MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Hemoglobinuria, Paroxysmal

(UMLS:C0019050)

Definition:: A condition characterized by the recurrence of HEMOGLOBINURIA caused by intravascular HEMOLYSIS. In cases occurring upon cold exposure (paroxysmal cold hemoglobinuria), usually after infections, there is a circulating antibody which is also a cold hemolysin. In cases occurring during or after sleep (paroxysmal nocturnal hemoglobinuria), the clonal hematopoietic stem cells exhibit a global deficiency of cell membrane proteins.
UMLS ID:: C0019050
MeSH ID:: D006457

Classification:

Name:

Hemic and Lymphatic Diseases
MeSH Tree Number(s):: C15.378.071.141.560|C15.378.190.625.460

Synonym(s)

Hemoglobinuria, Paroxysmal

Paroxysmal hemoglobinuria

hemoglobinuria; paroxysmal

paroxysmal haemoglobinuria

paroxysmal hemoglobinuria

paroxysmal; hemoglobinuria

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Chloramphenicol	16212156	CTD
2	Cyclosporine	15720958	CTD
3	Danazol	2133530	CTD
4	Oxymetholone	48615	CTD
5	Prednisone	48615	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Disseminated Intravascular Coagulation	35.5%
2	Protein S Deficiency	35.5%
3	Thrombocythemia, Essential	34.1%
4	Blood Coagulation Disorders	33.3%
5	Blood Platelet Disorders	33.3%
6	Hemorrhagic Disorders	33.3%
7	Leukocyte Disorders	33.3%
8	Methemoglobinemia	33.3%
9	Pancytopenia	33.3%
10	Polycythemia	33.3%
11	Sulfhemoglobinemia	33.3%
12	Thrombophilia	33.3%
13	Erythrocytosis	33.3%
14	Anemia, Macrocytic	32.6%
15	Bone Marrow Neoplasms	31.6%
16	Thrombocytosis	30.9%
17	Polycythemia Vera	28%
18	Anemia, Diamond-Blackfan	26.9%
19	Transfusion Reaction	26.3%
20	Hypotensive Transfusion Reaction	26.3%
21	Thrombasthenia	26.2%
22	Antithrombin III Deficiency	26.2%
23	Protein C Deficiency	26.2%
24	Leukemoid Reaction	25.8%
25	Pregnancy Complications, Hematologic	25.4%
26	Hematologic Neoplasms	25.4%
27	Anemia, Neonatal	25%
28	Anemia, Sickle Cell	24.5%
29	Thalassemia	24.5%
30	Hemolytic-Uremic Syndrome	24.1%
31	Vitamin K Deficiency	23.5%
32	Afibrinogenemia	22.8%
33	Factor VII Deficiency	22.8%
34	Factor X Deficiency	22.8%
35	Factor XII Deficiency	22.8%
36	Hemophilia A	22.8%
37	Activated Protein C Resistance	22.8%
38	Factor II deficiency	22.8%
39	Factor VIII Deficiency	22.8%
40	Factor V deficiency	22.8%
41	Factor XI Deficiency	22.8%
42	Hypoprothrombinemias	22.8%
43	Primary Myelofibrosis	21.5%
44	Anemia, Megaloblastic	21.5%
45	Myelofibrosis	21.5%
46	Myeloid Metaplasia	21.5%
47	bone marrow fibrosis	21.5%
48	Lymphatic Diseases	20.9%
49	Eosinophilia	19.6%
50	Hypoproteinemia	19.6%
51	Leukopenia	19.6%
52	Thrombocytopenia	19.6%
53	Leukostasis	19.6%
54	Sickle Cell Trait	18.5%
55	Atypical Hemolytic Uremic Syndrome	18.3%
56	Anemia	16.7%
57	Bone Marrow Diseases	16.7%
58	Fanconi Anemia	16.2%
59	Leukemia, Myelomonocytic, Chronic	16.1%
60	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	16.1%
61	Agammaglobulinemia	16%
62	Wiskott-Aldrich Syndrome	16%
63	Purpura, Thrombotic Thrombocytopenic	15.8%
64	Leukocytosis	15%
65	Paraproteinemias	15%
66	Pelger-Huet Anomaly	15%
67	Pleocytosis	15%
68	Acute Chest Syndrome	14.2%
69	Infectious Mononucleosis	13.1%
