MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Paraproteinemias

(UMLS:C0030489)

Definition:: A group of related diseases characterized by an unbalanced or disproportionate proliferation of immunoglobulin-producing cells, usually from a single clone. These cells frequently secrete a structurally homogeneous immunoglobulin (M-component) and/or an abnormal immunoglobulin.
UMLS ID:: C0030489
MeSH ID:: D010265

Classification 1:

Name:

Hemic and Lymphatic Diseases
MeSH Tree Number(s):: C15.378.147.780

Classification 2:

Name:

Immune System Diseases
MeSH Tree Number(s):: C20.683.780

Synonym(s)

Paraproteinemias

Monoclonal hypergammaglobulinemia

Paraproteinaemia

Paraproteinemia

paraproteinaemia

paraproteinemia

paraproteinemias

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Clozapine	17224722	CTD
2	Dexamethasone	18452093	CTD
3	Lenalidomide	18452093	CTD
4	Octreotide	9803143	CTD
5	Penicillamine	5645186	CTD
6	Phenytoin	2511368	CTD
7	Sulfasalazine	12235076	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Hypergammaglobulinemia	36.1%
2	Protein S Deficiency	35.1%
3	Hypoproteinemia	31.8%
4	Agammaglobulinemia	27.4%
5	Antithrombin III Deficiency	27.4%
6	Protein C Deficiency	27.4%
7	Transfusion Reaction	27.3%
8	Hypotensive Transfusion Reaction	27.3%
9	Lymphoproliferative Disorders	26.3%
10	Disseminated Intravascular Coagulation	24.3%
11	Hypoalbuminemia	23.6%
12	Thrombocythemia, Essential	22.4%
13	Monoclonal Gammopathy of Undetermined Significance	21.7%
14	Anemia	20.9%
15	Blood Coagulation Disorders	20.9%
16	Blood Platelet Disorders	20.9%
17	Bone Marrow Diseases	20.9%
18	Hemorrhagic Disorders	20.9%
19	Leukocyte Disorders	20.9%
20	Methemoglobinemia	20.9%
21	Pancytopenia	20.9%
22	Polycythemia	20.9%
23	Sulfhemoglobinemia	20.9%
24	Thrombophilia	20.9%
25	Erythrocytosis	20.9%
26	Infectious Mononucleosis	19%
27	Tumor Lysis Syndrome	18.6%
28	Thrombasthenia	18.4%
29	Thrombocytosis	17.6%
30	Autoimmune Lymphoproliferative Syndrome	17.2%
31	Sezary Syndrome	17.1%
32	Afibrinogenemia	16.7%
33	Factor VII Deficiency	16.7%
34	Factor X Deficiency	16.7%
35	Factor XII Deficiency	16.7%
36	Hemophilia A	16.7%
37	Activated Protein C Resistance	16.7%
38	Factor II deficiency	16.7%
39	Factor VIII Deficiency	16.7%
40	Factor V deficiency	16.7%
41	Factor XI Deficiency	16.7%
42	Hypoprothrombinemias	16.7%
43	Bone Marrow Neoplasms	16.2%
44	Vitamin K Deficiency	16.1%
45	Pregnancy Complications, Hematologic	15.8%
46	Hematologic Neoplasms	15.8%
47	Autoimmune thrombocytopenia	15.6%
48	Immune thrombocytopenic purpura	15.6%
49	Plasmacytoma	15.3%
50	Lymphoma	15.1%
51	Hemoglobinuria, Paroxysmal	15%
52	Leukemoid Reaction	15%
53	Polycythemia Vera	14.8%
54	Autoimmune Diseases	14.6%
55	Hypersensitivity	14.6%
56	Immunologic Deficiency Syndromes	14.6%
57	Immune reconstitution syndrome	14.6%
58	Immune Reconstitution Inflammatory Syndrome	14.6%
59	Lymphopenia	14.5%
60	Wiskott-Aldrich Syndrome	14.3%
61	Thrombocytopenic purpura	13.8%
62	Anemia, Hemolytic	13.6%
63	Anemia, Macrocytic	13.6%
64	Eosinophilia	13.6%
65	Leukopenia	13.6%
66	Thrombocytopenia	13.6%
67	Leukostasis	13.6%
68	MYELODYSPLASTIC SYNDROME	13.6%
69	Transfusion-Related Acute Lung Injury	13.6%
