MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Methemoglobinemia

(UMLS:C0025637)

Definition:: The presence of methemoglobin in the blood, resulting in cyanosis. A small amount of methemoglobin is present in the blood normally, but injury or toxic agents convert a larger proportion of hemoglobin into methemoglobin, which does not function reversibly as an oxygen carrier. Methemoglobinemia may be due to a defect in the enzyme NADH methemoglobin reductase (an autosomal recessive trait) or to an abnormality in hemoglobin M (an autosomal dominant trait). (Dorland, 27th ed)
UMLS ID:: C0025637
MeSH ID:: D008708

Classification:

Name:

Hemic and Lymphatic Diseases
MeSH Tree Number(s):: C15.378.619

Synonym(s)

Methemoglobinemia

Increased methemoglobin

METHAEMOGLOBINAEMIA

METHEMOGLOBINEMIA

Methaemoglobinaemia

Methaemoglobinaemia, unspecified

Methemoglobin concentration increased above normal

Methemoglobinemia, NOS

Methemoglobinemia, unspecified

Associated Drug(s)

	Name	Reference(s)	Data Source
1	3,4-dichloroaniline	4714336	CTD
2	3,4-dichlorophenylhydroxylamine	2315934	CTD
3	4-biphenylamine	12030840	CTD
4	4-chloronitrobenzene	3710033	CTD
5	4-dichlorobenzene	19369838	CTD
6	4-nitroaniline	3710033	CTD
7	Acetaminophen	7585440	CTD
8	Benzocaine	View details 2933656 3537620 9779022 17122537 17612444 20565405	CTD
9	Chloroquine	3537620	CTD
10	Cimetidine	7888363 12030789	CTD
11	Dapsone	View details 454569 952745 4151976 6703568 7171199 7888363 8757424 11710542 11878540 12030789 16212642 16639690 18602405 19998329	CTD
12	Dichlorvos	1308751	CTD
13	Famotidine	12030789	CTD
14	Glutathione	1308751	CTD
15	Lidocaine, Prilocaine Drug Combination	16967588 17341877	CTD
16	Lidoderm	3537620 17612444	CTD
17	Methylene Blue	7075467 17122537 17612444	CTD
18	N-hydroxyphenetidine	1949026	CTD
19	Nitrates	7075467	CTD
20	Nitric Oxide	8179406	CTD
21	Nitrites	7075467	CTD
22	Nitroglycerin	3537620	CTD
23	Perphenazine	6859031	CTD
24	Phenazopyridine	View details 1879765 2922627 7075467 16897003	CTD
25	Phenetidine	1949026	CTD
26	Prednisone	6703568	CTD
27	Prilocaine	3537620 5313657	CTD
28	Primaquine	3537620 8757424 11303037	CTD
29	Propanil	2237922 2315934 4714336	CTD
30	Ranitidine	12030789	CTD
31	Saridon	View details 1949026 3537620 4834387 16296465	CTD
32	Sulfasalazine	4151648	CTD
33	Thalidomide	2985516	CTD
34	Zidovudine	11710542	CTD
35	aniline	7075467	CTD
36	dimethyl-4-toluidine	27638505	CTD
37	malachite green	18363129	CTD
38	nitrobenzene	8050629	CTD
39	phenylhydroxylamine	27638505	CTD
40	sodium chlorate	28084674	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Disseminated Intravascular Coagulation	45.8%
2	Protein S Deficiency	45.8%
3	Anemia	42.9%
4	Blood Coagulation Disorders	42.9%
5	Blood Platelet Disorders	42.9%
6	Bone Marrow Diseases	42.9%
7	Hemorrhagic Disorders	42.9%
8	Leukocyte Disorders	42.9%
9	Pancytopenia	42.9%
10	Polycythemia	42.9%
11	Sulfhemoglobinemia	42.9%
12	Thrombocythemia, Essential	42.9%
13	Thrombophilia	42.9%
14	Erythrocytosis	42.9%
15	Thrombocytosis	37.1%
16	Thrombasthenia	34.2%
17	Antithrombin III Deficiency	34.2%
18	Protein C Deficiency	34.2%
19	Hemoglobinuria, Paroxysmal	33.3%
20	Leukemoid Reaction	33.3%
21	Afibrinogenemia	32%
22	Factor VII Deficiency	32%
23	Factor X Deficiency	32%
24	Factor XII Deficiency	32%
25	Hemophilia A	32%
26	Activated Protein C Resistance	32%
27	Factor II deficiency	32%
28	Factor VIII Deficiency	32%
29	Factor V deficiency	32%
30	Factor XI Deficiency	32%
31	Hypoprothrombinemias	32%
32	Anemia, Hemolytic	31%
33	Anemia, Macrocytic	31%
34	Eosinophilia	31%
35	Hypoproteinemia	31%
36	Leukopenia	31%
37	Thrombocytopenia	31%
38	Leukostasis	31%
39	MYELODYSPLASTIC SYNDROME	31%
40	Bone Marrow Neoplasms	30.5%
41	Vitamin K Deficiency	30.1%
42	Transfusion Reaction	30%
43	Hypotensive Transfusion Reaction	30%
44	Polycythemia Vera	29.6%
45	Pregnancy Complications, Hematologic	28.6%
