetalis	1.9%
151	Atypical Hemolytic Uremic Syndrome	1.7%
152	Eosinophilia-Myalgia Syndrome	1.7%
153	Pulmonary Eosinophilia	1.7%
154	Eosinophilic Pneumonia	1.7%
155	Chronic granulomatous disease	1.6%
156	Shwartzman Phenomenon	1.6%
157	Hemangioma, Cavernous	1.6%
158	Scurvy	1.6%
159	Purpura Fulminans	1.6%
160	Waterhouse-Friderichsen Syndrome	1.6%
161	Leukemia, Myeloid, Chronic-Phase	1.6%
162	Anemia, Pernicious	1.6%
163	Acute Chest Syndrome	1.5%
164	Kernicterus	1.4%
165	POEMS Syndrome	1.3%
166	Pseudoxanthoma Elasticum	0.8%

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120238