70	Anemia, Diamond-Blackfan	13.2%
71	Job Syndrome	12.6%
72	Purpura, Thrombotic Thrombocytopenic	12.3%
73	Lymphatic Diseases	12.2%
74	Hodgkin Disease	12%
75	Lymphoma, Non-Hodgkin	12%
76	Leukemia, T-Cell	11.9%
77	Leukemia, B-Cell	11.9%
78	Multiple Myeloma	11.3%
79	Anemia, Sickle Cell	10.9%
80	Thalassemia	10.9%
81	Lymphoma, Follicular	10.5%
82	T-Cell Lymphoma	10.5%
83	Mantle cell lymphoma	10.5%
84	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	10.5%
85	Leukemia, Large Granular Lymphocytic	10.5%
86	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	10.5%
87	Anemia, Neonatal	10.3%
88	Leukocytosis	10.3%
89	Pelger-Huet Anomaly	10.3%
90	Pleocytosis	10.3%
91	Hydrops Fetalis	10.2%
92	Primary Myelofibrosis	10.1%
93	Agranulocytosis	10.1%
94	Anemia, Megaloblastic	10.1%
95	Lymphocytosis	10.1%
96	Myelofibrosis	10.1%
97	Myeloid Metaplasia	10.1%
98	Hypereosinophilic syndrome	10.1%
99	bone marrow fibrosis	10.1%
100	Thrombotic Microangiopathies	10.1%
101	Chronic granulomatous disease	10.1%
102	Primary amyloidosis	10.1%
103	Leukemia, Plasma Cell	10%
104	Composite Lymphoma	10%
105	Lymphangioleiomyomatosis	9.9%
106	Lymphoma, T-Cell, Cutaneous	9.8%
107	Lymphoma, AIDS-Related	9.8%
108	Enteropathy-Associated T-Cell Lymphoma	9.8%
109	Primary Effusion Lymphoma	9.8%
110	Mycosis Fungoides	9.4%
111	Lymphomatoid Papulosis	9.4%
112	Plasmablastic lymphoma	9.4%
113	Immune Complex Diseases	9.3%
114	Antiphospholipid Syndrome	9.3%
115	Latex allergy	9.3%
116	Hemolytic-Uremic Syndrome	9%
117	Sickle Cell Trait	8.6%
118	Purpura, Hyperglobulinemic	8.5%
119	Kernicterus	8.4%
120	Neutropenia	8.4%
121	Fanconi Anemia	8.3%
122	Lymphomatoid Granulomatosis	8.3%
123	Glomerulonephritis, Membranoproliferative	8.3%
124	Ecchymosis	8.1%
125	Petechiae	8.1%
126	Purpura	8.1%
127	Atypical Hemolytic Uremic Syndrome	7.7%
128	Febrile Neutropenia	7.5%
129	Leukemia, Myelomonocytic, Chronic	7.5%
130	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	7.5%
131	Environmental Illness	7.3%
132	Lupus Erythematosus, Systemic	7%
133	Overlap syndrome	7%
134	Burkitt Lymphoma	7%
135	Adenitis	7%
136	Histiocytosis	7%
137	Lymphadenitis	7%
138	Lymphangitis	7%
139	Lymphedema	7%
140	Splenic Diseases	7%
141	Thymus Hyperplasia	7%
142	Pseudolymphoma	7%
143	Lymphadenopathy	7%
144	Addison Disease	6.9%
145	Pemphigus	6.9%
146	Autoimmune thyroiditis	6.9%
147	Primary Adrenal Insufficiency	6.9%
148	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	6.8%
149	Autoimmune hepatitis	6.8%
150	anaphylaxis	6.8%
151	Food Allergy	6.8%
152	Anaphylactic shock	6.8%
153	Acute Chest Syndrome	6.6%
154	Pulmonary Eosinophilia	6.4%
155	Eosinophilic Pneumonia	6.4%
156	Waterhouse-Friderichsen Syndrome	6.2%
157	Leukemia, Myeloid, Chronic-Phase	6.2%
158	Anemia, Pernicious	6.2%
159	Eosinophilia-Myalgia Syndrome	6.1%
160	Serum Sickness	6.1%
161	Shwartzman Phenomenon	6%
162	Hemangioma, Cavernous	6%
163	Scurvy	6%
164	Purpura Fulminans	6%
165	Asthma, Aspirin-Induced	5.8%
166	Eosinophilic Granuloma	5.7%
167	Milk Allergy	5.6%
168	Wheat Hypersensitivity	5.6%
169	Latent Autoimmune Diabetes in Adults	5.5%
170	Dermatitis Herpetiformis	5.5%
171	Kounis Syndrome	5.5%
172	HIV Infections	5.4%
173	Waldenstrom Macroglobulinemia	5.4%
174	Lymphangiectasis, Intestinal	5.4%
