MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Thymus Hyperplasia

(UMLS:C0040115)

Definition:: Enlargement of the thymus. A condition described in the late 1940's and 1950's as pathological thymic hypertrophy was status thymolymphaticus and was treated with radiotherapy. Unnecessary removal of the thymus was also practiced. It later became apparent that the thymus undergoes normal physiological hypertrophy, reaching a maximum at puberty and involuting thereafter. The concept of status thymolymphaticus has been abandoned. Thymus hyperplasia is present in two thirds of all patients with myasthenia gravis. (From Segen, Dictionary of Modern Medicine, 1992; Cecil Textbook of Medicine, 19th ed, p1486)
UMLS ID:: C0040115
MeSH ID:: D013952

Classification:

Name:

Hemic and Lymphatic Diseases
MeSH Tree Number(s):: C15.604.816

Synonym(s)

Thymus Hyperplasia

Enlarged thymus

Thymic hyperplasia

Thymus hyperplasia

hyperplasia thymus

hyperplasia; thymus

thymus hyperplasia

thymus; hyperplasia

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Arsenicals	27289040	CTD
2	Cytarabine	11860447	CTD
3	Daunorubicin	11860447	CTD
4	Penicillamine	930944 6535556 7282112	CTD
5	Phenytoin	9046861	CTD
6	titanium dioxide	28646487	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Adenitis	42.9%
2	Histiocytosis	42.9%
3	Lymphadenitis	42.9%
4	Lymphangitis	42.9%
5	Lymphedema	42.9%
6	Splenic Diseases	42.9%
7	Pseudolymphoma	42.9%
8	Lymphadenopathy	42.9%
9	Elephantiasis	31%
10	Hypersplenism	31%
11	Sarcoidosis	31%
12	Elephantiasis Nostras Verrucosa	31%
13	Lymphangiectasis, Intestinal	30.5%
14	Lymphocele	28.6%
15	Lymphoproliferative Disorders	28.6%
16	Lymphatic Abnormalities	28.6%
17	Thymus Neoplasms	27.9%
18	Lymphohistiocytosis, Hemophagocytic	25.4%
19	Erdheim-Chester Disease	25.4%
20	Granuloma	20.9%
21	Histiocytic Disorders, Malignant	20.9%
22	Splenic Infarction	20.9%
23	Splenic Neoplasms	20.9%
24	Agammaglobulinemia	20.7%
25	Mucocutaneous Lymph Node Syndrome	20.7%
26	Histiocytosis, Langerhans-Cell	20.5%
27	Tumor Lysis Syndrome	20.5%
28	Heavy Chain Disease	19.3%
29	Malignant histiocytosis	16.9%
30	Sarcoidosis, Pulmonary	16.9%
31	Histiocytic sarcoma	16.9%
32	Sezary Syndrome	16.6%
33	Infectious Mononucleosis	16.1%
34	Splenic Rupture	15.8%
35	Lymphoma	15.5%
36	Disseminated Intravascular Coagulation	15.3%
37	Protein S Deficiency	15.3%
38	Thymoma	15.1%
39	Anemia	14.3%
40	Blood Coagulation Disorders	14.3%
41	Blood Platelet Disorders	14.3%
42	Bone Marrow Diseases	14.3%
43	Hemorrhagic Disorders	14.3%
44	Leukocyte Disorders	14.3%
45	Methemoglobinemia	14.3%
46	Pancytopenia	14.3%
47	Polycythemia	14.3%
48	Sulfhemoglobinemia	14.3%
49	Thrombocythemia, Essential	14.3%
50	Thrombophilia	14.3%
51	Erythrocytosis	14.3%
52	Waldenstrom Macroglobulinemia	13.3%
53	Splenosis	12.6%
54	Hodgkin Disease	12.5%
55	Lymphoma, Non-Hodgkin	12.5%
56	Autoimmune Lymphoproliferative Syndrome	12.5%
57	Leukemia, T-Cell	12.4%
58	Leukemia, B-Cell	12.4%
59	Thrombocytosis	12.4%
60	Thrombasthenia	11.4%
61	Antithrombin III Deficiency	11.4%
62	Protein C Deficiency	11.4%
63	Eosinophilic Granuloma	11.2%
64	Hemoglobinuria, Paroxysmal	11.1%
65	Leukemoid Reaction	11.1%
66	Lymphoma, Follicular	11.1%
67	T-Cell Lymphoma	11.1%