46	Hematologic Neoplasms	28.6%
47	Anemia, Diamond-Blackfan	27.6%
48	Primary Myelofibrosis	25.4%
49	Agranulocytosis	25.4%
50	Anemia, Megaloblastic	25.4%
51	Lymphocytosis	25.4%
52	Myelofibrosis	25.4%
53	Myeloid Metaplasia	25.4%
54	Hypoalbuminemia	25.4%
55	Hypereosinophilic syndrome	25.4%
56	bone marrow fibrosis	25.4%
57	Thrombotic Microangiopathies	25.4%
58	Purpura, Thrombotic Thrombocytopenic	24%
59	Lymphatic Diseases	23.1%
60	Neutropenia	22.7%
61	Wiskott-Aldrich Syndrome	22.1%
62	Febrile Neutropenia	21.3%
63	Anemia, Sickle Cell	21.1%
64	Thalassemia	21.1%
65	Anemia, Neonatal	20.9%
66	Leukocytosis	20.9%
67	Paraproteinemias	20.9%
68	Pelger-Huet Anomaly	20.9%
69	Pleocytosis	20.9%
70	Agammaglobulinemia	20.7%
71	Cryoglobulinemia	20%
72	Monoclonal Gammopathy of Undetermined Significance	20%
73	Hemolytic-Uremic Syndrome	18.6%
74	Autoimmune thrombocytopenia	18.4%
75	Immune thrombocytopenic purpura	18.4%
76	Sickle Cell Trait	18.2%
77	Fanconi Anemia	17.9%
78	Heavy Chain Disease	17.6%
79	Lymphopenia	17.2%
80	Waldenstrom Macroglobulinemia	17.1%
81	Atypical Hemolytic Uremic Syndrome	17%
82	Job Syndrome	16.9%
83	Leukemia, Myelomonocytic, Chronic	16.7%
84	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	16.7%
85	Purpura, Hyperglobulinemic	16.5%
86	Thrombocytopenic purpura	16.1%
87	Infectious Mononucleosis	16.1%
88	Hypergammaglobulinemia	15.8%
89	Pulmonary Eosinophilia	15.4%
90	Eosinophilic Pneumonia	15.4%
91	Transfusion-Related Acute Lung Injury	15.4%
92	Ecchymosis	15.3%
93	Petechiae	15.3%
94	Purpura	15.3%
95	Leukemia, Myeloid, Chronic-Phase	14.8%
96	Anemia, Pernicious	14.8%
97	Adenitis	14.3%
98	Histiocytosis	14.3%
99	Lymphadenitis	14.3%
100	Lymphangitis	14.3%
101	Lymphedema	14.3%
102	Multiple Myeloma	14.3%
103	Splenic Diseases	14.3%
104	Thymus Hyperplasia	14.3%
105	Pseudolymphoma	14.3%
106	Lymphadenopathy	14.3%
107	Acute Chest Syndrome	13.3%
108	Hydrops Fetalis	13.1%
109	Eosinophilia-Myalgia Syndrome	12.8%
110	Chronic granulomatous disease	12.6%
111	Shwartzman Phenomenon	12.6%
112	Hemangioma, Cavernous	12.5%
113	Scurvy	12.4%
114	Purpura Fulminans	12.4%
115	Eosinophilic Granuloma	11.2%
116	Waterhouse-Friderichsen Syndrome	10.7%
117	Elephantiasis	10.3%
118	Hypersplenism	10.3%
119	Sarcoidosis	10.3%
120	Elephantiasis Nostras Verrucosa	10.3%
121	Lymphangiectasis, Intestinal	10.2%
122	POEMS Syndrome	10%
123	Lymphocele	9.5%
124	Lymphoproliferative Disorders	9.5%
125	Lymphatic Abnormalities	9.5%
126	Thymus Neoplasms	9.3%
127	Kernicterus	8.7%
128	Lymphohistiocytosis, Hemophagocytic	8.5%
129	Erdheim-Chester Disease	8.5%
130	Granuloma	7%
131	Histiocytic Disorders, Malignant	7%
132	Splenic Infarction	7%
133	Splenic Neoplasms	7%
134	Mucocutaneous Lymph Node Syndrome	6.9%
135	Histiocytosis, Langerhans-Cell	6.8%
136	Tumor Lysis Syndrome	6.8%
137	Pseudoxanthoma Elasticum	6.3%
138	Malignant histiocytosis	5.6%
139	Sarcoidosis, Pulmonary	5.6%
140	Histiocytic sarcoma	5.6%
141	Sezary Syndrome	5.5%
142	Splenic Rupture	5.3%
143	Lymphoma	5.2%
144	Thymoma	5%
145	Splenosis	4.2%
146	Hodgkin Disease	4.2%
147	Lymphoma, Non-Hodgkin	4.2%
148	Autoimmune Lymphoproliferative Syndrome	4.2%
149	Leukemia, T-Cell	4.1%
150	Leukemia, B-Cell	4.1%
151	Lymphoma, Follicular	3.7%
152	T-Cell Lymphoma	3.7%
153	Mantle cell lymphoma	3.7%
154	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	3.7%
155	Leukemia, Large Granular Lymphocytic	3.7%
156	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	3.7%
157	Lymphoma, T-Cell, Cutaneous	3.5%
158	Lymphoma, AIDS-Related	3.5%
159	Enteropathy-Associated T-Cell Lymphoma	3.5%
160	Primary Effusion Lymphoma	3.5%
161	Mycosis Fungoides	3.3%
162	Lymphomatoid Papulosis	3.3%
163	Plasmablastic lymphoma	3.3%
164	Composite Lymphoma	3.3%
165	Lymphangioleiomyomatosis	3.3%
166	Lymphomatoid Granulomatosis	2.8%
167	Burkitt Lymphoma	2.3%
168	Niemann-Pick Disease, Type C	1.3%

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