175	Respiratory Hypersensitivity	5.4%
176	Lymphocele	5.3%
177	Lymphatic Abnormalities	5.3%
178	Sick Building Syndrome	5.2%
179	Multiple Chemical Sensitivity	5.2%
180	Thymus Neoplasms	5.2%
181	Urticaria	5.1%
182	Vasculitis, Leukocytoclastic, Cutaneous	5.1%
183	HTLV-I Infections	5%
184	Cryoglobulinemia	5%
185	Rheumatoid Arthritis	4.6%
186	Juvenile arthritis	4.6%
187	Elephantiasis	4.5%
188	Graves Disease	4.5%
189	Hypersplenism	4.5%
190	Sarcoidosis	4.5%
191	Elephantiasis Nostras Verrucosa	4.5%
192	Anti-Glomerular Basement Membrane Disease	4.5%
193	Mastocytosis, Systemic	4.1%
194	Myasthenia Gravis, Autoimmune, Experimental	4.1%
195	Mucocutaneous Lymph Node Syndrome	4.1%
196	Myasthenia Gravis	4.1%
197	Uveomeningoencephalitic Syndrome	4.1%
198	Mastocytosis	4.1%
199	Drug Eruptions	4.1%
200	Granulomatosis with polyangiitis	4%
201	Dermatitis, Allergic Contact	4%
202	HIV Seropositivity	4%
203	Granuloma	3.4%
204	Histiocytic Disorders, Malignant	3.4%
205	Splenic Infarction	3.4%
206	Splenic Neoplasms	3.4%
207	Stiff-Person Syndrome	3.4%
208	Polyradiculoneuropathy	3.4%
209	Polyradiculoneuritis	3.4%
210	Histiocytosis, Langerhans-Cell	3.4%
211	Angioedema	3.4%
212	Lymphohistiocytosis, Hemophagocytic	3.4%
213	Pseudoxanthoma Elasticum	3.4%
214	Erdheim-Chester Disease	3.4%
215	Acquired Immunodeficiency Syndrome	3.4%
216	AIDS related complex	3.4%
217	Multiple Sclerosis	3.4%
218	Felty Syndrome	3.3%
219	Acute Generalized Exanthematous Pustulosis	3.3%
220	Lupus Nephritis	3.3%
221	Neuromyelitis Optica	3.1%
222	Leukoencephalitis, Acute Hemorrhagic	3.1%
223	Ataxia Telangiectasia	3%
224	Asthma, Exercise-Induced	3%
225	Status Asthmaticus	3%
226	Multiple Sclerosis, Chronic Progressive	3%
227	Multiple Sclerosis, Relapsing-Remitting	3%
228	AIDS-Related Opportunistic Infections	2.9%
229	Vasculitis, Central Nervous System	2.9%
230	Dermatitis, Atopic	2.9%
231	Asthma	2.9%
232	HIV Wasting Syndrome	2.9%
233	Rheumatoid Vasculitis	2.8%
234	AIDS Dementia Complex	2.8%
235	AIDS-Associated Nephropathy	2.8%
236	Hereditary Angioedema Type III	2.8%
237	Hereditary Angioedema Types I and II	2.8%
238	Splenic Rupture	2.8%
239	Encephalomyelitis, Acute Disseminated	2.8%
240	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	2.8%
241	Lupus Vasculitis, Central Nervous System	2.8%
242	Erythema Nodosum	2.8%
243	Neuritis, Autoimmune, Experimental	2.8%
244	Dermatitis, Photoallergic	2.7%
245	Heavy Chain Disease	2.7%
246	Thymoma	2.7%
247	Asthma, Occupational	2.6%
248	Lambert-Eaton Myasthenic Syndrome	2.5%
249	Farmer's Lung	2.5%
250	Malignant histiocytosis	2.5%
251	Sarcoidosis, Pulmonary	2.5%
252	Histiocytic sarcoma	2.5%
253	Angioedemas, Hereditary	2.5%
254	Sicca Syndrome	2.5%
255	Sjogren's Syndrome	2.5%
256	Hay fever	2.5%
257	Rhinitis, Allergic, Perennial	2.5%
258	HIV-Associated Lipodystrophy Syndrome	2.5%
259	Aspergillosis, Allergic Bronchopulmonary	2.4%
260	Guillain-Barre Syndrome	2.4%
261	Toxic Epidermal Necrolysis	2.1%
262	Stevens-Johnson Syndrome	2.1%
263	Splenosis	2%
264	Giant Cell Arteritis	1.8%
265	Temporal Arteritis	1.8%
266	Myelitis, Transverse	1.7%
267	Miller Fisher Syndrome	1.5%
268	Niemann-Pick Disease, Type C	0.7%

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