70	Cryoglobulinemia	13%
71	Monoclonal Gammopathy of Undetermined Significance	13%
72	Agranulocytosis	12.9%
73	Lymphocytosis	12.9%
74	Hypoalbuminemia	12.9%
75	Hypereosinophilic syndrome	12.9%
76	Thrombotic Microangiopathies	12.9%
77	Autoimmune thrombocytopenia	12.6%
78	Immune thrombocytopenic purpura	12.6%
79	Waldenstrom Macroglobulinemia	12.3%
80	Hypergammaglobulinemia	12.2%
81	Leukemia, Myeloid, Chronic-Phase	12%
82	Anemia, Pernicious	12%
83	Transfusion-Related Acute Lung Injury	11.9%
84	Ecchymosis	11.8%
85	Petechiae	11.8%
86	Purpura	11.8%
87	Heavy Chain Disease	11.8%
88	Adenitis	11.1%
89	Histiocytosis	11.1%
90	Lymphadenitis	11.1%
91	Lymphangitis	11.1%
92	Lymphedema	11.1%
93	Purpura, Hyperglobulinemic	11.1%
94	Splenic Diseases	11.1%
95	Thymus Hyperplasia	11.1%
96	Pseudolymphoma	11.1%
97	Lymphadenopathy	11.1%
98	Thrombocytopenic purpura	10%
99	Lymphopenia	9.9%
100	Hydrops Fetalis	9.9%
101	Multiple Myeloma	9.8%
102	Anemia, Hemolytic	9.8%
103	MYELODYSPLASTIC SYNDROME	9.8%
104	Job Syndrome	9.8%
105	Hemoglobinuria, Paroxysmal	9.7%
106	Neutropenia	9.6%
107	Waterhouse-Friderichsen Syndrome	8.8%
108	Lymphocele	8.5%
109	Lymphoproliferative Disorders	8.5%
110	Lymphatic Abnormalities	8.5%
111	Thymus Neoplasms	8.3%
112	Febrile Neutropenia	8%
113	Eosinophilia-Myalgia Syndrome	7.9%
114	Lymphangiectasis, Intestinal	7.9%
115	Chronic granulomatous disease	7.8%
116	Shwartzman Phenomenon	7.8%
117	Hemangioma, Cavernous	7.8%
118	Scurvy	7.8%
119	Purpura Fulminans	7.7%
120	Eosinophilic Granuloma	7.5%
121	Kernicterus	7.5%
122	Pulmonary Eosinophilia	7.4%
123	Eosinophilic Pneumonia	7.4%
124	Mucocutaneous Lymph Node Syndrome	6.7%
125	Elephantiasis	6.5%
126	Hypersplenism	6.5%
127	Sarcoidosis	6.5%
128	POEMS Syndrome	6.5%
129	Elephantiasis Nostras Verrucosa	6.5%
130	Granuloma	5%
131	Histiocytic Disorders, Malignant	5%
132	Splenic Infarction	5%
133	Splenic Neoplasms	5%
134	Histiocytosis, Langerhans-Cell	4.9%
135	Tumor Lysis Syndrome	4.9%
136	Pseudoxanthoma Elasticum	4.4%
137	Lymphohistiocytosis, Hemophagocytic	4.3%
138	Erdheim-Chester Disease	4.3%
139	Splenic Rupture	4.1%
140	Lymphoma	4%
141	Thymoma	3.9%
142	Sezary Syndrome	3.8%
143	Autoimmune Lymphoproliferative Syndrome	3.4%
144	Malignant histiocytosis	3.3%
145	Sarcoidosis, Pulmonary	3.3%
146	Histiocytic sarcoma	3.3%
147	Splenosis	2.6%
148	Hodgkin Disease	2.6%
149	Lymphoma, Non-Hodgkin	2.6%
150	Leukemia, T-Cell	2.6%
151	Leukemia, B-Cell	2.6%
152	Composite Lymphoma	2.2%
153	Lymphangioleiomyomatosis	2.2%
154	Lymphoma, Follicular	1.9%
155	T-Cell Lymphoma	1.9%
156	Mantle cell lymphoma	1.9%
157	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	1.9%
158	Leukemia, Large Granular Lymphocytic	1.9%
159	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	1.9%
160	Lymphoma, T-Cell, Cutaneous	1.6%
161	Lymphoma, AIDS-Related	1.6%
162	Enteropathy-Associated T-Cell Lymphoma	1.6%
163	Primary Effusion Lymphoma	1.6%
164	Mycosis Fungoides	1.4%
165	Lymphomatoid Papulosis	1.4%
166	Plasmablastic lymphoma	1.4%
167	Lymphomatoid Granulomatosis	1.4%
168	Burkitt Lymphoma	1.1%
169	Niemann-Pick Disease, Type C	0.8%

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