68	Mantle cell lymphoma	11.1%
69	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	11%
70	Leukemia, Large Granular Lymphocytic	11%
71	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	11%
72	Afibrinogenemia	10.7%
73	Factor VII Deficiency	10.7%
74	Factor X Deficiency	10.7%
75	Factor XII Deficiency	10.7%
76	Hemophilia A	10.7%
77	Activated Protein C Resistance	10.7%
78	Factor II deficiency	10.7%
79	Factor VIII Deficiency	10.7%
80	Factor V deficiency	10.7%
81	Factor XI Deficiency	10.7%
82	Hypoprothrombinemias	10.7%
83	Lymphoma, T-Cell, Cutaneous	10.4%
84	Lymphoma, AIDS-Related	10.4%
85	Enteropathy-Associated T-Cell Lymphoma	10.4%
86	Primary Effusion Lymphoma	10.4%
87	Anemia, Hemolytic	10.3%
88	Anemia, Macrocytic	10.3%
89	Eosinophilia	10.3%
90	Hypoproteinemia	10.3%
91	Leukopenia	10.3%
92	Thrombocytopenia	10.3%
93	Leukostasis	10.3%
94	MYELODYSPLASTIC SYNDROME	10.3%
95	Bone Marrow Neoplasms	10.2%
96	Vitamin K Deficiency	10%
97	Mycosis Fungoides	10%
98	Lymphomatoid Papulosis	10%
99	Plasmablastic lymphoma	10%
100	Transfusion Reaction	10%
101	Composite Lymphoma	10%
102	Hypotensive Transfusion Reaction	10%
103	Polycythemia Vera	9.9%
104	Lymphangioleiomyomatosis	9.9%
105	Pregnancy Complications, Hematologic	9.5%
106	Hematologic Neoplasms	9.5%
107	Anemia, Diamond-Blackfan	9.2%
108	Primary Myelofibrosis	8.5%
109	Agranulocytosis	8.5%
110	Anemia, Megaloblastic	8.5%
111	Lymphocytosis	8.5%
112	Myelofibrosis	8.5%
113	Myeloid Metaplasia	8.5%
114	Hypoalbuminemia	8.5%
115	Hypereosinophilic syndrome	8.5%
116	bone marrow fibrosis	8.5%
117	Thrombotic Microangiopathies	8.5%
118	Lymphomatoid Granulomatosis	8.4%
119	Purpura, Thrombotic Thrombocytopenic	8%
120	Neutropenia	7.6%
121	Wiskott-Aldrich Syndrome	7.4%
122	Febrile Neutropenia	7.1%
123	Anemia, Sickle Cell	7%
124	Thalassemia	7%
125	Anemia, Neonatal	7%
126	Leukocytosis	7%
127	Paraproteinemias	7%
128	Pelger-Huet Anomaly	7%
129	Pleocytosis	7%
130	Burkitt Lymphoma	6.9%
131	Cryoglobulinemia	6.7%
132	Monoclonal Gammopathy of Undetermined Significance	6.7%
133	Hemolytic-Uremic Syndrome	6.2%
134	Autoimmune thrombocytopenia	6.1%
135	Immune thrombocytopenic purpura	6.1%
136	Sickle Cell Trait	6.1%
137	Fanconi Anemia	6%
138	Lymphopenia	5.7%
139	Atypical Hemolytic Uremic Syndrome	5.7%
140	Job Syndrome	5.6%
141	Leukemia, Myelomonocytic, Chronic	5.6%
142	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	5.6%
143	Purpura, Hyperglobulinemic	5.5%
144	Thrombocytopenic purpura	5.4%
145	Hypergammaglobulinemia	5.3%
146	Pulmonary Eosinophilia	5.1%
147	Eosinophilic Pneumonia	5.1%
148	Transfusion-Related Acute Lung Injury	5.1%
149	Ecchymosis	5.1%
150	Petechiae	5.1%
151	Purpura	5.1%
152	Leukemia, Myeloid, Chronic-Phase	4.9%
153	Anemia, Pernicious	4.9%
154	Multiple Myeloma	4.8%
155	Acute Chest Syndrome	4.4%
156	Hydrops Fetalis	4.4%
157	Eosinophilia-Myalgia Syndrome	4.3%
158	Chronic granulomatous disease	4.2%
159	Shwartzman Phenomenon	4.2%
160	Hemangioma, Cavernous	4.2%
161	Scurvy	4.1%
162	Purpura Fulminans	4.1%
163	Niemann-Pick Disease, Type C	3.9%
164	Waterhouse-Friderichsen Syndrome	3.6%
165	POEMS Syndrome	3.3%
166	Kernicterus	2.9%
167	Pseudoxanthoma Elasticum	2.1%

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